Articles tagged with Breast Cancer
Researchers discovered a new combination of treatments that may benefit patients with certain gene mutations. Inhibiting the protein AKT suppressed growth of tumour cells in animal models, while combining dexamethasone with AKT inhibition showed better results.
Researchers at Moffitt Cancer Center discovered specific molecules, TAp63, long noncoding RNA (lncRNA), and proteins WDR26 and NOLC1 that regulate AKT signaling pathway to promote tumor development and progression.
Research suggests that performing physical activity in the morning can significantly reduce breast and prostate cancer risk. The study found that exercising between 8-10 am had the strongest protective effect, particularly for individuals with late chronotypes.
Michigan State University researchers are developing a precision nanotherapy that turns the body's own cells into weapons against breast cancer. The approach targets cancer cells' CD47 protein, which defends against immune cells, and uses ultra-thin carbon tubes to arm immune cells for a covert attack.
Researchers at CNIO successfully applied CRISPR technology to eliminate fusion genes causing tumors, leading to the death of cancer cells while leaving healthy cells unaffected. This breakthrough approach could lead to the development of targeted cancer therapies.
A new digital dashboard, NAVIFY Tumor Board, has been shown to significantly reduce the time spent preparing for cancer treatment cases by 30%, while also improving access to relevant clinical data. The study found that this improvement was sustained over time and resulted in reduced administrative burdens for healthcare professionals.
Researchers have developed a new hyperpolarisation technique to monitor cancer drug efficacy, potentially replacing tissue biopsies. The method detects biomarkers like FOXM1, indicating drug resistance in ER-positive breast cancer.
A recent study published in the American College of Surgeons found that over 80% of young women can successfully breastfeed or bottle-feed after undergoing surgery for benign breast conditions. The research aimed to address concerns among breast surgeons and pediatricians about the impact of surgery on future breastfeeding capability.
Spanish-speaking women are less likely to receive screening mammograms due to language barriers. Women with limited English proficiency had 27% lower rates of mammogram screenings, according to the study. This disparity affects approximately 450,000 eligible women in the US.
Researchers found that minority-serving hospitals offer a strong level of evidence-based care for early-stage breast cancer, with similar rates of following recommended surgical procedures as non-minority hospitals. However, disparities exist in access to high-quality care and adherence to treatment guidelines among minority-serving ho...
Research at the European Breast Cancer Conference highlights a significant difference in survival rates between breast cancers detected during screening and those detected in the interval between screenings. Screen-detected cancers have higher eight-year distant metastasis-free interval rates, even among high-risk tumours.
A study by Spanish researchers found that women with incident, proliferative benign breast disease are at a nearly four-fold increased risk of developing breast cancer compared to those with no BBD. The study analyzed data from over 629,000 women and recommends personalized screening strategies based on individual risk factors.
The NeoALTTO BIG-06 trial found that women who achieved pathological complete response (pCR) after treatment had better long-term survival without cancer recurrence. Patients receiving both lapatinib and trastuzumab in combination also had a higher rate of pCR, resulting in improved overall survival rates.
Researchers used computer analysis of CT scans to identify women at high risk of cardiovascular disease, with those having the highest CAC score showing a 3.7 times greater risk. The study showed that treating breast cancer means finding a balance between tackling tumors and minimizing side effects, including cardiovascular disease.
Researchers are exploring how patterns of collagens serve as biomarkers for breast cancer risk and progression, with a focus on addressing health disparities. A $3 million grant is supporting the study, led by Dr. Peggi Angel at the Medical University of South Carolina.
A new study suggests that the pandemic may lead to an increase in breast cancer deaths, but delaying or increasing capacity can lower this risk. Increasing staff and equipment would be needed for a full catch-up, but a temporary age limit raise or re-starting as normal with final screenings could be effective alternatives.
Breast and lung cancer cells use the Slit2 protein, normally produced by neurons, to signal their migration. This intricate mechanism enables them to escape primary tumors and spread to other organs. The findings could lead to novel diagnostics and treatments for metastasis.
A new genetic test identifies patients with invasive lobular carcinoma (ILC) at high risk of recurring and progressing. The 70-gene signature test showed that ILC patients whose genetic make-up puts them at high risk may benefit from additional adjuvant therapy.
A new study published in Frontiers In Oncology found a negative association between beta-blocker use and survival outcomes in patients with HER2 positive advanced breast cancer. The research highlights a subgroup of patients whose survival outcomes are poorer and calls for further investigation to improve treatment outcomes.
A new CDK 4/6 inhibitor, abemaciclib, has been shown to reduce the risk of breast cancer recurrence in high-risk patients with hormone receptor-positive (HR+) early-stage disease by 25%. The monarchE study found that adding abemaciclib to standard hormone therapy significantly improved patient outcomes.
