Articles tagged with Breast Cancer
A meta-analysis found that circulating tumor cell dynamics were associated with overall survival in patients with metastatic breast cancer. Changes in CTC levels before and after treatment were linked to prognosis, with median overall survival greatest for those who remained CTC-negative.
For older patients with hormone receptor-positive breast cancer, omitting postoperative radiation therapy did not compromise survival or increase risk of distant metastasis. Local recurrence rates were higher in those who didn't receive radiation therapy.
A new study found that physicians did not recognize significant symptoms in over half of breast cancer patients who reported pain, itchy skin, swelling, or fatigue during radiation therapy. The under-recognition was more common among younger patients and those from Black backgrounds, suggesting the need for better symptom detection met...
A new clinical trial suggests that postmenopausal patients with hormone receptor-positive and HER2-negative breast cancer and a low recurrence score of 25 or lower may safely avoid chemotherapy. In contrast, premenopausal patients who receive chemotherapy show improved invasive disease-free survival and overall survival rates.
A new UCLA-led research study shows that mindfulness meditation can significantly reduce depressive symptoms and related issues such as fatigue and sleep disturbance in younger breast cancer survivors. The six-week interventions were effective in improving the mental health of women diagnosed with breast cancer at a young age.
KU Leuven researchers Christine Desmedt, Tias Guns, Simon Kuhn, and Lukas Van Oudenhove have been awarded ERC Consolidator Grants. Their projects focus on breast cancer, optimisation software, reactors for sustainable chemical industry, and the impact of gut bacteria on emotions.
A study found that under-recognition of symptoms is common among breast cancer patients receiving radiation, with younger patients and Black patients being more likely to experience this. The researchers identified several factors associated with symptom under-recognition, including age, race, and treatment regimen.
A meta-analysis of breast cancer survivors found they are less likely to get pregnant due to higher risks of complications. However, when they do conceive, most deliver healthy babies with no adverse effects on their long-term survival or overall health.
Researchers discovered that melatonin may regulate gene expression and intensify tumor suppressor genes, leading to increased tumor cell death and reduced proliferation. The study identified target genes for melatonin, which could guide personalized therapies for breast cancer patients.
A study published in the journal CANCER found that Black women with early breast cancer have significantly higher obesity rates (62%) and comorbidities, such as hypertension and diabetes, than white women. Despite similar treatment decisions, these disparities contribute to a 40% mortality gap.
A new method, nnU-Net, has been developed to configure self-learning algorithms for a large number of different imaging datasets, enabling the interpretation of three-dimensional imaging data and distinguishing between tumor and non-tumor tissue.
A study published in Radiology found that digital breast tomosynthesis (DBT) improved cancer detection and reduced false negative rates compared to digital mammography. DBT also showed advantages in imaging women with dense breasts, leading to lower recall rates and more effective cancer screening.
Researchers at the University of Illinois Urbana-Champaign have found that combining exercise and mindfulness training can significantly reduce fatigue in breast cancer survivors. The study used a feasibility trial with 40 women, who reported a drop in fatigue levels after participating in a combination of both interventions.
SWOG Cancer Research Network members will share results of five network-led studies at SABCS, advancing breast cancer science and medicine. The research includes findings from RxPONDER, a trial that may change practice in breast cancer treatment.
Researchers at Memorial Sloan Kettering Cancer Center found that tumors with high mutation burden, particularly those with BRCA2 mutations, respond better to immunotherapy. This discovery may lead to more precise treatments for patients with BRCA2 mutations.
The Oncotarget journal has launched a special collection on breast cancer, featuring newly published scientific papers on prognostic markers, risk factors, therapies, and gene studies. This free-to-read resource aims to promote a better understanding of the latest breast cancer research.
A new deep learning model predicts breast cancer risk with greater accuracy, leveraging subtle imaging biomarkers in mammograms. The model outperforms traditional risk assessment models, providing more accurate and cost-effective care for patients.
The ESMO Immuno-Oncology Congress 2020 discussed the latest developments in cancer treatment, including adjuvant and neoadjuvant treatments, tumour microenvironments, and novel therapeutics. The event also examined the impact of COVID-19 on immunotherapy in cancer patients.
A new study published in Neurology found that people with multiple sclerosis (MS) had a 72% greater risk of developing bladder cancer compared to those without the disease. However, breast and colorectal cancers did not show a significant association with MS.
Researchers found that providing genetic feedback to high-risk individuals improves their understanding and perceived value of the information. The study aims to improve healthcare by enabling personalized prevention plans and treatments for people with hereditary predispositions.
Researchers are exploring unique biomarkers in normal breast tissue of Black women to improve treatment options for aggressive breast cancer. DNA analysis revealed a genetic mutation called duffy, which may contribute to higher breast cancer rates and aggressiveness in Black women.
