Articles tagged with Breast Cancer
The University of Arizona Cancer Center has been awarded $6.85 million to continue its efforts in cancer research, training, and outreach programs serving Arizona Native American communities. The new funding extends the Partnership for Native American Cancer Prevention (NACP) partnership for five years through 2024.
A clinical trial found that palbociclib can be safely taken by African American and other women with benign ethnic neutropenia who have advanced breast cancer. The trial showed that 58% of participants had the gene alteration associated with lower neutrophil counts, but none developed life-threatening infections or discontinued treatment.
Researchers from the SWOG Cancer Research Network confirmed two biomarkers - DDIR signature and sTILs - can serve as prognostic markers for patients with triple negative breast cancer. These tests could guide cancer treatment personalized to individual patient biology.
The NRG Oncology clinical trial found that accelerated partial-breast irradiation (APBI) did not meet the criteria for equivalence to whole-breast irradiation (WBI) in controlling ipsilateral breast tumor recurrence. APBI did show a 1% difference in 10-year cumulative incidence of IBTR compared to WBI.
Researchers at Baylor College of Medicine discovered that immune checkpoint genes are more actively expressed in resistant tumors, which could be targeted with immunotherapy. This finding highlights the importance of personalized medicine and proper stratification of patients before treatment.
A study published by NIH found that frequent use of permanent hair dye and chemical straighteners increases breast cancer risk, especially among African American women. Women who regularly used permanent dyes were 9% more likely to develop breast cancer than those who didn't use hair dye.
A new study found that stricter alcohol policies are associated with a reduced risk of cancer mortality. The research, published in Chemico-Biological Interactions, suggests that stronger regulations may be a promising means of preventing cancer deaths at the population level.
Researchers at McGill University identified a key protein that promotes resistance to chemotherapy in triple negative breast cancer. Targeting this protein, perilipin4, causes nearly all resistant cells to stop growing and die, holding promise for treating more patients with chemotherapeutic resistant TNBC.
Researchers at Lancaster University have developed a new AI diagnostic tool for breast cancer using Raman spectroscopy to identify unique chemical fingerprints of different types of breast cancers. The algorithm successfully predicted diagnostic patterns for four subtypes with high accuracy, ranging between 70% and 100%.
A study published in SPIE Journal of Biomedical Optics found that diffuse reflectance spectroscopy can reliably discriminate between healthy tissue and tumor tissue, regardless of neoadjuvant chemotherapy status. The technique's feasibility for tumor-margin assessment during breast-conserving surgery has been demonstrated.
Research reveals that inhibiting Mcl-1 protein can induce apoptosis in estrogen receptor-positive breast cancer cells, suggesting a potential therapeutic strategy for this type of cancer. The study also found that combining Mcl-1 inhibition with ABT-263 increased cell death in ER+ breast cancer cells.
A new study found that biennial mammography screening resulted in smaller and less advanced breast cancer tumors compared to annual screenings. The study also discovered that women receiving biennial screenings tended to have more aggressive treatment options, such as chemotherapy and axillary lymph node dissection.
Researchers have identified a splicing factor called TRA2B as a key driver of triple negative breast cancer's ability to grow and spread. Blocking TRA2B expression in cells has been shown to prevent metastasis, providing a potential new treatment avenue for this devastating form of breast cancer.
A new study published in the European Heart Journal found that over one in ten cancer patients die from cardiovascular disease, including heart disease and stroke. The study analyzed data from over 3.2 million US patients diagnosed with cancer between 1973 and 2012, revealing that certain types of cancer, such as breast and prostate ca...
A new trial shows that breast cancer patients who experience a local recurrence in the same breast after lumpectomy and radiation can benefit from partial-breast re-irradiation as an alternative to mastectomy. The treatment targets the affected area with high-dose radiation, reducing exposure to surrounding tissue.
People living with or beyond cancer are more than twice as likely to die of a stroke compared to the general population. Certain types of cancer, such as breast, prostate, and colorectum cancers, were found to be most commonly associated with fatal strokes.
The University of Illinois Chicago will help young breast cancer survivors navigate post-treatment care and survival with a $1.8 million CDC grant. The program aims to reduce disparities in survival and quality of life due to social factors among breast cancer survivors.
Women from Appalachia are less likely to receive breast reconstruction surgery following a mastectomy due to lack of adequate care and patient education. Researchers highlight the need for better comprehensive breast cancer care, including access to reconstructive plastic surgeons.
The new guidelines call for better access to CDK4/6 inhibitors and anti-HER2 therapies for patients with advanced breast cancer. Experts also stress the need for adequate pain control, particularly in countries where opioids are scarce or misused.
Researchers from Boston University School of Medicine have developed a novel computational method, iEDGE, which identified several candidate breast cancer drivers and multiple pan-cancer drivers, including TRIP13 and TPX2.
