Articles tagged with Breast Cancer
The USPSTF recommends assessing risk in women with a history of breast, ovarian, fallopian tube, or peritoneal cancer, as well as those with an ancestry associated with BRCA1/2 mutations. Genetic counseling and testing are offered to those with a positive result after counseling.
New USPSTF recommendations for BRCA1/2 genetic testing are beneficial, increasing use of genetic counseling and testing for those with high risk. However, concerns remain about large-panel genetic tests, direct-to-consumer multi-panel tests, and racial and socioeconomic disparities in genetic testing uptake.
A new study published in the European Respiratory Journal found that women with sleep apnea are at a higher risk of developing cancer. The research, based on registry data from over 20,000 adult patients, shows a possible link between intermittent hypoxia and increased cancer prevalence among women, but not men.
Researchers have identified a combination therapy of MDM2 compounds and CDK4/6 inhibitors as a possible solution for overcoming resistance to these drugs in melanoma patients. The therapy was shown to reverse resistance mechanisms in multiple mouse models and human tumor slice culture assays.
A pan-Canadian clinical trial will investigate a new way to treat metastatic breast cancer by making it impossible for breast cancer cells to manufacture proteins needed to be aggressive. The Dream Team, led by Nahum Sonenberg and Michael Pollak, aims to find ways to overcome translational dysregulation and prevent cancer spread.
Researchers found that DNA methylation patterns can affect the impact of aspirin on mortality in women with breast cancer. Women with certain DNA characteristics who take aspirin before a breast cancer diagnosis may live longer, according to the study published in Cancer journal.
A new study suggests that aspirin use can have varying effects on breast cancer patients depending on their DNA methylation profiles. Patients with methylated tumor promoters had a higher mortality risk, while those with unmethylated promoters saw a decrease in breast cancer-specific mortality.
Researchers found that combining therapies reduced tumor relapse and side effects in mouse models of kinase mutated breast cancer. The study suggests using two therapies together, rather than one after the other, to improve treatment outcomes.
Adults aged 85 years and older account for the fastest-growing age group in the US, with higher cancer incidence rates but lower screening and treatment rates. The most common cancers among this population are lung, breast, prostate, and colorectum, but late-stage diagnosis and poorer survival outcomes are also reported.
A study analyzing published research found Nordic walking reduces swelling and improves physical fitness in breast cancer patients. However, more well-designed studies are needed to explore its full potential.
A recent study found that increasing consumption of red meat was associated with a higher risk of invasive breast cancer, while consuming poultry was linked to decreased risk. Substituting poultry for red meat may be a simple way to reduce breast cancer incidence.
Scientists have developed a personalized platform called TARDIS that accurately detects circulating tumor DNA and signs of residual disease in breast cancer patients. The assay demonstrated a significant improvement in sensitivity, enabling earlier detection of tumors and monitoring patient response to chemotherapy.
A new 'liquid biopsy' blood test called TARDIS detects circulating tumor DNA in patient blood, enabling precise monitoring of disease progression and response to treatment. The test's high sensitivity could help plan surgical resection and radiation therapy after pre-operative therapy.
Researchers used artificial intelligence to identify five new types of breast cancer with distinct patterns of response to treatment, including two that are more likely to benefit from immunotherapy. The study aims to personalize treatment for women with breast cancer by selecting patients for different drugs in clinical trials.
Researchers analyzed 10,225 patient samples from 32 different cancers to better understand TP53 mutations. They found that TP53 mutations were more frequent in patients with poorer survival rates but also identified a way to predict prognosis based on four upregulated genes.
Antonio Giordano, a Hollings Cancer Center clinical scholar, is researching novel treatments for triple-negative breast cancer. He aims to develop a PLK1-inhibitor drug and explore the role of tumor-infiltrating lymphocytes in prognosis.
A novel laboratory test developed at Johns Hopkins Medicine can accurately detect malignant and benign breast tumors in a mere 5 hours, significantly reducing the wait time for diagnosis. The test exploits epigenetic alterations and has the potential to dramatically reduce wait times and improve survival rates in resource-poor settings.
A new treatment uses cellular soldiers created from the body's own defenses to track down and kill escaping cancer cells during surgeries, preventing metastasis. The innovative method has shown promise in clinical trials with triple negative breast cancer patients, increasing five-year survival rates.
Researchers at Champalimaud Centre for the Unknown discovered a cell-competition mechanism called fitness fingerprints that allows cancer cells to disguise themselves as healthy cells. By blocking this mechanism, they found that tumour growth can be slowed down, but not eliminated.