A recent study shows that most older women with breast cancer can safely undergo surgery, reducing the gap in survival rates between older and younger women. The research found that surgery is generally well-tolerated and offers slightly lower survival rates for those who don't have it.
A recent study found that COVID-19-related interruptions in rehabilitation care for women with breast cancer led to increased emotional distress and reduced physical activity. The study, published in Rehabilitation Oncology, surveyed 15 breast cancer survivors who experienced cancelled appointments due to the pandemic.
A new study reveals that surgical treatment of breast asymmetry in young women yields significant and sustained improvements in psychosocial quality of life. The procedure corrected severe breast asymmetry, averaging two cup sizes difference between breasts, and led to notable enhancements in self-esteem, social functioning, and emotio...
Researchers at Lund University developed a computational model to detect and identify genetic mutations in breast tumours using RNA sequencing. The study found that almost 87% of patients had at least one mutation for which potential drugs exist, with specific genes like PIK3CA associated with good prognosis.
A computational pipeline predicts tumour response to different cancer treatments by identifying complex response markers from the patterns of co-occurrence between cancer driver genes. The system achieved 66% accuracy in predicting responses, offering a key factor in precision medicine for patients.
Scientists at UT Austin identified a protein that promotes DNA damage in BRCA 1/2-mutated cancer cells, making them resistant to PARP inhibitors. The finding may help create more effective treatment plans for patients with these cancers.
A new method for identifying sentinel lymph nodes (SLNs) in breast cancer uses photoacoustic microscopy and CD44 and SR-B1 dual-targeting nanoparticles. The technique distinguishes between metastatic SLNs and inflamed LNs, providing a potential solution for reducing complications during surgery.
A new study published in Cancer found that Black women experience longer waits for treatment initiation and prolonged duration of treatment after a breast cancer diagnosis. The research, which analyzed data from over 2,800 participants, identified financial and transportation issues as key contributors to these delays.
A recent study published in the journal Cancer found that Black women with breast cancer experience delays in starting treatment and have extended durations of treatment compared to white women. The study, led by UNC Lineberger Comprehensive Cancer Center researchers, also identified socioeconomic status as a significant factor influen...
The PROfound trial demonstrates the efficacy of PARP inhibitor olaparib in treating metastatic castration-resistant prostate cancer (mCRPC) with at least one alteration in BRCA1 or BRCA2 genes. Olaparib significantly improves overall survival, particularly in patients with alterations in these genes.
A study at ESMO 2020 found that adding abemaciclib to hormonal therapy reduces the risk of cancer recurrence by 25% in patients with high-risk early hormone receptor positive breast cancer. This new treatment approach improves invasive disease free survival and may spare chemotherapy in this group of patients.
Researchers found that asymptomatic breast cancer patients with brain metastases had fewer and smaller tumors, received less aggressive treatment, and lived longer than those who developed symptoms. The study suggests that early detection of brain metastases could improve survival rates for these patients.
Researchers found a pattern of gut bacteria, specifically SCFAs, that may influence the effectiveness of chemotherapy in breast cancer patients. These chemicals play a role in the immune system and may help patients mount an immune response against cancer cells.
Researchers investigated quality of life among younger women after breast cancer surgery, finding differences in physical functioning and body image between mastectomy and breast conserving surgery. Anxiety and depressive symptoms also varied by surgical approach.
Researchers at Boston University School of Medicine aim to create new breast tumor models that represent women with comorbidities like diabetes, which can lead to improved outcomes in survival. The project's goal is to address the unmet clinical need for better treatment options for these patients.
Researchers at Case Western Reserve University are developing a novel technique using nanotechnology to wake up 'cold' tumors, allowing immune cells to locate and neutralize them. The approach aims to improve treatment outcomes for metastatic breast cancer patients by combining nanotechnology with immunotherapy.
Researchers at Huntsman Cancer Institute discovered that HIF-1α is linked to aggressive tumors, metastasis, and poor patient survival, while HIF-2α is associated with less aggressive tumors and better outcomes. The study suggests a potential new paradigm for understanding kidney cancer.
A new study from Northwestern Medicine reveals that biological sex has a small but significant impact on gene expression in every type of human tissue. The researchers found over 37% of genes were expressed differently in males and females, with diverse molecular functions involved, including disease-related traits.
A major clinical trial found that a blood test can reliably match women with advanced breast cancer to effective targeted treatments by tracking disease evolution and mutations. The plasmaMATCH trial showed promising results, validating the use of liquid biopsies in routine care for patients with rare subtypes of breast cancer.
A retrospective study from George Washington University found that spironolactone is not associated with increased risk of female breast cancer recurrence. The drug may be used as an additional treatment option for alopecia in female breast cancer patients who are disease-free.
