Articles tagged with Breast Cancer
Scientists at Princess Margaret Cancer Centre discover a promising approach to identify the best patients for targeted therapy in triple negative breast cancer. Using patient-derived cell lines, researchers found a correlation between levels of RB1 protein and decreased growth in cancer cells.
Scientists present research on negative side effects of opioids influenced by the immune system, a new type of immunotherapy extending survival in mouse models of breast cancer, detectable micro- and nanoplastics in human tissues, interactions between ocean microbes and pollution influencing climate, bio-based communication networks co...
A single dose of targeted radiotherapy during surgery is comparable to conventional radiotherapy in efficacy for most women with early breast cancer. This reduces the need for extra hospital visits and minimizes side effects. The long-term results show no significant difference in survival or likelihood of cancer recurrence.
A study by researchers at the University of Illinois Chicago found that nearly half of breast cancer survivors in the US experienced delays in care due to COVID-19. The most commonly reported delay was for routine follow-up visits, with other common delays including chemotherapy and radiation treatments.
A Singapore breast surgical unit developed strategies to balance COVID-19 battle with breast cancer care, emphasizing multidisciplinary teamwork and patient stratification. Prompt adaptation to restricted resources and balancing risks are crucial in providing optimal patient care.
A new immunotherapy approach using nanoparticles has shown promising results in extending the survival of mice with triple negative breast cancer. The treatment, which incorporates oxidized tumor cell lysates, triggered a stronger immune response and led to complete remission in two-thirds of treated mice.
Research finds strong association between smoking and reduced cancer screening services use among postmenopausal women, leading to advanced disease diagnosis. Current smokers are nearly 3 times as likely to be diagnosed with late stage breast cancer, and over twice as likely to be diagnosed with late stage bowel cancer.
A team of researchers has identified four subtypes of cells in triple negative breast cancer that contain promising new therapeutic targets. The study found that one subtype produces molecules that suppress immune cells, which may help cancer cells evade the immune system.
A new study led by Queen Mary University of London found that breast screening women aged 40-49 reduces breast cancer mortality with minimal increased overdiagnosis. The study analyzed data from 160,000 women and found a 25% reduction in breast cancer mortality in the first ten years.
Researchers found that breast cancer diagnosis via diffusion-tensor imaging (DTI) was equivalent before and after gadolinium-based contrast agent administration. DTI parameters showed a statistically significant reduction in cancer lesions after contrast enhancement, leading to increased conspicuity for radiologists.
A new study from the American College of Surgeons found that longer time to surgical treatment does not lower overall survival for women with early-stage breast cancer who underwent delayed operations before the pandemic. Patients who received neoadjuvant endocrine therapy also showed no decreased survival, according to the research.
A new study published in the Journal of the American College of Surgeons found that surgical delays for very early stage breast cancer patients did not impact overall survival. In fact, increased time to surgery was associated with a small increase in pathological upstaging, but no significant difference in survival rates.
Researchers at GW Cancer Center demonstrate that HDAC6 inhibitors can both enhance immunotherapy's effectiveness and decrease breast cancer's invasiveness, offering new treatment options for triple-negative breast cancer patients.
Scientists at IRB Barcelona have discovered a new type of hypermutation called mutation fog, which generates hundreds of mutations in every cell and accumulates in critical genome regions. This process is linked to normal DNA repair and APOBEC enzyme activity, suggesting it may be a major source of cancer mutations.
A group of Russian scientists, including ITMO University researchers, has proposed a system to update existing MRI scanners. The device uses electromagnetic coupling with an additional dielectric resonator to localize the magnetic field in the breast.
Researchers at the University of Cambridge discovered that G-quadruplexes form in regions of DNA rich in guanine, playing a role in transcription and driving tumour growth. The structures are prevalent within genes and genetic regions active in breast cancer cells.
A new vaccine targeting HER2-positive breast cancers has been shown to work effectively in combination with immune checkpoint inhibitors, resulting in pronounced tumor reduction and long-term tumor-free survival. The study found that the vaccine primes the immune system, allowing the checkpoint inhibitor to rally T-cells to action.
Researchers discovered that tumour T cells produce immunosuppressive steroids to evade the immune system, reducing tumour growth in mice. Preventing steroid production using a key gene or drug significantly slowed tumour formation and progression, suggesting new drug targets for cancer immunotherapy.
A new study found that digital breast tomosynthesis (DBT) outperforms digital mammography in detecting cancers and reducing recalls. However, women with extremely dense breasts do not experience the same level of benefit from DBT. Most women with dense breasts saw an increase in cancer detection rates with DBT.
