Articles tagged with Breast Cancer
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A study analyzing 93 precision oncology studies revealed significant underrepresentation of racial and ethnic minority populations in cancer research. These disparities affect the representation of diverse patient groups in clinical trials, which can impact treatment efficacy and outcomes.
Research reveals that cancer cells have softer membranes than normal cells, but stiffening them can prevent abnormal changes in structure and motility. Stiffened breast cancer cells lost the ability to spread to the lungs in mouse experiments, suggesting a potential strategy for cancer treatments.
According to experts, half of patients with two common subtypes of advanced breast cancer may live for five years or longer. The new guidelines also aim to improve treatment options for triple-negative breast cancer patients.
Researchers found that combining selinexor with olaparib induces robust anti-tumor activity in vitro and in vivo in triple negative breast cancer cell lines. The combination therapy overcomes the poor prognosis associated with TNBC, characterized by low disease-free and overall survival rates.
COVID-19 vaccinations have been shown to be safe for advanced breast cancer patients, with no notable differences between vaccine brands. The second dose is crucial to induce an immune response, which has been found in 80% of patients with solid tumours.
A recent survey of advanced breast cancer patients in the UK reveals that only 14% have been recruited to a trial, highlighting a need for improved access. Patients often face barriers, including clinician reluctance to discuss trials and a lack of patient-friendly databases.
A team of researchers at George Washington University has identified DDR1 as a key molecule that prevents immune cells from entering and killing breast tumor cells. Deactivating this molecule allows immune cells to infiltrate the tumor and kill cancer cells, opening up new avenues for therapeutic agents.
A major global study found that the risk of breast cancer spreading to other parts of the body ranges from 6% to 22%. Younger women and those diagnosed with larger tumours face a higher risk. The study also sheds light on how many people develop advanced breast cancer, a gap in knowledge until now.
Researchers in mice found that chemotherapy enhances cancer's spread by making blood vessel walls more receptive, allowing cancer cells to latch on. The study shows how a chemo drug like cyclophosphamide alters non-cancer cells' properties, facilitating the cancer cells' attachment and progression.
A new study improves AI diagnoses by penalizing algorithms for false negatives, which can be more urgent than accuracy. Researchers achieved significant improvements in precision and recall for chronic kidney disease and other conditions using cost sensitivity techniques.
Researchers at Boston University have developed a new online risk prediction model for breast cancer in Black women, suitable for use in primary care settings. The model is well-calibrated and discriminatory accurate, with the highest accuracy for women under age 40.
A genetic signature has been discovered that can identify drivers of poor outcomes in advanced estrogen-receptor positive (ER+) breast cancer. The signature detects the presence of mutations and translocations in the ER gene that confer tumor independence from estrogen, making it resistant to current therapies.
Researchers at the University of Alabama at Birmingham have developed a method to identify non-responding tumors using hypoxia imaging, which shows promise for improving response rates. Investigational new drug evofosfamide was found beneficial in treating hypoxic tumors with immunotherapy.
Researchers from Kazan Federal University have developed a gene-cell preparation that uses membrane vesicles to target and kill cancer cells. The technology has shown promise in treating various types of cancer, including breast, lung, and colon cancer.
Researchers have opened a novel study for a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease. The phase I trial will determine the maximum tolerated dose of the vaccine in patients with early-stage triple-negative breast cancer.
A new study finds that high-dose radiation therapy can lengthen progression-free survival for people with advanced lung cancer when systemic therapy has not fully halted tumor growth or spread. Stereotactic body radiation therapy (SBRT) shows promise in treating oligoprogressive, metastatic lung and breast cancer.
A new study found that surgery benefits men with Stage IV breast cancer, particularly those responsive to systemic therapy. Trimodal therapy, including surgery and radiation, shows improved 5-year overall survival rates compared to systemic therapy alone.
A new, bacteria-based system can detect cancer cells and release therapeutic drugs directly into them, leaving healthy cells intact. The technology has shown promising results in preclinical tests on mice, particularly for liver cancer.
Researchers have trained a neural network to detect anomalies in medical images, adapting it to the nature of medical imaging and achieving better results. The new method uses weakly supervised training and can spot small-scale anomalies, accelerating the work of histopathologists and radiologists.
A study published in Psycho-Oncology found that breast cancer patients with low resilience are more likely to experience depressive symptoms and poor health-related quality of life during chemotherapy. Patients with high resilience, on the other hand, were less likely to develop depression and reported better health outcomes.