Researchers at Oxford University have identified a genetic vulnerability in nearly 10% of all breast cancer tumors, which can be exploited to selectively kill cancer cells. The discovery also suggests that the same defect leaves cells entirely reliant on their centrosomes for cell division.
The journal features original research articles on Parkinson's Disease and drug-induced interstitial lung disease, as well as a case report and opinion piece on breast cancer management during the COVID-19 pandemic. Open access publishing and author support are also highlighted.
A study by Professor Nicola Aceto's research group at the University of Basel found that a lack of oxygen in tumors triggers the formation of metastases. The team discovered that cancer cells with insufficient oxygen leave the primary tumor to migrate and form new tissues.
A new study found that a protein called BIK triggers failed apoptosis, leading to DNA damage and mutations in ER-positive breast cancer cells. This process makes the cancer cells more aggressive and evasive of therapy.
UT Dallas researchers developed a proof-of-concept model that quantifies thermal characteristics of breast cancer, detecting temperature differences and increased blood flow. The study aims to improve digital infrared thermal imaging for monitoring breast cancer and its treatment.
Researchers at Massachusetts General Hospital have developed a method to identify clinical markers that predict patient response to immune checkpoint inhibitors. The approach involves analyzing gene signatures from cancer tumors and correlating them with patient outcomes, revealing distinct patterns between responders and non-responders.
Researchers at UT Southwestern Medical Center have discovered two experimental drugs that can suppress the growth and spread of non-small cell lung cancer (NSCLC) by affecting its blood vessels, oxygen levels, and other environmental factors. The findings highlight the potential of these drugs for NSCLC treatment.
Researchers found widespread imbalances in chromosomal gains and losses between cells taken from different parts of tumors, indicating ongoing evolution and selection for preferred traits. This high-level variation was observed across all tumor types analyzed, with some regions showing mirrored subclonal allele imbalance.
Research published in Nature Precision Oncology reveals that honeybee venom and its compound melittin rapidly destroy triple-negative and HER2-enriched breast cancer cells. The venom's potency allows for selective cell death with minimal effects on normal cells.
Researchers found that overexpression of gene BIRC2 makes cancer cells resistant to immunotherapy drugs. The study suggests that BIRC2 could be a key marker for identifying patients who may not respond to immunotherapy, paving the way for personalized treatment approaches.
A study of over 180 girls found that those entering puberty early have a longer window of susceptibility to breast cancer, with higher growth hormone levels and slower pubertal progression. This can be mitigated through healthy lifestyle habits, such as exercise, balanced diet, and reduced exposure to endocrine disruptors.
Researchers are developing a novel, noninvasive method to target and kill cancerous cells in breast tissue using nanoparticles and ultrasound. This approach, nanoparticle-mediated histotripsy (NMH), aims to improve the safety of treatment for metastatic breast cancer patients by reducing harsh side effects associated with chemotherapy....
A new study shows that implant-based breast reconstruction remains stable for both aesthetic and patient-reported outcomes over a 12-year follow-up period. The research contradicts conventional wisdom among surgeons, suggesting that women can expect long-lasting results from this procedure.
The ESMO Virtual Congress 2020 showcased promising results in triple negative breast cancer, a new class myeloid specific antibody in solid cancer, and health-related quality of life data from a phase 3 immunotherapy study. Keynote lecturers discussed the impact of COVID-19 on patients, oncologists, and healthcare systems.
A new breast cancer treatment developed by UIC researchers has shown safety and effectiveness in Phase 1 clinical trials, with no toxic side effects reported. The drug, TTC-352, halted disease progression in six patients with metastatic breast cancer, offering a promising alternative to traditional hormone therapy.
Researchers at Karolinska Institutet have found that one AI algorithm is as accurate as the average radiologist in identifying breast cancer from mammograms. The study compared three AI algorithms and showed significant differences between them, with one outperforming others and rivaling human detection accuracy.
A new combination therapy targeting breast cancer tumors in the brain has been shown to reduce tumor size and increase survival in a study with mice. The treatment, which combines vinorelbine and I-BET-762, was found to be effective in curing up to 75% of mice with brain metastases.
Prof. Hans-Joachim Schmoll receives the ESMO Award 2020 for his pioneering work in developing medical oncology as a specialty, while Prof. Nadia Harbeck wins the Lifetime Achievement Award for her global cancer research and education contributions.
Breast cancer cells can exist in different cellular states, ranging from stem-like cells to more differentiated cells. Researchers identified a complex spectrum of cell states between different tumor types, which can range from stem-cells to 'beginner cells' and more differentiated cells.
A study by Hokkaido University scientists found that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer. High levels of IL-34 were associated with poor prognosis in TNBC patients.