Articles tagged with Breast Cancer
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Researchers found a pattern of gut bacteria, specifically SCFAs, that may influence the effectiveness of chemotherapy in breast cancer patients. These chemicals play a role in the immune system and may help patients mount an immune response against cancer cells.
Researchers investigated quality of life among younger women after breast cancer surgery, finding differences in physical functioning and body image between mastectomy and breast conserving surgery. Anxiety and depressive symptoms also varied by surgical approach.
Researchers at Boston University School of Medicine aim to create new breast tumor models that represent women with comorbidities like diabetes, which can lead to improved outcomes in survival. The project's goal is to address the unmet clinical need for better treatment options for these patients.
Researchers at Case Western Reserve University are developing a novel technique using nanotechnology to wake up 'cold' tumors, allowing immune cells to locate and neutralize them. The approach aims to improve treatment outcomes for metastatic breast cancer patients by combining nanotechnology with immunotherapy.
Researchers at Huntsman Cancer Institute discovered that HIF-1α is linked to aggressive tumors, metastasis, and poor patient survival, while HIF-2α is associated with less aggressive tumors and better outcomes. The study suggests a potential new paradigm for understanding kidney cancer.
A new study from Northwestern Medicine reveals that biological sex has a small but significant impact on gene expression in every type of human tissue. The researchers found over 37% of genes were expressed differently in males and females, with diverse molecular functions involved, including disease-related traits.
A major clinical trial found that a blood test can reliably match women with advanced breast cancer to effective targeted treatments by tracking disease evolution and mutations. The plasmaMATCH trial showed promising results, validating the use of liquid biopsies in routine care for patients with rare subtypes of breast cancer.
A retrospective study from George Washington University found that spironolactone is not associated with increased risk of female breast cancer recurrence. The drug may be used as an additional treatment option for alopecia in female breast cancer patients who are disease-free.
Researchers at Oxford University have identified a genetic vulnerability in nearly 10% of all breast cancer tumors, which can be exploited to selectively kill cancer cells. The discovery also suggests that the same defect leaves cells entirely reliant on their centrosomes for cell division.
The journal features original research articles on Parkinson's Disease and drug-induced interstitial lung disease, as well as a case report and opinion piece on breast cancer management during the COVID-19 pandemic. Open access publishing and author support are also highlighted.
A study by Professor Nicola Aceto's research group at the University of Basel found that a lack of oxygen in tumors triggers the formation of metastases. The team discovered that cancer cells with insufficient oxygen leave the primary tumor to migrate and form new tissues.
A new study found that a protein called BIK triggers failed apoptosis, leading to DNA damage and mutations in ER-positive breast cancer cells. This process makes the cancer cells more aggressive and evasive of therapy.
UT Dallas researchers developed a proof-of-concept model that quantifies thermal characteristics of breast cancer, detecting temperature differences and increased blood flow. The study aims to improve digital infrared thermal imaging for monitoring breast cancer and its treatment.
Researchers at Massachusetts General Hospital have developed a method to identify clinical markers that predict patient response to immune checkpoint inhibitors. The approach involves analyzing gene signatures from cancer tumors and correlating them with patient outcomes, revealing distinct patterns between responders and non-responders.
Researchers at UT Southwestern Medical Center have discovered two experimental drugs that can suppress the growth and spread of non-small cell lung cancer (NSCLC) by affecting its blood vessels, oxygen levels, and other environmental factors. The findings highlight the potential of these drugs for NSCLC treatment.
Researchers found widespread imbalances in chromosomal gains and losses between cells taken from different parts of tumors, indicating ongoing evolution and selection for preferred traits. This high-level variation was observed across all tumor types analyzed, with some regions showing mirrored subclonal allele imbalance.
Research published in Nature Precision Oncology reveals that honeybee venom and its compound melittin rapidly destroy triple-negative and HER2-enriched breast cancer cells. The venom's potency allows for selective cell death with minimal effects on normal cells.
Researchers found that overexpression of gene BIRC2 makes cancer cells resistant to immunotherapy drugs. The study suggests that BIRC2 could be a key marker for identifying patients who may not respond to immunotherapy, paving the way for personalized treatment approaches.
A study of over 180 girls found that those entering puberty early have a longer window of susceptibility to breast cancer, with higher growth hormone levels and slower pubertal progression. This can be mitigated through healthy lifestyle habits, such as exercise, balanced diet, and reduced exposure to endocrine disruptors.
Researchers are developing a novel, noninvasive method to target and kill cancerous cells in breast tissue using nanoparticles and ultrasound. This approach, nanoparticle-mediated histotripsy (NMH), aims to improve the safety of treatment for metastatic breast cancer patients by reducing harsh side effects associated with chemotherapy....
