Articles tagged with Breast Cancer
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A mouse study suggests that time-restricted eating can delay the development of tumors and reduce tumor growth in obese mice with high-fat diets. The results imply that this intervention could be effective in preventing breast cancer.
A new animal study suggests that exposure to dim light at night may contribute to the spread of breast cancer to bones. Researchers created a mouse model of bone metastatic breast cancer and found that mice exposed to a light/dim light cycle had larger tumors and increased bone damage compared to those in a standard light/dark cycle.
Researchers developed a nano-bomb targeting POLR2A, a viable target for treating triple negative breast cancer. The nano-bomb kills only cancerous cells while leaving healthy cells alive.
A new study suggests that consuming thermally abused cooking oil may trigger genetic changes that promote the progression of late-stage breast cancer. Mice fed thermally abused oil developed more tumors and aggressive growth than those fed fresh soybean oil, highlighting a potential link between diet and cancer recurrence.
New state laws recommending supplemental screening tests for women with dense breast tissue resulted in modestly boosted cancer detection rates, specifically increased breast ultrasound and cancer detection rates
Researchers discovered BRCA1 protein helps neuroblastoma cells cope with stress by opening a side track for repair. This mechanism enables tumours to grow rapidly despite DNA damage.
Researchers developed dual-complementary liposomes loaded with doxorubicin to target ICAM1 and EGFR receptors, achieving 40% reduction in tumor growth and no lung metastasis development. The treatment showed significantly improved survival without liver or kidney toxicity.
A new study published in Radiology found that digital breast tomosynthesis (DBT) significantly reduces the number of women who undergo breast biopsy for non-cancerous lesions. DBT detected 142 cancers with a biopsy rate of 69%, while reducing false positive biopsies by 52%.
A new study found that digital mammography is associated with a lower likelihood of high-density breast tissue compared to digital breast tomosynthesis (DBT) or synthetic mammography. This could have implications for personalized screening and recommendations for supplemental screening.
Scientists at the University of Wisconsin-Madison have discovered an unexpected regulator of the p53 protein, which plays a crucial role in cancer development. The research team found that an enzyme called PIPK1-alpha and its lipid messenger, PIP2, drive the stability of mutant p53, leading to cancer progression.
Breast cancer death rates are predicted to fall in all EU countries except Poland, where they will rise by 2%. The burden of the disease is expected to increase due to an aging population. Lung cancer remains the biggest killer in both sexes, with a predicted decrease in men's death rates.
Researchers at GW Cancer Center discovered USP15 as a potential biomarker for treatments of breast and pancreatic cancers. The enzyme regulates homologous recombination repair and cancer cell response to PARP inhibitors.
Breast cancer researchers found that stress hormones increase glucocorticoid receptor activity in metastatic cells, leading to tumor heterogeneity and reduced chemotherapy effectiveness. Synthetic derivatives of stress hormones also decrease chemotherapy efficacy.
Scientists have developed a statistical tool to predict breast cancer recurrence and progression, using molecular patterns from nearly 2000 women. The research identified distinct clinical trajectories for different breast cancer subtypes, highlighting the importance of personalized treatment options.
Researchers at the University of Illinois have found that free fatty acids in the blood promote proliferation and growth of breast cancer cells in obese women. The study suggests a potential link between obesity and an increased risk of ER-positive breast cancer after menopause.
A study of over 64,000 women found that infertility is associated with a higher risk of developing cancer compared to non-fertile women. The absolute risk is very low at just 2%, but still significantly higher among infertile women.
Researchers at the University of North Carolina Health Care discovered the enzyme USP21 promotes basal-like breast cancer proliferation and is upregulated in patient tumors. Targeting USP21 may sensitize cancer cells to existing therapies.
PARP inhibitors have been found to enhance the immune response against cancer cells with DNA repair defects, suggesting a new approach to treating various types of cancer. This discovery could lead to increased effectiveness of immunotherapies and improved treatment outcomes for patients.
Research confirms that women with BRCA1 and BRCA2 mutations experience a decreased risk of breast cancer after multiple full-term pregnancies. The study found that breastfeeding also reduces breast cancer risk for these women. However, the timing of pregnancy appears to play a crucial role in determining the level of risk reduction.
A team of Australian and US researchers has identified a potential therapeutic drug target for aggressive breast cancers. The Oncomix method enabled them to 'zoom in' on genetic information from cancer patients and identify genes with distinct activity patterns, revealing five genes that promote tumour growth.
