Articles tagged with Breast Cancer
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City of Hope scientists develop blood test to forecast breast cancer recurrence risk in patients with solid tumors. The innovative approach aims to personalize treatment strategies and improve patient outcomes.
A new study published in the Journal of Cancer reveals significant disparities in triple-negative breast cancer diagnoses among women of color and younger women. The research found that non-Hispanic black women had a 2.3-times higher odds of being diagnosed with triple-negative breast cancer compared to non-Hispanic white women.
Ashkenazi Jewish women with known BRCA status have a 98% 5-year survival rate compared to 74% for those without knowledge, requiring less chemotherapy and extensive surgery. Early testing could prevent breast cancer or start high-risk screening at an earlier age.
Researchers developed molecularly imprinted nanoparticles that selectively bind to HER2 receptors, inhibiting tumor cell multiplication and growth. The particles were produced using a special method and demonstrated significant efficacy in reducing tumor growth in vitro and in mice.
A study of 298,434 patients found that married women had a better prognosis after breast cancer diagnosis compared to single or divorced patients. Single patients showed improved outcomes only among white patients and those aged over 35 with hormone receptor-positive tumors.
University of Birmingham researchers found that the BRCA1 gene changes shape to protect vulnerable DNA until copying machinery can be restarted. This discovery could help understand how cancers develop and potentially identify new ways to suppress tumors.
Researchers are using computer models developed by astronomers to create a rapid diagnostic test that can detect cancerous tissue without unnecessary biopsies. The technology has also shown promise in treating non-melanoma skin cancer, with simulations indicating that it could be effective in killing cancer cells.
A study by the National Cancer Institute found a clear dose-response relationship between radioactive iodine treatment and long-term risk of death from solid cancers, including breast cancer. The study estimated that for every 1,000 patients treated with standard doses, about 20-30 additional solid cancer deaths would occur.
Researchers at the University of Akron have developed 3D tumor models that more accurately replicate human tumors than traditional 2D cultures. These models are being used to test new drugs and understand the drivers of triple-negative breast cancer, a type of cancer with limited treatment options.
A new diagnostic test has the potential to determine if breast cancer patients require chemotherapy, giving them control over their treatment. The test uses gene profiling to identify low-risk patients who may not benefit from chemotherapy.
A new clinical trial has successfully treated women with HER2-positive breast cancer who have no other treatment options by combining Herceptin with chemotherapy. The two-in-one treatment extended life for patients with high and low levels of the HER2 protein, offering a promising solution to drug resistance.
A recent study calling for expanded genetic testing for hereditary breast cancer has been criticized by researchers at the University of Cambridge. The criticism highlights methodological flaws in the study and potential conflicts of interest among its authors, leading to concerns about the accuracy and practicality of such tests.
Researchers at RIT and RRHS have developed a non-invasive infrared imaging technology to detect breast cancer tumors hidden behind dense tissues. The technology takes 20 minutes to produce images that are more sensitive than current methods.
A new study aims to identify genes that are unique to African Americans and contribute to hereditary breast cancer. The research will analyze large datasets of over 18,500 African American women, including those with diagnosed and cancer-free individuals.
Research suggests that being a morning person is associated with a lower risk of developing breast cancer. Sleeping longer than the recommended 7-8 hours may also increase the risk. The findings have implications for influencing sleep habits to improve health.
A multidisciplinary team at LSU Health is using two new research techniques to study the link between obesity and breast cancer. They will observe breast tumor development in real-time using a biomimetic tissue-engineered 3D culture system, and analyze the extracellular matrix of breast cancer tumors using decellularization technique.
A novel radiotracer has been identified that can detect nearly 30 types of cancer using positron emission tomography/computed tomography (PET/CT). This technology shows promise for new applications in noninvasive diagnosis, staging and treatment.
Researchers have created a new chemoradiotherapy formulation that could reduce side effects in advanced stage head and neck cancer patients. The formulation, which stays within tumors, is predicted to be effective while minimizing harm to healthy cells.
A recent study published in JAMA Internal Medicine found that the use of 3D mammography has risen substantially in the US, with DBT being more rapidly adopted in areas with higher incomes, greater education, and larger white populations. However, disparities in care persist, reflecting uneven adoption across regions and demographics.
Researchers at the University of Alberta have identified a specific genetic marker linked to an increased risk of breast cancer in premenopausal women. The study found that up to 40% of women carrying the genetic variation are at higher risk of developing breast cancer compared to those without it.
