Articles tagged with Breast Cancer
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A new study published in Cell reveals that RNA splicing therapeutics can activate antiviral immune pathways in triple negative breast cancers, triggering tumor cell death and signaling the body's immune response. The discovery highlights a novel mechanism for turning on the immune system in aggressive cancers.
A new risk assessment tool, CARG-BC Score, helps oncologists make personalized treatment recommendations for elderly patients with early-stage breast cancer. The score combines eight disease and patient-reported predictors to predict the likelihood of severe chemotherapy side effects.
A team of UT Southwestern researchers has identified the gene ZMYND8 as being increased in breast cancer conditions and correlating with poor survival rates. The gene regulates DNA stability and inhibits antitumor immunity, but removing or inhibiting it allows lymphocytes to invade tumors and prevent growth.
A new study suggests that Dense Breast Notifications (DBNs) have achieved partial success in informing women about their breast density, with higher rates of notification and discussions with providers in states with mandated DBN laws. However, the study also found disparities in knowledge and awareness among women of different race/et...
A new study found that up to 20% of glioblastomas are fueled by overactive mitochondria, making them potentially treatable with current clinical trial drugs. Researchers discovered four types of brain cancer, including the mitochondrial subtype, which has a slightly better prognosis.
Scientists at The Wistar Institute have developed an ACSS2 inhibitor that impairs cancer growth in preclinical models by depriving malignant cells of a critical nutrient source. This approach targets acetate metabolism, which is essential for tumor growth under conditions of low nutrient and oxygen availability.
A study from Johns Hopkins Medicine reveals that exposure to B. fragilis toxin can increase the risk of breast cancer by leaving a lasting impression on cells. Researchers found that breast tissue cells exposed to the toxin retained a long-term memory, leading to tumor growth and metastasis in mice.
A uOttawa study finds that mindfulness can significantly impact the brain of women suffering from neuropathic pain related to breast cancer treatment. The research shows major reductions in brain activity and a significant improvement in brain health as well as pain perception.
A new study suggests that adding a small molecule to CAR-T cell therapy can boost the effectiveness of immunotherapy against breast cancer and other solid tumors. Researchers found that the addition of cGAMP activated an immune response, leading to enhanced T cell proliferation and tumor growth reduction.
Researchers found that combining CAR T cells with a proinflammatory environment created by STING pathway activation can improve their ability to attack tumor cells. This approach, combined with therapeutic antibodies, led to the complete eradication of breast tumors in mice.
Researchers found that surgery in addition to treatments like chemotherapy and radiation therapy increased survival for stage four breast cancer patients. Patients with hormone receptor-positive tumors saw a prolonged length of survival when their treatment plan included surgery.
Researchers developed two new mammogram-based measures of risk, combining them to predict breast cancer risk more effectively than known genetic and breast density factors. The new measures could improve screening, reduce mortality, and make it less stressful for women.
Researchers found that surgery in addition to treatments like chemotherapy and radiation therapy increased the length of survival for stage four breast cancer patients. The study, published in Annals of Surgical Oncology, suggests that knowing a cancer's biological subtype can help determine effective treatment plans.
Researchers at CSHL have discovered a gene-regulating RNA that contributes to breast cancer metastasis. By targeting this RNA, they found a molecule that can reduce tumor growth and metastases in animal experiments.
A recent study found that macrophages play a crucial role in suppressing the effectiveness of PARP inhibitor therapy in breast cancer patients. The researchers identified CSF-1R-positive macrophages as the key suppressive cells, which can be targeted to enhance anti-tumor responses.
A new study by MIT scholars suggests that mammogram screening may be more effective for targeted testing, rather than age-based recommendations. Women who start getting mammograms at age 40 are found to be healthier and less likely to have cancer, making targeting higher-risk groups a potential solution.
A type of immune cell known as regulatory T cells acts as a major driver of breast cancer growth by preventing the accumulation of a specific protein that induces anti-tumor responses. Targeting these cells could lead to improved treatment outcomes for patients.
A new RNA drug-discovery tool called Chem-CLIP-Fragment Mapping has been developed to address the challenge of 'undruggable' proteins. The tool uses functionalized fragments that can bind to RNAs and modify their structure, enabling the design of medicines against previously untreatable diseases.
A clinical trial combining microbubbles with radiation therapy has shown promising results in treating liver cancer. The treatment increased tumor response rates by 93% compared to standard radiation alone, and improved patient outcomes, including longer overall survival and reduced need for retreatments.
Researchers developed a polygenic risk score to assess breast cancer risk in carriers of high-risk mutations. The score provides a more accurate estimate, especially for close relatives, and has the potential to save lives by targeting cancer screening.
