Articles tagged with Breast Cancer
A new study from WashU Medicine found a strong association between high physical activity and maintaining cognitive function among breast cancer patients treated with chemotherapy. The research suggests that moderate to vigorous exercise may help ward off 'chemo brain,' a decline in cognitive function common during cancer treatment.
Researchers at Massachusetts General Hospital have identified two separate genetic alterations that enable triple-negative breast cancer cells to develop resistance to a highly effective drug. The findings could help improve therapy and prolong survival for patients with this aggressive form of breast cancer.
A new study investigated the benefits of patient participation in tumour conferences for complex cancer cases. Most respondents perceived their participation as a positive experience, finding it informative and recommended to others. However, some patients reported feelings of fear and uncertainty after participating in the conference.
Researchers found that the drug Vismodegib altered tumor-associated macrophage metabolism, shifting them from immunosuppressive M2 macrophages to pro-inflammatory M1 macrophages. This shift led to a decrease in tumor-promoting properties and improved immune response.
A single-center retrospective study found that AI-CAD reduced recall rates and improved accuracy compared to digital mammography (DM) and DBT. The study showed lower recall rates and higher accuracy for DM with AI-CAD, indicating a practical addition to lowering false-positive findings.
Scientists investigated a method to enhance immunotherapy for lung cancer and found that combining it with certain chemotherapy drugs could eliminate harmful immune cells. This approach showed promising results in preclinical studies, inducing the regression of about 70% of tumors.
Researchers at UVA Health System discovered that combining drug palbociclib with ruxolitinib could effectively treat myelofibrosis by preventing bone marrow scarring and improving blood cell counts. This potential new treatment offers a promising approach to devastating blood disorder.
Researchers at Queen Mary University of London confirmed HER2's role in predicting DCIS recurrence and response to adjuvant radiotherapy. HER2 overexpression is associated with a significantly increased risk of in situ recurrence.
A systematic review of epidemiological studies found that muscle strengthening exercises associated with aerobic activities can significantly reduce cancer mortality. The analysis suggested that strength training twice a week can protect against cancer, with the benefit being even greater when combined with aerobic activities.
Researchers analyzed association of high-sensitivity C-reactive protein (hsCRP) with breast cancer (BC) by molecular subtype among 296 cases and 259 healthy controls. High hsCRP was associated with increased odds of triple-negative BC, luminal A BC, and HER2-enriched BC.
A recent UNSW study found that women who received their polygenic risk score (PRS) for breast cancer experienced minimal regret and reduced distress compared to those who declined. The researchers also discovered that more women reported regret about not knowing their PRS score, highlighting the importance of providing clear informatio...
Researchers found that pre-treatment T2-weighted MRI texture features can accurately predict the response to neoadjuvant chemotherapy in patients with locally advanced breast cancer. The study identified 7 significant texture features and achieved high classification accuracy using a k-nearest neighbor model.
A recent study evaluated the association between COVID-19 and breast cancer screening in a San Francisco safety-net hospital. The researchers found that during the pandemic, there was a significant decrease in breast cancer screening rates, which had implications for patient health outcomes.
Researchers from UNC School of Medicine, MAHEC, and community partners will address racial disparities in maternal care by improving data accountability and providing community-based doula support. The study aims to decrease pregnancy complications for Black women and improve outcomes in maternal care.
A significant association was found between statin use and improved outcomes in women with stage I-III triple-negative breast cancer. Statin use was associated with a 58% relative improvement in breast cancer-specific survival and a 30% relative improvement in overall survival.
Mayo Clinic researchers used advanced imaging technology to visualize the BRCA1-BARD1 protein complex and its interaction with chromatin. The study provides new insights into how BRCA1-BARD1 functions, which could lead to improved cancer prevention efforts and drug development.
Lobular breast cancer patients often experience recurrence or metastasis despite hormonal therapies. CU Cancer Center researcher Matthew Sikora is studying the role of MDC1 in this subtype, finding it linked to estrogen receptor activity and potentially a novel target for treatment.
Researchers have identified a biomarker, MHC-II, that predicts response to immunotherapies in breast cancer patients. The study found that MHC-II expression is associated with response to standard chemotherapy plus durvalumab or pembrolizumab, but not to standard neoadjuvant chemotherapy alone.
A new study by Mayo Clinic researchers suggests that most women with breast cancer diagnosed over 65 should be offered hereditary cancer genetic testing. The study found mutations in actionable breast cancer risk genes in 3.2% of women with breast cancer, highlighting the need for broader testing regardless of age or family history.
Researchers at the University of Illinois have developed a new compound called ErSO that kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases. The compound targets the anticipatory Unfolded Protein Response pathway, which is already active in many breast cancer cells.
