Analysis by surgical trainees examines recommendations for mastectomy across the UK
Most UK mastectomies are advised for large tumours; standard hormone therapy and chemotherapy could reduce number of women needing surgery.
Breast Cancer
Articles tagged with Breast Cancer
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Increase in physical activity after breast cancer diagnosis may lower risk of death
Researchers found that increasing physical activity after a breast cancer diagnosis is associated with a lower risk of death, regardless of pre-diagnosis activity levels. Postmenopausal women who were insufficiently active before diagnosis but sufficiently active after diagnosis had a 50% reduced risk of overall mortality.
Weight-loss surgery may counter genetic risk for developing breast cancer
Women with a genetic predisposition for breast cancer were 2.5 times more likely to develop malignancy without weight-loss surgery, but the risk was significantly reduced after bariatric or weight-loss surgery. The study found that weight-loss surgery cut the overall risk of developing cancers linked to obesity by 20 percent.
Scientists identify protein that promotes brain metastasis
Researchers have identified CEMIP as a key protein promoting brain metastasis in breast and lung cancers. By blocking CEMIP, it may be possible to prevent or treat brain metastases, which are a common cause of cancer deaths. High levels of CEMIP in primary tumors have been linked to a faster progression to brain metastasis.
CNIO researchers describe a molecular strategy that helps prevent tumour formation in mice
A team of researchers led by Miguel Quintela-Fandino has discovered the link between FASN and cancer development. They found that FASN is essential for anchorage-independent growth, a hallmark of cancer transformation.
Simple blood test for early detection of breast cancer
Researchers have developed a simple blood test that detects breast cancer up to five years before clinical signs appear, identifying tumor-associated antigens and autoantibodies. The test shows promising accuracy in detecting breast cancer with reasonable accuracy, especially when using panels of multiple antigens.
Estrogen's opposing effects on mammary tumors in dogs
A new study has found that spaying dogs reduces their risk of developing mammary tumors, but may increase the risk of more aggressive cancers. Higher serum estrogen levels in spayed animals with mammary tumors were associated with longer times to metastasis and improved survival times.
Five-year breast cancer survival rates at a safety net hospital rival national averages
Patients treated for breast cancer at a safety net hospital achieved comparable five-year survival outcomes to national averages, despite having more advanced disease and socioeconomic challenges. A multidisciplinary clinic streamlines diagnosis, treatment, and follow-up, resulting in high-quality clinical outcomes.
It takes more than a catchy headline for health awareness campaigns to inspire action
A study published in Lancet Oncology reveals that online popularity of health awareness campaigns does not always lead to increased interest in related health behaviors. Researchers analyzed Google Trends data for specific keywords associated with each campaign and found that only breast cancer-related searches were influenced by the P...
New method identifies aggressive breast cancer
A new method has been developed to identify aggressive breast cancer by analyzing tumor tissue signatures, showing a correlation with poor outcome in patients. The study used mouse models and bioinformatics expert to isolate macrophages from mice affected by breast cancer and compared them with those from healthy breast tissue.
Living through Katrina associated with higher death rate among breast cancer patients
A University of Michigan researcher found that breast cancer patients who endured Hurricane Katrina in 2005 have a 15% higher mortality rate than those not exposed to the storm. The study suggests disaster-related healthcare disruptions and highlights the need for improved access to healthcare during disasters.
Professor Fatima Cardoso wins Advanced Breast Cancer Award
Professor Fatima Cardoso will receive the award for her foresight in understanding advanced breast cancer and launching the ABC Global Alliance. The alliance, now an independent organization, aims to improve lives of patients worldwide through awareness and advocacy.
Breast cancer: AI predicts which pre-malignant breast lesions will progress to advanced cancer
A new AI-powered analysis has improved understanding of stage 0 breast cancer, identifying which patients are most likely to progress to invasive cancer. The research suggests that some patients may not need radiation therapy, contrary to current prevailing wisdom.
New research shows lower rates of cancer screening in women with diabetes
New research found that women with diabetes are up to a quarter less likely to undergo recommended cancer screenings, including cervical, breast, and colorectal cancer tests. The study suggests that the burden of diabetes care management in primary care may contribute to lower uptake of cancer screening.
Sentinel lymph node biopsy has no benefits for stage zero breast cancer
A study by Yale University found that sentinel lymph node biopsies do not reduce the risk of death from breast cancer or decrease invasive cancer development in women with ductal carcinoma in situ (DCIS), a non-invasive breast cancer. The procedure also increases the risk of pain, wound infection, and lymphedema.
