Articles tagged with Breast Cancer
Researchers identified a potential intervention for triple-negative breast cancer by targeting the MYCN oncogene. Experimental drugs called BET inhibitors showed promise when combined with MEK inhibition in model systems overexpressing MYCN.
Researchers at Boston Children's Hospital have discovered a new approach to cancer immunotherapy by reactivating the gasdermin E gene, which can convert 'cold' tumors into 'hot' ones that the immune system can target. The team showed that re-introducing gasdermin E in mouse models triggered pyroptosis and suppressed tumor growth in var...
A recent study of over 4,500 postmenopausal women diagnosed with breast cancer found that about 1 in 40 have BRCA1 or BRCA2 gene mutations. These mutations increase the risk of other cancers, including ovarian cancer, and may benefit from genetic testing.
A new study published in Radiology found that digital breast tomosynthesis (DBT) improved cancer detection rates and reduced false positives compared to digital mammography (DM). DBT screening detected a higher proportion of poor prognosis cancers than DM, with better visualization of lesions and reduced tissue superimposition.
New research suggests that higher concentrations of insulin-like growth factor-1 (IGF-1) may be a probable cause of breast cancer. Studies found an association between IGF-1 and breast cancer development, with higher levels linked to increased risk. The findings support a causal role of the IGF pathway in breast cancer development.
A new imaging agent has been developed to identify cancer cells and their supporting compromised cells. The compound binds to activated annexin A2 protein present in many solid tumors, allowing for targeted imaging and potential dual targeting of the tumor and surrounding cells with chemotherapy drugs.
Researchers have identified a new target in 'normal cells' for a potential treatment of triple negative breast cancer. Using PIK3Cδ inhibitors, the study found a reduction in tumour growth and improved survival outcomes when levels of the protein were controlled in surrounding healthy tissue.
Scientists create micrometric scaffolding with gold nanoparticles to detect biomarkers and track cell displacement in real time. The SERS technology allows for precise monitoring of tumor growth and evolution, providing insights into cancer treatment.
Researchers have discovered that breast cancer cells change their metabolism to move to other parts of the body, a finding that could lead to new strategies for preventing the spread of cancer. This shift in metabolism may be targeted with drugs to prevent metastasis and improve survival rates.
Dartmouth engineers are developing a multi-modal breast imaging platform combining Microwave and Magnetic Resonance Imaging to improve diagnostic accuracy and reduce anxiety in patients. The approach aims to minimize unnecessary biopsies and eliminate the need for gadolinium contrast injection.
Researchers have identified a promising new drug combination that can help the immune system target and kill cancer cells. By combining an anti-nausea drug with existing cancer treatments, the treatment works by altering the surface of tumor cells to make them more recognizable to the immune system.
Researchers discovered a new function of neurofibromatin, directly repressing estrogen receptor-alpha expression and causing treatment resistance in ER+ breast cancer. A combination therapy of SERD and MEK inhibitor was shown to be effective in animal models and is being tested in clinical trials.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that young women with breast cancer experience substantial financial difficulties after diagnosis, even if they have stable jobs and insurance coverage. The study highlights the need for better financial planning and awareness of the costs associated with cancer care.
A new trial led by Beth Israel Deaconess Medical Center found that platinum-based therapy was not superior to standard chemotherapy in treating patients with BRCA mutations. The study, known as INFORM, compared the efficacy of cisplatin to a standard treatment regimen in patients with breast cancer.
A study by Mayo Clinic researchers suggests that all women with a breast cancer diagnosis under the age of 66 be offered germline genetic testing. This approach would identify 98% of women with BRCA1 and BRCA2 mutations, while avoiding testing of 20% of all breast cancers.
A study predicts a rise in cancer cases in Canada in 2020, with nearly 1 in 2 Canadians expected to receive a diagnosis. Lung cancer will be the leading cause of death, responsible for about 1 in 4 deaths from cancer.
A new study published in JAMA found that Fast Breast MRI detected significantly more breast cancers than digital breast tomosynthesis (3-D mammography) in average-risk women with dense breast tissue. The study showed that Fast Breast MRI was almost two and a half times more effective at detecting breast cancers in these women.
Researchers at CNIO propose a novel approach using CDK4/6 inhibitors after chemotherapy to prevent tumor cells from resisting treatments. This strategy shows promising results in preventing tumor growth and death in mice with pancreatic adenocarcinoma, suggesting new avenues for improving cancer treatment.
The study demonstrates that MLN4924 treatment induces DNA damage and accumulates cells in S phase, enhancing sensitivity when combined with cisplatin. In vivo results show reduced tumor growth in a NOD-SCID mouse xenograft model treated with MLN4924 alone or in combination with cisplatin.
