Articles tagged with Breast Cancer
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A study of over 400,000 UK adults found that higher BMI, body fat, and larger waist and hips pose similar risks for developing 10 common cancers. The researchers estimated that excess weight could be responsible for around 40% of endometrial and uterine cancer cases.
A study reveals nearly 30% of breast cancer patients convert to HER2-low status, offering potential treatment opportunities for hard-to-treat tumours. The findings also suggest that HER2-low expression is more frequent in hormone receptor-positive tumours.
Researchers have developed a six-color imaging platform inspired by mantis shrimp eyes to accurately label tumors in mice and visualize lymph nodes near breast cancer tumors. The system detected cancerous tissue in 92% of cases and successfully integrated into the operating room without disrupting surgeons' workflow.
A study at Karolinska Institutet found that low PDGFRb protein levels are associated with better radiotherapy results in women with early-stage DCIS. Combining PDGFRb blocking drugs may improve treatment efficacy.
Risk-reducing mastectomy saves lives of women with hereditary or other risk factors, but also considers quality-of-life issues. Women with BRCA1 and BRCA2 gene mutations have a very high lifetime risk of developing breast cancer.
Researchers are testing cognitive behavioral therapy called Memory and Attention Adaptation Training (MAAT) to improve memory problems and emotional resilience among breast cancer survivors. The study aims to evaluate the effects of MAAT and supportive therapy on cognitive dysfunction after chemotherapy.
Researchers cultivated tumor microenvironments using metastatic triple-negative breast cancer cells and studied the genetic information of entire systems. They found that cellular communication in the microenvironment drives physiological changes in tumor behavior, including growth and movement.
A study at ESMO Breast Cancer 2021 Virtual Congress reveals breast cancer survivors experience varying levels of symptoms after treatment, with some requiring active symptom management. Patients with comorbidities, such as heart disease and diabetes, are more likely to experience a high symptom burden.
A new study reveals that higher body mass index (BMI) is associated with worse survival in early breast cancer patients but improved survival in advanced disease. The 'obesity paradox' highlights the need to understand the biological basis of obesity impacts on breast cancer diagnosis and treatment.
Fertility concerns significantly affect young women with hormone receptor-positive breast cancer treatment decisions, new research shows. Women who express fertility concerns are more likely to choose not to start or discontinue endocrine therapy.
The COVID-19 pandemic led to a significant decline in cancer screenings for breast, colorectal, and prostate cancers. According to the study, screening rates dropped by an estimated 22% during the pandemic.
Breast cancer patients experience frequent job changes after diagnosis, with around ten percent reporting involuntary changes. The study suggests that a supportive work environment and understanding from managers can facilitate a satisfactory return to work.
The 2021 ESMO Breast Cancer Congress presented nearly 200 studies on various aspects of breast cancer, including adjuvant, neoadjuvant, and immunotherapy. The congress also highlighted the importance of personalized follow-up care for breast cancer patients.
Researchers found that sanguinarine, a natural compound, reduces cell viability and growth in triple-negative breast cancer cells. The treatment activated different genes in cells from African American ancestry, suggesting potential therapeutic benefits for this population.
Recent studies at VCU Massey Cancer Center discovered a link between prolactin and breast cancer development. The hormone was found to act as a major contributor to breast cancer growth and could inform the creation of targeted drugs to treat multiple forms of the disease.
A study by the University of Southern Denmark found that Football Fitness improves balance, strengthens muscles, and increases bone density in women treated for breast cancer. The 12-month training program reduced the risk of falls and broken bones, making everyday activities easier.
Researchers at Dartmouth's Norris Cotton Cancer Center have found that cycling between estrogen treatment and anti-estrogen therapies can dramatically increase the duration of tumor regression in mice. This unconventional approach suggests treating short-term with estrogen before resistance occurs, leading to better long-term control.
A small proportion of women with anti-estrogen treatment after breast cancer surgery have worse outcomes due to mutations in the estrogen receptor gene. Research found that 1% of breast cancer cases already at initial diagnosis have these resistant mutations, leading to poorer response to hormonal treatment and higher risk of recurrence.
Researchers discovered that distinct Notch family members are modified differently by phosphorylation, leading to opposite effects on transcriptional activity and oncogenic behavior. The study suggests that targeting PIM or Notch proteins may provide new treatment options for hormone-dependent breast cancer with poor prognosis.
A new study from Ohio State University reveals that women with high-risk profiles struggle to access genetic counseling and testing due to financial constraints. The research emphasizes the need for greater transparency in healthcare pricing and policies to eliminate barriers to early cancer detection.
A global phase 3 clinical study confirms the effectiveness of targeted antibody drug conjugates against refractory metastatic triple-negative breast cancer. The ADC drug sacituzumab govitecan delivered a high dose of a cancer-killing drug to tumor cells, improving progression-free and overall survival.
