Articles tagged with Breast Cancer
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Researchers found that exposure to brominated flame retardants can cause premature development of the mammary glands, increasing the risk of breast cancer. The study, led by Professor Isabelle Plante, suggests that young women exposed to BFRs in utero and through breastfeeding are now at higher risk for breast cancer.
A new analysis of US-funded cancer research reveals that online news stories mention significantly fewer studies than other forms of news media. The study found that certain types of cancer, such as breast and prostate cancer, receive more coverage relative to mortality rates.
Women with breast cancer who consumed non-diet soda five times or more per week were 85% more likely to die from breast cancer. The study also found a 62% higher likelihood of dying from any causes among these patients compared to those who never drank non-diet soda.
UC researchers found that cooperation between HER2 and MED1 genes promotes breast tumor growth, spread, and treatment resistance. Targeting MED1 alone or in combination with current therapies may be an effective treatment strategy for nearly 90% of breast cancer patients.
Researchers developed a tissue-section analysis system that integrates morphological, molecular, and histological data for diagnosing breast cancer. The system provides heatmaps to explain the AI decision-making process, enabling doctors to assess results plausibility.
Decision theory enhances treatment choices by considering multiple possibilities in contradictory diagnostic findings, as shown in a study of 3753 breast cancer patients. The approach outperformed conventional statistics, providing more accurate results and improving patient outcomes.
The basement membrane surrounding tumors may control their growth and spread by becoming stiffer as it expands. Researchers used a simple technique to isolate the membrane and measure its elasticity, finding it to be nonlinearly elastic, unlike balloons made of linearly elastic materials.
African American breast cancer survivors are at a higher risk for cardiovascular disease due to increased prevalence of risk factors, yet their knowledge about CVD is low. Participants with healthier diets and higher education levels had better CVD knowledge.
Scientists have isolated a peptide, EnnA, from a fungus in Morocco that directly inhibits HSP90, a powerful cell protector hijacked by cancer. Early evidence shows EnnA induces immune cells to attack cancer cells, promoting immunogenic cell death and potentially offering a new treatment for triple negative breast cancer.
A study of over half a million Swedish women found that attending consecutive mammography screens reduces fatal breast cancer incidence by 50% and mortality by 22-33%. Repeated attendance confers greater protection than single-screen attendance, highlighting the importance of regular screening.
Purdue researchers developed a regenerative tissue filler that restored breast shape and consistency, supported new breast tissue formation, and prevented wound contraction and scar formation. The filler represents the first planned medical product using innovative collagen polymer technology.
A large study of over half a million women found that skipping even one scheduled mammography screening before a breast cancer diagnosis significantly increases the risk of dying from the cancer. Regular participation in all scheduled screens confers the greatest reduction in risk of dying from breast cancer.
A research team from MedUni Vienna has confirmed a threshold value for a non-invasive imaging biomarker in breast cancer screening. This can be incorporated into short standard MRI scans to reduce biopsy rates by 30%. DWI, a special MRI technique, measures the motion of water molecules and can indicate whether a biopsy is necessary.
Radiologists at Massachusetts General Hospital have developed an approach to manage swollen lymph nodes on mammograms in women who have recently received COVID-19 vaccinations. The approach aims to reduce delays in vaccinations and breast cancer diagnoses while reassuring patients that the swelling is a normal response to vaccination.
A trial in Mumbai found that regular clinical breast examination led to earlier diagnosis and reduced deaths from breast cancer, especially among women aged 50 and older. The study suggests that implementation of population screening by trained health workers is feasible in low and middle income countries.
Researchers have identified a novel mechanism of resistance to immunotherapy targeting HER2, where cancer cells adopt a strategy to evade clearance by redirected lymphocytes. The study found that disrupting interferon-gamma signaling confers resistance to these immunotherapies, promoting disease progression.
NYUAD researchers have developed a new technology that enables the creation of high throughput arrays of miniaturized 3D tumor models, which can be safely cryopreserved and stored for on-demand drug testing use. This technology has the potential to revolutionize personalized medicine by predicting the outcomes of drug efficacy.
Researchers at Mayo Clinic have combined a functional test with clinical information to determine the clinical importance of BRCA2 gene variants of uncertain significance. The findings improved reclassification rates for VUS from 10% to 86%, enabling more accurate patient care and targeted therapy options.
Research reveals women of minority races and ethnicities with less education and income have lower access to 3D mammography, a technology that improves breast cancer detection. Despite FDA approval for over a decade, the technology's benefits are not equally shared across sub-populations.
A study reveals that women undergoing breast cancer surgery often feel left out of the decision-making process for reconstructive surgery, with surgeons having more say than patients. The research found that approximately one in three women believed their surgeon made decisions on their behalf.