CRISPR-edited C. elegans identifies vulnerabilities in cancer
Researchers used CRISPR gene editing to mimic human SF3B1 mutations in C. elegans worms, identifying three splicing factors as potential targets for cancer therapy. The study also humanized a region of the SF3B1 protein binding site, enabling testing of Pladienolide B-derived molecules.
Zeroing in on how a tumor suppressor protein is cast away
Researchers from the Stowers Institute for Medical Research have discovered that BRK kinase binds to and leads to the breakdown of SMAD4, a key tumor suppressor protein. This finding suggests that targeting BRK may help retain SMAD4 function, reducing or stopping tumor growth in breast cancer.
Aggressive form of breast cancer influenced by dual action of genes and RNA
Researchers found a panel of 17 small RNA molecules influenced by genetic alterations in cancer cells, which could lead to targeted treatments for Latinas with TNBC. The study suggests that racial and ethnic differences in miRNA expression may impact breast cancer incidence rates.
Men with breast cancer face high mortality rates: Study
A Vanderbilt University study found men with breast cancer have a 19% higher five-year mortality rate than women, attributed to clinical characteristics and undertreatments. The disparity persists even when considering cancer types, access to care, and lifestyle factors like smoking and obesity.
New organelle that helps prevent cancer discovered in our cells
Scientists discovered a new organelle that prevents cancer by ensuring correct genetic material sorting. The organelle's discovery offers a way for doctors to personalize cancer treatments, sparing up to 40% of patients with breast cancer.
Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein
Research found that KLK6 overexpression induces HMGA2 expression in colon cancer cells, contributing to CRC progression and metastasis. High KLK6 scores were linked to disease recurrence, suggesting its potential role as a biomarker.
Cell stiffness may indicate whether tumors will invade
Researchers found that cells on a tumor's periphery are softer and more likely to invade surrounding tissues. This softness enables the cells to spread through the body's vasculature, forming 'invasive tips' that break away from the tumor.
Dr. Josef Steiner Cancer Research Award 2019 goes to Serena Nik-Zainal
Bioinformatician Serena Nik-Zainal is awarded the Dr. Josef Steiner Cancer Research Award for her development of new methods to classify tumors using bioinformatics. Her research aims to improve cancer diagnosis and prognosis by making comprehensive computational infrastructure accessible to clinicians.
Combination of AI & radiologists more accurately identified breast cancer
A new AI tool, trained on a large dataset of mammography images, accurately identified breast cancer with 90% accuracy when combined with radiologist analysis. The study suggests that AI can augment human radiologists' diagnoses, reducing false-positive and false-negative results.
Digital breast tomosynthesis increases cancer detection over full-field mammography
A recent study comparing digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) found that DBT significantly increased cancer detection rates for invasive, minimal, estrogen receptor-positive invasive, and node-negative cancers. However, the difference was not significant for ductal carcinoma in situ.
Report: Progress in global cancer fight is not only possible, but achievable
The third edition of the Cancer Atlas highlights patterns and inequities in cancer burden worldwide, emphasizing the need for access to information and services. The report also emphasizes the impact of lifestyle factors such as smoking, unhealthy diet, and physical inactivity on cancer risk.
Acceptance and commitment therapy may ease fear of recurrence in cancer survivors
Breast cancer survivors who received Acceptance and Commitment Therapy (ACT) showed significant improvements in reducing fear of recurrence compared to other treatment approaches. ACT helps patients focus on living a meaningful life, rather than being driven by fear.
New treatment combination could work against broader array of cancer cells, study finds
Researchers at University of Maryland School of Medicine identify new pathway to destroy cancer cells using PARP inhibitor and DNA methyltransferase inhibitor combination. The therapy has a synergistic effect when combined with radiation therapy, potentially expanding treatment options for non-small cell lung cancer patients.
NCI awards grant for study of financial navigators to aid patients with cancer care costs
Researchers at UNC Lineberger Comprehensive Cancer Center will study the impact of financial navigation services on rural cancer patients in North Carolina. The study aims to connect patients with potential financial support resources and reduce financial toxicity associated with cancer care.
The ONCOMMUN Program will receive close to €900,000 grant from EIT Health
The ONCOMMUN Program aims to improve patient experience and reduce the impact of cancer in Europe. The program combines monitoring of health and emotional status with video-consultations, online education, and social networking to increase quality of life and therapeutic adherence.
