Articles tagged with Breast Cancer
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A new study explores women's knowledge and perceptions of breast density and breast cancer screening across three states with varying notification laws. Women from all states had varying knowledge about their own breast density and breast density in general, and expressed a strong desire for more information.
Researchers at Penn Medicine used MRI scans to characterize tumor heterogeneity and predict 10-year breast cancer recurrence. High tumor heterogeneity was found to be a strong predictor of recurrence in patients with primary invasive breast cancer.
A new study led by Christine B. Ambrosone found that breast cancer patients taking antioxidants during chemotherapy had a 41% increased risk of disease recurrence and a similar but weaker risk of death. Patients using vitamin B12, iron, and omega-3 fatty acid supplements also showed poorer outcomes.
A phase 2 clinical trial has demonstrated an effective alternative to mastectomy for breast cancer patients experiencing recurrence after initial lumpectomy and whole-breast radiation. The treatment involved a second lumpectomy followed by partial breast reirradiation, resulting in long-term cancer control and low toxic side effects.
Researchers have identified a genetic signature associated with the degree of pathological angiogenesis in breast cancer tumors. The study combined gene expression profiles from public databases with analysis of retinopathy models to uncover key genes involved in pathological angiogenesis, providing a new tool for breast cancer treatment.
A national survey of women found that DBNs are not achieving their desired effects in reducing breast cancer awareness and screening. The study revealed greater anxiety and confusion among black women with higher incomes, while white women with higher incomes had more knowledge about breast density.
A new AI model developed by researchers can predict which women are at future risk of breast cancer with higher accuracy than existing models. The deep neural network-based approach has a lower false negative rate, indicating that it can identify women who would benefit from additional screening with MRI.
A large new study finds that sustained weight loss is associated with lower breast cancer risk in women over 50. Women who lost weight after age 50 and kept it off had a 13-26% lower risk of breast cancer compared to those whose weight remained stable.
A large US population-based analysis found that breast cancer survivors face significant non-cancer-related deaths, including heart diseases and Alzheimer's. Most deaths occurred within 10 years of diagnosis, with patients at higher risk for chronic liver disease and other conditions compared to the general population.
A retrospective study found that women with government insurance had lower survival rates, increased risk of dying, and were more likely to stop treatment early in breast cancer clinical trials. The study also did not find a significant association between neighborhood socioeconomic status and trial outcomes.
Researchers found that residual cancer burden index and classification are accurate and reliable tools to assess patient prognosis. The results suggest that continuous RCB index can predict risk of breast cancer recurrence across all four breast cancer subtypes.
Researchers found that women who used ibuprofen or naproxen had a 40% reduced breast cancer risk, while aspirin use offered no benefit. Young women with HER2-positive breast cancer may preserve fertility by choosing less intensive chemotherapy regimens.
A team of researchers from IU School of Medicine has discovered a way to predict the recurrence of triple negative breast cancer in women. They found that patients without circulating tumor DNA in their plasma had an 81% chance of being cancer-free after two years, compared to 56% for those with detectable levels.
The American College of Medical Genetics and Genomics recommends evaluating all breast cancer patients for hereditary predisposition. However, they caution that there is insufficient evidence to support genetic testing for BRCA1/2 or multi-gene panels in all breast cancer patients.
A recent NRG Oncology study found that breast-conserving treatment without surgery is not feasible based on the study's criteria. The study showed a negative predictive value of 77.5% for tumor bed biopsies, which falls short of the required threshold to support omitting surgery.
Breast cancer incidence rates are significantly higher in black men than white men, particularly for hormone receptor-positive subtypes. These racial differences have significant implications for patient outcomes and may be linked to genetic and non-genetic factors.
The NRG Oncology/NSABP B-42 trial found that extending letrozole therapy for five additional years improved disease-free survival in postmenopausal women with HR+ breast cancer. The study showed a 26% decrease in the risk of breast-cancer-free interval events and a 29% reduction in distant recurrence rates.
Researchers at Baylor College of Medicine classified over 500 cancers into 10 subtypes based on protein analysis, revealing novel molecular pathways and potential new players in cancer. Four subtypes were found to be linked to the tumor microenvironment, while three others were associated with previously unknown cellular components.
Researchers at Dartmouth's Norris Cotton Cancer Center found that breast cancer cells can take up large quantities of fat from the bloodstream through a novel mechanism called endocytosis of lipoproteins. This uptake provides a reliable source of energy for cancer cell proliferation.
Recent study suggests a modest association between radioiodine treatment for hyperthyroidism and increased risk of solid cancer, including breast cancer. The Society for Endocrinology and British Thyroid Association advise caution in interpreting the findings and highlight the need for further research.