A free cancer screening program, See, Test & Treat, has been implemented to address barriers to healthcare for under-served women in Mississippi. The program offers same-day results and improves knowledge of cancer screenings and self-efficacy for seeking regular check-ups, with positive effects on health behaviors.
Researchers at UC Davis Comprehensive Cancer Center are investigating whether turmeric can successfully reduce joint pain in breast cancer patients and improve their quality of life. The study aims to provide important data on the safety and effectiveness of using turmeric with oral anti-estrogen therapy.
The COVID-19 pandemic has been linked to a potential increase in breast cancer mortality, with estimated excess deaths reaching 2,487 by 2030. Researchers used simulation models to predict the impact of screening, diagnosis, and treatment disruptions on breast cancer mortality.
A new WHO study found an association between alcohol consumption and a substantially higher risk of several forms of cancer, including breast, colon, and oral cancers. In Canada, alcohol use was linked to 7,000 new cases of cancer in 2020.
A WVU researcher led a task group to develop guidelines for reducing data transfer errors in radiation therapy. The measures aim to safeguard against medical errors in treatments that over half of all cancer patients receive.
A global study estimates that 4% of all newly diagnosed cancers in 2020 are associated with drinking alcohol, with men accounting for more than three-quarters of those cases. Moderate drinking was found to be problematic, contributing to over 103,000 cases.
Researchers at UTA are developing a new diagnostic tool for small breast tumors, using nanoparticles and ultrasound to detect temperature differences in the body. The technique has the potential to reduce anxiety and costs associated with biopsy procedures, while also improving treatment outcomes.
A new study published in PNAS has identified a protein called AXL as a crucial player in hypoxia, which promotes cancer progression and resistance to treatment. By blocking the action of this protein, researchers observed improved recovery of blood vessels and revitalization of the tumour's immune environment.
Researchers studied the mechanism of liposome accumulation in tumors using fluorescent microscopy and imaging. They found that different lipids have varying abilities to accumulate in tumors, with one lipid type showing remarkable extravasation and reaching immune and tumor cells.
A new study introduces K2Taxonomer, a software tool that analyzes high-throughput data to identify novel cell types within tumors and their microenvironments. The analysis of breast tumor-infiltrating lymphocytes revealed a transcriptional signature associated with better survival rates in cancer patients.
Researchers from Nagoya University have successfully measured the shape distributions of cell-derived nanoparticles, or extracellular vesicles, in body fluids. This study may help identify types of cancer with a painless and non-invasive method.
A new study found that lung metastases from triple-negative breast cancer contain a more diverse array of cancer cells compared to liver metastases. The researchers identified specific genes responsible for this difference, which may inform targeted therapies for breast cancer treatment.
The study found a decline in women's use of preventive health services, including sexually transmitted infection screenings and breast cancer screenings. Women also experienced reduced access to contraceptives from pharmacies during the pandemic.
Researchers develop a non-invasive imaging method to track IDO1 activity, providing a promising alternative to invasive biopsies. The study found that IDO1 status in the mesenteric lymph node is a surrogate marker for cancer-immune set point and predicts immunotherapeutic efficacy.
Researchers at NYU Abu Dhabi have determined the structure of a nanobody, Nb23, using liquid state techniques. This breakthrough could lead to better understanding of its disease-fighting potential and exploration of alternative therapeutic uses.
Breast cancer mortality rates have decreased among Black and Hispanic women since 1990, narrowing the gap with white women. However, Black women still experience double the mortality rates of non-Hispanic white women.
A team of researchers has identified a protein complex that promotes breast cancer growth, which can be disrupted to hinder tumor development. Non-toxic peptides were developed to prevent the abnormal interaction between RBM39 and MLL1 proteins in breast cancer cells.
Researchers found that a maternal diet rich in canola oil, compared to corn oil, protected mice from breast cancer development. The study showed slower-growing and smaller tumors in offspring whose mothers were fed canola oil.
A study by the American Cancer Society found a 10.2% decline in real-time electronic pathology reports from population-based cancer registries in 2020 compared to 2019. The study suggests substantial delays in diagnosis and treatment services for cancers during the pandemic.
Researchers at the University of Tennessee Health Science Center have found that obesity in mice models led to accelerated tumor growth, but anti-PD-1 immune checkpoint blockade successfully blocked this progression. The study suggests that obese patients with breast cancer may respond better to immunotherapies like checkpoint inhibitors.
Researchers at City of Hope have identified the genetic changes that occur in breast cancer cells when they become resistant to hormone therapies. These findings suggest that tumor cells can quickly change and rewire signaling pathways to persist despite treatment, providing new opportunities for targeted therapy interventions.
