Articles tagged with Breast Cancer
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Researchers found significant molecular differences in DNA repair genes and cellular signals controlling cell growth between healthy and tumor tissue of Black and white women. These differences may lead to improved treatment strategies for ER+ breast cancer, including earlier use of CDK inhibitors.
A new study by Virginia Commonwealth University researchers finds that triplatin is effective against triple negative breast cancer with high sulfated glycosaminoglycans (sGAG) levels. The drug accumulates inside cancer cells, causing damage and slowing tumor growth.
A new study published in The Lancet Oncology found that aromatase inhibitors are more effective than tamoxifen at reducing the risk of breast cancer recurrence in premenopausal and postmenopausal women. Aromatase inhibitors were shown to be particularly beneficial for younger women, reducing the risk of recurrence by 30%.
The ACC cardiooncology course is designed to educate clinicians on improving awareness, identification, monitoring, and management of cardiovascular diseases in cancer patients. The course aims to help clinicians minimize cardiotoxicity from cancer therapies, leading to improved overall survival and quality of life for oncology patients.
Researchers used a patient's own immune cells to target unique mutations in tumor DNA, leading to measurable tumor shrinkage in 67% of patients with metastatic breast cancer. The approach has potential as a personalized treatment for hormone receptor-positive breast cancers.
A study led by RCSI researchers found that almost half of tumours with metastatic breast cancer in the brain have changes in DNA repair pathways, making them vulnerable to PARP inhibitor drugs. This discovery opens up potential novel treatment strategies for patients with limited targeted therapy options.
Researchers investigated geographic disparities in initial breast cancer care, finding significant regional variations and unequal distribution of resources. The study suggests that both patient-level factors and regional characteristics contribute to these disparities, affecting treatment outcomes.
A new study by WVU researcher William Walker found that the blood-brain barrier is dynamic and more receptive to chemotherapy at night. This could lead to better treatment outcomes for patients with brain metastasis.
Ovarian cancer death rates are predicted to decrease by 17% in the UK and 7% in EU countries in 2022. The main contributor is the long-term use of oral contraceptives, reducing the risk by 40%. Other factors include improved diagnosis, treatment, and advancements in treatments for other cancers.
A recent study has found that faulty versions of the BRCA1 and BRCA2 genes are associated with an increased risk of developing prostate and pancreatic cancers in men. The study analyzed data from over 3,200 families and estimated that men who carry a BRCA2 mutation have a 27% risk of developing prostate cancer by age 80.
Researchers analyzed DNA sequences and electronic health records of thousands of individuals to discover that the chance a pathogenic genetic variant may cause a disease is relatively low, about 7 percent. However, some variants are linked to wide range of risks for disease.
Researchers at Rice University and Baylor College of Medicine have created an antibody with an engineered peptide that effectively targets and attacks bone tumors in breast cancer. The study shows the therapeutic efficacy is best when a moderate amount of the drug compound is delivered, offering new hope for treating bone metastases.
Researchers at Hiroshima University discovered that a broccoli compound, DIM, induces controlled cell death and recycling of cellular components in fission yeast. The study suggests that targeting the nuclear envelope could be an early target for future anti-cancer treatments.
Researchers have identified nine new factors involved in DNA repair, a critical process for human cell health. The findings can help develop new cancer drugs and improve existing therapies.
A study by Mayo Clinic researchers found that cancer patients receiving chemotherapy and targeted therapies may mount inadequate immune responses to COVID-19 vaccination. The authors recommend antibody level testing and booster vaccinations for these patients.
Four MUSC Hollings Cancer Center researchers received American Cancer Society Institutional Research Grants worth $35,000 each. The grants support promising projects that aim to push cancer care forward. Researchers are working on various innovative projects, including a digital literacy training program for community health workers an...
Researchers at Duke University developed an artificial intelligence platform that analyzes potentially cancerous lesions in mammography scans. The algorithm is interpretable, showing physicians how it came to its conclusions, making it more trustworthy and useful for training students and aiding physicians in sparsely populated regions.
A study published in Cell Metabolism reveals unique features of brain metastasis in breast cancers, highlighting potential new targets for therapies. Researchers found that metabolically distinct cells have varying levels of glucose and glutamine usage, which can be targeted to reduce metastatic activity.
Researchers at Baylor College of Medicine have identified MAPK4 as a key player in triple-negative breast cancer growth and resistance to therapies. Eliminating or inhibiting MAPK4 reduces TNBC cell growth and sensitizes cells to PI3K inhibitors.
A study published in Cancer Epidemiology, Biomarkers & Prevention found a lower risk of breast cancer among Puerto Rican women with greater sun exposure. Researchers believe this association may be linked to the production of vitamin D and its effects on inflammation and circadian rhythms.
