Articles tagged with Breast Cancer
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A new study reveals that habit, tradeoffs, and resource barriers are key factors influencing breast cancer therapy discontinuation. Black women were more likely to report challenges related to these barriers, highlighting the need for multi-barrier intervention strategies.
Researchers compared treatment and survival rates between African American and white women with mammography-detected triple-negative breast cancer. African American women have a higher rate of death from breast cancer, likely due to the aggressive nature of this type of breast cancer.
For the first time, a cancer patient has given birth to a healthy baby using lab-matured eggs that were frozen, thawed, and fertilized five years later. The breakthrough achievement demonstrates the potential of in vitro maturation (IVM) for fertility preservation in cancer patients.
A study found that targeting a specific protein involved in lipid uptake and metabolism could selectively disrupt the activity of regulatory T cells in tumors, boosting the effects of cancer immunotherapy. The researchers also discovered that CD36 deficiency induced a form of cell suicide in these immune cells, reducing tumor burden an...
Scientists created a detailed map of breast cancer, showing how genetic changes affect the physical tumour landscape. This technique could provide doctors with an unparalleled wealth of information about each patient's tumour upon diagnosis.
Thoracic radiation therapy increases fatigue and difficulty breathing in cancer patients, but engaging in physical activity prior to treatment may help improve these symptoms over time. High levels of physical activity are associated with concurrent improvements in fatigue and shortness of breath.
Researchers at City of Hope have discovered a link between the circadian rhythm gene BMAL1 and the suppression of tumor growth in obese and prediabetic mice. The study found that mice without the BMAL1 protein experienced accelerated breast tumor growth, suggesting that increasing BMAL1 levels may slow cancer progression.
Researchers from Massachusetts General Hospital Cancer Center identified an adaptation by cancer cells that facilitates their spreading to distant sites. Targeted therapies disrupting the ribosome function and inhibiting cancer cell growth slows the spread of breast cancer in a mouse model.
Researchers at Huntsman Cancer Institute have identified a critical protein called ETV4 that promotes estrogen signaling in endometrial cancer cells. By removing ETV4, tumor growth can be significantly reduced, offering new avenues for treatment development.
Researchers analyzed genomes of nearly 50 tumor samples from angiosarcoma patients and found dozens of mutated genes, including new clues about therapeutic possibilities for some subtypes. The study suggests that drugs approved for other types of cancer might be useful in treating angiosarcoma.
A new study found that higher genetic testosterone levels increase the risk of type 2 diabetes by 37% in women and reduce it by 14% in men. Similarly, higher testosterone levels increase the risk of breast and endometrial cancers in women and prostate cancer in men.
Scientists have developed a simple and precise cancer therapy approach based on selective electrochemical generation of H2 in tumor regions. The H2-ECT method enables large-scale tumor therapy with ideal selectivity and targeting to kill tumors with minimal damage to normal tissue.
A new study found that breast cancer treatment among women who test positive for an inherited genetic mutation is less in line with practice guidelines, particularly for radiation therapy and chemotherapy. The researchers found distinct differences in surgery, radiation, and chemotherapy treatments among BRCA-positive patients.
Researchers have compiled a global catalogue of cancer mutations to help doctors tailor treatments and improve patient outcomes. The study found that 95% of cancer occurrences can be explained by genetic mutations, paving the way for precision medicine.
Researchers have completed the most comprehensive study of whole cancer genomes to date, revealing key mutations driving cancer growth. The atlas provides a solid foundation for understanding which genes are damaged in each cancer type.
A new study suggests that targeting Hsp47 could block cancer cell-platelet interaction and inhibit metastasis in triple-negative breast cancer patients. The protein is often amplified in the genes of metastatic breast cancer tissue, potentially serving as a biomarker for metastasis.
A global study of 18,541 women in 40 countries found that 71% are unhappy with their breast size, with 48% wanting larger breasts and 29% satisfied. The study also linked breast size dissatisfaction to poorer psychological well-being, lower self-esteem, and reduced breast cancer awareness.
A new therapy option has been identified for early-stage breast cancer using the radiopharmaceutical 223RaCl2, which delays the growth of disseminated tumor cells. The treatment shows promise in delaying tumor progression and may be an adjuvant therapy option for select patients.
Researchers are developing a new non-invasive test that analyzes breast milk to detect breast cancer in its earliest stages in high-risk breastfeeding women. The study aims to identify profiles of breast cells that may indicate increased risk of breast disease and shed light on breast cancer development.
Researchers found that tumor-derived ANGPTL2 stimulates lung epithelial cells, promoting primary tumor-induced neutrophil recruitment and pre-metastatic niche formation. Targeting ANGPTL2 signaling reduced metastatic load in lungs.