A comprehensive systematic review of epidemiological research found a link between certain endocrine-disrupting chemicals and increased breast cancer risk. For example, DDT, PCBs, and PFOA were associated with higher breast cancer incidence in some studies, while phytoestrogens like genistein showed potential protective effects.
A new study from the University of Bergen reveals that targeted therapy using PARP inhibitors can be effective in treating early-stage triple negative breast cancers. The study found a significant response rate among patients not harboring germline mutations, highlighting a potential for improved personalized treatment.
A study published in JAMA Network Open found that treating older patients with early-stage breast cancer did not improve survival rates and may cause harm. Researchers analyzed data from over 3,000 women aged 70 and found that omitting treatments like sentinel lymph node biopsy and radiotherapy did not affect recurrence or survival rates.
Researchers have identified specific super-enhancers that stimulate the activity of critical cancer genes in triple-negative breast cancer (TNBC). The study reveals that deleting certain super-enhancers can reduce tumour cell growth and improves survival chances. Dr Rebecca Chin and Dr Wang Xin's findings may lead to the development of...
A new study found that granddaughters whose grandmothers were exposed to DDT have higher rates of obesity and earlier first menstrual periods. This may increase the granddaughters' risk for breast cancer, high blood pressure, diabetes, and other cardiometabolic diseases.
Researchers at HSE University have identified key molecules responsible for breast cancer metastasis by developing an algorithm that recreates the networks of intercellular interactions in cancer cells. The program detects prognostic genes, with transcription factor E2F1 playing a major role in predicting patient outcomes.
Researchers found that breast cancer cells trigger uncontrolled inflammation and remodel tissue, making the cancer more aggressive. The study suggests targeting inflammatory pathways could improve treatment outcomes for pregnant women with breast cancer.
Researchers found that exercise training in mice with human breast cancer grew tumors more slowly and responded better to immunotherapy, with increased anti-tumor immune responses. Exercise also enhanced the activity of cytotoxic T lymphocytes (CD8+ T cells), which killed cancer cells.
Researchers at the Francis Crick Institute found that blocking a specific protein, DNPH1, sensitised BRCA-defective cancer cells to treatment with PARP inhibitors. The discovery suggests a promising potential treatment combination that could lead to improved therapy for patients with inheritable breast cancers.
Researchers have found that standard definition infrared spectroscopy can be sufficient for accurate diagnosis in urgent situations, challenging the notion that high-definition imaging is always superior. The study provides guidelines for choosing the optimal technology and instrument configuration for clinical work.
A recent study published in Radiology found that 3D-mammography reduces the number of breast cancer cases diagnosed between routine screenings. The study included almost 15,000 women who received both 3D-mammography and traditional mammography, and compared cancers detected in between screenings.
A new study by NYU Rory Meyers College of Nursing found that breast cancer survivors with high genomic test scores report higher overall fear and greater perceived consequences compared to those with low scores. Anxiety and emotional response to cancer are the best predictors of fear, explaining 58% of variance in fear of recurrence.
Researchers at UVA Cancer Center discovered that antibody approaches targeting death receptor-5 could be revived by co-targeting negative biological processes with immune-activating therapy. This combination therapy increased the effectiveness of cancer killer immune cells, shrinking tumors and improving survival in lab mice.
A study published in Radiology found that digital breast tomosynthesis (DBT) reduces the rate of interval cancers, which are more aggressive than screen-detected cancers. The study suggests that DBT may contribute to lower breast cancer mortality by detecting rapidly growing cancers with poorer prognosis.
A large multi-center study trains convolutional neural networks to classify breast lesions from ultrasound images, achieving high accuracy rates. The model's performance is compared to that of experienced ultrasonologists, showcasing the potential of AI in speeding up early cancer detection and reducing workload.
A new study suggests removing additional tissue around the tumor cavity can reduce positive margins in patients with ductal carcinoma in situ (DCIS) by nearly 65%. Achieving clear margins is crucial in decreasing cancer recurrence, and this technique should be considered for DCIS patients.
Researchers found that tumors with a softer matrix are more resistant to treatment, activating signaling pathways that promote cell survival. Targeting this pathway could enhance the effectiveness of chemo- and radiotherapy.
Researchers have identified a pair of microRNAs that help maintain breast cancer stem cells and drive tumor growth. Targeting these microRNAs may improve the prognosis of patients with aggressive forms of breast cancer by making cancer stem cells more susceptible to chemotherapy.
Breast cancer cells that spread to the brain must boost fatty acid production to survive due to limited access to fats. Inhibiting this process with a fatty acid synthase inhibitor may lead to tumor shrinkage.
