Articles tagged with Breast Cancer
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A new oral selective estrogen receptor degrader (SERD) called giredestrant has been shown to significantly reduce tumor activity in women with ER-positive and HER2-negative early breast cancers. The treatment resulted in a 80% drop in Ki67 levels, compared to a 67% reduction in patients treated with the standard care aromatase inhibitor.
The MONALEESA-2 trial found that adding a CDK 4/6 inhibitor to first-line hormonal treatment prolongs survival by one year for postmenopausal women with HR-positive, HER2-negative advanced breast cancer. The combination of endocrine therapy and the CDK 4/6 inhibitor ribociclib also extends progression-free survival.
Two phase III trials by VHIO researchers reveal significant clinical activity of trastuzumab deruxtecan in HER2-positive metastatic breast cancer, with over half of patients experiencing two years without disease progression. Trastuzumab duocarmazine also shows promise in treating HER2-negative breast cancer and other tumor types.
A Phase III trial showed a significant overall survival benefit of 63.9 months with ribociclib, compared to 51.4 months with hormone therapy alone. The estimated six-year survival rate was 44.2% with ribociclib, compared to 32% for placebo.
Novartis presents Phase III MONALEESA-2 study results demonstrating improved overall survival with Kisqali (ribociclib) in combination with letrozole. The analysis shows a statistically significant and clinically meaningful improvement in survival, with median OS of 63.9 months.
The study found that treating women with HER2 positive metastatic breast cancer with trastuzumab deruxtecan significantly prolongs the length of time the disease is controlled and cancer growth is halted. Patients who received the drug had a 72% improvement in progression-free survival compared to trastuzumab emtansine.
Researchers at MD Anderson Cancer Center presented new findings on novel therapeutic approaches, including cell therapy for solid tumors and antibody drug conjugates targeting TROP2. The therapies achieved partial responses in six patients, with an overall response rate of 35.3% and disease control rate of 70.6%.
A new treatment approach investigated by researchers at the Garvan Institute of Medical Research may help stop breast cancer cells from spreading. By targeting a signalling molecule called Rac1, the study found that breast cancer cells became more vulnerable to physical stresses in the bloodstream and less likely to survive the journey.
Breast and colorectal cancer screening rates increased following the introduction of national quality indicators, with greater reductions in socioeconomic disparities. Cervical cancer screening rates remained unchanged due to its exclusion from initial quality indicators.
A new study found that genome-wide association studies (GWAS) results from people with European ancestry can still be applied to predict breast and prostate cancer risk in diverse groups. However, the findings emphasize the need for more diverse participants in GWAS analyses to realize the full potential of polygenic risk scores.
Researchers developed a treatment using cowpea mosaic virus nanoparticles that target lung tumors, slowing tumor growth and preventing cancer spread. The treatment showed efficacy against aggressive cancer cell lines and may offer protection to patients at high risk of metastatic disease.
Researchers found that patients with low sTK1 levels live longer and have slower disease progression after anti-estrogen treatment. Patients with high sTK1 levels tend to have shorter progression-free survival times and die sooner.
Researchers identified DNA mutations from platinum-based chemotherapies in AML patients, suggesting treatment-associated cancer development. The study's findings imply that clonal hematopoiesis precedes chemotherapy exposure.
Researchers have discovered 50 distinct breast cancer subtypes and nine 'ecotypes', each linked to different clinical outcomes, offering a potential framework for personalized treatments. The study's findings could inform therapy strategies and identify patients most likely to respond to specific treatments.
Eosinophils, a type of white blood cell, play a crucial role in destroying malignant tumors by recruiting T-cells and releasing destructive proteins. The study, published in Cancer Research, reveals that eosinophils combat cancer effectively but require the help of T-cells to do so.
Recent study by Okayama University researchers reveals three photoinitiators cause faster increase in breast tumor growth in mice, with tamoxifen pretreatment reducing toxicity. The findings suggest photoinitiators could act as hormonal disruptions, raising concerns for patients and healthy individuals.
Individualized breast cancer risk estimates led to a significant increase in annual mammography rates among women at high risk. The study found that nearly all Hispanic or Black women who received personalized risk assessments used mammography more frequently, with rates rising from 37% to 51%.
Researchers found that notification legislation was not significantly associated with lower odds of late-stage diagnoses, but insurance coverage laws were linked to decreased chances of later-stage diagnoses. Younger women and Hispanic women tended to benefit more from these laws.
A recent study of 100 high-risk breast cancer patients revealed that the timing of breast reconstruction does not significantly affect long-term body image scores. Women who received immediate, delayed, or no reconstruction recover from negative impacts within four years of surgery.