The article discusses drug-induced interstitial lung diseases caused by breast cancer treatments, which can be fatal. Multi-disciplinary integration of clinical practice and pharmacology may reduce the incidence of these diseases.
A deep learning algorithm can quickly and accurately screen cancer patient biopsies for genetic alterations that inform treatment options and likelihood to respond to specific therapies. The study found detectable mutations in 13 out of 14 tested tumor types, including lung, colorectal, breast, and gastric cancers.
Researchers discovered a way to target cancer cells by blocking functions of Flap Endonuclease 1 (FEN1), which is involved in DNA replication and repair. The approach preferentially killed BRCA1 and BRCA2 mutant cancer cell lines, with normal cells recovering from FEN1 inhibition.
A new study reveals significant increases in premenopausal breast cancer rates globally, particularly in higher-income nations like Canada. The study also finds that postmenopausal breast cancer is increasing more rapidly in lower-income countries, often due to adopting Western lifestyles and lack of early screening.
Dr Patricia Ganz shares her expertise on assessing quality of life in cancer patients, with a focus on breast cancer survivorship. She highlights the importance of centering patients' needs in both US and UK healthcare systems.
Researchers at UTSW Medical Center have identified BBOX1 enzyme as a viable target for triple negative breast cancer treatment. Overexpressing BBOX1 causes TNBC cells to proliferate, while eliminating it stops tumor growth.
A USC-led team found a fasting-mimicking diet combined with hormone therapy may increase the power of cancer hormone drugs and delay resistance in small clinical trials and mouse studies. Researchers observed reduced insulin, IGF1, and leptin levels, leading to potential anti-cancer activity.
Researchers at the University of Arkansas have developed a new nano drug candidate that kills triple negative breast cancer cells. The discovery aims to target breast cancer cells directly, reducing adverse and toxic side effects associated with chemotherapy.
A global study led by Queen Mary University of London found that screening entire populations for breast and ovarian cancer genes can prevent millions more cases than current clinical practice. The research shows that cost-effective genetic testing can be implemented in high and upper-middle income countries to save lives.
A new study published in Nature Medicine found that breast cancer patients who experience a heart attack have a higher risk of cancer recurrence, spread, and death. The research suggests that heart attacks can trigger an immune reaction that makes it easier for cancer cells to grow.
Researchers at Northwestern University have developed a new immunotherapy that extends the survival time of mice with triple-negative breast cancer by 150% and prevents tumor reoccurrence. The therapy, which uses spherical nucleic acids, stimulates an immune response to combat cancer cells.
The new volume uses a health equity approach to focus on factors associated with cancer disparities research and identifies potential solutions. Studies highlight the impact of lifestyle on breast cancer risk and link mammary gland development to breast cancer disparity.
Researchers at Johns Hopkins University School of Medicine discovered that breast cancer cells can alter the function of NK cells to facilitate their spread. The study suggests preventing this reprogramming might stop breast cancer from metastasizing, a major cause of death in breast cancer patients.
Indian University researchers identify circulating tumor DNA and cells in plasma as indicators of disease recurrence and survival. The study, published in JAMA Oncology, enables stratification of patients for targeted therapies.
The new vaccine targets key tumour cells, maximising effectiveness while minimising side effects. It can be produced as an 'off the shelf' clinical grade formulation, addressing financial and logistical issues.
A ground-breaking clinical trial is underway at Sheba Medical Center in Israel to evaluate the Immunicom LW-02 plasma filtration device as a monotherapy and in combination with an anti-PD-1 immune checkpoint inhibitor. The trial aims to treat resistant metastatic melanoma, triple-negative breast cancer, renal cell carcinoma, and non-sm...
Starting at age 25 prevented marginally more deaths, but with more testing and emotional stress. All annual screening approaches save lives, with a combined approach of both breast MRI and mammography beginning at age 25 preventing the most deaths.
A new study suggests that early initiation of annual breast cancer screening with MRI and mammography may reduce breast cancer mortality by half or more in female childhood cancer survivors previously exposed to chest radiation. The findings highlight the importance of MRI in reducing deaths from breast cancer in this population.
A 20-year study found that 16% of cancer patients used their frozen eggs and embryos, with a remarkable 71% birth rate among those who did. Fertility preservation can be effective for young women diagnosed with cancer, with ovarian tissue cryopreservation and oocyte freezing offering good options.
Researchers found that Medicaid expansion under the Affordable Care Act is associated with improved breast cancer stage at diagnosis. The study also revealed disparities in insurance status, age, and race/ethnicity among patients before and after the expansion.
Researchers found that IQGAP1 controls centrosome function and defines molecular variants of breast cancer. IQGAP1 modulates nuclear-centrosome crosstalk to regulate cell division, suggesting a common target for personalized medicine in triple-negative breast cancer.