New UW center receives NIH grant to improve the fight against cancer
The UW's Optimizing Implementation in Cancer Control Center will develop knowledge and tools to support optimal implementation of proven cancer interventions. The center will focus on optimizing screening evidence-based interventions for cervical, colorectal, breast, and ovarian cancers.
Imaging tumor stiffness could help enhance treatment for breast and pancreatic cancer
A non-invasive imaging technique can assess tumor stiffness, providing valuable diagnostic information about breast and pancreatic tumors. The technique, magnetic resonance elastography, may help select the best treatment course for some cancer patients.
Lymphoma stage at diagnosis may predict when and where new cancer forms
A Colorado study found that lymphoma stage at diagnosis impacts types of second cancers that may form after treatment. Early-stage patients had a higher risk of solid tumors, while late-stage patients were more likely to develop hematologic malignancies.
Mapping normal breast development to better understand cancer
Researchers used state-of-the-art technology to profile each cell during normal breast development, creating a molecular map to understand how breast tissues are formed and maintained. The team found that cells were already poised to become either basal or luminal cells before birth, with abnormal alterations leading to tumor development.
Hormone therapy has a bigger impact than chemotherapy on women's quality of life in bc
A new analysis published in Annals of Oncology suggests that hormone therapy has a greater impact on women's quality of life compared to chemotherapy, especially in postmenopausal patients. This finding challenges current international guidelines recommending prolonged hormone therapy for 5-10 years.
Researchers discover critical process for how breast cancer spreads in bones
Breast cancer researchers at the University of Notre Dame have identified a pair of proteins, CXCL5 and CXCR2, critical for spreading breast cancer to bone. These proteins cause cancer cells to rapidly reproduce and spread throughout the bone and marrow.
Study provides insights on treatment and prognosis of male breast cancer
A recent analysis reveals that treatment of male breast cancer has evolved over the years, with certain patient- and tumor-related factors linked to better survival. The study found that older age, black race, multiple comorbidities, high tumor grade, and undergoing total mastectomy were associated with worse overall survival.
New evolution-busting drug overcomes resistance in aggressive breast cancers
A new type of drug that blocks one of cancer's key evolutionary escape routes from chemotherapy has been shown to reinvigorate the response to chemotherapy in cancers that had become resistant. The drug, BOS172722, works by forcing cancer cells through cell division too quickly, leading to fatal errors.
Study: Aggressive breast cancers store large amounts of energy, which enables it to spread
A recent study found that aggressive breast cancers store large amounts of glycogen, a stored collection of glucose molecules. This stored energy enables the cancer cells to grow and spread. Researchers believe that targeting the enzyme PYG could be a potential target to treat or prevent breast cancer metastasis.
New insights into the genomic landscape of meningiomas identified FGFR3 in a subset of patients with favorable prognoses
Researchers have identified FGFR3 mutations in a subset of meningioma patients with favorable prognoses, suggesting potential for targeted therapy. These mutations may enhance diagnostic accuracy and clinical decision-making.
Cost-effectiveness of multigene testing of all patients with breast cancer
Researchers found that multigene testing for all patients with breast cancer can be a cost-effective approach, reducing healthcare costs and improving patient outcomes. The study compared the cost-effectiveness of multigene testing to selective testing based on family history or clinical criteria.
Decades-long drop in breast cancer death rate continues
The breast cancer death rate has slowed in recent years, but the gap between black and white women remains significant. Breast cancer incidence rates have continued to rise, with a greater increase seen in hormone receptor-positive disease.
Discovery of new source of cancer antigens may expand cancer vaccine capabilities
Researchers at Arizona State University have discovered a common source of tumor mutations that could lead to the development of universal cancer vaccines. They found that errors in RNA transcription and splicing in tumors can produce unique protein fragments, or peptides, that can be recognized by the immune system.
NIH grant aims to reduce neuromuscular effects of chemotherapy in breast cancer survivors
A University of South Florida researcher is studying whether a home-based exercise program can decrease the severity of nerve and muscle symptoms from chemotherapy-induced peripheral neuropathy in breast cancer survivors. The study aims to provide an evidence-based intervention for patients suffering from persistent neuropathy.
Research to focus on small molecule that can help fight breast cancer
Researchers at UC Riverside are developing a novel small molecule that selectively targets the PCNA protein in breast cancer cells. The project aims to create a new series of AOH1160-like molecules to improve the clinical management of breast cancer patients, while sparing non-cancerous cells.