Research published in BMJ Open reveals that only one in five women attending breast clinics and screening appointments know that alcohol is a risk factor for breast cancer. The study suggests that understanding modifiable risk factors for the disease needs to be increased, particularly through brief information on health risks associat...
A pre-clinical study led by Duke University Medical Center identified an enzyme in cells involved in regulating breast cancer growth and spread. Inhibiting this enzyme's activity allowed T-cells to mount an immune attack on cancer cells, potentially improving treatment outcomes for breast cancer patients.
Researchers found that FOLFIRINOX prolonged patients' lives by an average of 22.2 months, increasing the chances of complete tumor removal through surgery. More than two-thirds of cancers responded well to treatment, allowing for surgical removal.
Researchers develop a bio-scoring system to improve prognostication for dogs with mammary tumors, identifying those at higher risk of metastasis. The system uses tumor stage, grade, and histological type to provide a clearer picture of treatment options.
A population-based cohort study from 4 Nordic countries found no link between TNFi use and increased cancer risk. However, a significant increase in malignant lymphomas was observed within the trial. Further analysis is needed to determine if this is due to psoriatic arthritis or TNFi treatment.
A new study finds significant variation in triple-negative breast cancer incidence among black women born in different US regions. U.S.-born and Western-African-born women have the highest rates, while Eastern-African-born women have lower rates compared to both groups.
Researchers developed a biomarker test to predict disease-free survival and recurrence risk in patients with triple-negative breast cancer. The test uses formalin-fixed, paraffin-embedded tissues and has shown promise in predicting patient outcomes.
A study by Melanie Rutkowski found that an unhealthy gut microbiome can make breast cancer more invasive and spread quickly. Disrupting the balance of microorganisms in mice resulted in chronic inflammation, priming tumor cells to disseminate and metastasize.
Researchers at Marshall University found that tart cherry consumption reduced mean pain levels by 34.7% compared to a placebo group, with no impact on the effectiveness of aromatase inhibitor treatments for non-metastatic breast cancer patients.
A novel radiopharmaceutical has proven effective in identifying nearly 30 types of malignant tumors with high uptake and image contrast. The tracer targets cancer-associated fibroblasts, which can contribute up to 90% of a tumor's mass.
Researchers have developed DNA nanorobots that recognize and bind to HER2 on breast cancer cells, targeting them for destruction. The nanorobots, consisting of a tetrahedral framework nucleic acid with an attached aptamer, persist in the bloodstream longer than free aptamers and selectively kill only HER2-positive cell lines.
A study found that listening to music at home reduced symptom severity, pain intensity, and fatigue in breast cancer patients. Music therapy also reduced physical and mental fatigue instantly.
A large study published in Radiology found that breast MRI screening for breast cancer survivors leads to higher cancer detection rates, but also results in more unnecessary biopsies. The study analyzed data from over 13,000 women and found no significant differences in sensitivity between breast MRI and mammography.
A UCLA-led study found that combining hormone therapy with the drug ribociclib significantly improved overall survival in premenopausal women with advanced hormone-receptor positive breast cancer. The study showed a 70% survival rate after 42 months compared to 46% for those receiving only hormone therapy.
The study found that partial breast irradiation (PBI) is more convenient than whole breast irradiation (WBI) for women with breast cancer who do not receive adjuvant chemotherapy. PBI participants reported less fatigue and were rated more convenient, but experienced slightly poorer cosmesis compared to WBI.
A nationwide survey of 487 women found that nearly two-thirds of breast cancer patients are unaware of surgical options that can minimize scarring. The study also revealed that many patients experience negative impacts from their scars, including feelings of self-consciousness and restricted clothing choices.
A pre-specified secondary analysis of the TAILORx trial found that assessing a woman's recurrence risk based on classic clinical features adds prognostic information complementary to the 21-gene Recurrence Score test. This integration may help identify young women who can forego chemotherapy and those who may benefit from more effectiv...
The NRG GOG 0261 clinical trial shows that paclitaxel plus carboplatin is not inferior to paclitaxel plus ifosfamide in treating women with stage I-IV, recurrent carcinosarcoma of the uterus or ovary. The treatment improved overall survival and progression-free survival outcomes.
Scientists at VCU Massey Cancer Center identified key biological pathways regulating tumor cell spread to vital organs. They discovered the SRC signaling pathway is highly activated in breast cancer metastases, warranting targeted therapies.
The MONALEESA-7 Phase III trial found that adding ribociclib to hormone therapy significantly improved overall survival in premenopausal patients with advanced HR+ breast cancer, with a 29% lower risk of death. The combination was well-tolerated, with no new side effects emerging.
