Articles tagged with Breast Cancer
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Indian University researchers identify circulating tumor DNA and cells in plasma as indicators of disease recurrence and survival. The study, published in JAMA Oncology, enables stratification of patients for targeted therapies.
The new vaccine targets key tumour cells, maximising effectiveness while minimising side effects. It can be produced as an 'off the shelf' clinical grade formulation, addressing financial and logistical issues.
A ground-breaking clinical trial is underway at Sheba Medical Center in Israel to evaluate the Immunicom LW-02 plasma filtration device as a monotherapy and in combination with an anti-PD-1 immune checkpoint inhibitor. The trial aims to treat resistant metastatic melanoma, triple-negative breast cancer, renal cell carcinoma, and non-sm...
Starting at age 25 prevented marginally more deaths, but with more testing and emotional stress. All annual screening approaches save lives, with a combined approach of both breast MRI and mammography beginning at age 25 preventing the most deaths.
A new study suggests that early initiation of annual breast cancer screening with MRI and mammography may reduce breast cancer mortality by half or more in female childhood cancer survivors previously exposed to chest radiation. The findings highlight the importance of MRI in reducing deaths from breast cancer in this population.
A 20-year study found that 16% of cancer patients used their frozen eggs and embryos, with a remarkable 71% birth rate among those who did. Fertility preservation can be effective for young women diagnosed with cancer, with ovarian tissue cryopreservation and oocyte freezing offering good options.
Researchers found that Medicaid expansion under the Affordable Care Act is associated with improved breast cancer stage at diagnosis. The study also revealed disparities in insurance status, age, and race/ethnicity among patients before and after the expansion.
Researchers found that IQGAP1 controls centrosome function and defines molecular variants of breast cancer. IQGAP1 modulates nuclear-centrosome crosstalk to regulate cell division, suggesting a common target for personalized medicine in triple-negative breast cancer.
Researchers found that olaparib depletes the store of immature eggs in mouse ovaries by 36%, potentially affecting a woman's fertility. Fertility preservation counselling should be considered for young female patients prior to olaparib treatment.
Researchers at the University of Pennsylvania used a glowing dye to illuminate cancerous tissue during surgery, which helped identify spread to lymph nodes. The technique could improve outcomes in breast cancer patients undergoing breast-conserving surgery.
A survey found that only 1 in 7 American women have heard of breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL), a rare cancer linked to textured breast implants. The study also showed that awareness increases among women who have received breast implants, with 51.7% being aware after receiving information about the risk.
A study has identified genetic variants that predispose to cancer and impair the immune system. The research found up to 57 genetic variants in 13 types of cancer, which affect the body's defenses. The immune system plays a key role in protecting against malignancies, but cancer cells have mechanisms to escape immune responses.
Researchers at the University of Cincinnati have found a potential new combination therapy for breast cancer that integrates use of the body's immune system with targeted treatment for a particular protein called FIP200. This study provides data that could eventually lead to a new breast cancer therapy.
The new technology uses low-frequency ultrasound to detonate tumor-targeted microbubbles, destroying up to 80% of cancer cells. An immunotherapy gene is co-injected to enhance the immune response, targeting and destroying remaining cancer cells.
The Pew Charitable Trusts and Alexander and Margaret Stewart Trust have partnered to support early-career cancer researchers with four-year grants. The five selected scholars will investigate various cancer-related applications, including early detection methods and molecular connections.
Dr. Ramachandran is exploring unique signatures from cell-free DNA to identify abnormal gene patterns associated with certain stages or types of cancers. His long-term goal is to use this knowledge to understand tumor processes without biopsies, identifying cancer biomarkers.
UCI researchers have discovered a protein responsible for genetic changes in various cancers and identified potential targets for effective therapy. By monitoring RNA hotspots, the team found that targeting the APOBEC3A protein's activity could disrupt cancer cell vulnerabilities.
Researchers at Hollings Cancer Center found a strong association between elevated AGEs in the body and breast cancer risk, particularly among women consuming high-AGE diets. The study's results suggest that reducing AGE intake through healthier food choices and physical activity may help lower cancer risk.
A new investigator-initiated clinical trial in metastatic breast cancer is underway at HUS Comprehensive Cancer Center, testing a combination treatment regimen that targets the MYC oncoprotein. The study aims to find the right dosage for further studies and biomarkers to guide patient selection with improved precision.
Research by the University of North Carolina at Chapel Hill found significantly higher medical costs for treating metastatic breast cancer in younger women compared to earlier-stage cancer patients or those without cancer. Treatment continues for longer and includes end-of-life care, contributing to high costs.