A national study found a strong rebound in breast cancer screening rates despite COVID-19 pandemic challenges, but significant disparities and missed appointments persist. The study highlights the need for targeted interventions to overcome barriers to healthcare utilization during the pandemic.
Researchers confirmed the molecular classification's predictive value for treatment benefits in advanced hormone-sensitive breast cancer. The study found that different subtypes responded differently to ribociclib and other treatments.
Researchers at Dartmouth's Geisel School of Medicine will engage breast cancer teams across the US in a learning collaborative to adopt and implement conversation aids for early-stage breast cancer treatment options. The goal is to improve patient involvement in decision-making and increase awareness of PCORI-funded research findings.
A Phase 1 study of Z-endoxifen in patients with solid tumors demonstrated antitumor activity and prolonged stable disease, even in those who had previously responded sub-optimally to tamoxifen. The trial found that 44.4% of patients at certain dose levels achieved partial responses or stable disease.
Researchers recommend a risk-based algorithm that maximizes cancer detection by considering clinical indication, breast symptoms, and age. The approach successfully detects high-risk individuals, accounting for 55% of cancers despite limited mammograms.
A large-scale study found that people living in areas with high background radiation had a 2.5-year longer life expectancy and lower rates of certain cancers, including lung, pancreatic, colon, and rectal cancer. The researchers suggest re-evaluating the linear no-threshold paradigm for low-dose radiation.
A novel method for single-cell DNA sequencing has enabled faster and deeper study of chromosome evolution in triple-negative breast cancers. The technique revealed that these cancers undergo continued genetic copy number changes after an initial burst of chromosomal instability, which may explain why treatments are not always effective.
A large study found a strong association between ultra-processed food consumption and an increased risk of colorectal cancer, with a 10% increment in consumption leading to an 11% increase in risk. Ultra-processed foods were also linked to less healthy diets among breast cancer cases, while no association was found with prostate cancer.
Researchers have identified YAP as a key regulator in the development and spread of basal-like breast cancer. Inhibiting YAP activity with medication can significantly reduce tumour volume, offering new hope for patients' survival.
A recent study published by The Endocrine Society has found that commonly used medications for type 2 diabetes and obesity, known as GLP-1 RAs, are not associated with an increased risk of breast cancer. This new research provides relief to concerns arising from previous clinical trials of liraglutide.
A new Mayo Clinic research found that tumor mutation burden is significantly inflated in Black patients with cancer compared to White patients, affecting therapy selection. The study suggests that accurate tumor mutational burden is crucial for predicting optimal treatment for patients with diverse ancestral backgrounds.
Researchers used quantitative proteomics to stratify fibroepithelial breast lesions, identifying three candidate biomarkers: MUCL1, HTRA1, and VEGFD. These markers show promise in augmenting existing diagnosis and monitoring disease progression.
A new study published in Journal of Clinical Oncology suggests that a lower dose of tamoxifen can reduce the risk of breast cancer while minimizing adverse reactions. The research involved 1,440 women who received different doses of the drug, with the lowest dose showing a significant reduction in mammographic density and side effects.
Research suggests that contrast-enhanced mammography (CEM) is concordant with MRI for staging in women with newly diagnosed breast cancer and breast augmentation. CEM was found to be effective in detecting additional cancers not identified by MRI, including two malignant lesions.
Researchers found that low doses of propylparaben can alter pregnancy-related changes in the breast, potentially lessening its protective effects against breast cancer. Propylparaben was shown to disrupt mammary gland development and increase cell proliferation rates in mice exposed during pregnancy.
A new study published in the Endocrine Society's journal found that low doses of propylparaben can alter pregnancy-related changes in the breast, reducing protection against breast cancer. The researchers tested mice exposed to environmentally relevant doses of propylparaben during pregnancy and breastfeeding, finding increased rates o...
Researchers from Queen Mary University of London confirmed the role of oestrogen receptor biomarker in ductal carcinoma in situ and developed a new, more accurate method to predict long-term outcomes. The study found ER expression is a strong prognostic factor for recurrence in DCIS.
Researchers found that people searching for objects in 3D image stacks are less successful than those searching for the same in single 2D images. This is due to a bottleneck in human vision and cognition, where humans under-explore 3D search areas and rely on peripheral visual processing.
Nearly 500 breast cancer centers in US have different starting ages for mammography, with some recommending 40-50 years old and others 35-39 years old. The study highlights the need for standardization to ensure optimal screening guidelines.
A new study found that a high rate of genetic mutations within a tumor (high tumor mutation burden) can predict clinical responses to immune checkpoint inhibitors in certain cancer types, such as melanoma, lung and bladder cancer. However, this was not the case for other cancers, including breast, prostate and brain cancers.