Researchers estimate that there may be as many as 10 million people worldwide suffering from a rare disease, which is likely to hinder treatment development due to inconsistent and imprecise definitions. The study calls for a unified definition of rare diseases to improve care for patients and develop effective treatments.
Researchers at UT Southwestern Medical Center have developed a new method for mapping out blood vessels before surgery to minimize the risk of complications in single breast reconstruction. The team found that this approach reduced fat necrosis by 2.7% compared to traditional methods, resulting in improved outcomes and breast shapes.
Researchers developed a microfluidic device to assess tumor cells' physical ability to adhere, which could improve cancer prognosis. Weakly adherent cells are more likely to migrate and invade other tissues, increasing the risk of tumor recurrence.
A new study published in Nature Communications found that sevoflurane anesthesia leads to more metastatic burden in the lung after breast tumor resecting surgery than propofol. The findings may guide clinicians in optimizing anesthesia choice for breast cancer surgery to achieve best long-term outcomes.
The study highlights the efficacy of Bluestar Genomics' 5-hmC signal detection technology for detecting breast, lung, pancreatic, and prostate cancer from a single blood draw. The technology demonstrated high performance in classifying samples with high Area Under the Curve measures.
Researchers identified mutant tumor protein 53 (mtp53) and poly-ADP-Polymerase (PARP) proteins as key drivers of growth in triple negative breast cancer cells. Suppressing these proteins with combined PARP-inhibiting therapies may offer a targeted treatment for this aggressive form of the disease.
Researchers analyzed over 23,000 human tumors and 1000 cancer cell lines to discover chromosome arm gains and losses can predict drug response better than genetic mutations. This finding has significant implications for personalized cancer treatments.
Researchers Dr. Leisha A. Emens and Dr. Xiang Zhang have received a Stand Up To Cancer Laura Ziskin Prize to explore the development of immune checkpoint inhibitors for breast cancer patients. Their collaboration aims to improve outcomes for breast cancer patients and reduce mortality rates.
Researchers have discovered how CDK8 is activated in healthy humans and identified a new method for developing CDK8-specific inhibitors. The study suggests that targeting the 'MED12 activation helix' may be crucial for inhibiting CDK8 activity, which is often mutated in various cancers.
A study examined racial and ethnic differences in genetic testing frequency and results among diverse young breast cancer patients. The study found that less than half of the participants completed hereditary breast and ovarian cancer genetic testing, but the percentage increased over time.
Researchers developed a new method that combines genomic and proteomic analysis to provide more detailed insights into cancer biology, tumor type, and response to therapy. The study showed promise for future clinical application and highlights the potential for precision medicine.
Researchers found that protein AKAP8 inhibits breast cancer metastasis by interfering with proteins that promote metastatic behavior. AKAP8 also predicts metastatic breast cancer outcomes in patients and can inhibit progression in animal models.
Consuming natural yoghurt daily may lower breast cancer risk by displacing harmful bacteria with beneficial ones. Breastfeeding also reduces the risk, likely due to lactose fermenting bacteria occupying breast ducts.
A University of Massachusetts Amherst researcher is studying the effects of endocrine-disrupting chemicals on breast density in college-age women, a strong risk factor for breast cancer. High breast density has been linked to increased breast cancer risk in older women, and this study aims to shed light on the link in younger women.
Researchers have discovered a two-drug combo that can counter resistance to a promising new breast cancer therapy. The combination of neratinib and everolimus effectively blocks the growth of cancer cells with HER2 mutations, providing a novel treatment option for patients with these types of cancers.
Researchers have identified several potentially useful breast cancer biomarkers that indicate the presence and risk of malignancy. PET/MRI imaging revealed differences in biomarkers between healthy contralateral breast tissue of patients with malignant and benign breast tumors.
Researchers developed a new compound that targets microRNA-21, a molecule linked to aggressive breast cancer, awakening its self-destruct system and killing cancer cells while leaving healthy cells unaffected. In mouse models, the compound showed promise in reducing breast cancer spread and decreasing invasiveness in other cancers.
Hyperpolarized 13C-Magnetic resonance imaging (HP 13C-MRI) reveals the conversion of pyruvate into lactate in breast cancer tumors, associated with higher tumor grades. The study suggests HP 13C-MRI as a noninvasive tool for characterizing and monitoring breast tumors.
Researchers have developed a new scanning technique using magnetized molecules to monitor breast cancer, detecting differences in tumor size, type, and grade. The scan reveals the 'topography' of tumors, providing detailed information on metabolism and identifying potential treatment options.