A new protocol has been established to guide clinicians in delivering optimal care to women with breast cancer who are breastfeeding. The protocol addresses the spectrum of care, including oncologic breast surgery, chemotherapy, and adjuvant therapy, while emphasizing the importance of breastfeeding for these mothers.
A scalable 'lab-on-a-chip' device detects early and advanced breast cancer in plasma samples with high accuracy, overcoming current diagnostic limitations. The EV-CLUE chip's noninvasive method shows promise for improving cancer detection and monitoring.
A new algorithm has been developed to select breast cancer patients in need of urgent surgery or chemotherapy during the COVID-19 pandemic. The algorithm uses data from international trials to identify postmenopausal patients with primary ER+HER2- breast cancer who have less endocrine-sensitive tumours and should be prioritized for ear...
Researchers at Cornell University have identified a protein called TiPARP that acts as a terminator for several cancer-causing transcription factors, including HIF-1. This discovery establishes TiPARP as a potential tumor suppressor and offers new insights into the mechanisms of cancer growth.
Researchers discover distinct effects of different tumor types on mouse immune system and human breast cancer patients, suggesting potential applications for cancer immunotherapy. Tumors cause widespread disruption of immune system, evolving over time, which can impact treatment efficacy.
A study published in the International Journal of Cancer found that outdoor light at night was associated with a 10% higher risk of developing breast cancer. The research analyzed satellite data on residential outdoor light exposure and followed 186,981 postmenopausal women for 16 years.
A study published in Oncotarget found that T-DM1 significantly improves response rates and median progression-free survival in patients with HER2 positive metastatic breast cancer. This suggests a preferred second-line choice for T-DM1 over trastuzumab emtansine.
A new study found that age does not necessarily disqualify older patients from breast cancer surgery, but serious adverse events are rare. Surgery can have a negative impact on quality of life and functional independence in older patients.
A study published in Oncotarget found that physical activity can modulate miRNAs involved in breast cancer progression, leading to reduced cancer cell viability. The researchers identified two specific miRNAs, miR-206 and anti-miR-30c, which showed promising results as non-invasive biomarkers for breast cancer prevention.
Researchers at Tulane University discovered a way to inhibit aggressive triple negative breast cancer by targeting the TRAF3IP2 gene. Suppressing this gene suppresses tumor growth and metastasis, while silencing another gene, Rab27a, only delays tumor growth but not metastasis.
A study found that satisfied breast cancer survivors have lower psychological stress and inflammation, which can promote overall health. The research suggests that fostering healthy relationships is crucial for breast cancer patients' well-being during a stressful time.
Scientists have made a breakthrough discovery in understanding small cell lung cancer, finding that it can change and adapt to evade treatments. The study suggests that the tumor is like a 'moving target' that requires multiple treatments to be effective.
Research reveals that cancer clusters exhibit higher metastatic potential than single cells due to increased resistance to natural killer cell-mediated destruction. The study suggests enhancing the ability of activated NK cells to eliminate cluster metastasis could provide a complementary cancer therapy approach.
A WPI-led research team has identified drugs that target triple-negative breast cancer tumors in mice without inducing toxic side effects. The targeted therapies use molecular recognition units to specifically target the tumors, reducing their sizes and eliminating them.
A comprehensive survey reveals that bacteria are widespread in human tumors, differing by tumor type. Different tumor types harbor distinct microbiomes, with breast tumors displaying a rich and diverse community of bacteria.
The study profiles 14 subtypes of immune cells in 100 brain tumor samples and reveals five types that predominantly sculpt the brain TME. The researchers found distinct patterns of immune cell composition and function among different glioma subtypes, including low-grade and high-grade gliomas.
A phase 3 trial found that surgery and radiation after initial systemic therapy did not improve overall survival for women with stage IV breast cancer. The study suggests that these treatments should not be routine practice, instead focusing on proven therapies to prolong life.
A study by the Hubrecht Institute found that oviduct cells are more prone to develop into tumors than ovarian surface epithelium cells. This suggests a possible shift in treatment approach, with earlier removal of fallopian tubes considered as a preventive measure for high-risk patients.
Boosting the activity of tumor proteasomes could improve chemotherapy treatment outcomes and enhance immunotherapy for aggressive triple-negative breast cancer. Researchers analyzed 3,500 breast tumors to make this finding.
A new study by the University of Copenhagen's researchers has revealed that the protein PP2A inhibits cancer development in mice by turning off an enzyme called ADAM17. This finding has significant implications for understanding the role of PP2A as a tumour suppressor and exploring potential therapeutic applications.
A new technique, multi-spectral optoacoustic mesoscopy (MSOM), enables high-resolution visualization of tumor tissue patterns without the need for surgical biopsies. MSOM allows researchers to study blood supply patterns, oxygenation levels, and drug efficacy with greater accuracy.