A study published in Journal of the American College of Surgeons found that financial toxicity among breast cancer patients is independently associated with worse psychological well-being. Even small improvements in financial pressure can lead to better mental well-being and higher patient satisfaction with breast reconstruction.
ReceptorNet, a deep-learning algorithm developed by Salesforce Research, can determine hormone-receptor status from inexpensive tissue images, improving treatment decision-making for breast cancer patients. This technology has the potential to make high-quality therapies more accessible globally.
A new study suggests that targeting the RANK signaling pathway can enhance antitumor immune responses, making breast cancer more responsive to immunotherapy. The findings come from a clinical trial and preclinical research, demonstrating the potential of this approach to convert 'cold' tumors into 'warm' ones.
Researchers found that adding an immune checkpoint inhibitor to standard chemotherapy for patients with early-stage breast cancer does not decrease their ability to perform daily activities. The study, based on data from the IMpassion031 trial, showed increased response rates and no significant impact on quality of life.
Women who receive mastectomy and reconstructive surgery are at increased risk of developing persistent use of opioids and sedative-hypnotic drugs. The study found that 13.1% of patients become new persistent opioid users after surgery, while 6.6% develop persistent sedative-hypnotic use.
A clinical trial found that postmenopausal women with low-risk breast cancer can forego chemotherapy without compromising their treatment outcomes. In contrast, premenopausal women with the same disease characteristics benefit from chemotherapy, suggesting a potential age-related difference in treatment effectiveness.
The new guidelines provide uniform standards for treating brain tumour complications such as epileptic attacks, brain edema, haemorrhage, or thrombosis worldwide. The initiative aims to increase patient safety and improve treatment outcomes.
Extended follow-up data from the monarchE trial shows that abemaciclib continues to improve IDFS among high-risk, node-positive, early-stage, HR-positive, HER2-negative breast cancer patients. The addition of abemaciclib to standard adjuvant endocrine therapy reduces the risk of invasive disease by 25 percent.
A meta-analysis found that circulating tumor cell dynamics were associated with overall survival in patients with metastatic breast cancer. Changes in CTC levels before and after treatment were linked to prognosis, with median overall survival greatest for those who remained CTC-negative.
For older patients with hormone receptor-positive breast cancer, omitting postoperative radiation therapy did not compromise survival or increase risk of distant metastasis. Local recurrence rates were higher in those who didn't receive radiation therapy.
A new study found that physicians did not recognize significant symptoms in over half of breast cancer patients who reported pain, itchy skin, swelling, or fatigue during radiation therapy. The under-recognition was more common among younger patients and those from Black backgrounds, suggesting the need for better symptom detection met...
A new clinical trial suggests that postmenopausal patients with hormone receptor-positive and HER2-negative breast cancer and a low recurrence score of 25 or lower may safely avoid chemotherapy. In contrast, premenopausal patients who receive chemotherapy show improved invasive disease-free survival and overall survival rates.
A new UCLA-led research study shows that mindfulness meditation can significantly reduce depressive symptoms and related issues such as fatigue and sleep disturbance in younger breast cancer survivors. The six-week interventions were effective in improving the mental health of women diagnosed with breast cancer at a young age.
KU Leuven researchers Christine Desmedt, Tias Guns, Simon Kuhn, and Lukas Van Oudenhove have been awarded ERC Consolidator Grants. Their projects focus on breast cancer, optimisation software, reactors for sustainable chemical industry, and the impact of gut bacteria on emotions.
A study found that under-recognition of symptoms is common among breast cancer patients receiving radiation, with younger patients and Black patients being more likely to experience this. The researchers identified several factors associated with symptom under-recognition, including age, race, and treatment regimen.
A meta-analysis of breast cancer survivors found they are less likely to get pregnant due to higher risks of complications. However, when they do conceive, most deliver healthy babies with no adverse effects on their long-term survival or overall health.
Researchers discovered that melatonin may regulate gene expression and intensify tumor suppressor genes, leading to increased tumor cell death and reduced proliferation. The study identified target genes for melatonin, which could guide personalized therapies for breast cancer patients.
A study published in the journal CANCER found that Black women with early breast cancer have significantly higher obesity rates (62%) and comorbidities, such as hypertension and diabetes, than white women. Despite similar treatment decisions, these disparities contribute to a 40% mortality gap.
A new method, nnU-Net, has been developed to configure self-learning algorithms for a large number of different imaging datasets, enabling the interpretation of three-dimensional imaging data and distinguishing between tumor and non-tumor tissue.
A study published in Radiology found that digital breast tomosynthesis (DBT) improved cancer detection and reduced false negative rates compared to digital mammography. DBT also showed advantages in imaging women with dense breasts, leading to lower recall rates and more effective cancer screening.
