Articles tagged with Breast Cancer
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Researchers found that adding venetoclax to hormone therapy and CDK4/6 inhibitors can kill senescent cancer cells, potentially prolonging cancer response to therapy. The findings have underpinned a phase 1 clinical trial in Melbourne combining the treatments.
A new tumour sampling method, representative sequencing, accurately detects genetic alterations in tumours by collecting data from a well-mixed representation of the whole tumour. This method has been shown to be more consistent and accurate than current methods, with implications for personalized cancer treatment.
Researchers at University of Pennsylvania activate G protein-coupled estrogen receptor (GPER) in human and mouse pancreatic cancer models, inhibiting growth and making tumors more sensitive to immunotherapy. This approach may improve efficacy of existing treatments in a type where PD-1 inhibitors have been ineffective.
Researchers at Harvard's Wyss Institute have created disc-shaped particles that control macrophage behavior to slow tumor growth and metastasis in mice. The 'backpacks' keep macrophages in their tumor-killing state for up to five days, reducing the size of tumors and metastatic nodules.
A new study led by Yale Cancer Center researchers shows that immunotherapy prior to surgery can increase the rate of complete eradication of high-risk HER2-negative breast cancer from the breast and lymph nodes. The treatment combination of durvalumab, a checkpoint inhibitor, with chemotherapy resulted in a higher pCR rate compared to ...
Researchers at Walter and Eliza Hall Institute have discovered a new population of immune cells called ductal macrophages that play a crucial role in maintaining healthy breast tissue by clearing away dying milk-producing cells. This discovery could lead to new insights into treating breast cancer.
The Phase III EMBRACA trial found talazoparib improved patient-reported quality-of-life measures and had a tolerable safety profile in patients with metastatic HER2-negative breast cancer and BRCA1/2 mutations. However, the study did not demonstrate a statistically significant overall survival benefit due to subsequent treatments.
Researchers at DKFZ successfully blocked a receptor that stimulates tumor growth and metastasis with an antibody, slowing down cancer progression. The study found that the antibody reduced metastases in treated mice without affecting blood vessel formation.
A study by King's College London found that cancer patients referred by GPs with suspected cancer had lower mortality rates and were more likely to be diagnosed at an earlier stage for breast, lung, and prostate cancer. Early GP referrals have made a significant impact in improving cancer outcomes in the NHS.
A new imaging technique combining high-resolution imaging with quantitative measurement of tissue elasticity can detect cancer within resected margins of breast-conserving surgery. The study found QME to have high sensitivity and specificity for detecting cancer, reducing the need for additional surgeries.
Researchers have developed a unique immunotherapy delivery system that can turn cold tumors into 'hot' tumors, making it effective in cancers such as breast and melanoma. The system uses a protein called interleukin 12 to inflame the tumor and activate the immune system.
A new study has identified a molecular pathway responsible for the progression and spread of triple-negative breast cancer (TNBC). By blocking the signaling pathway, researchers found that tumors grew and spread more slowly. The findings suggest that patients with low ELF5 protein levels should be given interferon-gamma signaling-block...
Researchers describe a possible mechanism linking obesity and breast cancer, proposing that fatty acid binding protein (FABP4) drives tumor growth. Elevated FABP4 levels in obese individuals promote breast cancer development through direct interaction with cancer cells.
Researchers developed a new imaging technique, XDFI-CT, to visualize the 3D internal structure of the nipple. The study reveals three distinct types of duct arrangements and provides evidence for the 'sick lobe theory' that non-invasive breast cancer begins in a single mammary lobe.
A study of 950,000 cancer patients found differences in stage at diagnosis, therapy use, and overall survival by racial and ethnic groups. The analysis revealed disparities in cancer care across various ethnicities.
A systematic review and meta-analysis of prospective studies found that consuming a diet high in fiber was associated with a reduced incidence of breast cancer. The findings suggest that soluble fiber and higher total fiber intake are linked to lower risks of breast cancer, particularly in premenopausal and postmenopausal women.
A new study published in Cancer Research found that Indigenous American ancestry is associated with a greater incidence of HER2-positive breast cancer in Latinas. The study analyzed data from over 1,300 patients and found that women with higher proportions of IA ancestry were more likely to develop HER2-positive tumors.
A Swedish cohort study found that breast density, microcalcifications, and masses have a significant genetic component, with heritability estimates of 58%, 23%, and 13% respectively. The study also identified positive associations between these traits and genetic predisposition to breast cancer.
Researchers discovered that activating the androgen receptor decreases tumor growth in estrogen receptor-positive (ER+) breast cancer. The study used enobosarm, an androgen receptor-stimulating drug, which stopped tumor growth in all models tested.
A large observational study compared radiologists' recall rates and cancer detection in breast cancer screenings using digital breast tomosynthesis (DBT) and digital mammography. The study found that DBT had higher cancer detection rates but lower recall rates than digital mammography.