R01 grant funds research examining small RNAs in metastatic breast cancer
Researchers will examine microRNAs and enhancer RNA to understand treatment resistance and metastasis of ER-positive breast cancer. The goal is to develop a new treatment strategy for patients with limited options.
Whole genome sequencing could enable personalised cancer treatment, study suggests
A study published in Nature Medicine suggests that whole genome sequencing of tumour cells can predict prognosis and identify effective treatments for patients with triple negative breast cancers. The technique reveals genetic signatures and mutations, providing clues to develop new drugs and improve treatment outcomes.
TAILORx: New data on cohort with recurrence score 26-100 shows 93% cancer-free rate at 5 years
The TAILORx trial has shown that women with high Recurrence Scores (26-100) have a 93% chance of being cancer-free after five years, with those receiving chemotherapy having a significantly better outcome. The findings support the use of adjuvant chemotherapy to improve treatment outcomes in early breast cancer patients.
Immune therapy eliminates tumour cells in early triple negative breast cancer
A new phase III trial found that immune therapy added to chemotherapy improved pathological complete response in patients with early triple negative breast cancer, leading to a clinically meaningful benefit and potential cure for more patients. The study also indicated an improvement in event-free survival.
Two studies show CDK4/6 inhibitors improve overall survival in advanced breast cancer
Two studies show that CDK4/6 inhibitors plus fulvestrant significantly improve overall survival in hormone receptor-positive advanced breast cancer. The combination is recommended as a standard of care for patients with metastatic disease.
Targeted therapy drug helps women with aggressive breast cancer live longer
A study by UCLA researchers found that adding ribociclib to standard hormone therapy significantly improves overall survival in postmenopausal women with advanced hormone-receptor positive/HER2- breast cancer. The combination treatment demonstrated a 28% reduction in risk of death and improved progression-free survival.
Ultrasound yields similar cancer detection rates after digital mammography, tomosynthesis
A study published in the American Journal of Roentgenology found that ultrasound screening after digital mammography and digital breast tomosynthesis yielded no significant difference in additional cancer detection rate. The findings suggest that DBT does not obviate additional US screening for women with dense breast tissue.
Women equally satisfied with cosmetic results of partial, whole breast radiation after lumpectomy
A new trial analysis found that women diagnosed with early stages of cancer who undergo lumpectomies and receive either partial or whole breast radiation have equivalent cosmetic outcomes, according to patient and physician ratings. The study's findings aim to guide women seeking breast-conserving therapy for early-stage disease.
Scientists tackle potential drug resistance by using new single-cell genetic method
Researchers used a new technique to identify genetic profiles of individual cells in a breast cancer tumor and found a drug combination that reversed resistance. The study suggests that clinicians could begin combination therapy before resistance occurs, given the effectiveness of the additional drug.
ECOG-ACRIN announces late-breaking TAILORx data at ESMO Congress 2019
ECOG-ACRIN announces late-breaking TAILORx data on chemotherapy regimens for early-stage breast cancer. The data, published concurrently in JAMA Oncology, focuses on patients with a score of 26-100 on the 21-tumor gene recurrence score assay.
Simple lifestyle modifications key to preventing large percentage of breast cancer cases
A study by The World Cancer Research Fund and the American Institute for Cancer Research suggests that lifestyle modifications can prevent up to 30% of breast cancer cases. The recommended modifications include maintaining a healthy weight, engaging in regular physical activity, and consuming a balanced diet rich in non-starch vegetables.
UMass Amherst researchers awarded $3.1 million NIH grant for breast cancer risk study
A UMass Amherst research team will investigate the effect of a fruit and vegetable-rich diet on breast cancer risk in lactating women. The New Moms Wellness Study, funded by a $3.1 million NIH grant, aims to assess biomarkers of breast cancer risk using breastmilk.
Study finds onion and garlic consumption may reduce breast cancer risk
A study published in Nutrition and Cancer found that consuming sofrito, which includes onions and garlic, was associated with a reduced risk of breast cancer. Women who ate sofrito more than once per day had a 67% decrease in risk compared to those who never ate it.
Fewer lymph node operations for breast cancer patients with new prediction models
Researchers developed new prediction models to improve personalized treatment of lymph nodes in breast cancer patients. The models show that up to one in three operations could be avoided, reducing surgical interventions by 30%.
Survival in women, men diagnosed with breast cancer
A study of nearly 1.9 million breast cancer patients found that men have lower three-year and five-year survival rates compared to women. The analysis attributed the difference to undertreatment and clinical characteristics.