US breast cancer patients experience significant economic burdens due to treatment side effects like lymphedema. Patients advocate for policy changes and institutional adaptations to address these challenges. Recommendations include improved insurance coverage, expanded support services, and enhanced financial assistance.
Researchers have found a pair of old drugs that can disrupt disease-causing pathways in triple negative breast cancer. Metformin and heme, previously used to treat diabetes and porphyria, were tested in mice and produced encouraging results when combined.
A new study found that AI systems can perform as accurately as radiologists in detecting breast cancer in digital mammography screening. This breakthrough suggests that AI may be a viable alternative to current methods, which are labor-intensive and facing staff shortages.
Researchers at UPMC and the University of Pittsburgh School of Medicine discovered genetic flags in 17% of tumors indicating susceptibility to existing chemotherapy drugs. The study's findings could lead to personalized treatment approaches for pancreatic cancer patients, increasing survival rates.
A new study explores an episodic bundled payment model for breast cancer screening reflecting the widespread adoption of DBT. The analysis found that non-DBT approaches to bundled payment models remain viable, but higher DBT-inclusive prices highlight the need to explore societal costs more broadly.
A study comparing 3D digital breast tomosynthesis and 2D digital mammography screening found that DBT was associated with improved detection of invasive cancers, particularly among younger women. The findings suggest a potential benefit of DBT in reducing false positives and improving overall cancer detection rates.
A recent study published in Preventing Chronic Disease found that immigrant Asian American women are at a higher risk for breast cancer compared to their U.S.-born counterparts. The researchers discovered that those who had immigrated and lived in the U.S. for more than 50% of their lives were three times as likely to have breast cancer.
A study of 160 breast cancer survivors found that most reported four times more positive than negative thoughts about changes they experienced due to their illness. Patients who participated in a psychological intervention program reported even more positive life changes.
Researchers outline a targeted therapeutic strategy to treat triple-negative breast cancer using POLR2A gene targeting. The proposed approach utilizes nanotechnology-based precision-targeting to kill TNBC cells while sparing normal cells, offering hope for improved treatment options.
A study of 872 young adults found that 14.4% borrowed over $10,000 due to illness or treatment, while 54% experienced mental task impairment. Cancer treatment with chemotherapy increased the risk of these issues significantly.
Researchers used DNA methylation to estimate biologic age and found that women with older biologic ages had higher breast cancer risks. The study suggests that biologic age may be tied to environmental exposures, potentially serving as an indicator of disease risk.
A new study using PET scans has identified a biomarker that predicts which women with HER2-positive breast cancer may benefit from standalone HER2-targeted agents without chemotherapy. Researchers found that patients with low sugar levels on PET scans at two weeks after treatment had the potential to be spared chemotherapy, indicating ...
A large-scale study validated four widely used breast cancer risk models, finding that family-history-based models outperform non-family-history based models. The study's findings suggest that all women would benefit from risk assessment involving detailed family histories.
A clinical trial found sacituzumab govitecan produced a significant treatment response in patients with difficult-to-treat metastatic triple-negative breast cancer, outperforming standard chemotherapy. The drug showed manageable side effects and improved treatment duration.
A new 'smart drug', sacituzumab govitecan, has shown significant tumor shrinkage and improved patient outcomes in a clinical trial for women with metastatic triple-negative breast cancer. The treatment resulted in better response rates and longer overall survival compared to traditional therapies.
A UC Riverside study found that spouses can help with coping by positively reframing the cancer experience and other negative experiences, associated with less stress. The researchers suggest that socially similar others, like romantic partners, can provide a roadmap for a more contented spouse.
Ralf Janknecht's research on the molecule DNPH1, overproduced in breast cancer, suggests it could serve as a new drug target for reducing cancer metastasis. The removal of DNPH1 from mouse models resulted in fewer tumors and a tenfold reduction in metastasis.
Two new forms of an older anti-cancer agent, s-DAB-IL-2 and s-DAB-IL-2(V6A), have been shown to enhance the immune system's ability to fight melanoma in mice. The agents depleted T regulatory cells and inhibited tumor growth when used individually or in combination with checkpoint blockade therapy.
A new study reveals that chronic stress promotes breast cancer growth and spread by activating a biochemical pathway involving the stress hormone epinephrine. Vitamin C has been identified as a potential therapeutic agent to target this pathway, potentially offering new hope for patients undergoing chronic stress.
A new study uses cellular barcoding to pinpoint cells responsible for breast cancer's spread, shedding light on how chemotherapy works and identifying targets for new treatments. Researchers hope to develop targeted therapies by understanding the molecular basis of cancer cell behavior.