Researchers found that olaparib depletes the store of immature eggs in mouse ovaries by 36%, potentially affecting a woman's fertility. Fertility preservation counselling should be considered for young female patients prior to olaparib treatment.
Researchers at the University of Pennsylvania used a glowing dye to illuminate cancerous tissue during surgery, which helped identify spread to lymph nodes. The technique could improve outcomes in breast cancer patients undergoing breast-conserving surgery.
A survey found that only 1 in 7 American women have heard of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL), a rare cancer linked to textured breast implants. The study also showed that awareness increases among women who have received breast implants, with 51.7% being aware after receiving information about the risk.
A study has identified genetic variants that predispose to cancer and impair the immune system. The research found up to 57 genetic variants in 13 types of cancer, which affect the body's defenses. The immune system plays a key role in protecting against malignancies, but cancer cells have mechanisms to escape immune responses.
Researchers at the University of Cincinnati have found a potential new combination therapy for breast cancer that integrates use of the body's immune system with targeted treatment for a particular protein called FIP200. This study provides data that could eventually lead to a new breast cancer therapy.
The new technology uses low-frequency ultrasound to detonate tumor-targeted microbubbles, destroying up to 80% of cancer cells. An immunotherapy gene is co-injected to enhance the immune response, targeting and destroying remaining cancer cells.
The Pew Charitable Trusts and Alexander and Margaret Stewart Trust have partnered to support early-career cancer researchers with four-year grants. The five selected scholars will investigate various cancer-related applications, including early detection methods and molecular connections.
Dr. Ramachandran is exploring unique signatures from cell-free DNA to identify abnormal gene patterns associated with certain stages or types of cancers. His long-term goal is to use this knowledge to understand tumor processes without biopsies, identifying cancer biomarkers.
UCI researchers have discovered a protein responsible for genetic changes in various cancers and identified potential targets for effective therapy. By monitoring RNA hotspots, the team found that targeting the APOBEC3A protein's activity could disrupt cancer cell vulnerabilities.
Researchers at Hollings Cancer Center found a strong association between elevated AGEs in the body and breast cancer risk, particularly among women consuming high-AGE diets. The study's results suggest that reducing AGE intake through healthier food choices and physical activity may help lower cancer risk.
A new investigator-initiated clinical trial in metastatic breast cancer is underway at HUS Comprehensive Cancer Center, testing a combination treatment regimen that targets the MYC oncoprotein. The study aims to find the right dosage for further studies and biomarkers to guide patient selection with improved precision.
Research by the University of North Carolina at Chapel Hill found significantly higher medical costs for treating metastatic breast cancer in younger women compared to earlier-stage cancer patients or those without cancer. Treatment continues for longer and includes end-of-life care, contributing to high costs.
A new protocol has been established to guide clinicians in delivering optimal care to women with breast cancer who are breastfeeding. The protocol addresses the spectrum of care, including oncologic breast surgery, chemotherapy, and adjuvant therapy, while emphasizing the importance of breastfeeding for these mothers.
A scalable 'lab-on-a-chip' device detects early and advanced breast cancer in plasma samples with high accuracy, overcoming current diagnostic limitations. The EV-CLUE chip's noninvasive method shows promise for improving cancer detection and monitoring.
A new algorithm has been developed to select breast cancer patients in need of urgent surgery or chemotherapy during the COVID-19 pandemic. The algorithm uses data from international trials to identify postmenopausal patients with primary ER+HER2- breast cancer who have less endocrine-sensitive tumours and should be prioritized for ear...
Researchers at Cornell University have identified a protein called TiPARP that acts as a terminator for several cancer-causing transcription factors, including HIF-1. This discovery establishes TiPARP as a potential tumor suppressor and offers new insights into the mechanisms of cancer growth.
Researchers discover distinct effects of different tumor types on mouse immune system and human breast cancer patients, suggesting potential applications for cancer immunotherapy. Tumors cause widespread disruption of immune system, evolving over time, which can impact treatment efficacy.
A study published in the International Journal of Cancer found that outdoor light at night was associated with a 10% higher risk of developing breast cancer. The research analyzed satellite data on residential outdoor light exposure and followed 186,981 postmenopausal women for 16 years.
A study published in Oncotarget found that T-DM1 significantly improves response rates and median progression-free survival in patients with HER2 positive metastatic breast cancer. This suggests a preferred second-line choice for T-DM1 over trastuzumab emtansine.
A new study found that age does not necessarily disqualify older patients from breast cancer surgery, but serious adverse events are rare. Surgery can have a negative impact on quality of life and functional independence in older patients.