Researchers analyzed large datasets to find biomarkers that could help select immunotherapy treatment for older patients. The analysis suggests that factors such as mutational burden and immune checkpoint protein expression are associated with increased response to immunotherapies in older patients, despite lower general immunity.
A review of 23 studies found AI systems were less accurate than humans and radiologists in detecting breast cancer. The quality of methods used was poor, and the applicability to European or UK breast cancer screening programmes was low.
Researchers have found that hormone profiles before and after treatment play a significant role in the success of therapy for breast cancer. This finding could lead to improved treatment options and better outcomes for patients.
Scientists at Scripps Research Institute have developed a set of compounds that target estrogen-sensitive breast cancer cells in two different ways, potentially overcoming common drug-resistance issues. The compounds work by distorting the shape of the estrogen receptor and binding with two different molecular side chains, offering a n...
A new study found that breast cancer screening rates dropped significantly among women aged 50-74 at community health centers serving lower-income populations. The decline would have resulted in 47,517 fewer mammograms and 242 missed breast cancer diagnoses if trends had continued.
Researchers at Duke University Medical Center identified a mechanism where breast cancer cells use cholesterol to develop tolerance to stress, allowing them to resist ferroptosis and proliferate. This finding highlights the importance of lowering cholesterol in preventing cancer progression and offers new approaches for treatment.
Researchers at Rice and Baylor are expanding their efforts to halt bone cancer metastasis using a molecule targeting osteoporosis and HER2 protein. Their goal is to improve drug concentration at tumor sites, inhibit secondary metastasis, and explore the therapeutic effect mechanism.
Researchers identified DSS1 as a critical protein in breast cancer progression and found that depleting it makes cancer cells more responsive to lower doses of anti-cancer drugs. This technique may reduce drug-induced side effects in breast cancer patients, providing a safer treatment option.
Researchers have found that breast cancer stem cells accumulate near a tumor arteriole, which they call the arteriolar niche. This niche promotes cancer cell features and potential development through the LPA/PKD-1 signaling pathway.
A new study from WashU Medicine found a strong association between high physical activity and maintaining cognitive function among breast cancer patients treated with chemotherapy. The research suggests that moderate to vigorous exercise may help ward off 'chemo brain,' a decline in cognitive function common during cancer treatment.
Researchers at Massachusetts General Hospital have identified two separate genetic alterations that enable triple-negative breast cancer cells to develop resistance to a highly effective drug. The findings could help improve therapy and prolong survival for patients with this aggressive form of breast cancer.
A new study investigated the benefits of patient participation in tumour conferences for complex cancer cases. Most respondents perceived their participation as a positive experience, finding it informative and recommended to others. However, some patients reported feelings of fear and uncertainty after participating in the conference.
Researchers found that the drug Vismodegib altered tumor-associated macrophage metabolism, shifting them from immunosuppressive M2 macrophages to pro-inflammatory M1 macrophages. This shift led to a decrease in tumor-promoting properties and improved immune response.
A single-center retrospective study found that AI-CAD reduced recall rates and improved accuracy compared to digital mammography (DM) and DBT. The study showed lower recall rates and higher accuracy for DM with AI-CAD, indicating a practical addition to lowering false-positive findings.
Scientists investigated a method to enhance immunotherapy for lung cancer and found that combining it with certain chemotherapy drugs could eliminate harmful immune cells. This approach showed promising results in preclinical studies, inducing the regression of about 70% of tumors.
Researchers at UVA Health System discovered that combining drug palbociclib with ruxolitinib could effectively treat myelofibrosis by preventing bone marrow scarring and improving blood cell counts. This potential new treatment offers a promising approach to devastating blood disorder.
Researchers at Queen Mary University of London confirmed HER2's role in predicting DCIS recurrence and response to adjuvant radiotherapy. HER2 overexpression is associated with a significantly increased risk of in situ recurrence.
A systematic review of epidemiological studies found that muscle strengthening exercises associated with aerobic activities can significantly reduce cancer mortality. The analysis suggested that strength training twice a week can protect against cancer, with the benefit being even greater when combined with aerobic activities.
Researchers analyzed association of high-sensitivity C-reactive protein (hsCRP) with breast cancer (BC) by molecular subtype among 296 cases and 259 healthy controls. High hsCRP was associated with increased odds of triple-negative BC, luminal A BC, and HER2-enriched BC.
A recent UNSW study found that women who received their polygenic risk score (PRS) for breast cancer experienced minimal regret and reduced distress compared to those who declined. The researchers also discovered that more women reported regret about not knowing their PRS score, highlighting the importance of providing clear informatio...