Researchers found that nanoparticles coated with trastuzumab were better retained in tumors and stimulated an anti-cancer immune response, even in HER2-negative tumors. The study suggests that the host's immune system plays a crucial role in determining nanoparticle retention and efficacy.
The study found that SRK-181 inhibits latent TGFβ1 activation with high selectivity and overcomes primary resistance to checkpoint blockade therapy by altering the tumor immune landscape. Preclinical results demonstrated improved preclinical safety profiles compared to conventional inhibitors of TGFβ signaling.
A team of researchers from Universities of Bonn and Ulm has investigated how a cell's proteasome can be programmed to degrade proteins that fuel cancer cell growth. By customizing molecular hybrids called PROTACs, they successfully targeted a protein essential for tumor cells to multiply.
In a phase I study, fam-trastuzumab deruxtecan-nxki (Enhertu) demonstrated clinical activity in patients with non-breast/non-gastric cancer types with HER2 overexpression or mutation. The overall objective response rate was 28.3 percent, with greatest response rates for NSCLC and HER2-mutant NSCLC.
Researchers have developed a new contrast agent that detects brain metastases in certain types of cancer, such as breast cancer, at an early stage using minimal amounts of contrast agent. The agent works by detecting the formation of new blood vessels, improving MRI sensitivity and visualization.
New research suggests that statin therapy may protect against heart damage caused by certain breast cancer therapies. A population-based study found a significantly lower risk of treatment-related heart failure among women taking statins while receiving anthracyclines or trastuzumab.
A new study found that the protein peptidyl arginine deiminase 4 (PAD4) promotes breast cancer metastasis in mice when expressed in cancer cells. PAD4 enables immune cells to trap bacteria, but its role in breast cancer has been unclear.
A new study benchmarks the technology, finding it effectively detects early arm swelling associated with lymphedema in breast cancer patients. The detection technology improves not only physical health but also peace of mind and finances.
Researchers identified a potential intervention for triple-negative breast cancer by targeting the MYCN oncogene. Experimental drugs called BET inhibitors showed promise when combined with MEK inhibition in model systems overexpressing MYCN.
Researchers at Boston Children's Hospital have discovered a new approach to cancer immunotherapy by reactivating the gasdermin E gene, which can convert 'cold' tumors into 'hot' ones that the immune system can target. The team showed that re-introducing gasdermin E in mouse models triggered pyroptosis and suppressed tumor growth in var...
A recent study of over 4,500 postmenopausal women diagnosed with breast cancer found that about 1 in 40 have BRCA1 or BRCA2 gene mutations. These mutations increase the risk of other cancers, including ovarian cancer, and may benefit from genetic testing.
A new study published in Radiology found that digital breast tomosynthesis (DBT) improved cancer detection rates and reduced false positives compared to digital mammography (DM). DBT screening detected a higher proportion of poor prognosis cancers than DM, with better visualization of lesions and reduced tissue superimposition.
New research suggests that higher concentrations of insulin-like growth factor-1 (IGF-1) may be a probable cause of breast cancer. Studies found an association between IGF-1 and breast cancer development, with higher levels linked to increased risk. The findings support a causal role of the IGF pathway in breast cancer development.
A new imaging agent has been developed to identify cancer cells and their supporting compromised cells. The compound binds to activated annexin A2 protein present in many solid tumors, allowing for targeted imaging and potential dual targeting of the tumor and surrounding cells with chemotherapy drugs.
Researchers have identified a new target in 'normal cells' for a potential treatment of triple negative breast cancer. Using PIK3Cδ inhibitors, the study found a reduction in tumour growth and improved survival outcomes when levels of the protein were controlled in surrounding healthy tissue.
Scientists create micrometric scaffolding with gold nanoparticles to detect biomarkers and track cell displacement in real time. The SERS technology allows for precise monitoring of tumor growth and evolution, providing insights into cancer treatment.
Researchers have discovered that breast cancer cells change their metabolism to move to other parts of the body, a finding that could lead to new strategies for preventing the spread of cancer. This shift in metabolism may be targeted with drugs to prevent metastasis and improve survival rates.
Dartmouth engineers are developing a multi-modal breast imaging platform combining Microwave and Magnetic Resonance Imaging to improve diagnostic accuracy and reduce anxiety in patients. The approach aims to minimize unnecessary biopsies and eliminate the need for gadolinium contrast injection.
Researchers have identified a promising new drug combination that can help the immune system target and kill cancer cells. By combining an anti-nausea drug with existing cancer treatments, the treatment works by altering the surface of tumor cells to make them more recognizable to the immune system.
