Articles tagged with Breast Cancer
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The study found a decline in women's use of preventive health services, including sexually transmitted infection screenings and breast cancer screenings. Women also experienced reduced access to contraceptives from pharmacies during the pandemic.
Researchers develop a non-invasive imaging method to track IDO1 activity, providing a promising alternative to invasive biopsies. The study found that IDO1 status in the mesenteric lymph node is a surrogate marker for cancer-immune set point and predicts immunotherapeutic efficacy.
Researchers at NYU Abu Dhabi have determined the structure of a nanobody, Nb23, using liquid state techniques. This breakthrough could lead to better understanding of its disease-fighting potential and exploration of alternative therapeutic uses.
Breast cancer mortality rates have decreased among Black and Hispanic women since 1990, narrowing the gap with white women. However, Black women still experience double the mortality rates of non-Hispanic white women.
A team of researchers has identified a protein complex that promotes breast cancer growth, which can be disrupted to hinder tumor development. Non-toxic peptides were developed to prevent the abnormal interaction between RBM39 and MLL1 proteins in breast cancer cells.
Researchers found that a maternal diet rich in canola oil, compared to corn oil, protected mice from breast cancer development. The study showed slower-growing and smaller tumors in offspring whose mothers were fed canola oil.
A study by the American Cancer Society found a 10.2% decline in real-time electronic pathology reports from population-based cancer registries in 2020 compared to 2019. The study suggests substantial delays in diagnosis and treatment services for cancers during the pandemic.
Researchers at the University of Tennessee Health Science Center have found that obesity in mice models led to accelerated tumor growth, but anti-PD-1 immune checkpoint blockade successfully blocked this progression. The study suggests that obese patients with breast cancer may respond better to immunotherapies like checkpoint inhibitors.
Researchers at City of Hope have identified the genetic changes that occur in breast cancer cells when they become resistant to hormone therapies. These findings suggest that tumor cells can quickly change and rewire signaling pathways to persist despite treatment, providing new opportunities for targeted therapy interventions.
Researchers found that HER3 gene mutations can amplify activity of a protein that spurs tumor growth in breast cancer. A new study suggests that targeting this protein may lead to more effective treatments for patients with both HER2 and HER3 mutations.
Researchers have developed an antibody conjugate called BonTarg that delivers drugs to bone tumors and inhibits metastasis. The combination of a breast cancer drug with a bone-targeting antibody was found to significantly enhance the concentration of the antibody at tumor sites, and inhibit secondary metastasis from infected organs.
A recent study by University of Missouri researcher Jennifer Hulett found a link between forgiveness, congregational support, and reduced stress biomarkers in breast cancer survivors. The findings suggest that spiritual practices like prayer, meditation, and yoga may improve physical health outcomes among cancer survivors.
Researchers at Memorial Sloan Kettering Cancer Center developed a machine-learning approach that accurately predicts how human breast cancer tumors will evolve. By analyzing genetic makeup of thousands of individual cells, the team created a model that can predict tumor behavior and identify potential relapse sites.
Researchers at MUSC discovered a new target and immune mechanism for treating aggressive metastatic pediatric osteosarcoma. The SFRP2-PD-1 combination therapy effectively blocked cancer cell growth, providing an additive beneficial effect in preclinical models.
A large study of over 1.8 million women has found no link between fertility drugs and an increased risk of breast cancer. The research, published in Fertility and Sterility journal, provides reassurance to women seeking fertility treatments.
The phase III trial found that adding an immune checkpoint inhibitor to anti-HER2 treatment in breast cancer does not improve pathological complete response rates. The study enrolled 454 patients with high-risk HER2-positive early breast cancer and evaluated the efficacy and safety of neoadjuvant atezolizumab versus placebo.
Researchers found novobiocin selectively killed tumor cells with abnormal BRCA1 or BRCA2 genes. The drug is effective even in tumors resistant to PARP inhibitors, which are a prime therapy for cancers with DNA-repair glitches.
Researchers identified a new class of POLQ inhibitors that specifically kill cancer cells with mutations in the BRCA genes while leaving healthy cells unharmed. The drugs show promise in treating cancers such as breast, ovarian, pancreatic, and prostate cancer with BRCA mutations.
Researchers developed a new computational approach, CancerCellNet, to evaluate research models. The tool uses RNA sequences to compare lab-grown cancer cells with human tumor data, finding that cell lines are genetically inferior to genetically engineered mice and tumoroids in 4 out of 5 tested tumor types.
Researchers at Clemson University developed a bifunctional protein that links natural killer cells to breast cancer tumor cells, triggering the killing of cancer cells. The approach has potential as a new treatment option for triple-negative breast cancer, which is often lethal due to its high heterogeneity and lack of efficient treatm...