A new study shows that implant-based breast reconstruction remains stable for both aesthetic and patient-reported outcomes over a 12-year follow-up period. The research contradicts conventional wisdom among surgeons, suggesting that women can expect long-lasting results from this procedure.
The ESMO Virtual Congress 2020 showcased promising results in triple negative breast cancer, a new class myeloid specific antibody in solid cancer, and health-related quality of life data from a phase 3 immunotherapy study. Keynote lecturers discussed the impact of COVID-19 on patients, oncologists, and healthcare systems.
A new breast cancer treatment developed by UIC researchers has shown safety and effectiveness in Phase 1 clinical trials, with no toxic side effects reported. The drug, TTC-352, halted disease progression in six patients with metastatic breast cancer, offering a promising alternative to traditional hormone therapy.
Researchers at Karolinska Institutet have found that one AI algorithm is as accurate as the average radiologist in identifying breast cancer from mammograms. The study compared three AI algorithms and showed significant differences between them, with one outperforming others and rivaling human detection accuracy.
A new combination therapy targeting breast cancer tumors in the brain has been shown to reduce tumor size and increase survival in a study with mice. The treatment, which combines vinorelbine and I-BET-762, was found to be effective in curing up to 75% of mice with brain metastases.
Prof. Hans-Joachim Schmoll receives the ESMO Award 2020 for his pioneering work in developing medical oncology as a specialty, while Prof. Nadia Harbeck wins the Lifetime Achievement Award for her global cancer research and education contributions.
Breast cancer cells can exist in different cellular states, ranging from stem-like cells to more differentiated cells. Researchers identified a complex spectrum of cell states between different tumor types, which can range from stem-cells to 'beginner cells' and more differentiated cells.
A study by Hokkaido University scientists found that Interleukin-34 is a prognostic marker and drug target for Triple Negative Breast Cancer. High levels of IL-34 were associated with poor prognosis in TNBC patients.
Scientists at Princess Margaret Cancer Centre discover a promising approach to identify the best patients for targeted therapy in triple negative breast cancer. Using patient-derived cell lines, researchers found a correlation between levels of RB1 protein and decreased growth in cancer cells.
Scientists present research on negative side effects of opioids influenced by the immune system, a new type of immunotherapy extending survival in mouse models of breast cancer, detectable micro- and nanoplastics in human tissues, interactions between ocean microbes and pollution influencing climate, bio-based communication networks co...
A single dose of targeted radiotherapy during surgery is comparable to conventional radiotherapy in efficacy for most women with early breast cancer. This reduces the need for extra hospital visits and minimizes side effects. The long-term results show no significant difference in survival or likelihood of cancer recurrence.
A study by researchers at the University of Illinois Chicago found that nearly half of breast cancer survivors in the US experienced delays in care due to COVID-19. The most commonly reported delay was for routine follow-up visits, with other common delays including chemotherapy and radiation treatments.
A Singapore breast surgical unit developed strategies to balance COVID-19 battle with breast cancer care, emphasizing multidisciplinary teamwork and patient stratification. Prompt adaptation to restricted resources and balancing risks are crucial in providing optimal patient care.
A new immunotherapy approach using nanoparticles has shown promising results in extending the survival of mice with triple negative breast cancer. The treatment, which incorporates oxidized tumor cell lysates, triggered a stronger immune response and led to complete remission in two-thirds of treated mice.
Research finds strong association between smoking and reduced cancer screening services use among postmenopausal women, leading to advanced disease diagnosis. Current smokers are nearly 3 times as likely to be diagnosed with late stage breast cancer, and over twice as likely to be diagnosed with late stage bowel cancer.
A team of researchers has identified four subtypes of cells in triple negative breast cancer that contain promising new therapeutic targets. The study found that one subtype produces molecules that suppress immune cells, which may help cancer cells evade the immune system.
A new study led by Queen Mary University of London found that breast screening women aged 40-49 reduces breast cancer mortality with minimal increased overdiagnosis. The study analyzed data from 160,000 women and found a 25% reduction in breast cancer mortality in the first ten years.
Researchers found that breast cancer diagnosis via diffusion-tensor imaging (DTI) was equivalent before and after gadolinium-based contrast agent administration. DTI parameters showed a statistically significant reduction in cancer lesions after contrast enhancement, leading to increased conspicuity for radiologists.
A new study from the American College of Surgeons found that longer time to surgical treatment does not lower overall survival for women with early-stage breast cancer who underwent delayed operations before the pandemic. Patients who received neoadjuvant endocrine therapy also showed no decreased survival, according to the research.
A new study published in the Journal of the American College of Surgeons found that surgical delays for very early stage breast cancer patients did not impact overall survival. In fact, increased time to surgery was associated with a small increase in pathological upstaging, but no significant difference in survival rates.