A clinical trial led by Queen Mary University of London found that immune therapy drug pembrolizumab significantly reduced the risk of cancer recurrence in patients with early triple negative breast cancer. Nearly 65% of women showed no sign of cancer after treatment, compared to 51% on chemotherapy alone.
The study found that patients whose breast cancer was completely eradicated by chemotherapy had a higher proportion of DNA mutational 'signature 3', indicating defects in DNA repair. This signature is associated with genes like BRCA, which could help doctors predict patient response to neoadjuvant chemotherapy.
In aggressive colorectal cancers, a structural framework called cancer-associated fibroblasts helps tumors evade the immune system by expressing high levels of CD73, an immune checkpoint enzyme. CAFs create a self-serving process that amplifies their own CD73 expression, suppressing immune responses.
A recent study published in BMC Cancer found that nearly two-thirds of women diagnosed with breast cancer experience significant weight gain, with the majority gaining over 20 kilograms. The study highlights the importance of early intervention and management strategies to prevent weight-related issues after a breast cancer diagnosis.
Breast cancer support groups play a crucial role in helping underserved African-American women in Memphis overcome economic, social, and psychological barriers to diagnosis and treatment. The groups act as connectors between healthcare providers and the community, reducing death rates from breast cancer among black women in the city.
A new study by Loma Linda University Health found that dairy milk consumption is associated with a higher risk of breast cancer in women. The study of nearly 53,000 North American women found that even moderate amounts of dairy milk can increase the risk of breast cancer, up to 80% depending on consumption levels.
A study published in JAMA found abbreviated breast MRI to be more effective than digital breast tomosynthesis in detecting breast cancer in women with dense breasts. The test detected significantly more cancers and showed promise as a new screening tool for these patients.
Researchers found a small mortality benefit for continuing mammography screening in women between 70-74 years old, but no benefit for those over 75. Women who continued screening were less likely to receive aggressive therapies for breast cancer.
Researchers have developed a non-invasive system that uses harmless microwaves and artificial intelligence to detect small tumors in minutes. The device costs under $5,000 to build and can detect anomalies as small as 1 cm in diameter, potentially reducing radiation exposure and improving patient comfort.
A recent study found that radiation can trigger an inflammatory response in breast cancer cells, leading to the survival and growth of triple-negative breast cancer cells. This finding highlights the importance of understanding the microenvironment in cancer development.
Researchers successfully used CRISPR to make targeted cuts in human breast cancer genes, allowing for efficient sequencing of critical alterations. The technique has the potential to streamline cancer treatment selection and use of targeted therapies.
The Beckman Institute has developed imaging techniques that capture more information about a tissue compared to traditional methods, allowing for better visualization of extracellular vesicles. These vesicles are known to increase in number and be associated with cancer, particularly breast cancer cells.
A study of over 925,000 adults with new cancer diagnoses found that Medicaid expansion improved insurance status, led to earlier cancer stage detection, and resulted in timely treatment. The findings suggest a positive association between Medicaid expansion and cancer care outcomes.
A new study reveals that habit, tradeoffs, and resource barriers are key factors influencing breast cancer therapy discontinuation. Black women were more likely to report challenges related to these barriers, highlighting the need for multi-barrier intervention strategies.
Researchers compared treatment and survival rates between African American and white women with mammography-detected triple-negative breast cancer. African American women have a higher rate of death from breast cancer, likely due to the aggressive nature of this type of breast cancer.
For the first time, a cancer patient has given birth to a healthy baby using lab-matured eggs that were frozen, thawed, and fertilized five years later. The breakthrough achievement demonstrates the potential of in vitro maturation (IVM) for fertility preservation in cancer patients.
A study found that targeting a specific protein involved in lipid uptake and metabolism could selectively disrupt the activity of regulatory T cells in tumors, boosting the effects of cancer immunotherapy. The researchers also discovered that CD36 deficiency induced a form of cell suicide in these immune cells, reducing tumor burden an...
Scientists created a detailed map of breast cancer, showing how genetic changes affect the physical tumour landscape. This technique could provide doctors with an unparalleled wealth of information about each patient's tumour upon diagnosis.
Thoracic radiation therapy increases fatigue and difficulty breathing in cancer patients, but engaging in physical activity prior to treatment may help improve these symptoms over time. High levels of physical activity are associated with concurrent improvements in fatigue and shortness of breath.
Researchers at City of Hope have discovered a link between the circadian rhythm gene BMAL1 and the suppression of tumor growth in obese and prediabetic mice. The study found that mice without the BMAL1 protein experienced accelerated breast tumor growth, suggesting that increasing BMAL1 levels may slow cancer progression.
Researchers from Massachusetts General Hospital Cancer Center identified an adaptation by cancer cells that facilitates their spreading to distant sites. Targeted therapies disrupting the ribosome function and inhibiting cancer cell growth slows the spread of breast cancer in a mouse model.