A new study from the University of Pennsylvania School of Medicine found that implementing an electronic health record nudge increased cancer screening orders by 22% and 14%, respectively. However, the study also showed that patients' follow-through on screenings remained largely unchanged. The researchers suggest that future intervent...
The study found that T-DM1 resulted in a third of patients experiencing objective response and nearly 40% continuing treatment for at least six months. Patients with central nervous system metastases had shorter progression-free survival rates, highlighting the need for inclusion in randomized trials.
UNC Lineberger researchers have discovered a method to identify triple negative breast cancer tumors that will respond to immunotherapy. The findings, published in the journal Cell, could help guide patients to the right treatments and lead to new approaches to make drugs work in cancers that don't initially respond.
Researchers developed nanoparticles that can deliver immunostimulants via inhalation to induce systemic immune response against lung cancer. The treatment converted cold tumors to hot, immune-responsive tumors and showed significant regression of tumors in both lungs and prolonged survival of mice.
Researchers at Princess Margaret Cancer Centre have identified new protein targets for drug development against prostate cancer by analyzing noncoding DNA regions. These regions, previously thought to be 'junk' DNA, were found to harbor important regulatory elements that determine gene expression.
Scientists at UCSF discovered that blocking the activity of MMP9 can prevent breast cancer from spreading to distant organs. The researchers found that MMP9 helps create a hospitable environment for cancer cells to form new tumors by remodeling healthy tissue and transforming it into safe havens.
Advanced breast cancer patients frequently receive inaccurate one-number estimates of their average survival time. Instead, a new method provides doctors with three scenarios: best-case, worst-case and typical survival times. This approach has been shown to be more helpful, easier to understand and reassuring for patients.
Complementary therapies used to treat breast cancer skin lesions may delay wound healing and interfere with systemic treatments. Herbal products like green chiretta and feverfew have been shown to negatively impact blood clotting, exacerbating scarring and dressing effectiveness.
A study published in JAMA reports that cardiac resynchronization therapy can significantly improve heart function in cancer survivors with congestive heart failure. After six months, the patients experienced improved heart function, reduced symptoms, and enhanced quality of life. The therapy offers a possible solution for patients who ...
The NIH RO1 grant aims to improve ultrasound tomography for breast cancer detection by developing physics-based computational models and advanced image reconstruction methods. The goal is to create high-resolution images that can detect subtle cancers, especially in younger women with denser breast tissue.
Researchers identify potential environmental risk factors and new treatment strategies for triple negative breast cancer (TNBC), an aggressive form of breast cancer. The study suggests that exposure to common chemicals may increase the risk of developing TNBC, and highlights the potential for combination therapy as a treatment option.
Research published in Public Relations Review debunks myths about Asian American health, revealing a lack of awareness and reluctance to seek care. Community engagement is crucial for addressing health disparities and promoting participation in healthcare initiatives.
Most UK mastectomies are advised for large tumours; standard hormone therapy and chemotherapy could reduce number of women needing surgery.
Researchers found that increasing physical activity after a breast cancer diagnosis is associated with a lower risk of death, regardless of pre-diagnosis activity levels. Postmenopausal women who were insufficiently active before diagnosis but sufficiently active after diagnosis had a 50% reduced risk of overall mortality.
Women with a genetic predisposition for breast cancer were 2.5 times more likely to develop malignancy without weight-loss surgery, but the risk was significantly reduced after bariatric or weight-loss surgery. The study found that weight-loss surgery cut the overall risk of developing cancers linked to obesity by 20 percent.
Researchers have identified CEMIP as a key protein promoting brain metastasis in breast and lung cancers. By blocking CEMIP, it may be possible to prevent or treat brain metastases, which are a common cause of cancer deaths. High levels of CEMIP in primary tumors have been linked to a faster progression to brain metastasis.
A team of researchers led by Miguel Quintela-Fandino has discovered the link between FASN and cancer development. They found that FASN is essential for anchorage-independent growth, a hallmark of cancer transformation.
Researchers have developed a simple blood test that detects breast cancer up to five years before clinical signs appear, identifying tumor-associated antigens and autoantibodies. The test shows promising accuracy in detecting breast cancer with reasonable accuracy, especially when using panels of multiple antigens.
A new study has found that spaying dogs reduces their risk of developing mammary tumors, but may increase the risk of more aggressive cancers. Higher serum estrogen levels in spayed animals with mammary tumors were associated with longer times to metastasis and improved survival times.
Patients treated for breast cancer at a safety net hospital achieved comparable five-year survival outcomes to national averages, despite having more advanced disease and socioeconomic challenges. A multidisciplinary clinic streamlines diagnosis, treatment, and follow-up, resulting in high-quality clinical outcomes.