A Kaiser Permanente study shows that well-designed depression screening programs can effectively identify patients in need of behavioral health care and increase referrals. The program was successfully integrated into the patient care workflow of medical oncology teams, leading to improved mental health care for breast cancer patients.
Researchers at Massachusetts General Hospital found that inhibiting the OR5B21 gene significantly decreased breast cancer metastasis to the brain, bones and lung. This discovery may lead to new therapeutic targets to prevent or delay breast cancer's spread.
A new study published in the Journal of Oncology found that breast cancer patients treated at hospitals and health systems with integrative health services have a better chance of survival. These services include complementary and lifestyle therapies, such as nutrition and exercise counseling, in addition to medical cancer treatments.
A phase 1/2 clinical trial tested an L-NMMA and taxane combination in patients with chemoresistant TNBC, showing a remodeling of the immune environment in responders. The study's results warrant further investigation in larger trials to identify potential biomarkers for predicting response.
Researchers have found that depleting copper levels in the body can greatly reduce the ability of cancer cells to metastasize, including aggressive breast cancer. The discovery provides hope for developing more effective treatments for high-risk triple-negative breast cancer.
Researchers simulated an attack that falsified mammogram images, fooling both AI breast cancer diagnosis models and human radiologist experts. The study highlights the need to develop ways to make AI models more robust to adversarial attacks, which could lead to incorrect cancer diagnoses.
Cancer cells secrete type III collagen to stay dormant, and when levels decrease, they wake up and create metastatic cancer. Researchers found that enriching the environment with collagen can force cells to remain in a dormant state and prevent tumor recurrence.
A new NRG Oncology clinical trial found that bupropion did not improve sexual desire in female cancer survivors. The trial evaluated the effects of extended-release bupropion on postmenopausal women with low baseline sexual desire scores.
Research reveals tamoxifen boosts PI3K signaling, potentially increasing uterine cancer risk in breast cancer patients. Preclinical studies show PI3K inhibitor alpelisib mitigates this effect.
Researchers at Weill Cornell Medicine are studying breast cancer as a series of inflection points to identify potential intervention points and develop therapeutics for triple negative breast cancer. The goal is to create a large repository of organoids from tissue samples to study gene expression, epigenetic changes, and immune response.
A recent study found that patients with hormone receptor-positive breast cancer who experience rising ESR1 mutations before disease progression can benefit from an early switch to fulvestrant plus palbociclib. This approach yields a statistically and clinically significant gain in progression-free survival, potentially justifying its a...
A recent study has found that Black women are significantly more likely to develop lymphedema following breast cancer treatment compared to white women. The study, which analyzed data from 304 breast cancer patients, also found that Hispanic women had a higher risk of developing the condition.
Researchers discovered that the SET2,3 index provides complementary prognostic information about breast cancer outcomes, particularly for patients with hormone receptor-positive breast cancer. The study suggests that using both clinical and molecular information from a patient's tumor can guide treatment decision-making.
A recent study found that pathologic complete response rates did not differ by racial groups, but HR-positive/HER2-negative breast cancer showed a significant survival disparity between Black and white women. The study suggests that tumor molecular subtype is a more significant factor in breast cancer survival than race.
Patients treated with pyrotinib plus capecitabine had a lower risk of death and longer progression-free survival compared to those receiving lapatinib plus capecitabine. Pyrotinib is an irreversible tyrosine kinase receptor inhibitor targeting HER2, EGFR, and HER4.
Researchers discovered that pregnancy triggers the activation of Natural Killer T (NKT) cells to prevent breast cancer. After pregnancy, breast epithelial cells produce a specific protein called CD1d, which attracts NKT cells to monitor and eliminate potential cancer cells.
The study used multigene sequencing to identify genomic alterations in patients with metastatic breast cancer. Patients with genomic alterations ranked as ESCAT I/II saw improved progression-free survival with targeted therapies matched to their genomic changes, while those without these alterations did not benefit from the treatment.
In a phase III trial, elacestrant showed significant benefits in decreasing death or disease progression and increasing progression-free survival compared to standard of care. The treatment was well-tolerated with manageable side effects, offering hope for patients with ER-positive/HER2-negative metastatic breast cancer.
Researchers used imaging mass cytometry to analyze protein expression and cell location in tumor samples. High density of antigen-presenting cells with high PD-L1 and IDO expression was associated with higher pathological complete response rate in patients treated with atezolizumab plus chemotherapy.
Investigators at Weill Cornell Medicine identified significant age-related differences in tumor characteristics across various cancers, suggesting potential for personalized treatment approaches. They found that tumors from younger patients showed advanced signs of aging and more mutations associated with aggressive disease.