Researchers at Huntsman Cancer Institute have identified a critical protein called ETV4 that promotes estrogen signaling in endometrial cancer cells. By removing ETV4, tumor growth can be significantly reduced, offering new avenues for treatment development.
Researchers analyzed genomes of nearly 50 tumor samples from angiosarcoma patients and found dozens of mutated genes, including new clues about therapeutic possibilities for some subtypes. The study suggests that drugs approved for other types of cancer might be useful in treating angiosarcoma.
A new study found that higher genetic testosterone levels increase the risk of type 2 diabetes by 37% in women and reduce it by 14% in men. Similarly, higher testosterone levels increase the risk of breast and endometrial cancers in women and prostate cancer in men.
Scientists have developed a simple and precise cancer therapy approach based on selective electrochemical generation of H2 in tumor regions. The H2-ECT method enables large-scale tumor therapy with ideal selectivity and targeting to kill tumors with minimal damage to normal tissue.
A new study found that breast cancer treatment among women who test positive for an inherited genetic mutation is less in line with practice guidelines, particularly for radiation therapy and chemotherapy. The researchers found distinct differences in surgery, radiation, and chemotherapy treatments among BRCA-positive patients.
Researchers have compiled a global catalogue of cancer mutations to help doctors tailor treatments and improve patient outcomes. The study found that 95% of cancer occurrences can be explained by genetic mutations, paving the way for precision medicine.
Researchers have completed the most comprehensive study of whole cancer genomes to date, revealing key mutations driving cancer growth. The atlas provides a solid foundation for understanding which genes are damaged in each cancer type.
A new study suggests that targeting Hsp47 could block cancer cell-platelet interaction and inhibit metastasis in triple-negative breast cancer patients. The protein is often amplified in the genes of metastatic breast cancer tissue, potentially serving as a biomarker for metastasis.
A global study of 18,541 women in 40 countries found that 71% are unhappy with their breast size, with 48% wanting larger breasts and 29% satisfied. The study also linked breast size dissatisfaction to poorer psychological well-being, lower self-esteem, and reduced breast cancer awareness.
A new therapy option has been identified for early-stage breast cancer using the radiopharmaceutical 223RaCl2, which delays the growth of disseminated tumor cells. The treatment shows promise in delaying tumor progression and may be an adjuvant therapy option for select patients.
Researchers are developing a new non-invasive test that analyzes breast milk to detect breast cancer in its earliest stages in high-risk breastfeeding women. The study aims to identify profiles of breast cells that may indicate increased risk of breast disease and shed light on breast cancer development.
Researchers found that tumor-derived ANGPTL2 stimulates lung epithelial cells, promoting primary tumor-induced neutrophil recruitment and pre-metastatic niche formation. Targeting ANGPTL2 signaling reduced metastatic load in lungs.
Researchers estimate that there may be as many as 10 million people worldwide suffering from a rare disease, which is likely to hinder treatment development due to inconsistent and imprecise definitions. The study calls for a unified definition of rare diseases to improve care for patients and develop effective treatments.
Researchers at UT Southwestern Medical Center have developed a new method for mapping out blood vessels before surgery to minimize the risk of complications in single breast reconstruction. The team found that this approach reduced fat necrosis by 2.7% compared to traditional methods, resulting in improved outcomes and breast shapes.
Researchers developed a microfluidic device to assess tumor cells' physical ability to adhere, which could improve cancer prognosis. Weakly adherent cells are more likely to migrate and invade other tissues, increasing the risk of tumor recurrence.
A new study published in Nature Communications found that sevoflurane anesthesia leads to more metastatic burden in the lung after breast tumor resecting surgery than propofol. The findings may guide clinicians in optimizing anesthesia choice for breast cancer surgery to achieve best long-term outcomes.
The study highlights the efficacy of Bluestar Genomics' 5-hmC signal detection technology for detecting breast, lung, pancreatic, and prostate cancer from a single blood draw. The technology demonstrated high performance in classifying samples with high Area Under the Curve measures.
Researchers identified mutant tumor protein 53 (mtp53) and poly-ADP-Polymerase (PARP) proteins as key drivers of growth in triple negative breast cancer cells. Suppressing these proteins with combined PARP-inhibiting therapies may offer a targeted treatment for this aggressive form of the disease.
Researchers analyzed over 23,000 human tumors and 1000 cancer cell lines to discover chromosome arm gains and losses can predict drug response better than genetic mutations. This finding has significant implications for personalized cancer treatments.
Researchers Dr. Leisha A. Emens and Dr. Xiang Zhang have received a Stand Up To Cancer Laura Ziskin Prize to explore the development of immune checkpoint inhibitors for breast cancer patients. Their collaboration aims to improve outcomes for breast cancer patients and reduce mortality rates.