Articles tagged with Breast Cancer
Researchers found that exercise training in mice with human breast cancer grew tumors more slowly and responded better to immunotherapy, with increased anti-tumor immune responses. Exercise also enhanced the activity of cytotoxic T lymphocytes (CD8+ T cells), which killed cancer cells.
Researchers at the Francis Crick Institute found that blocking a specific protein, DNPH1, sensitised BRCA-defective cancer cells to treatment with PARP inhibitors. The discovery suggests a promising potential treatment combination that could lead to improved therapy for patients with inheritable breast cancers.
Researchers have found that standard definition infrared spectroscopy can be sufficient for accurate diagnosis in urgent situations, challenging the notion that high-definition imaging is always superior. The study provides guidelines for choosing the optimal technology and instrument configuration for clinical work.
A recent study published in Radiology found that 3D-mammography reduces the number of breast cancer cases diagnosed between routine screenings. The study included almost 15,000 women who received both 3D-mammography and traditional mammography, and compared cancers detected in between screenings.
A new study by NYU Rory Meyers College of Nursing found that breast cancer survivors with high genomic test scores report higher overall fear and greater perceived consequences compared to those with low scores. Anxiety and emotional response to cancer are the best predictors of fear, explaining 58% of variance in fear of recurrence.
Researchers at UVA Cancer Center discovered that antibody approaches targeting death receptor-5 could be revived by co-targeting negative biological processes with immune-activating therapy. This combination therapy increased the effectiveness of cancer killer immune cells, shrinking tumors and improving survival in lab mice.
A study published in Radiology found that digital breast tomosynthesis (DBT) reduces the rate of interval cancers, which are more aggressive than screen-detected cancers. The study suggests that DBT may contribute to lower breast cancer mortality by detecting rapidly growing cancers with poorer prognosis.
A large multi-center study trains convolutional neural networks to classify breast lesions from ultrasound images, achieving high accuracy rates. The model's performance is compared to that of experienced ultrasonologists, showcasing the potential of AI in speeding up early cancer detection and reducing workload.
A new study suggests removing additional tissue around the tumor cavity can reduce positive margins in patients with ductal carcinoma in situ (DCIS) by nearly 65%. Achieving clear margins is crucial in decreasing cancer recurrence, and this technique should be considered for DCIS patients.
Researchers found that tumors with a softer matrix are more resistant to treatment, activating signaling pathways that promote cell survival. Targeting this pathway could enhance the effectiveness of chemo- and radiotherapy.
Researchers have identified a pair of microRNAs that help maintain breast cancer stem cells and drive tumor growth. Targeting these microRNAs may improve the prognosis of patients with aggressive forms of breast cancer by making cancer stem cells more susceptible to chemotherapy.
Breast cancer cells that spread to the brain must boost fatty acid production to survive due to limited access to fats. Inhibiting this process with a fatty acid synthase inhibitor may lead to tumor shrinkage.
A national study found a strong rebound in breast cancer screening rates despite COVID-19 pandemic challenges, but significant disparities and missed appointments persist. The study highlights the need for targeted interventions to overcome barriers to healthcare utilization during the pandemic.
Researchers confirmed the molecular classification's predictive value for treatment benefits in advanced hormone-sensitive breast cancer. The study found that different subtypes responded differently to ribociclib and other treatments.
Researchers at Dartmouth's Geisel School of Medicine will engage breast cancer teams across the US in a learning collaborative to adopt and implement conversation aids for early-stage breast cancer treatment options. The goal is to improve patient involvement in decision-making and increase awareness of PCORI-funded research findings.
A Phase 1 study of Z-endoxifen in patients with solid tumors demonstrated antitumor activity and prolonged stable disease, even in those who had previously responded sub-optimally to tamoxifen. The trial found that 44.4% of patients at certain dose levels achieved partial responses or stable disease.
Researchers recommend a risk-based algorithm that maximizes cancer detection by considering clinical indication, breast symptoms, and age. The approach successfully detects high-risk individuals, accounting for 55% of cancers despite limited mammograms.
A large-scale study found that people living in areas with high background radiation had a 2.5-year longer life expectancy and lower rates of certain cancers, including lung, pancreatic, colon, and rectal cancer. The researchers suggest re-evaluating the linear no-threshold paradigm for low-dose radiation.
A novel method for single-cell DNA sequencing has enabled faster and deeper study of chromosome evolution in triple-negative breast cancers. The technique revealed that these cancers undergo continued genetic copy number changes after an initial burst of chromosomal instability, which may explain why treatments are not always effective.
A large study found a strong association between ultra-processed food consumption and an increased risk of colorectal cancer, with a 10% increment in consumption leading to an 11% increase in risk. Ultra-processed foods were also linked to less healthy diets among breast cancer cases, while no association was found with prostate cancer.