A UK-wide study found mammography screening reduces breast cancer mortality by 37% for women screened at least once. The benefit persists for 3-4 years in younger women, making the program highly relevant across all age groups.
Researchers at University of Virginia Health System identified gene TRIM37 responsible for triple-negative breast cancer metastasis and developed potential treatment approach using nanoparticles. The approach shows promising results in lab mice, offering a new way to target a driver of metastasis and potentially improve overall survival.
Women with frozen eggs and ovarian tissue had more children after breast cancer diagnosis compared to those without fertility preservation. The study highlights the importance of reproductive counseling for young breast cancer patients.
Research finds that women with food and housing insecurity are at risk of undiagnosed breast cancer due to lapses in follow-up appointments. The study, presented at the Radiological Society of North America meeting, found that these unmet social needs lead to longer intervals between diagnostic imaging and biopsy.
A study reveals that methylation of the DVDMR region in the IGF2 gene determines its protein expression levels in breast cancer cells and tissues, suggesting a potential novel epigenetic biomarker for BC aggressiveness. The findings imply that IGF2 levels contribute to BC metastasis and chemoresistance.
Researchers applied proteogenomics to identify precise diagnostics for known treatment targets, new tumor susceptibilities, and mechanisms involved in breast cancer treatment resistance. The study provides insights into the metabolic vulnerabilities of ER+ and ER- breast cancers and suggests potential targets for diagnosis and treatment.
Researchers develop a new approach to treating lung metastasis by delivering chemokine CXCL10 via red blood cells, stimulating the immune system to attack tumors. Treatment with erythrocyte-anchored systemic immunotherapy (EASI) halts tumor growth and induces an immune response in mice.
Researchers have developed a sensitive optical method to detect formaldehyde in exhaled breath, which could lead to an inexpensive and fast way to screen for lung and breast cancer. The new approach uses multipass spectroscopy with optical fringe quenching technique, allowing detection of formaldehyde at low concentrations.
A recent study published in Science Advances suggests that LMTK3 inhibitors could be an effective treatment for breast cancer and potentially other types of cancer. The researchers successfully demonstrated the anticancer effects of LMTK3 inhibitors in cells and breast cancer models in mice.
A new biomaterial-based cancer vaccine has shown promise in treating aggressive triple-negative breast cancer (TNBC) in mice, with 100% survival rate after a subsequent injection of cancer cells. The vaccine combines chemotherapy and immunotherapy to generate a sustained anti-cancer response.
Researchers found that methylation of a specific region in the IGF2 gene, known as DVDMR, determines IGF2 protein expression levels in breast cancer. High IGF2 levels are associated with increased BC aggressiveness and metastasis.
A study published in Radiology found that digital breast tomosynthesis (DBT) with synthetic mammography improved cancer detection rates compared to traditional digital mammography. The technique reduced radiation exposure and detected a higher proportion of early-stage cancers, particularly among women with dense breasts.
A randomized clinical trial demonstrated the reliability of using circulating tumor cell count to guide frontline therapy choice for patients with estrogen receptor-positive (ER+) HER2-negative (HER2) metastatic breast cancer. The CTC count significantly improved progression-free survival for patients with high CTC counts, while hormon...
A new study shows that the introduction of new cancer drugs between 2000 and 2016 led to a significant reduction in mortality rates for patients with 15 common types of cancer, including breast, lung, and colorectal cancer. The study estimates that these drug approvals saved over 1.2 million lives during this period.
Researchers found a significant increase in cancer survival rates among Medicaid expansion states compared to non-expansion states. The study analyzed data from breast, colorectal, and lung cancer patients and discovered improved survival outcomes following the expansion of healthcare coverage.
Researchers found a significant impact on mortality if cancer treatment is delayed, whether it's surgery, chemotherapy, or radiotherapy. A four-week delay in treatment was associated with an increased risk of death across all common forms of cancer treatment.
Researchers found that Trop-2 expression is a predictive biomarker for sacituzumab govitecan efficacy in triple-negative breast cancer. Increasing Trop-2 expression improved SG efficacy in mice with HRR-proficient tumors, suggesting a potential clinical benefit for patients with high Trop-2 levels.
A Mayo Clinic study found that 13.5% of cancer patients had inherited genetic mutations associated with their cancer development. The discovery could lead to targeted cancer therapies and improved survival rates for patients with these high-risk mutations.
Emanuel Petricoin, Co-Director of CAPMM, is receiving $280,696 in funding to discover protein biomarkers for response prediction in stage II/III breast cancer patients. The project aims to utilize data from the ISPY2 TRIAL to develop novel targeted therapy agents.