The American College of Medical Genetics and Genomics recommends evaluating breast cancer patients for genetic testing based on existing clinical criteria. Genetic testing should include full gene sequencing and be conducted in a lab certified by the College of American Pathologists or Clinical Laboratory Improvement Amendments.
The IBIS-II study confirms anastrozole offers long term protection for women at high risk of developing breast cancer, with a 49% reduction in breast cancer incidence 12 years after stopping treatment. This is significantly higher than the 28% decrease in breast cancer recorded for women who take tamoxifen.
A phase III clinical trial shows tucatinib significantly improves survival rates in women with HER2+ breast cancer, especially those with brain metastases. The study found nearly tripled one-year progression-free survival and doubled two-year overall survivor compared to standard treatment.
Hyperactive FOXA1 signaling triggers genome-wide reprogramming in endocrine-resistant breast cancer cells, leading to enhanced resistance to treatment and metastatic behaviors. An inhibitor of HIF-2a reduces migration and invasion of these cells, providing a potential therapeutic strategy.
The trial showed that adding tucatinib to capecitabine and trastuzumab improved progression-free and overall survival in advanced HER2-positive breast cancer patients, regardless of whether they had brain metastasis. The treatment combination also increased the overall response rate compared to standard care.
Researchers at Hollings Cancer Center discovered that combining a polo-like kinase 1 inhibitor with a standard chemotherapeutic agent reduced TNBC tumor volume four times more effectively than the agent alone. The combination also reduces cancer stem cells, associated with metastasis.
A Japanese study of 63,232 patients with cancer and controls found a linear association between alcohol consumption and increased cancer risk. Those who drank two or fewer drinks per day had an elevated cancer risk regardless of how long they had consumed alcohol.
Researchers at The Mount Sinai Hospital have discovered a potential therapy, MS1943, that selectively degrades EZH2 protein in cancer cells. Effective against triple-negative breast cancer, it reduces EZH2 levels and kills cancer cells.
The University of Arizona Cancer Center has been awarded $6.85 million to continue its efforts in cancer research, training, and outreach programs serving Arizona Native American communities. The new funding extends the Partnership for Native American Cancer Prevention (NACP) partnership for five years through 2024.
A clinical trial found that palbociclib can be safely taken by African American and other women with benign ethnic neutropenia who have advanced breast cancer. The trial showed that 58% of participants had the gene alteration associated with lower neutrophil counts, but none developed life-threatening infections or discontinued treatment.
Researchers from the SWOG Cancer Research Network confirmed two biomarkers - DDIR signature and sTILs - can serve as prognostic markers for patients with triple negative breast cancer. These tests could guide cancer treatment personalized to individual patient biology.
The NRG Oncology clinical trial found that accelerated partial-breast irradiation (APBI) did not meet the criteria for equivalence to whole-breast irradiation (WBI) in controlling ipsilateral breast tumor recurrence. APBI did show a 1% difference in 10-year cumulative incidence of IBTR compared to WBI.
Researchers at Baylor College of Medicine discovered that immune checkpoint genes are more actively expressed in resistant tumors, which could be targeted with immunotherapy. This finding highlights the importance of personalized medicine and proper stratification of patients before treatment.
A study published by NIH found that frequent use of permanent hair dye and chemical straighteners increases breast cancer risk, especially among African American women. Women who regularly used permanent dyes were 9% more likely to develop breast cancer than those who didn't use hair dye.
A new study found that stricter alcohol policies are associated with a reduced risk of cancer mortality. The research, published in Chemico-Biological Interactions, suggests that stronger regulations may be a promising means of preventing cancer deaths at the population level.
Researchers at McGill University identified a key protein that promotes resistance to chemotherapy in triple negative breast cancer. Targeting this protein, perilipin4, causes nearly all resistant cells to stop growing and die, holding promise for treating more patients with chemotherapeutic resistant TNBC.
Researchers at Lancaster University have developed a new AI diagnostic tool for breast cancer using Raman spectroscopy to identify unique chemical fingerprints of different types of breast cancers. The algorithm successfully predicted diagnostic patterns for four subtypes with high accuracy, ranging between 70% and 100%.
A study published in SPIE Journal of Biomedical Optics found that diffuse reflectance spectroscopy can reliably discriminate between healthy tissue and tumor tissue, regardless of neoadjuvant chemotherapy status. The technique's feasibility for tumor-margin assessment during breast-conserving surgery has been demonstrated.
Research reveals that inhibiting Mcl-1 protein can induce apoptosis in estrogen receptor-positive breast cancer cells, suggesting a potential therapeutic strategy for this type of cancer. The study also found that combining Mcl-1 inhibition with ABT-263 increased cell death in ER+ breast cancer cells.