A study published in Lancet Oncology reveals that online popularity of health awareness campaigns does not always lead to increased interest in related health behaviors. Researchers analyzed Google Trends data for specific keywords associated with each campaign and found that only breast cancer-related searches were influenced by the P...
A new method has been developed to identify aggressive breast cancer by analyzing tumor tissue signatures, showing a correlation with poor outcome in patients. The study used mouse models and bioinformatics expert to isolate macrophages from mice affected by breast cancer and compared them with those from healthy breast tissue.
A University of Michigan researcher found that breast cancer patients who endured Hurricane Katrina in 2005 have a 15% higher mortality rate than those not exposed to the storm. The study suggests disaster-related healthcare disruptions and highlights the need for improved access to healthcare during disasters.
Professor Fatima Cardoso will receive the award for her foresight in understanding advanced breast cancer and launching the ABC Global Alliance. The alliance, now an independent organization, aims to improve lives of patients worldwide through awareness and advocacy.
A new AI-powered analysis has improved understanding of stage 0 breast cancer, identifying which patients are most likely to progress to invasive cancer. The research suggests that some patients may not need radiation therapy, contrary to current prevailing wisdom.
New research found that women with diabetes are up to a quarter less likely to undergo recommended cancer screenings, including cervical, breast, and colorectal cancer tests. The study suggests that the burden of diabetes care management in primary care may contribute to lower uptake of cancer screening.
A study by Yale University found that sentinel lymph node biopsies do not reduce the risk of death from breast cancer or decrease invasive cancer development in women with ductal carcinoma in situ (DCIS), a non-invasive breast cancer. The procedure also increases the risk of pain, wound infection, and lymphedema.
Researchers used CRISPR gene editing to mimic human SF3B1 mutations in C. elegans worms, identifying three splicing factors as potential targets for cancer therapy. The study also humanized a region of the SF3B1 protein binding site, enabling testing of Pladienolide B-derived molecules.
Researchers from the Stowers Institute for Medical Research have discovered that BRK kinase binds to and leads to the breakdown of SMAD4, a key tumor suppressor protein. This finding suggests that targeting BRK may help retain SMAD4 function, reducing or stopping tumor growth in breast cancer.
Researchers found a panel of 17 small RNA molecules influenced by genetic alterations in cancer cells, which could lead to targeted treatments for Latinas with TNBC. The study suggests that racial and ethnic differences in miRNA expression may impact breast cancer incidence rates.
A Vanderbilt University study found men with breast cancer have a 19% higher five-year mortality rate than women, attributed to clinical characteristics and undertreatments. The disparity persists even when considering cancer types, access to care, and lifestyle factors like smoking and obesity.
Scientists discovered a new organelle that prevents cancer by ensuring correct genetic material sorting. The organelle's discovery offers a way for doctors to personalize cancer treatments, sparing up to 40% of patients with breast cancer.
Research found that KLK6 overexpression induces HMGA2 expression in colon cancer cells, contributing to CRC progression and metastasis. High KLK6 scores were linked to disease recurrence, suggesting its potential role as a biomarker.
Researchers found that cells on a tumor's periphery are softer and more likely to invade surrounding tissues. This softness enables the cells to spread through the body's vasculature, forming 'invasive tips' that break away from the tumor.
Bioinformatician Serena Nik-Zainal is awarded the Dr. Josef Steiner Cancer Research Award for her development of new methods to classify tumors using bioinformatics. Her research aims to improve cancer diagnosis and prognosis by making comprehensive computational infrastructure accessible to clinicians.
A new AI tool, trained on a large dataset of mammography images, accurately identified breast cancer with 90% accuracy when combined with radiologist analysis. The study suggests that AI can augment human radiologists' diagnoses, reducing false-positive and false-negative results.
A recent study comparing digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) found that DBT significantly increased cancer detection rates for invasive, minimal, estrogen receptor-positive invasive, and node-negative cancers. However, the difference was not significant for ductal carcinoma in situ.
The third edition of the Cancer Atlas highlights patterns and inequities in cancer burden worldwide, emphasizing the need for access to information and services. The report also emphasizes the impact of lifestyle factors such as smoking, unhealthy diet, and physical inactivity on cancer risk.
Breast cancer survivors who received Acceptance and Commitment Therapy (ACT) showed significant improvements in reducing fear of recurrence compared to other treatment approaches. ACT helps patients focus on living a meaningful life, rather than being driven by fear.
Researchers at University of Maryland School of Medicine identify new pathway to destroy cancer cells using PARP inhibitor and DNA methyltransferase inhibitor combination. The therapy has a synergistic effect when combined with radiation therapy, potentially expanding treatment options for non-small cell lung cancer patients.