Researchers discovered a new function of neurofibromatin, directly repressing estrogen receptor-alpha expression and causing treatment resistance in ER+ breast cancer. A combination therapy of SERD and MEK inhibitor was shown to be effective in animal models and is being tested in clinical trials.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that young women with breast cancer experience substantial financial difficulties after diagnosis, even if they have stable jobs and insurance coverage. The study highlights the need for better financial planning and awareness of the costs associated with cancer care.
A new trial led by Beth Israel Deaconess Medical Center found that platinum-based therapy was not superior to standard chemotherapy in treating patients with BRCA mutations. The study, known as INFORM, compared the efficacy of cisplatin to a standard treatment regimen in patients with breast cancer.
A study by Mayo Clinic researchers suggests that all women with a breast cancer diagnosis under the age of 66 be offered germline genetic testing. This approach would identify 98% of women with BRCA1 and BRCA2 mutations, while avoiding testing of 20% of all breast cancers.
A study predicts a rise in cancer cases in Canada in 2020, with nearly 1 in 2 Canadians expected to receive a diagnosis. Lung cancer will be the leading cause of death, responsible for about 1 in 4 deaths from cancer.
A new study published in JAMA found that Fast Breast MRI detected significantly more breast cancers than digital breast tomosynthesis (3-D mammography) in average-risk women with dense breast tissue. The study showed that Fast Breast MRI was almost two and a half times more effective at detecting breast cancers in these women.
Researchers at CNIO propose a novel approach using CDK4/6 inhibitors after chemotherapy to prevent tumor cells from resisting treatments. This strategy shows promising results in preventing tumor growth and death in mice with pancreatic adenocarcinoma, suggesting new avenues for improving cancer treatment.
The study demonstrates that MLN4924 treatment induces DNA damage and accumulates cells in S phase, enhancing sensitivity when combined with cisplatin. In vivo results show reduced tumor growth in a NOD-SCID mouse xenograft model treated with MLN4924 alone or in combination with cisplatin.
A clinical trial led by Queen Mary University of London found that immune therapy drug pembrolizumab significantly reduced the risk of cancer recurrence in patients with early triple negative breast cancer. Nearly 65% of women showed no sign of cancer after treatment, compared to 51% on chemotherapy alone.
The study found that patients whose breast cancer was completely eradicated by chemotherapy had a higher proportion of DNA mutational 'signature 3', indicating defects in DNA repair. This signature is associated with genes like BRCA, which could help doctors predict patient response to neoadjuvant chemotherapy.
In aggressive colorectal cancers, a structural framework called cancer-associated fibroblasts helps tumors evade the immune system by expressing high levels of CD73, an immune checkpoint enzyme. CAFs create a self-serving process that amplifies their own CD73 expression, suppressing immune responses.
A recent study published in BMC Cancer found that nearly two-thirds of women diagnosed with breast cancer experience significant weight gain, with the majority gaining over 20 kilograms. The study highlights the importance of early intervention and management strategies to prevent weight-related issues after a breast cancer diagnosis.
Breast cancer support groups play a crucial role in helping underserved African-American women in Memphis overcome economic, social, and psychological barriers to diagnosis and treatment. The groups act as connectors between healthcare providers and the community, reducing death rates from breast cancer among black women in the city.
A new study by Loma Linda University Health found that dairy milk consumption is associated with a higher risk of breast cancer in women. The study of nearly 53,000 North American women found that even moderate amounts of dairy milk can increase the risk of breast cancer, up to 80% depending on consumption levels.
A study published in JAMA found abbreviated breast MRI to be more effective than digital breast tomosynthesis in detecting breast cancer in women with dense breasts. The test detected significantly more cancers and showed promise as a new screening tool for these patients.
Researchers found a small mortality benefit for continuing mammography screening in women between 70-74 years old, but no benefit for those over 75. Women who continued screening were less likely to receive aggressive therapies for breast cancer.
Researchers have developed a non-invasive system that uses harmless microwaves and artificial intelligence to detect small tumors in minutes. The device costs under $5,000 to build and can detect anomalies as small as 1 cm in diameter, potentially reducing radiation exposure and improving patient comfort.
A recent study found that radiation can trigger an inflammatory response in breast cancer cells, leading to the survival and growth of triple-negative breast cancer cells. This finding highlights the importance of understanding the microenvironment in cancer development.
Researchers successfully used CRISPR to make targeted cuts in human breast cancer genes, allowing for efficient sequencing of critical alterations. The technique has the potential to streamline cancer treatment selection and use of targeted therapies.
The Beckman Institute has developed imaging techniques that capture more information about a tissue compared to traditional methods, allowing for better visualization of extracellular vesicles. These vesicles are known to increase in number and be associated with cancer, particularly breast cancer cells.
A study of over 925,000 adults with new cancer diagnoses found that Medicaid expansion improved insurance status, led to earlier cancer stage detection, and resulted in timely treatment. The findings suggest a positive association between Medicaid expansion and cancer care outcomes.