A new study found that biennial mammography screening resulted in smaller and less advanced breast cancer tumors compared to annual screenings. The study also discovered that women receiving biennial screenings tended to have more aggressive treatment options, such as chemotherapy and axillary lymph node dissection.
Researchers have identified a splicing factor called TRA2B as a key driver of triple negative breast cancer's ability to grow and spread. Blocking TRA2B expression in cells has been shown to prevent metastasis, providing a potential new treatment avenue for this devastating form of breast cancer.
A new study published in the European Heart Journal found that over one in ten cancer patients die from cardiovascular disease, including heart disease and stroke. The study analyzed data from over 3.2 million US patients diagnosed with cancer between 1973 and 2012, revealing that certain types of cancer, such as breast and prostate ca...
A new trial shows that breast cancer patients who experience a local recurrence in the same breast after lumpectomy and radiation can benefit from partial-breast re-irradiation as an alternative to mastectomy. The treatment targets the affected area with high-dose radiation, reducing exposure to surrounding tissue.
People living with or beyond cancer are more than twice as likely to die of a stroke compared to the general population. Certain types of cancer, such as breast, prostate, and colorectum cancers, were found to be most commonly associated with fatal strokes.
The University of Illinois Chicago will help young breast cancer survivors navigate post-treatment care and survival with a $1.8 million CDC grant. The program aims to reduce disparities in survival and quality of life due to social factors among breast cancer survivors.
Women from Appalachia are less likely to receive breast reconstruction surgery following a mastectomy due to lack of adequate care and patient education. Researchers highlight the need for better comprehensive breast cancer care, including access to reconstructive plastic surgeons.
The new guidelines call for better access to CDK4/6 inhibitors and anti-HER2 therapies for patients with advanced breast cancer. Experts also stress the need for adequate pain control, particularly in countries where opioids are scarce or misused.
Researchers from Boston University School of Medicine have developed a novel computational method, iEDGE, which identified several candidate breast cancer drivers and multiple pan-cancer drivers, including TRIP13 and TPX2.
A new study from the University of Pennsylvania School of Medicine found that implementing an electronic health record nudge increased cancer screening orders by 22% and 14%, respectively. However, the study also showed that patients' follow-through on screenings remained largely unchanged. The researchers suggest that future intervent...
The study found that T-DM1 resulted in a third of patients experiencing objective response and nearly 40% continuing treatment for at least six months. Patients with central nervous system metastases had shorter progression-free survival rates, highlighting the need for inclusion in randomized trials.
UNC Lineberger researchers have discovered a method to identify triple negative breast cancer tumors that will respond to immunotherapy. The findings, published in the journal Cell, could help guide patients to the right treatments and lead to new approaches to make drugs work in cancers that don't initially respond.
Researchers developed nanoparticles that can deliver immunostimulants via inhalation to induce systemic immune response against lung cancer. The treatment converted cold tumors to hot, immune-responsive tumors and showed significant regression of tumors in both lungs and prolonged survival of mice.
Researchers at Princess Margaret Cancer Centre have identified new protein targets for drug development against prostate cancer by analyzing noncoding DNA regions. These regions, previously thought to be 'junk' DNA, were found to harbor important regulatory elements that determine gene expression.
Scientists at UCSF discovered that blocking the activity of MMP9 can prevent breast cancer from spreading to distant organs. The researchers found that MMP9 helps create a hospitable environment for cancer cells to form new tumors by remodeling healthy tissue and transforming it into safe havens.
Advanced breast cancer patients frequently receive inaccurate one-number estimates of their average survival time. Instead, a new method provides doctors with three scenarios: best-case, worst-case and typical survival times. This approach has been shown to be more helpful, easier to understand and reassuring for patients.
Complementary therapies used to treat breast cancer skin lesions may delay wound healing and interfere with systemic treatments. Herbal products like green chiretta and feverfew have been shown to negatively impact blood clotting, exacerbating scarring and dressing effectiveness.
A study published in JAMA reports that cardiac resynchronization therapy can significantly improve heart function in cancer survivors with congestive heart failure. After six months, the patients experienced improved heart function, reduced symptoms, and enhanced quality of life. The therapy offers a possible solution for patients who ...
The NIH RO1 grant aims to improve ultrasound tomography for breast cancer detection by developing physics-based computational models and advanced image reconstruction methods. The goal is to create high-resolution images that can detect subtle cancers, especially in younger women with denser breast tissue.
Researchers identify potential environmental risk factors and new treatment strategies for triple negative breast cancer (TNBC), an aggressive form of breast cancer. The study suggests that exposure to common chemicals may increase the risk of developing TNBC, and highlights the potential for combination therapy as a treatment option.
Research published in Public Relations Review debunks myths about Asian American health, revealing a lack of awareness and reluctance to seek care. Community engagement is crucial for addressing health disparities and promoting participation in healthcare initiatives.