Researchers used imaging mass cytometry to analyze 35 protein biomarkers in breast cancer patients, identifying four subcategories of the disease with varying molecular profiles. This breakthrough has the potential to change clinical practice by enabling precision medicine and personalized treatment approaches.
Research links proton pump inhibitors to poorer concentration and memory in breast cancer patients. Cognitive problems reported by PPI users were 20-29% more severe than those in non-users. The study suggests an association between PPI use and cognitive decline in breast cancer survivors.
Researchers discover that hormone resistant ER+ breast cancers have a 'rewired' 3D structure of DNA, altering gene activation and silencing. This change may explain how cancer cells evade hormone therapy, offering a potential path for reversal using existing drugs.
Researchers discovered that restoring BMP4 activity blocks distant metastasis in multiple organs, including the lung and bone. High levels of BMP4 are associated with better patient outcomes.
Researchers developed a new nanoparticle drug formulation targeting specific receptors on cancer cells, dispersing chemotherapy drug paclitaxel evenly throughout tumors. The study found the 'DART' nanoparticles significantly increased median overall survival compared to Abraxane treatment in animal studies.
UMass Amherst researchers discovered that benzophenone-3 and propylparaben can cause DNA damage in breast cells with estrogen receptors, even at low concentrations. This finding suggests a new mechanism by which estrogens and xenoestrogens may promote breast cancer.
Researchers developed an integrated genomic approach to predict which lung cancer patients will respond to immunotherapy. They found a correlation between tumor mutational burden and tumor purity, and corrected TMB estimates improved prediction of overall survival.
Researchers developed an interactive health counselor to educate women about breast density, with participants showing increased knowledge and satisfaction. The prototype aims to empower women with accurate information throughout the breast cancer screening process.
A new study published in JAMA Oncology finds that lack of insurance coverage is a major cause of delayed breast cancer screening and treatment among minority women. The research highlights the need for adequate health insurance to reduce racial outcome disparities in breast cancer.
A new study shows that the 21-gene recurrence score test, commonly used to predict disease recurrence and chemotherapy benefit in breast cancer patients, may also help determine whether radiation therapy is necessary. Patients with intermediate or high scores are more likely to see their cancer return and benefit from radiation.
A new study suggests that state-mandated notifications on mammogram reports intended to inform women of the health risks related to breast density are not worded effectively, particularly for those with lower education levels.
The American Cancer Society's annual report on cancer rates and trends shows a steady 26-year decline in overall cancer mortality, with long-term drops in lung, colorectal, breast, and prostate cancers. Lung cancer death rates have dropped by 51% since 1990, with the most rapid progress in recent years.
A nationwide Danish study found that overweight and obesity were associated with a 12% higher risk of several common cancers. The study included 20,706 cancers among 313,321 adults diagnosed with overweight and obesity compared to expected cancers in the general population.
A new study found that US patients are less likely to undergo breast conserving therapy compared to European and Asian patients, with a higher rate of mastectomy. The study suggests that insurance coverage and costs may be factors influencing this difference.
A research team at UC Riverside has received a four-year NIH grant to investigate luminal B breast cancer and triple-negative breast cancer, with the goal of improving early detection and patient survival. The project aims to develop resources and training programs for diverse therapeutics researchers.
The study found significant tumor shrinkage in two out of three patients with salivary gland tumors treated with T-DM1. The benefit lasted for at least two years in one patient, suggesting a promising activity for this rare cancer type.
Researchers have developed new drug compounds that inhibit the activity of FOXM1, a transcription factor that regulates cell proliferation and development. The compounds suppress tumor growth in human cells and mouse models of several types of breast cancer.
A major international study has identified over 350 DNA 'errors' that increase breast cancer risk, providing the most detailed picture yet of how differences in our DNA put some women at greater risk. The researchers found that 191 genes are likely target genes for these variants.
Researchers have discovered a novel combination of antibodies that significantly enhances the effectiveness of cancer immunotherapy, particularly in 'cold' tumors. The combination stabilizes tumor blood vessels and strengthens the immune system, leading to improved tumor tissue destruction.
Researchers found that combining valproic acid and hydralazine reversed some aspects of breast cancer in offspring of high-risk mice, but increased risk in those not fed a high fat diet during pregnancy. The study suggests potential implications for breast cancer risk in humans, particularly related to prenatal exposure to certain chem...
A recent study found that obesity is a significant risk factor for cardiotoxicity in breast cancer patients treated with chemotherapy, particularly those receiving anthracyclines and trastuzumab. The study suggests that overweight and obese individuals may benefit from careful cardiac screening and follow-up during treatment.