A novel protocol combining intensive chemotherapy, radiation therapy and blood-pressure drug losartan has allowed complete removal of tumors in 61% of participants with locally advanced pancreatic cancer. The treatment significantly improved survival rates and was found to activate immune system pathways.
A new clinical calculator, CTS5, can accurately identify patients at a significantly low risk of their breast cancer returning. This allows them to avoid unnecessary hormone therapy for five years, reducing side effects and psychological burden. The algorithm was tested on 2428 non-trial patients and confirmed its prognostic value.
The latest Annual Report to the Nation on Cancer finds that overall cancer death rates continue to decline in the US. However, a special section reveals a different picture for adults ages 20-49, with higher incidence and mortality among women than men.
A new study conducted by Vanderbilt University found that bioimpedance spectroscopy (BIS) is more effective than traditional tape measures in assessing the risk of developing lymphedema after breast cancer surgery. The technology reduces rates of progression by approximately 10%, a clinically meaningful improvement.
SWOG researchers present numerous high-impact trials at ASCO, focusing on symptom control, survivorship, and quality of care. Studies explore the effectiveness of text messaging for medication adherence in breast cancer patients and investigate gender disparities in severe adverse events among chemotherapy recipients.
A new study found that states that expanded Medicaid saw larger increases in colorectal cancer screening, with an additional 236,573 people screened. The study suggests that Medicaid expansion can improve cancer screening rates among low-income adults.
A study published in JNCI Cancer Spectrum found that diets high in soy foods are associated with a decreased risk of osteoporotic bone fractures in pre-menopausal breast cancer survivors. Soy intake was linked to a 77% reduced risk of fractures, particularly among younger women.
A clinical trial at the University of Cincinnati is investigating the use of targeted proton radiation in early-stage breast cancer. The study aims to evaluate the effectiveness and cosmetic outcomes of this treatment, as well as its side effects and cancer recurrence rates.
Researchers from FAU Harbor Branch Oceanographic Institute are investigating the use of marine natural compounds as potential treatments for triple negative breast cancers. They plan to identify clinically active compounds that could revolutionize treatment regimens and improve survival rates.
Researchers analyzed large volumes of genomic data to determine better research models to fight breast cancer's spread. They found substantial differences between lab-created cell lines and actual advanced tumor samples, with some cell lines showing little genomic similarities to patient tumor samples.
A new blood biopsy technique allows for comprehensive genetic profiling of cancer cells, capturing variation among cells within a single patient. This improves treatment monitoring and targeting by identifying genes active in cancer cells and tracking their response to therapy.
A large Dutch study found that transgender women using hormone treatment have an increased risk of breast cancer, while trans men have a lower risk. The absolute risk is still relatively low and sufficient for current screening guidelines.
A Brazilian research team developed a new strategy to slow the growth of triple negative breast cancer cells by cutting them off from two major food sources: fatty acids and glutamine. The study found that inhibiting both metabolic pathways slowed the growth and migration of resistant TNBC cells.
A study found that cancer screening rates decrease as the day goes on for patients seen later in the day. Decision fatigue and overwhelmed clinicians may contribute to this trend, leading to lower completion rates for screenings like mammograms and colonoscopies.
The FRAX tool accurately determines fracture risk for women with breast cancer treated with aromatase inhibitors when combined with bone mineral density measurements. However, using the tool alone without bone mineral density can lead to overestimation of fracture risk.
The American Cancer Society aims to lower overall cancer mortality 40% between 2015 and 2035, primarily through reducing risk factors like smoking and excess body weight. The goal is based on applying favorable cancer mortality trends among college graduates to the entire population.
A new AI-based method predicts an individual woman's likelihood of being diagnosed with breast cancer using deep learning and full-resolution mammograms. The model outperforms traditional methods in risk discrimination across different races, ages, and family histories.
A retrospective database review of 28 MRI examinations with new suspicious findings found that nearly all were benign, with only a small percentage being proven malignant.
A study led by Vanderbilt University Medical Center's Sheila Ridner found bioimpedance spectroscopy to be more accurate than a tape measure in identifying women at risk of developing lymphedema. The technology reduced rates of progression by approximately 10%, a clinically meaningful improvement.
A study found that BI-RADS 3 lesions in baseline vs non-baseline high-risk screening MRI exams have different cancer yields, with lower rates in baseline exams. Most cancers diagnosed on follow-up are early stage and detected at or before the 6-month mark.