Researchers at UMass Lowell have developed a new 3D imaging technique that uses specialized dye to better visualize human tissue inside the body. The technology, funded by the Massachusetts Life Sciences Center, has the potential to revolutionize medical imaging and improve diagnosis accuracy for breast cancer and other diseases.
Researchers developed a new X-ray imaging scanner that provides surgeons with a full 3D image of extracted tissue lumps, allowing for improved detection of diseased tissue. This technology has the potential to significantly reduce the need for repeat operations in breast cancer patients.
A phase I clinical trial reveals adipose-derived stem cells alleviate symptoms of lymphedema, improving upper extremity function and reducing treatment use. Patients experienced sustained benefits for up to four years after treatment.
Researchers discovered that tumors with low glycolysis levels respond better to CTLA-4 blockade, which destabilizes and reprograms regulatory T cells. This approach aims to personalize anti-CTLA-4 therapy for patients with these tumors.
A new radioactive bone cement has been developed as an alternative to conventional radiation therapy for treating spinal tumors. The cement can be injected into the spine to directly irradiate tumors without harming the spinal cord, promising to eliminate side effects and limit treatment options.
Researchers used positron emission tomography (PET) imaging with 18F-fluoroestradiol to predict response to a novel treatment for ER-positive, HER2-negative metastatic breast cancer patients. The study found that higher baseline 18F-fluoroestradiol uptake was associated with longer progression-free survival.
The study found that AKT isoforms have distinct expression patterns in triple-negative breast cancers, with AKT1 associated with invasiveness and sensitivity to drug treatment. Loss of AKT1 function was linked to reduced sensitivity to cisplatin, while the presence of AKT2 promoted stemness and invasion.
A study published in Nature suggests that limiting tumor cells' glucose consumption could improve immunotherapy efficacy by freeing up energy for immune cells. This approach may help overcome resistance to checkpoint blockade therapies, which have varying success rates.
A collaboration between George Mason University and Rutgers Cancer Institute aims to validate a new test for measuring HER2 biomarkers, which can predict patient response to treatment. The test uses advanced technology to analyze tissue samples and identify specific therapies for individual patients.
New study reveals that breast cancer mortality rates have stopped decreasing among women aged 20-39, with distant-stage cancers on the rise. Researchers attribute this change to increased incidence of late-stage breast cancers, highlighting the importance of mammography screening for early detection.
A new drug, ProAgio, has been shown to be effective in treating pancreatic cancer and prolonging survival in mice. It works by inducing apoptosis in cancer-associated fibroblasts, reducing the dense stroma that protects tumors from immune systems and conventional drugs.
A mammography screening strategy based on a baseline breast density measure at age 40 is the most effective and cost-effective way to reduce breast cancer mortality. The study suggests that this approach can lead to a significant reduction in breast cancer mortality, but also increases the number of mammograms performed and false posit...
UC researchers discovered that stopping autophagy in cancer cells can help treat HER2-positive breast cancer. By blocking this process, cancer cells were unable to develop and grow, and the HER2 protein was altered in a way that prevented its role in cancer development.
Researchers aim to establish a quantitative cut point assay level for HER2+ breast cancer using pCR. They will also validate the test on a retrospective cohort of patients receiving standard-of-care treatment at the Rutgers Cancer Center.
A randomized clinical trial found that endocrine therapies can reduce estradiol levels in men with hormone receptor-positive breast cancer after three months of treatment. The study suggests a potential new approach for male breast cancer patients.
The CIC biomaGUNE BioNanoPlasmonics research team has grown three-dimensional tumours in scaffolds containing plasmonic nanoparticles to study cancer growth and dynamics. They aim to gain insight into tumour evolution over time by monitoring metabolites, temperature, and pH.
Researchers found that long-term occupational exposure to sunlight is associated with a lower risk of breast cancer in women after the age of 50. Vitamin D levels may protect against the disease, but the study's limitations highlight the need for further investigation.
A national survey found that four-fifths of US physicians believe significant disabilities are associated with worse quality of life. The study highlights the need for medical education to include training on disability and awareness of unconscious bias.
A recent study discovered that SORLA protein plays a crucial role in the growth of breast cancer cells in the brain and their resistance to HER2 therapy. Removing SORLA from cancer cells sensitizes them to anti-HER2 treatment, offering new possibilities for targeting drug-resistant cancers.
Researchers discovered that the RPS-12 protein triggers triple-negative breast cancer and possibly other malignancies by activating an important signaling pathway. The protein's overproduction also leads to developmental abnormalities in fruit fly eyes.