Researchers have identified Creld2 as a key player in the development and growth of aggressive breast cancers. High levels of this protein are found in triple negative breast cancers, which have poor survival rates and are difficult to treat.
Researchers have developed a new combined treatment using a senescence inducer and a senolytic nanoparticle that selectively removes senescent cells, delaying tumor growth and reducing metastasis in aggressive breast cancer. The study provides new therapeutic methodologies to be developed in subsequent stages and clinical trials.
A study found that breast cancer survivors underutilize recommended strategies for reducing fatigue, despite high prevalence and persistence. The analysis also revealed differences in utilization of physical activity and supportive care depending on the type of fatigue experienced.
Researchers have created a high-performance cancer vaccine utilizing self-healing polylactic acid microcapsules, which efficiently activate the immune system and inhibit tumor growth. The vaccine achieves effective T cell response, potent tumor inhibition, and anti-metastatic effects in various tumor models.
Researchers identified two novel biomarkers, PDL1/CD274 copy number alteration and PD-L1 combined positive score, that correlate with improved outcomes in patients with metastatic breast cancer treated with immunotherapy. These biomarkers may help identify patients most likely to benefit from this treatment.
A comprehensive analysis of exercise and its protective role for high-risk breast cancer patients reveals that even a modest amount of exercise can be beneficial, reducing the risk of cancer recurrence by 55%, and death by 68%. The study found that starting exercise after treatment also offers significant survival benefits.
Researchers found that African American women have a higher risk of breast cancer due to shared genes with white women, including BRCA1, BRCA2, and PALB2. Current breast cancer testing panels can be used for African American women, increasing the chances of early detection and prevention.
A new study published in Radiology found that women with probably benign breast lesions (BI-RADS 3) should have six-month follow-up imaging surveillance. The study showed that 1.9% of these women were diagnosed with cancer within six months, with a higher risk of malignancy than those downgraded to BI-RADS 1 or 2.
A recent study has identified 32 new sites on the human genome where variations in DNA appear to alter the risks of getting specific subtypes of breast cancer. The analysis, covering over 266,000 women, may eventually improve the ability to predict breast cancer risks at a subtype level.
Researchers from SWOG will make 31 digital presentations at the ASCO20 Virtual Scientific Program, reporting on trials involving chemotherapy regimens, financial toxicity, and multiple myeloma treatments. The studies found that pre-surgery chemotherapy can be done safely and has good outcomes regardless of the drugs used.
Researchers at IRB Barcelona have identified CPEB2 as a crucial factor in the development of luminal breast cancer. The study found that CPEB2 is essential for protein synthesis after hormonal stimulation, leading to less cell proliferation and better prognosis in patients with low expression levels.
Researchers have identified a new breast cancer gene, RBBP8, that may explain why some young women develop the disease. The study found that mutations in this gene can lead to cancer by damaging DNA and increasing the risk of genetic variants.
A recent NIH-funded project explores how the fear of cancer recurrence affects the well-being and relationships of breast cancer patients and their spouses. The research team, led by Jean-Philippe Laurenceau, will focus on three main health behaviors that can be influenced by recurrence fears.
A new study by SWOG Cancer Research Network found that simple text reminders do not improve breast cancer hormone therapy adherence. The study enrolled 724 post-menopausal women and tested the effectiveness of brief, twice-weekly text messages reminding them to take their medication.
The EULAR 2020 study investigates the connection between breast cancer, anti-hormonal therapy, and rheumatoid arthritis. The results show that the risk of breast cancer in women with RA is lower than in women with healthy joints, and no association was found between anti-hormonal breast cancer prophylaxis and later RA.
This review article discusses the features of challenging cold tumors and potential approaches to transform them into hot tumors, which are more responsive to immunotherapy. The authors summarize current strategies for enhancing T cell trafficking and discuss the limitations of existing immunotherapeutic approaches.
Researchers have discovered that patients with breast cancer develop alterations in monocytes, a type of leukocyte, early in the disease course. This finding paves the way for enhanced diagnosis and treatment of breast cancer, potentially allowing for earlier identification of aggressive tumors and personalized immunotherapy strategies.
A new study by Mount Sinai researchers found that insulin resistance is a key factor mediating racial disparities in breast cancer prognosis. Black women with invasive breast cancer had higher rates of insulin resistance and more aggressive tumors than white women.
A Swedish study of over half a million women reveals that early mammography screening significantly lowers the rates of advanced and fatal breast cancers. The analysis found a 41% reduction in fatal breast cancers and a 25% reduction in advanced breast cancer cases among screened participants.