Researchers have identified YAP as a key regulator in the development and spread of basal-like breast cancer. Inhibiting YAP activity with medication can significantly reduce tumour volume, offering new hope for patients' survival.
A recent study published by The Endocrine Society has found that commonly used medications for type 2 diabetes and obesity, known as GLP-1 RAs, are not associated with an increased risk of breast cancer. This new research provides relief to concerns arising from previous clinical trials of liraglutide.
A new Mayo Clinic research found that tumor mutation burden is significantly inflated in Black patients with cancer compared to White patients, affecting therapy selection. The study suggests that accurate tumor mutational burden is crucial for predicting optimal treatment for patients with diverse ancestral backgrounds.
Researchers used quantitative proteomics to stratify fibroepithelial breast lesions, identifying three candidate biomarkers: MUCL1, HTRA1, and VEGFD. These markers show promise in augmenting existing diagnosis and monitoring disease progression.
A new study published in Journal of Clinical Oncology suggests that a lower dose of tamoxifen can reduce the risk of breast cancer while minimizing adverse reactions. The research involved 1,440 women who received different doses of the drug, with the lowest dose showing a significant reduction in mammographic density and side effects.
Research suggests that contrast-enhanced mammography (CEM) is concordant with MRI for staging in women with newly diagnosed breast cancer and breast augmentation. CEM was found to be effective in detecting additional cancers not identified by MRI, including two malignant lesions.
Researchers found that low doses of propylparaben can alter pregnancy-related changes in the breast, potentially lessening its protective effects against breast cancer. Propylparaben was shown to disrupt mammary gland development and increase cell proliferation rates in mice exposed during pregnancy.
A new study published in the Endocrine Society's journal found that low doses of propylparaben can alter pregnancy-related changes in the breast, reducing protection against breast cancer. The researchers tested mice exposed to environmentally relevant doses of propylparaben during pregnancy and breastfeeding, finding increased rates o...
Researchers from Queen Mary University of London confirmed the role of oestrogen receptor biomarker in ductal carcinoma in situ and developed a new, more accurate method to predict long-term outcomes. The study found ER expression is a strong prognostic factor for recurrence in DCIS.
Researchers found that people searching for objects in 3D image stacks are less successful than those searching for the same in single 2D images. This is due to a bottleneck in human vision and cognition, where humans under-explore 3D search areas and rely on peripheral visual processing.
Nearly 500 breast cancer centers in US have different starting ages for mammography, with some recommending 40-50 years old and others 35-39 years old. The study highlights the need for standardization to ensure optimal screening guidelines.
A new study found that a high rate of genetic mutations within a tumor (high tumor mutation burden) can predict clinical responses to immune checkpoint inhibitors in certain cancer types, such as melanoma, lung and bladder cancer. However, this was not the case for other cancers, including breast, prostate and brain cancers.
Researchers found that exposure to brominated flame retardants can cause premature development of the mammary glands, increasing the risk of breast cancer. The study, led by Professor Isabelle Plante, suggests that young women exposed to BFRs in utero and through breastfeeding are now at higher risk for breast cancer.
A new analysis of US-funded cancer research reveals that online news stories mention significantly fewer studies than other forms of news media. The study found that certain types of cancer, such as breast and prostate cancer, receive more coverage relative to mortality rates.
Women with breast cancer who consumed non-diet soda five times or more per week were 85% more likely to die from breast cancer. The study also found a 62% higher likelihood of dying from any causes among these patients compared to those who never drank non-diet soda.
UC researchers found that cooperation between HER2 and MED1 genes promotes breast tumor growth, spread, and treatment resistance. Targeting MED1 alone or in combination with current therapies may be an effective treatment strategy for nearly 90% of breast cancer patients.
Researchers developed a tissue-section analysis system that integrates morphological, molecular, and histological data for diagnosing breast cancer. The system provides heatmaps to explain the AI decision-making process, enabling doctors to assess results plausibility.
Decision theory enhances treatment choices by considering multiple possibilities in contradictory diagnostic findings, as shown in a study of 3753 breast cancer patients. The approach outperformed conventional statistics, providing more accurate results and improving patient outcomes.
The basement membrane surrounding tumors may control their growth and spread by becoming stiffer as it expands. Researchers used a simple technique to isolate the membrane and measure its elasticity, finding it to be nonlinearly elastic, unlike balloons made of linearly elastic materials.
African American breast cancer survivors are at a higher risk for cardiovascular disease due to increased prevalence of risk factors, yet their knowledge about CVD is low. Participants with healthier diets and higher education levels had better CVD knowledge.