Women with breast implants after mastectomy are at high risk of developing cardiovascular disease due to chemotherapy and radiation. Inaccuracies in cardiac imaging studies, such as echocardiography and nuclear tests, have been reported in some cases.
A study found that racial disparities in mammography screening worsened after COVID-19 closures, with non-white patients facing reduced access to facilities. Early interventions aimed at expanding access to these facilities helped to recover late recovery volumes for patients of races other than white.
Moffitt researchers have developed a HER3-specific dendritic cell cancer vaccine that delays tumor growth and prolongs survival in mouse models. The vaccine targets the HER3 protein, which is involved in the growth and spread of many different cancer types.
A Michigan Tech-developed machine learning model uses probability to classify breast cancer shown in histopathology images and evaluate the uncertainty of its predictions. The model outperforms similar models and can measure uncertainty, promising time savings and referrals to human experts.
A large clinical trial has found that postmenopausal women with hormone receptor-positive, HER2-negative breast cancer and a 21-gene recurrence score of 25 or lower can safely skip chemotherapy. In contrast, premenopausal patients with positive nodes and low RS scores benefit from chemotherapy.
A new diagnostic tool for breast cancer uses a low-voltage electrical current to detect changes in lymphatic interstitial fluid, showing 70% effectiveness in predicting cancer presence. The device can be used repeatedly on women of any age, providing an additional diagnostic option for younger patients and those with dense breast tissue.
The AACR and Pelotonia launch a grants program to recognize five influential female researchers in breast and gynecologic cancers. Nomination deadlines are January 14, 2022, with awards presented at the AACR Annual Meeting 2022.
Researchers at Princeton University have discovered a new compound that can disable the MTDH gene, which is essential for cancer progression and metastasis. The compound shows promise in treating major human cancers, including breast, prostate, lung, and colon cancers.
Researchers found that tumor cells contribute differently to metastases and therapy resistance depending on their EMT status. Partial EMT breast cancer cells act as pioneer cells leading collective cell migration and promote lung metastases, while full EMT cells rarely appear in metastases.
Researchers have discovered a new therapeutic approach that prevents the growth of metastatic tumors in mice by forcing cancer cells into a dormant state. The drug C26 activates NR2F1, a protein that can induce cancer cell dormancy and prevent recurrence and metastasis.
A modeling study found that annual mammography screening beyond age 75 may provide little to no benefit in terms of lives saved, while increasing costs and potential harms from overdiagnosis. Biennial screening up to age 80 is more cost-effective but yields a small number of deaths averted.
Researchers at the University of Helsinki and Aalto University have developed a gel-grown mini-breast cancer model that can effectively treat hormone-dependent breast cancers. The discovery opens new avenues for hormonal therapies, individual drug responses, and drug resistance mechanisms.
A fraction of patients with high dihydrolipoamide S-Succinyltransferase (DLST) expression in their tumor cells may benefit from CPI-613, a drug targeting the TCA cycle. DLST plays a crucial role in TNBC pathogenesis, and its expression could serve as a biomarker for targeted therapy.
Women with breast cancer are at a higher risk of developing atrial fibrillation and dying from heart-related issues within the first year. The condition was more common in women who did not receive surgery or radiation as their initial treatment.
A new study found that tumors with one mutant copy of the PIK3CA gene tend to have lower PI3K activity, while those with two or more copies often have higher PIK3α activity, leading to more aggressive tumors and poorer prognosis. The research also discovered a counterintuitive relationship between PI3K mutations, PI3K activity, and ste...
This study found that aerobic exercise enhances doxorubicin's ability to kill cancer cells while minimizing its toxic effects on the heart. In addition, exercise has been shown to reduce the risk of breast cancer recurrence and improve quality-of-life parameters in cancer patients.
A UArizona Health Sciences study found that American Indian and Alaska Native women with early-stage breast cancer had a higher percentage of mastectomy and a lower percentage of lumpectomy compared to white women. The study suggests that geographic and socioeconomic factors may contribute to these disparities.
A study published in The BMJ found that early post-operative exercise improves shoulder and arm mobility, reduces pain, and increases quality of life for women after non-reconstructive breast cancer surgery. The exercise programme is also cost-effective, with an average saving of £387 per patient.
A Johns Hopkins-led study found that leptin cancels out the effects of Tamoxifen, making it ineffective for obese patients with breast cancer. Researchers suggest that interventions targeting leptin or Med1 may improve Tamoxifen's success in this group.
Researchers discovered melatonin's antitumor effects in gallbladder cancer cells, promoting ROS-mediated apoptosis and suppressing the PI3K/Akt/mTOR signaling pathway. The study suggests melatonin as a potential novel candidate for gallbladder cancer treatment.