Researchers found that pre-treatment T2-weighted MRI texture features can accurately predict the response to neoadjuvant chemotherapy in patients with locally advanced breast cancer. The study identified 7 significant texture features and achieved high classification accuracy using a k-nearest neighbor model.
A recent study evaluated the association between COVID-19 and breast cancer screening in a San Francisco safety-net hospital. The researchers found that during the pandemic, there was a significant decrease in breast cancer screening rates, which had implications for patient health outcomes.
Researchers from UNC School of Medicine, MAHEC, and community partners will address racial disparities in maternal care by improving data accountability and providing community-based doula support. The study aims to decrease pregnancy complications for Black women and improve outcomes in maternal care.
A significant association was found between statin use and improved outcomes in women with stage I-III triple-negative breast cancer. Statin use was associated with a 58% relative improvement in breast cancer-specific survival and a 30% relative improvement in overall survival.
Mayo Clinic researchers used advanced imaging technology to visualize the BRCA1-BARD1 protein complex and its interaction with chromatin. The study provides new insights into how BRCA1-BARD1 functions, which could lead to improved cancer prevention efforts and drug development.
Lobular breast cancer patients often experience recurrence or metastasis despite hormonal therapies. CU Cancer Center researcher Matthew Sikora is studying the role of MDC1 in this subtype, finding it linked to estrogen receptor activity and potentially a novel target for treatment.
Researchers have identified a biomarker, MHC-II, that predicts response to immunotherapies in breast cancer patients. The study found that MHC-II expression is associated with response to standard chemotherapy plus durvalumab or pembrolizumab, but not to standard neoadjuvant chemotherapy alone.
A new study by Mayo Clinic researchers suggests that most women with breast cancer diagnosed over 65 should be offered hereditary cancer genetic testing. The study found mutations in actionable breast cancer risk genes in 3.2% of women with breast cancer, highlighting the need for broader testing regardless of age or family history.
Researchers at the University of Illinois have developed a new compound called ErSO that kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases. The compound targets the anticipatory Unfolded Protein Response pathway, which is already active in many breast cancer cells.
A free cancer screening program, See, Test & Treat, has been implemented to address barriers to healthcare for under-served women in Mississippi. The program offers same-day results and improves knowledge of cancer screenings and self-efficacy for seeking regular check-ups, with positive effects on health behaviors.
Researchers at UC Davis Comprehensive Cancer Center are investigating whether turmeric can successfully reduce joint pain in breast cancer patients and improve their quality of life. The study aims to provide important data on the safety and effectiveness of using turmeric with oral anti-estrogen therapy.
The COVID-19 pandemic has been linked to a potential increase in breast cancer mortality, with estimated excess deaths reaching 2,487 by 2030. Researchers used simulation models to predict the impact of screening, diagnosis, and treatment disruptions on breast cancer mortality.
A new WHO study found an association between alcohol consumption and a substantially higher risk of several forms of cancer, including breast, colon, and oral cancers. In Canada, alcohol use was linked to 7,000 new cases of cancer in 2020.
A WVU researcher led a task group to develop guidelines for reducing data transfer errors in radiation therapy. The measures aim to safeguard against medical errors in treatments that over half of all cancer patients receive.
A global study estimates that 4% of all newly diagnosed cancers in 2020 are associated with drinking alcohol, with men accounting for more than three-quarters of those cases. Moderate drinking was found to be problematic, contributing to over 103,000 cases.
Researchers at UTA are developing a new diagnostic tool for small breast tumors, using nanoparticles and ultrasound to detect temperature differences in the body. The technique has the potential to reduce anxiety and costs associated with biopsy procedures, while also improving treatment outcomes.
A new study published in PNAS has identified a protein called AXL as a crucial player in hypoxia, which promotes cancer progression and resistance to treatment. By blocking the action of this protein, researchers observed improved recovery of blood vessels and revitalization of the tumour's immune environment.
Researchers studied the mechanism of liposome accumulation in tumors using fluorescent microscopy and imaging. They found that different lipids have varying abilities to accumulate in tumors, with one lipid type showing remarkable extravasation and reaching immune and tumor cells.
A new study introduces K2Taxonomer, a software tool that analyzes high-throughput data to identify novel cell types within tumors and their microenvironments. The analysis of breast tumor-infiltrating lymphocytes revealed a transcriptional signature associated with better survival rates in cancer patients.
Researchers from Nagoya University have successfully measured the shape distributions of cell-derived nanoparticles, or extracellular vesicles, in body fluids. This study may help identify types of cancer with a painless and non-invasive method.
A new study found that lung metastases from triple-negative breast cancer contain a more diverse array of cancer cells compared to liver metastases. The researchers identified specific genes responsible for this difference, which may inform targeted therapies for breast cancer treatment.