Scientists have isolated a peptide, EnnA, from a fungus in Morocco that directly inhibits HSP90, a powerful cell protector hijacked by cancer. Early evidence shows EnnA induces immune cells to attack cancer cells, promoting immunogenic cell death and potentially offering a new treatment for triple negative breast cancer.
A study of over half a million Swedish women found that attending consecutive mammography screens reduces fatal breast cancer incidence by 50% and mortality by 22-33%. Repeated attendance confers greater protection than single-screen attendance, highlighting the importance of regular screening.
Purdue researchers developed a regenerative tissue filler that restored breast shape and consistency, supported new breast tissue formation, and prevented wound contraction and scar formation. The filler represents the first planned medical product using innovative collagen polymer technology.
A large study of over half a million women found that skipping even one scheduled mammography screening before a breast cancer diagnosis significantly increases the risk of dying from the cancer. Regular participation in all scheduled screens confers the greatest reduction in risk of dying from breast cancer.
A research team from MedUni Vienna has confirmed a threshold value for a non-invasive imaging biomarker in breast cancer screening. This can be incorporated into short standard MRI scans to reduce biopsy rates by 30%. DWI, a special MRI technique, measures the motion of water molecules and can indicate whether a biopsy is necessary.
Radiologists at Massachusetts General Hospital have developed an approach to manage swollen lymph nodes on mammograms in women who have recently received COVID-19 vaccinations. The approach aims to reduce delays in vaccinations and breast cancer diagnoses while reassuring patients that the swelling is a normal response to vaccination.
A trial in Mumbai found that regular clinical breast examination led to earlier diagnosis and reduced deaths from breast cancer, especially among women aged 50 and older. The study suggests that implementation of population screening by trained health workers is feasible in low and middle income countries.
Researchers have identified a novel mechanism of resistance to immunotherapy targeting HER2, where cancer cells adopt a strategy to evade clearance by redirected lymphocytes. The study found that disrupting interferon-gamma signaling confers resistance to these immunotherapies, promoting disease progression.
NYUAD researchers have developed a new technology that enables the creation of high throughput arrays of miniaturized 3D tumor models, which can be safely cryopreserved and stored for on-demand drug testing use. This technology has the potential to revolutionize personalized medicine by predicting the outcomes of drug efficacy.
Researchers at Mayo Clinic have combined a functional test with clinical information to determine the clinical importance of BRCA2 gene variants of uncertain significance. The findings improved reclassification rates for VUS from 10% to 86%, enabling more accurate patient care and targeted therapy options.
Research reveals women of minority races and ethnicities with less education and income have lower access to 3D mammography, a technology that improves breast cancer detection. Despite FDA approval for over a decade, the technology's benefits are not equally shared across sub-populations.
A study reveals that women undergoing breast cancer surgery often feel left out of the decision-making process for reconstructive surgery, with surgeons having more say than patients. The research found that approximately one in three women believed their surgeon made decisions on their behalf.
Researchers at UMass Lowell have developed a new 3D imaging technique that uses specialized dye to better visualize human tissue inside the body. The technology, funded by the Massachusetts Life Sciences Center, has the potential to revolutionize medical imaging and improve diagnosis accuracy for breast cancer and other diseases.
Researchers developed a new X-ray imaging scanner that provides surgeons with a full 3D image of extracted tissue lumps, allowing for improved detection of diseased tissue. This technology has the potential to significantly reduce the need for repeat operations in breast cancer patients.
A phase I clinical trial reveals adipose-derived stem cells alleviate symptoms of lymphedema, improving upper extremity function and reducing treatment use. Patients experienced sustained benefits for up to four years after treatment.
Researchers discovered that tumors with low glycolysis levels respond better to CTLA-4 blockade, which destabilizes and reprograms regulatory T cells. This approach aims to personalize anti-CTLA-4 therapy for patients with these tumors.
A new radioactive bone cement has been developed as an alternative to conventional radiation therapy for treating spinal tumors. The cement can be injected into the spine to directly irradiate tumors without harming the spinal cord, promising to eliminate side effects and limit treatment options.
Researchers used positron emission tomography (PET) imaging with 18F-fluoroestradiol to predict response to a novel treatment for ER-positive, HER2-negative metastatic breast cancer patients. The study found that higher baseline 18F-fluoroestradiol uptake was associated with longer progression-free survival.
The study found that AKT isoforms have distinct expression patterns in triple-negative breast cancers, with AKT1 associated with invasiveness and sensitivity to drug treatment. Loss of AKT1 function was linked to reduced sensitivity to cisplatin, while the presence of AKT2 promoted stemness and invasion.
A study published in Nature suggests that limiting tumor cells' glucose consumption could improve immunotherapy efficacy by freeing up energy for immune cells. This approach may help overcome resistance to checkpoint blockade therapies, which have varying success rates.