Researchers at UT Southwestern Medical Center discovered a new molecular mechanism that indicates PARP inhibitors could be effective in treating all cancers where the drugs are used, including ovarian and prostate cancers. A potential biomarker has been identified, which may indicate when patients can benefit from these drugs.
A study by University of Notre Dame researcher Siyuan Zhang and collaborators identified a gene that makes triple-negative breast cancer (TNBC) cells vulnerable to existing therapies. The discovery suggests that a targeted drug therapy may be effective for this aggressive type of breast cancer.
Researchers will investigate loss of DNA repair mechanisms and secondary mutations leading to cancer. The goal is to develop improved cancer treatment regimens and predict drug efficacy.
A new study published in Annals of Surgical Oncology suggests that delaying chemotherapy after breast cancer surgery can lead to poorer overall survival. The research found that patients who received postoperative chemotherapy within four months of diagnosis had better survival rates than those whose treatment was delayed.
Researchers at IDIBELL confirm use of PDX models for studying methylation patterns associated with breast cancer subtypes and response to docetaxel. The study validates the models' representation of human tumor samples, enabling more accurate drug preclinical studies.
A recent study published in Nutrients found that an inflammatory diet increases the risk of colorectal cancer by almost twice. The researchers suggest adopting a Mediterranean diet rich in fruits, vegetables, nuts, whole grains, and healthy oils to reduce the risk of colon cancer.
Researchers found that patients undergoing combined breast and gynecologic surgeries had significantly longer hospital stays and higher complication rates compared to those with single-site surgery. The study highlights the importance of separating these procedures for better patient outcomes.
Researchers developed a reusable device using carbon dioxide to power a cancer tissue-freezing probe, eliminating the need for expensive argon and anesthesia. The tool shows promise in reducing complications and increasing accessibility to breast cancer treatment in lower-income countries.
Research aims to reprogram immune system cells to target urothelial bladder cancer, a high-recurrence rate type with limited treatment breakthroughs. The new immunotherapy strategy could revolutionize bladder cancer treatment and increase survival rates.
Researchers have developed an AI algorithm that can analyze breast ultrasound images to detect cancer with high accuracy. The algorithm uses synthetic data to train itself, achieving nearly 100% classification rate on real-world images.
A recent study published in CANCER found significant disparities in triple-negative breast cancer diagnoses among women of color and younger women. Non-Hispanic black women had a significantly higher incidence of the disease, with over 21% diagnosed compared to under 11% for other ethnic groups.
A large French study suggests that high sugary drink consumption may contribute to an increased risk of cancer. The researchers found a strong association between daily consumption of sugary drinks and breast cancer, as well as overall cancer risk.
A recent study by Chiaki Takahashi at Kanazawa University discovered that the cancer gene RB promotes tumor growth by altering the tumor microenvironment (TME). The TME changes enable the accumulation of immunosuppressive cells, which overpower the body's natural defense system.
City of Hope scientists develop blood test to forecast breast cancer recurrence risk in patients with solid tumors. The innovative approach aims to personalize treatment strategies and improve patient outcomes.
A new study published in the Journal of Cancer reveals significant disparities in triple-negative breast cancer diagnoses among women of color and younger women. The research found that non-Hispanic black women had a 2.3-times higher odds of being diagnosed with triple-negative breast cancer compared to non-Hispanic white women.
Ashkenazi Jewish women with known BRCA status have a 98% 5-year survival rate compared to 74% for those without knowledge, requiring less chemotherapy and extensive surgery. Early testing could prevent breast cancer or start high-risk screening at an earlier age.
Researchers developed molecularly imprinted nanoparticles that selectively bind to HER2 receptors, inhibiting tumor cell multiplication and growth. The particles were produced using a special method and demonstrated significant efficacy in reducing tumor growth in vitro and in mice.
A study of 298,434 patients found that married women had a better prognosis after breast cancer diagnosis compared to single or divorced patients. Single patients showed improved outcomes only among white patients and those aged over 35 with hormone receptor-positive tumors.
University of Birmingham researchers found that the BRCA1 gene changes shape to protect vulnerable DNA until copying machinery can be restarted. This discovery could help understand how cancers develop and potentially identify new ways to suppress tumors.
Researchers are using computer models developed by astronomers to create a rapid diagnostic test that can detect cancerous tissue without unnecessary biopsies. The technology has also shown promise in treating non-melanoma skin cancer, with simulations indicating that it could be effective in killing cancer cells.