Women with dense breast tissue are at increased risk of developing breast cancer, which can be masked by mammograms. Mayo Clinic expert Suneela Vegunta recommends supplemental screening to diagnose additional cancers; however, consensus-based guidelines and randomized controlled studies are needed.
The new ESMO Clinical Practice Guideline provides comprehensive guidance on diagnosing, staging, and treating patients with metastatic breast cancer. The guideline incorporates recent clinical trial data to inform treatment choices, taking into account tumour biology and emerging targeted therapies.
Researchers at the University of Notre Dame discovered that aging breast tissue can lead to increased invasiveness-related gene expression in normal epithelial cells. This finding suggests that a decline in extracellular matrix composition and structure may contribute to the development of invasive breast cancer.
Researchers developed a new treatment for breast cancer by targeting the nervous system around the tumor. Cancer cells recruit nerve cells to aid their growth and proliferation, but the new treatment paralyzes these nerves and disconnects them from cancer cells.
Researchers developed a compact photonic resonator absorption microscope for point-of-care diagnostics, using photonic crystal biosensors to detect proteins or other biomarkers linked to gold nanoparticles. The portable instrument costs $7,000 and has potential applications in detecting various cancers.
Researchers found that aggressive triple-negative breast cancer cells use swiprosin-1 to hijack a cellular conveyor belt, increasing integrin circulation and cell migration. High swiprosin-1 expression correlates with metastasis formation and malignancy in breast cancer.
Physician attitudes and beliefs contribute to racial disparities in referrals for genetic counseling and testing. Black women are less likely to be referred for these services, despite having a higher breast cancer mortality rate than white women.
Researchers at the University of Copenhagen have discovered that the BRCA2 gene requires a specific enzyme, PP2A-B56, to repair DNA damage. This finding may pave the way for more targeted treatment of cancer patients with certain mutations.
Researchers identify key neurons and signaling pathway regulating female activity before ovulation. Discoveries could lead to new treatments for menopause that sidestep estrogen and reactivates the circuit with CRISPRa technology.
A Loma Linda University Health research study found that mammogram cancellations increased during the early months of the COVID-19 pandemic before decreasing to pre-pandemic levels. The study's findings could help breast cancer surgeons prepare for a potential surge of patients presenting with more advanced stages of breast cancer.
Researchers at Sunnybrook Health Sciences Centre have successfully delivered antibody therapy to breast cancer metastases in the brain using focused ultrasound. The treatment, which temporarily opens the blood-brain barrier, has shown promising results with tumor size reductions of up to 21% in patients.
This case-control study suggests that TP53 somatic mutations detected by next-generation sequencing are associated with an adverse prognosis in breast cancer. Co-existence of PIK3CA mutation was a common finding in TP53-mutant tumors.
Researchers created polymersomes that target highly invasive cancer cells, delivering anticancer drugs and preventing metastasis. The nanomachines showed strong antitumor effects in breast cancer models, inhibiting lung metastasis and prolonging survival.
High BRCA1 mRNA levels in breast cancer correlate with better survival, while LMNB2's role in CRC reveals conflicting results. Young CRC patients exhibit low p21 expression, suggesting a link between BRCA1 mRNA and tumor progression.
A new trial has found that vaginal laser therapy treatments claim to reduce negative vaginal symptoms of menopause – experienced by about half of all women – by up to 100 per cent. However, the study shows they might not work at all, with no difference found between the laser treatment and a placebo.
A survey of breast cancer patients found that nearly half use cannabis to alleviate pain, fatigue, and other symptoms while undergoing treatment. Physicians are often unaware of patients' cannabis use, highlighting the need for informed conversations about its potential benefits and risks.
Researchers from Boston University developed a risk prediction model tailored to U.S. Black women, using epidemiologic data from three case-control studies and follow-up data from the Boston University Black Women’s Health Study. The model is simple to use and can be easily incorporated into primary care settings.
A study found that chronic stress, measured by allostatic load, was associated with a lower likelihood of completing chemotherapy and lower overall survival rate in patients with lymph node-positive or high-risk lymph node-negative HER2-negative breast cancer. Allostatic load may be a better predictor than genetic ancestry for chemothe...
A new study from the University of Eastern Finland and Kuopio University Hospital found that liquid biopsy can accurately identify patients with poor breast cancer prognosis. High integrity of circulating DNA is associated with a poor prognosis, enabling earlier and more accurate detection of breast cancer. The study's findings have si...
Scientists have developed a new mouse model that enables the growth and metastatic spread of human breast tumors in mice. This breakthrough could lead to more effective treatments for estrogen receptor-positive breast cancer, which is responsible for most breast cancer deaths.