Researchers found that HER3 gene mutations can amplify activity of a protein that spurs tumor growth in breast cancer. A new study suggests that targeting this protein may lead to more effective treatments for patients with both HER2 and HER3 mutations.
Researchers have developed an antibody conjugate called BonTarg that delivers drugs to bone tumors and inhibits metastasis. The combination of a breast cancer drug with a bone-targeting antibody was found to significantly enhance the concentration of the antibody at tumor sites, and inhibit secondary metastasis from infected organs.
A recent study by University of Missouri researcher Jennifer Hulett found a link between forgiveness, congregational support, and reduced stress biomarkers in breast cancer survivors. The findings suggest that spiritual practices like prayer, meditation, and yoga may improve physical health outcomes among cancer survivors.
Researchers at Memorial Sloan Kettering Cancer Center developed a machine-learning approach that accurately predicts how human breast cancer tumors will evolve. By analyzing genetic makeup of thousands of individual cells, the team created a model that can predict tumor behavior and identify potential relapse sites.
Researchers at MUSC discovered a new target and immune mechanism for treating aggressive metastatic pediatric osteosarcoma. The SFRP2-PD-1 combination therapy effectively blocked cancer cell growth, providing an additive beneficial effect in preclinical models.
A large study of over 1.8 million women has found no link between fertility drugs and an increased risk of breast cancer. The research, published in Fertility and Sterility journal, provides reassurance to women seeking fertility treatments.
The phase III trial found that adding an immune checkpoint inhibitor to anti-HER2 treatment in breast cancer does not improve pathological complete response rates. The study enrolled 454 patients with high-risk HER2-positive early breast cancer and evaluated the efficacy and safety of neoadjuvant atezolizumab versus placebo.
Researchers found novobiocin selectively killed tumor cells with abnormal BRCA1 or BRCA2 genes. The drug is effective even in tumors resistant to PARP inhibitors, which are a prime therapy for cancers with DNA-repair glitches.
Researchers identified a new class of POLQ inhibitors that specifically kill cancer cells with mutations in the BRCA genes while leaving healthy cells unharmed. The drugs show promise in treating cancers such as breast, ovarian, pancreatic, and prostate cancer with BRCA mutations.
Researchers developed a new computational approach, CancerCellNet, to evaluate research models. The tool uses RNA sequences to compare lab-grown cancer cells with human tumor data, finding that cell lines are genetically inferior to genetically engineered mice and tumoroids in 4 out of 5 tested tumor types.
Researchers at Clemson University developed a bifunctional protein that links natural killer cells to breast cancer tumor cells, triggering the killing of cancer cells. The approach has potential as a new treatment option for triple-negative breast cancer, which is often lethal due to its high heterogeneity and lack of efficient treatm...
A new study of nearly 30,000 patients found that Black and white women have the same prevalence of genetic mutations associated with breast cancer risk. Younger age and ER-negative breast cancer were identified as risk factors in genes including BRCA1 and BRCA2.
A survey study among women with breast cancer in Mexico found a high hesitancy rate toward COVID-19 vaccination due to concerns about vaccine safety and efficacy. The study highlights the need for healthcare providers to address these concerns and improve access to vaccination services for this vulnerable population.
Researchers found two gene variants associated with an increased risk of triple negative breast cancer (TNBC) in African American women. The ANKLE1 gene variant is protective against TNBC, but a version found in African Americans may be oncogenic. A mutation in the Duffy gene also increases TNBC risk in African American women.
A large-scale study analyzing dietary patterns in over 350,000 women found that consuming pro-inflammatory foods increases breast cancer risk, with the strongest associations seen among premenopausal women. The study suggests that adopting an anti-inflammatory diet may help lower this risk.
A study on Saudi Arabian breast cancer patients identified somatic mutations in tumor suppressor genes, including BRCA1, BRCA2, and PIK3CA. The findings highlight the importance of routine genetic sequencing for precision therapies in the region. Novel mutations were also discovered, with potential implications for targeted treatments.
Researchers have found a new treatment with the potential to improve outcomes for patients with hereditary BRCA mutations and high-risk, early-stage breast cancer. The study shows that olaparib, a PARP inhibitor, significantly reduces the risk of breast cancer returning in high-risk patients following standard therapies.
A national survey of breast cancer patients and oncologists reveals that nearly three-quarters of patients use complementary medicine during treatment, yet doctors often fail to discuss integrative health with patients. Patients report finding hope and improving quality of life through these therapies.
Researchers found that diet can alter the breast microbiome to affect breast cancer risk. The study, published in Cancer Research, showed that a high-fat diet led to more aggressive tumors and reduced effectiveness of fish oil supplements.