A new study of nearly 30,000 patients found that Black and white women have the same prevalence of genetic mutations associated with breast cancer risk. Younger age and ER-negative breast cancer were identified as risk factors in genes including BRCA1 and BRCA2.
A survey study among women with breast cancer in Mexico found a high hesitancy rate toward COVID-19 vaccination due to concerns about vaccine safety and efficacy. The study highlights the need for healthcare providers to address these concerns and improve access to vaccination services for this vulnerable population.
Researchers found two gene variants associated with an increased risk of triple negative breast cancer (TNBC) in African American women. The ANKLE1 gene variant is protective against TNBC, but a version found in African Americans may be oncogenic. A mutation in the Duffy gene also increases TNBC risk in African American women.
A large-scale study analyzing dietary patterns in over 350,000 women found that consuming pro-inflammatory foods increases breast cancer risk, with the strongest associations seen among premenopausal women. The study suggests that adopting an anti-inflammatory diet may help lower this risk.
A study on Saudi Arabian breast cancer patients identified somatic mutations in tumor suppressor genes, including BRCA1, BRCA2, and PIK3CA. The findings highlight the importance of routine genetic sequencing for precision therapies in the region. Novel mutations were also discovered, with potential implications for targeted treatments.
Researchers have found a new treatment with the potential to improve outcomes for patients with hereditary BRCA mutations and high-risk, early-stage breast cancer. The study shows that olaparib, a PARP inhibitor, significantly reduces the risk of breast cancer returning in high-risk patients following standard therapies.
A national survey of breast cancer patients and oncologists reveals that nearly three-quarters of patients use complementary medicine during treatment, yet doctors often fail to discuss integrative health with patients. Patients report finding hope and improving quality of life through these therapies.
Researchers found that diet can alter the breast microbiome to affect breast cancer risk. The study, published in Cancer Research, showed that a high-fat diet led to more aggressive tumors and reduced effectiveness of fish oil supplements.
Researchers at Washington University in St. Louis have developed a predictive model using tumor biomarkers and imaging parameters to forecast chemotherapy response. The model's accuracy reaches 0.94, allowing for early adjustments to treatment plans and reduced use of toxic chemotherapy drugs.
Researchers found a higher De Ritis ratio to be an independent risk factor for cancer progression in high-risk NMIBC patients. Non-BCG treatment was also identified as a risk factor for recurrence.
Researchers employed iTRAQ based quantitative proteomics to characterize protein alterations in fibroepithelial lesions (FELs) of the breast. The study identified three candidate biomarkers: MUCL1, HTRA1, and VEGFD, which were uniquely expressed in FAD, borderline, and malignant PTs, respectively.
Researchers at EPFL found that certain progestins in hormonal contraceptives can stimulate cell proliferation in the breast, while others do not. This suggests that informed choices about contraceptive composition may help prevent breast cancer risk.
Researchers at University College London have pioneered a single-dose radiotherapy approach for breast cancer treatment that is as effective as traditional radiotherapy and avoids potential damage to nearby organs. The treatment, TARGIT-IORT, has been shown to reduce the risk of fatal cardiovascular disease and other cancers in patients.
The ECOG-ACRIN Cancer Research Group presented new research results on patients with breast and HPV-associated throat cancers. A phase III trial found platinum chemotherapy ineffective in preventing recurrence of basal-like triple-negative breast cancer, while a study on severe joint pain in postmenopausal women with hormone receptor-p...
Researchers are investigating CAV1's dual role in tumor metastasis and suppression using machine learning-based analyses of super-resolution microscopy. They leverage computer vision and AI to automatically analyze data, capturing three-dimensional coordinates with nanometer resolution.
Even among insured individuals, up to 10% of cancer survivors delayed follow-up care due to financial constraints. Financial stress and anxiety hinder timely survivorship care, particularly among vulnerable populations such as racial minorities, women, and those with lower incomes.
Researchers found socioeconomic and racial inequities in breast cancer screenings before and during the pandemic. The study analyzed data from a large statewide nonprofit community health care system, revealing significant disparities among sociodemographic groups.
A new study using data from the Black Women's Health Study found no association between moderate or heavy use of hair relaxers and breast cancer risk in black women. However, heavy users of lye-containing products were found to have a 30% increased risk of estrogen receptor-positive breast cancer.
The study found a 49% decrease in breast cancer screening mammograms completed across Washington state, with significantly larger decreases for non-white women. Rural women saw a 59% reduction in mammograms, while urban women experienced a 50% drop.
A Spanish research team has developed a low-cost, easy-to-use biosensor to detect breast cancer in its earliest stages. The biosensor provides results in under an hour and can help address limitations of current diagnostic methods.