Researchers mapped cancer through protein interactions, revealing biomarkers and potential new treatments for breast and head and neck cancers. The study provides a new definition of biomarkers based on large, multi-protein complexes, offering a more precise way to explain mutation effects.
Researchers at Karolinska Institutet developed an AI-based tool to improve breast cancer diagnosis and predict recurrence risk. The method divides patients with grade 2 tumours into high-risk and low-risk sub-groups, enabling personalized treatment.
For women with extremely dense breasts, MRI screenings have been found to be more effective than mammography in detecting breast cancer. The additional costs of MRI screenings are more than compensated by their improved effectiveness in preventing death from breast cancer.
A new PET imaging agent has been shown to solve 87% of diagnostic dilemmas in breast cancer patients, providing valuable information for personalized treatment decision-making. The agent's ability to visualize estrogen receptor expression across the body may improve patient outcomes and support broader implementation in clinical practice.
A promising radionuclide treatment has been identified for HER2-positive breast cancer patients, combining radioactive iodine therapy with single-domain antibodies targeting the HER2 antigen. The treatment demonstrates safety and efficacy in a phase I study, paving the way for further clinical development.
Mayo Clinic researchers propose a comprehensive approach to breast cancer prevention, including risk assessment, lifestyle modification, and preventive medications. The approach aims to reduce hormone-sensitive breast cancers with good prognosis and unfavorable triple-negative tumors.
Researchers developed VarSAn, a computational tool that analyzes SNPs to predict disease pathways, including breast and prostate cancer. The tool uses network analysis to identify perturbed pathways, offering a new approach to understanding genetic variation.
A new AI system developed by NYU and NYU Abu Dhabi researchers achieves radiologist-level accuracy in identifying breast cancer in ultrasound images. The system helps decrease false-positive findings and requested biopsies while maintaining sensitivity.
A new study shows an artificial intelligence tool improved radiologists' ability to correctly identify breast cancer in ultrasound exams, with a 37% increase in accuracy. The tool also reduced the number of tissue samples needed to confirm suspect tumors by 27%.
Patients with certain gene mutations are at high risk of fatal chemotherapy toxicity, with a 25-times increased risk detected in those with uncommon DPYD variants. The study suggests that adding pre-treatment screening may help prevent avoidable deaths without interrupting standard care.
The study found that participants who completed the Active Living After Cancer program showed significant improvements in physical activity, six-minute walk distance, and mental health. The program is effective for minority and medically underserved cancer survivors and can be implemented through a community-based model.
UCSF researchers found that Erα plays a crucial role in overcoming innate anti-cancer mechanisms and developing resistance to treatment. Inhibiting Erα RNA-binding activity restored tamoxifen's potency against breast cancer tumors, making the cells more sensitive to stress and apoptosis.
The University of Helsinki-led research project partners with UCSF to develop new therapies targeting MYC cancer gene vulnerabilities. The goal is to create next-generation cancer drugs that selectively kill cancer cells while leaving normal cells unharmed.
Researchers analyzed data from over 3,200 brain metastatic tumors and discovered that different types of cancer tend to spread to specific parts of the brain. The study's findings may help predict where a particular cancer will metastasize and inform treatment strategies.
Research at CNRS reveals that compressed cell nuclei can lead to DNA damage and accelerated aging in healthy cells. In breast tumors, this damage enables tumor cells to invade neighboring tissues with increased risk of metastasis.
A new study finds that left-sided breast cancer radiation therapy increases the risk of coronary artery disease in younger survivors, with a significant increase in risk seen at 10.5% for those who received left-sided radiation therapy compared to 5.8% for right-sided.
A study of nearly 200,000 patients found that Black women have a three-fold increased risk of triple negative breast cancer, which has a poor prognosis. Higher breast density and obesity are associated with increased risk among this group.
Researchers developed an AI model to classify patients with localized breast cancer as high or low risk of metastatic relapse. The study shows that AI can accurately assess relapse risk with an AUC of 81%, providing a valuable aid for therapeutic decisions and avoiding unnecessary chemotherapy.
Researchers find PADI4 and HIF-1 proteins work together to deliver oxygen and nutrients to tumors, allowing them to grow. The discovery provides new avenues for anti-cancer therapies targeting blood vessel development.
Scientists discovered a protein, IL13Ra2, that promotes brain metastases in breast cancer patients. High levels of this protein are associated with poor survival rates. Researchers aim to develop targeted therapies for this specific population.