A study of 44,541 women found that taking metformin to treat type 2 diabetes may protect against developing ER-positive breast cancer. However, the risk of triple negative breast cancer was increased by 74% among those treated with metformin. The link between type 2 diabetes and breast cancer varied by breast cancer subtype.
A nationwide panel developed guidelines recommending discontinuing routine mammograms for survivors with a life expectancy under five years. Guidelines also suggest stopping screening for those with a 5-10-year life expectancy, and continuing annual or biennial mammography when life expectancy exceeds 10 years.
A new machine learning algorithm named Mirai estimates breast cancer risk in women more accurately than current models, identifying 41.5% of patients at risk within 5 years. The model was effective across various races and ethnicities, supporting its potential to inform screening guidelines for diverse populations.
Breast cancer cells can evade immune attacks by increasing the level of protein MAL2 on their surface, leading to enhanced tumor growth. Targeting this action could improve immunotherapy for patients. Researchers identified MAL2 as a key protein and found that inhibiting it can almost completely stop tumor growth.
A TGen-led study has developed a test to detect infinitesimally small breast cancer biomarkers in blood samples, improving detection accuracy. The test uses a highly specific protein signature to identify the earliest stages of breast cancer with no false positives.
Researchers at UToledo have received funding to advance a new chemotherapy treatment for triple negative breast cancer, which shows promise in overcoming multidrug resistance. The treatment targets a unique cell death pathway, potentially offering new hope for patients with poor prognosis.
Researchers found that time-restricted feeding, a form of intermittent fasting aligned with circadian rhythms, improved metabolic health and reduced tumor growth in mice with obesity-driven postmenopausal breast cancer. Elevated insulin levels drove accelerated tumor growth, which was mitigated by reducing insulin levels.
A new multi-institution study provides more accurate estimates of breast cancer risk for US women with inherited mutations in breast cancer predisposition genes. The findings may allow healthcare providers to better assess the risk of breast cancer and provide more appropriate risk management strategies.
A study found that Anastrozole-induced bone loss partially reverses, especially at the lumbar spine, when treatment is stopped. The results suggest improved bone health, encouraging physicians to weigh risks and benefits in high-risk women eligible for the drug.
Researchers at NUI Galway have contributed to a significant international study identifying nine specific genes linked to breast cancer risk. The study, published in the New England Journal of Medicine, used DNA samples from 2,000 Irish patients and controls to uncover key genetic associations.
A recent study published in JAMA Oncology found significant racial disparities in breast cancer prognosis testing among Black women, who have higher recurrence and mortality rates than non-Hispanic white women. The study suggests that genomic tumor tests may require re-calibration to reflect racial differences.
The Minnesota Partnership has awarded five teams with nearly $5 million in research grants to develop a long-lasting COVID-19 vaccine, new treatments for breast and other cancers, and gene-editing techniques to prevent birth defects. The projects will focus on improving treatment of diseases such as cancer and genetic disorders.
A large international consortium has identified nine genes that increase breast cancer risk, which can now be used to personalize follow-up and screening programs. The study analyzed 113,000 samples and confirms the importance of these genes in predicting breast cancer risk.
A new drug targeting enzymes involved in myristoylation has shown promise in treating both breast and blood cancers. Researchers found that patients with specific enzyme NMT2 were more likely to die, and the drug slowed tumour growth by 90% in mice with human breast cancer.
Scientists have discovered a link between nicotine and the spread of breast cancer cells into the lungs, which can lower survival rates by 33%. Nicotine exposure creates an environment ripe for metastatic growth, attracting immune cells that promote tumor growth.
Researchers have identified a molecular crowbar that enables cancer cells to invade surrounding tissues. Hepsin, normally a glue-like protein, becomes a destructive enzyme when activated by Ras, leading to the breakdown of the basement membrane and cancer cell invasion.
Researchers have found that androgen receptor activation by natural androgens or a new drug has potent anti-tumour activity in all estrogen receptor positive breast cancers, even those resistant to current treatments. This study provides new evidence for an alternative treatment strategy.
Researchers at RCSI University of Medicine and Health Sciences have discovered a molecule, BAS-2, that selectively kills cells of triple negative breast cancer while sparing normal cells. The molecule inhibits an enzyme called HDAC6, playing a key role in altering energy in these cancer cells.
Researchers developed CopyKAT, a new computational technique that accurately differentiates between cancer and normal cells in solid tumor samples. The tool uses gene expression data to identify aneuploidy and distinct subpopulations within cancer cells.
A team of engineers at Rensselaer Polytechnic Institute developed an in vitro lymphatic vessel model to study tumor emboli growth. Researchers found that the model showed different growth behaviors based on cell type, linked to force generation capability, and has implications for therapeutic design.