Researchers at the University of Illinois Urbana-Champaign have found that combining exercise and mindfulness training can significantly reduce fatigue in breast cancer survivors. The study used a feasibility trial with 40 women, who reported a drop in fatigue levels after participating in a combination of both interventions.
SWOG Cancer Research Network members will share results of five network-led studies at SABCS, advancing breast cancer science and medicine. The research includes findings from RxPONDER, a trial that may change practice in breast cancer treatment.
Researchers at Memorial Sloan Kettering Cancer Center found that tumors with high mutation burden, particularly those with BRCA2 mutations, respond better to immunotherapy. This discovery may lead to more precise treatments for patients with BRCA2 mutations.
The Oncotarget journal has launched a special collection on breast cancer, featuring newly published scientific papers on prognostic markers, risk factors, therapies, and gene studies. This free-to-read resource aims to promote a better understanding of the latest breast cancer research.
A new deep learning model predicts breast cancer risk with greater accuracy, leveraging subtle imaging biomarkers in mammograms. The model outperforms traditional risk assessment models, providing more accurate and cost-effective care for patients.
The ESMO Immuno-Oncology Congress 2020 discussed the latest developments in cancer treatment, including adjuvant and neoadjuvant treatments, tumour microenvironments, and novel therapeutics. The event also examined the impact of COVID-19 on immunotherapy in cancer patients.
A new study published in Neurology found that people with multiple sclerosis (MS) had a 72% greater risk of developing bladder cancer compared to those without the disease. However, breast and colorectal cancers did not show a significant association with MS.
Researchers found that providing genetic feedback to high-risk individuals improves their understanding and perceived value of the information. The study aims to improve healthcare by enabling personalized prevention plans and treatments for people with hereditary predispositions.
Researchers are exploring unique biomarkers in normal breast tissue of Black women to improve treatment options for aggressive breast cancer. DNA analysis revealed a genetic mutation called duffy, which may contribute to higher breast cancer rates and aggressiveness in Black women.
A UK-wide study found mammography screening reduces breast cancer mortality by 37% for women screened at least once. The benefit persists for 3-4 years in younger women, making the program highly relevant across all age groups.
Researchers at University of Virginia Health System identified gene TRIM37 responsible for triple-negative breast cancer metastasis and developed potential treatment approach using nanoparticles. The approach shows promising results in lab mice, offering a new way to target a driver of metastasis and potentially improve overall survival.
Women with frozen eggs and ovarian tissue had more children after breast cancer diagnosis compared to those without fertility preservation. The study highlights the importance of reproductive counseling for young breast cancer patients.
Research finds that women with food and housing insecurity are at risk of undiagnosed breast cancer due to lapses in follow-up appointments. The study, presented at the Radiological Society of North America meeting, found that these unmet social needs lead to longer intervals between diagnostic imaging and biopsy.
A study reveals that methylation of the DVDMR region in the IGF2 gene determines its protein expression levels in breast cancer cells and tissues, suggesting a potential novel epigenetic biomarker for BC aggressiveness. The findings imply that IGF2 levels contribute to BC metastasis and chemoresistance.
Researchers applied proteogenomics to identify precise diagnostics for known treatment targets, new tumor susceptibilities, and mechanisms involved in breast cancer treatment resistance. The study provides insights into the metabolic vulnerabilities of ER+ and ER- breast cancers and suggests potential targets for diagnosis and treatment.
Researchers develop a new approach to treating lung metastasis by delivering chemokine CXCL10 via red blood cells, stimulating the immune system to attack tumors. Treatment with erythrocyte-anchored systemic immunotherapy (EASI) halts tumor growth and induces an immune response in mice.
Researchers have developed a sensitive optical method to detect formaldehyde in exhaled breath, which could lead to an inexpensive and fast way to screen for lung and breast cancer. The new approach uses multipass spectroscopy with optical fringe quenching technique, allowing detection of formaldehyde at low concentrations.
A recent study published in Science Advances suggests that LMTK3 inhibitors could be an effective treatment for breast cancer and potentially other types of cancer. The researchers successfully demonstrated the anticancer effects of LMTK3 inhibitors in cells and breast cancer models in mice.
A new biomaterial-based cancer vaccine has shown promise in treating aggressive triple-negative breast cancer (TNBC) in mice, with 100% survival rate after a subsequent injection of cancer cells. The vaccine combines chemotherapy and immunotherapy to generate a sustained anti-cancer response.
Researchers found that methylation of a specific region in the IGF2 gene, known as DVDMR, determines IGF2 protein expression levels in breast cancer. High IGF2 levels are associated with increased BC aggressiveness and metastasis.