The black-white cancer mortality gap has closed considerably over the past several decades, with faster declines among black Americans. The disparities have narrowed for lung, prostate, and colorectal cancers, and have stabilized since 2010 for breast cancer.
A study by Flinders University found that middle-aged Australian women are not aware of the link between alcohol consumption and an increased risk of breast cancer. The study suggests targeted messages addressing short-term risks caused by alcohol will be most effective in reducing current consumption levels.
Researchers developed a reversible antiplatelet therapy using deactivated platelets that can reduce the risk of blood clots and prevent cancer metastasis. By adding fresh platelets, the inhibition of normal platelet activity is rapidly reversed, allowing patients to quickly regain their ability to form blood clots.
A six-decade-long study found that all women exposed to high levels of DDT are at increased risk for breast cancer before age 54, with the timing of cancer risk depending on when they were first exposed. Women exposed in infancy and early childhood were most likely to develop premenopausal breast cancer.
A six-decade-long study found that all women exposed to high levels of DDT before age 54 are at increased breast cancer risk. The timing of first exposure matters, with early infancy and puberty linked to premenopausal cancer and later childhood and adolescence to postmenopause diagnosis.
A pilot project by Springer Nature and BCRF enables researchers to make their datasets accessible alongside published articles. Dedicated Research Data Editors will help authors draft descriptions and deposit datasets in a journal data repository.
Researchers at the University of California San Diego discovered that breast tissue stiffening triggers multiple pathways to promote cancer cell formation. The study, published in PNAS, found that a subpopulation of mammary cells do not respond to stiffening, potentially leading to fewer or smaller primary tumors.
A new study found that up to one-third of primary care physicians discussed breast cancer treatment options with patients. However, many reported notable gaps in their knowledge of these topics. The research highlights the importance of educating primary care providers on cancer treatment options and supporting them in making informed ...
A large study examining phthalate exposure and postmenopausal breast cancer found no association between the two. The research, published in the Journal of the National Cancer Institute, suggests that more research is needed to investigate younger women and potential associations between phthalate exposure and breast cancer risk.
Researchers identified a new genetic cause of multi-tumor syndrome, which increases lifetime risk for patients with colorectal and breast cancers. The study found that rare NTHL1 gene mutations lead to the development of both diseases.
A recent study found that hundreds of thousands of US women's lives have been saved by mammography and improvements in breast cancer treatment since 1989. The study estimates that cumulative breast cancer deaths averted ranged from 384,000 to 614,500 over the past three decades.
Researchers have found that a new PET imaging agent, 18F-FFNP, can measure changes in progesterone receptor levels resulting from hormone therapy for breast cancer patients. This could provide an earlier indicator of therapy effectiveness and inform individualized treatment decisions.
Researchers have developed a new imaging and platelet targeting chemotherapy agent for early detection and treatment of cancers. The approach holds promise for diagnosing and treating tumors without major side effects.
Researchers at Scripps Research Institute have developed a new approach to shifting breast cancer cells into HER2-positive status using RNA-targeting precision medicines. The proof-of-concept study suggests that this technology could expand treatment options for patients with dwindling choices.
Researchers found that combining metformin with venetoclax and a PD-1-targeted antibody can efficiently kill breast tumor cells and prevent tumor growth. The treatment strategy was tested in animal models and showed promising results.
Research highlights distinct racial disparities in social support needs for breast cancer patients among White and Black women. The study found that White participants relied on other breast cancer survivors as a key source of social support, whereas Black participants did not.
A new study has identified a pair of genes that can mimic the effects of BRCA proteins, potentially making tumor cells susceptible to PARP inhibitors. The researchers found that targeting these genes could improve treatment options for people with breast or ovarian cancer caused by BRCA defects.
A Rutgers study found that hormone concentrations in early fetal development are significantly affected by maternal age, body mass index, and race. Older mothers, heavier women, and those of African descent had distinct hormone profiles, with potential implications for future health risks such as breast and ovarian cancer.
Researchers at McGill University discovered a shared genetic marker that could effectively treat rare and common types of cancer, including ovarian and lung cancers. The breakthrough is based on targeting the cyclin-dependent kinases 4/6, which are vulnerable to existing drugs used in breast cancer treatment.
Researchers found a causal connection between MDMX overexpression and triple-negative breast cancer metastasis. The study suggests targeting the MDMX protein could prevent cancer spread, offering potential for new treatments.