Researchers at GW Cancer Center demonstrate that HDAC6 inhibitors can both enhance immunotherapy's effectiveness and decrease breast cancer's invasiveness, offering new treatment options for triple-negative breast cancer patients.
Scientists at IRB Barcelona have discovered a new type of hypermutation called mutation fog, which generates hundreds of mutations in every cell and accumulates in critical genome regions. This process is linked to normal DNA repair and APOBEC enzyme activity, suggesting it may be a major source of cancer mutations.
A group of Russian scientists, including ITMO University researchers, has proposed a system to update existing MRI scanners. The device uses electromagnetic coupling with an additional dielectric resonator to localize the magnetic field in the breast.
Researchers at the University of Cambridge discovered that G-quadruplexes form in regions of DNA rich in guanine, playing a role in transcription and driving tumour growth. The structures are prevalent within genes and genetic regions active in breast cancer cells.
A new vaccine targeting HER2-positive breast cancers has been shown to work effectively in combination with immune checkpoint inhibitors, resulting in pronounced tumor reduction and long-term tumor-free survival. The study found that the vaccine primes the immune system, allowing the checkpoint inhibitor to rally T-cells to action.
Researchers discovered that tumour T cells produce immunosuppressive steroids to evade the immune system, reducing tumour growth in mice. Preventing steroid production using a key gene or drug significantly slowed tumour formation and progression, suggesting new drug targets for cancer immunotherapy.
A new study found that digital breast tomosynthesis (DBT) outperforms digital mammography in detecting cancers and reducing recalls. However, women with extremely dense breasts do not experience the same level of benefit from DBT. Most women with dense breasts saw an increase in cancer detection rates with DBT.
The article discusses drug-induced interstitial lung diseases caused by breast cancer treatments, which can be fatal. Multi-disciplinary integration of clinical practice and pharmacology may reduce the incidence of these diseases.
A deep learning algorithm can quickly and accurately screen cancer patient biopsies for genetic alterations that inform treatment options and likelihood to respond to specific therapies. The study found detectable mutations in 13 out of 14 tested tumor types, including lung, colorectal, breast, and gastric cancers.
Researchers discovered a way to target cancer cells by blocking functions of Flap Endonuclease 1 (FEN1), which is involved in DNA replication and repair. The approach preferentially killed BRCA1 and BRCA2 mutant cancer cell lines, with normal cells recovering from FEN1 inhibition.
A new study reveals significant increases in premenopausal breast cancer rates globally, particularly in higher-income nations like Canada. The study also finds that postmenopausal breast cancer is increasing more rapidly in lower-income countries, often due to adopting Western lifestyles and lack of early screening.
Dr Patricia Ganz shares her expertise on assessing quality of life in cancer patients, with a focus on breast cancer survivorship. She highlights the importance of centering patients' needs in both US and UK healthcare systems.
Researchers at UTSW Medical Center have identified BBOX1 enzyme as a viable target for triple negative breast cancer treatment. Overexpressing BBOX1 causes TNBC cells to proliferate, while eliminating it stops tumor growth.
A USC-led team found a fasting-mimicking diet combined with hormone therapy may increase the power of cancer hormone drugs and delay resistance in small clinical trials and mouse studies. Researchers observed reduced insulin, IGF1, and leptin levels, leading to potential anti-cancer activity.
Researchers at the University of Arkansas have developed a new nano drug candidate that kills triple negative breast cancer cells. The discovery aims to target breast cancer cells directly, reducing adverse and toxic side effects associated with chemotherapy.
A global study led by Queen Mary University of London found that screening entire populations for breast and ovarian cancer genes can prevent millions more cases than current clinical practice. The research shows that cost-effective genetic testing can be implemented in high and upper-middle income countries to save lives.
A new study published in Nature Medicine found that breast cancer patients who experience a heart attack have a higher risk of cancer recurrence, spread, and death. The research suggests that heart attacks can trigger an immune reaction that makes it easier for cancer cells to grow.
Researchers at Northwestern University have developed a new immunotherapy that extends the survival time of mice with triple-negative breast cancer by 150% and prevents tumor reoccurrence. The therapy, which uses spherical nucleic acids, stimulates an immune response to combat cancer cells.
The new volume uses a health equity approach to focus on factors associated with cancer disparities research and identifies potential solutions. Studies highlight the impact of lifestyle on breast cancer risk and link mammary gland development to breast cancer disparity.
Researchers at Johns Hopkins University School of Medicine discovered that breast cancer cells can alter the function of NK cells to facilitate their spread. The study suggests preventing this reprogramming might stop breast cancer from metastasizing, a major cause of death in breast cancer patients.