A study identified a tumor marker that can predict which breast cancer patients will benefit from early HER2 targeted therapy, helping to avoid disease relapse. The research found that low or absent MLH1 and PMS2 gene expression may indicate an increased risk of death from the disease.
A new study shows that breast cancer treatments, including chemotherapy, do not significantly increase the risk of Covid-19 infection or death. Researchers analyzed data from over 3,000 women treated for breast cancer during the pandemic and found that only 2% contracted the virus.
A new study reveals that breast cancer survivors have a 20-44% higher risk of developing new cancer diagnoses compared to healthy individuals. The research identifies specific breast cancer subtypes and diagnosis ages associated with increased risk of subsequent primary cancers.
A large survey of women in California found significant racial and ethnic differences in personal care product use, with Black women more heavily exposed to endocrine-disrupting chemicals. The study aims to fill the gap in data on products used by women of color and informs guidance for self-protection and policy development.
High levels of RANK protein trigger senescence in early stages of tumors, delaying their onset, but promote stem cell accumulation and tumour growth in advanced stages. This discovery sheds light on the complex mechanisms underlying breast cancer development and progression.
Researchers at the University of Zurich have developed a new technology called SHREAD that enables cancer tumors to produce therapeutic agents on demand, reducing side effects and improving delivery of Covid-related therapies.
A Phase 1 study of Z-endoxifen in patients with solid tumors reported partial responses in three patients and prolonged stable disease in eight. The study suggests that Z-endoxifen can benefit patients who have progressed on tamoxifen treatment, particularly those with desmoid tumors.
Breast cancer researchers followed the progression of cancer in an animal model and found a path that transforms slow-growing ER+/HER2+ cancer into fast-growing ER-/HER2+ cancer. The study suggests different treatments may be needed for each subtype, depending on the path the cells follow.
A new study suggests that cardioprotective drugs during adjuvant breast cancer therapy may not be necessary for most patients, especially those at low risk of heart disease. The research found no significant differences in heart function between patients who received these medications and placebos.
Researchers found that lasofoxifene outperformed fulvestrant in reducing primary tumor growth and preventing metastasis in the lung, liver, bone, and brain. Additionally, lasofoxifene prevents unwanted side effects, including menopausal-like symptoms.
Researchers discovered a mechanism behind Herceptin resistance in HER2-positive breast cancer cells, citing increased IGF2/IRS1 signaling. A new approach may help overcome this resistance, offering hope for refractory breast cancer patients.
A new study finds that non-Hispanic African American women with triple-negative breast cancer have a 28% increased risk of death compared to their white counterparts. The disparity is attributed to lower rates of surgery and chemotherapy, as well as differences in tumor biology and socioeconomic factors.
A study published in the European Journal of Preventive Cardiology found that nearly one in four heart failure patients experience depression or anxiety, compared to 23% of breast cancer patients, 22% of prostate cancer patients, and 15% of digestive organ cancer patients. Heart failure patients are also at a higher risk of developing ...
Researchers created an RNA atlas detailing the diverse cells in healthy and cancerous breast tissue, revealing changes that occur during cancer development. The study provides a high-resolution view of breast tissue cell types and will be an important resource for breast cancer research.
Scientists at Sanford Burnham Prebys Medical Discovery Institute identified lipid kinases as essential for balancing cellular metabolism and promoting overall health. The findings support targeting these proteins as a promising approach to treating diseases like cancer.
Moffitt researchers found that inhibiting TIM-3 enhances immune cell activity and prevents tumor growth in mice. The study suggests targeting TIM-3 to activate the STING pathway in dendritic cells as a potential therapy for certain types of cancer.
Researchers have developed a novel nano-carrier to deliver the Chinese medicine compound gambogic acid, enhancing its anti-cancer effect and reducing off-target toxicity. The treatment shows promise in treating triple-negative breast cancer with improved efficacy and reduced damage to organs.
The BreastPathQ Grand Challenge produced encouraging results, indicating a path toward integrating artificial intelligence to streamline clinical assessment of breast cancer. Thirty-nine teams from 12 countries developed automated methods for analyzing microscopy images of breast tissue and assessing pathology.
A new study suggests that CDK4 and CDK6 inhibitors can improve immune-cell therapies for treating recurrent ER-positive metastatic breast cancer. The study found that these inhibitors cause breast tumors to secrete chemokines that attract T cells, improving patients' response to cancer immunotherapies.
A Danish study of over 173,000 women found that girls with a higher BMI during childhood had lower breast cancer risks both before and after menopause. The research suggests an inverse association between childhood BMI and breast cancer risk, but further studies are needed to understand the underlying mechanisms.