Nelson will lead a collaborative research team to address shortcomings in breast cancer management, diagnosis, and therapy. He aims to eliminate mortality associated with metastatic breast cancer by leveraging cholesterol homeostasis.
Researchers are exploring glycans in breast cancer cells to develop an earlier test for breast cancer through liquid biopsies. By identifying unique sugar patterns, the team aims to improve diagnostic accuracy and catch cancers at their earliest stage.
A team of researchers discovered that the mammary basal cell lineage contributes to breast cancer heterogeneity, fueling the outgrowth of multiple aggressive tumor subpopulations. By activating a signaling pathway driven by protein kinase A (PKA), they can limit self-renewal potential and impede metastasis.
A new study published in The BMJ provides updated estimates of the increased risks of breast cancer associated with hormone replacement therapy (HRT) use. For longer-term HRT use, the increased risks are lower than previously reported, while a more pronounced decline in risk is observed once HRT has stopped.
A new three-dimensional imaging technique has been developed to improve the visibility of brain tumors in MRI scans, doubling contrast between tumors and normal brain tissue. This could enable earlier detection and more effective treatment of malignant tumors.
A study aims to identify geographic and racial disparities in mammography screening rates among Black and Hispanic women. The research will inform targeted interventions to improve access to screening and reduce mortality from breast cancer.
A new technology makes it possible to analyze all the tissue removed from a tumor in 3D without cutting, significantly increasing the reliability of diagnosis. This revolutionizes pathology and provides new insights into cancer development, potentially leading to improved treatment options.
Researchers at the University of Virginia have discovered that cancer alters the three-dimensional structure of chromosomes to create a comfortable home for itself inside cells. This remodeling is linked to changes in gene expression and can be targeted with specific drugs, offering new approaches to cancer treatment.
A new 'fast' MRI test has been shown to detect breast cancers that 3-D mammograms may miss in women with dense breasts. The test, which is an abbreviated version of traditional breast MRI, detected 27 cancers per 1,000 women screened.
A new technique has found extremely high stiffness in tiny regions of aggressive breast cancer tumors, suggesting only a few areas need to stiffen for metastasis to occur. This could lead to improved cancer detection and mapping.
This issue of Acta Pharmaceutica Sinica B features three original research articles exploring novel mechanisms and treatments for various diseases, including cerebral ischemia-reperfusion injury, anti-atherosclerosis, and breast cancer. The articles discuss the potential benefits of IL-4 supplementation, berberine's gut-absorption-enha...
A collaborative team developed an organs-on-a-chip system to monitor heart toxicity from breast cancer drugs. The dual-organ system closely mimics bodily tissues and provides evidence that the interplay between the heart and breast cancer tissues influences cell function and disease progression.
A new study reveals that women over 65 with breast cancer have a significant risk of developing the disease due to disease-causing mutations in predisposition genes. The researchers found that up to 20% of these women may still be at high risk for breast cancer, even without prior diagnosis.
Research suggests that genetic predisposition to increased weight is causally protective for breast and prostate cancer. Heavier women are less likely to develop breast cancer due to additional differences between groups, while heavier men are less likely to develop prostate cancer, particularly when exposed to carcinogenic substances.
Researchers found that Indian and Pakistani women are diagnosed with breast cancer at a younger age and at more advanced stages than non-Hispanic white women. The study highlights the need for culturally relevant strategies to improve preventive healthcare in this growing population.
Researchers have identified certain features of a patient's tumor that can predict whether axillary lymph node dissection is necessary, sparing women from disabling arm swelling. A UCLA study found over 40% of women with lymph node involvement at diagnosis have only 1-3 positive nodes at surgery.
Researchers at Texas A&M University developed a method to detect and monitor pediatric brain cancer using epigenetic markers in cerebrospinal fluid. The approach, which overcomes limitations of liquid biopsy, holds promise for giving clinicians real-time insights into treatment response.
Research found that vitamin D3 reduces both HAS2 gene expression and hyaluronic acid synthesis in multiple models of breast cancer. The study suggests a novel role for vitamin D3 and the VDR in control of HA synthesis, which likely contributes to its anti-cancer actions.
A new study suggests that controlling two proteins, ANP32E and H2AZ, could prevent cancer by regulating cell division and tumor growth. With high levels of H2AZ found in breast and brain cancers, targeting these proteins may make cancer cells more sensitive to anti-cancer drugs or immune-system attack.
Researchers found that combining Th1 cytokines IFN-gamma and TNF-alpha with the small molecule Akt antagonist MK-2206 maximizes indicators of apoptotic cell death in breast cancer cells. The study also suggests a combined therapy approach for Akt-targeting drugs that incorporates recombinant Interferon-gamma.