A study by the National Cancer Institute found a clear dose-response relationship between radioactive iodine treatment and long-term risk of death from solid cancers, including breast cancer. The study estimated that for every 1,000 patients treated with standard doses, about 20-30 additional solid cancer deaths would occur.
Researchers at the University of Akron have developed 3D tumor models that more accurately replicate human tumors than traditional 2D cultures. These models are being used to test new drugs and understand the drivers of triple-negative breast cancer, a type of cancer with limited treatment options.
A new diagnostic test has the potential to determine if breast cancer patients require chemotherapy, giving them control over their treatment. The test uses gene profiling to identify low-risk patients who may not benefit from chemotherapy.
A new clinical trial has successfully treated women with HER2-positive breast cancer who have no other treatment options by combining Herceptin with chemotherapy. The two-in-one treatment extended life for patients with high and low levels of the HER2 protein, offering a promising solution to drug resistance.
A recent study calling for expanded genetic testing for hereditary breast cancer has been criticized by researchers at the University of Cambridge. The criticism highlights methodological flaws in the study and potential conflicts of interest among its authors, leading to concerns about the accuracy and practicality of such tests.
Researchers at RIT and RRHS have developed a non-invasive infrared imaging technology to detect breast cancer tumors hidden behind dense tissues. The technology takes 20 minutes to produce images that are more sensitive than current methods.
A new study aims to identify genes that are unique to African Americans and contribute to hereditary breast cancer. The research will analyze large datasets of over 18,500 African American women, including those with diagnosed and cancer-free individuals.
Research suggests that being a morning person is associated with a lower risk of developing breast cancer. Sleeping longer than the recommended 7-8 hours may also increase the risk. The findings have implications for influencing sleep habits to improve health.
A multidisciplinary team at LSU Health is using two new research techniques to study the link between obesity and breast cancer. They will observe breast tumor development in real-time using a biomimetic tissue-engineered 3D culture system, and analyze the extracellular matrix of breast cancer tumors using decellularization technique.
A novel radiotracer has been identified that can detect nearly 30 types of cancer using positron emission tomography/computed tomography (PET/CT). This technology shows promise for new applications in noninvasive diagnosis, staging and treatment.
Researchers have created a new chemoradiotherapy formulation that could reduce side effects in advanced stage head and neck cancer patients. The formulation, which stays within tumors, is predicted to be effective while minimizing harm to healthy cells.
A recent study published in JAMA Internal Medicine found that the use of 3D mammography has risen substantially in the US, with DBT being more rapidly adopted in areas with higher incomes, greater education, and larger white populations. However, disparities in care persist, reflecting uneven adoption across regions and demographics.
Researchers at the University of Alberta have identified a specific genetic marker linked to an increased risk of breast cancer in premenopausal women. The study found that up to 40% of women carrying the genetic variation are at higher risk of developing breast cancer compared to those without it.
Research published in BMJ Open reveals that only one in five women attending breast clinics and screening appointments know that alcohol is a risk factor for breast cancer. The study suggests that understanding modifiable risk factors for the disease needs to be increased, particularly through brief information on health risks associat...
A pre-clinical study led by Duke University Medical Center identified an enzyme in cells involved in regulating breast cancer growth and spread. Inhibiting this enzyme's activity allowed T-cells to mount an immune attack on cancer cells, potentially improving treatment outcomes for breast cancer patients.
Researchers found that FOLFIRINOX prolonged patients' lives by an average of 22.2 months, increasing the chances of complete tumor removal through surgery. More than two-thirds of cancers responded well to treatment, allowing for surgical removal.
Researchers develop a bio-scoring system to improve prognostication for dogs with mammary tumors, identifying those at higher risk of metastasis. The system uses tumor stage, grade, and histological type to provide a clearer picture of treatment options.
A population-based cohort study from 4 Nordic countries found no link between TNFi use and increased cancer risk. However, a significant increase in malignant lymphomas was observed within the trial. Further analysis is needed to determine if this is due to psoriatic arthritis or TNFi treatment.
A new study finds significant variation in triple-negative breast cancer incidence among black women born in different US regions. U.S.-born and Western-African-born women have the highest rates, while Eastern-African-born women have lower rates compared to both groups.
Researchers developed a biomarker test to predict disease-free survival and recurrence risk in patients with triple-negative breast cancer. The test uses formalin-fixed, paraffin-embedded tissues and has shown promise in predicting patient outcomes.
A study by Melanie Rutkowski found that an unhealthy gut microbiome can make breast cancer more invasive and spread quickly. Disrupting the balance of microorganisms in mice resulted in chronic inflammation, priming tumor cells to disseminate and metastasize.