Articles tagged with Breast Cancer
Researchers at the University of Missouri have found a combination drug therapy reduces the spread of triple negative breast cancer to other locations by 50 percent. This new approach uses APR-246 and 2aG4 to target mutant p53 and prevent cancer growth, offering a promising solution for personalized medicine.
A new American Cancer Society study highlights the need to better identify patients with metastatic cancer who may not benefit from aggressive treatment. The study found wide variations in treatment patterns among patients who died within a month of diagnosis.
Researchers used mass cytometry to analyze millions of cancer and immune cells from 140 patients, discovering unique cellular compositions in each tumor. The study found that aggressive tumors are dominated by a single type of cell, while immune therapy may work for previously unsuitable breast cancer patients.
Researchers from CNIO have successfully removed advanced pancreatic ductal adenocarcinoma (PDA) in animal models through combined inhibition of EGFR and c-RAF kinase. This breakthrough has shown significant promise for developing new cancer treatments.
A new surgical guideline has been shown to decrease re-operation rates for breast cancer patients undergoing lumpectomy. According to a study by UBC medical student Alex Monaghan, women with early-stage breast cancer are now 72% less likely to require additional surgery.
A comprehensive SWOG Cancer Research Network study has identified a host of targets for new or existing cancer drugs. The research, published in the Journal for ImmunoTherapy of Cancer, found higher counts of cancer-fighting TILs in pre-treatment tissue samples of breast cancer patients who achieved complete response to chemotherapy.
Researchers at Mount Sinai have developed an innovative approach to cancer immunotherapy by injecting immune stimulants directly into a tumor. This 'in situ vaccination' teaches the immune system to destroy not only the primary tumor but also other tumor cells throughout the body, effectively turning the tumor into a vaccine factory.
The American College of Physicians (ACP) has issued a new guidance statement on breast cancer screening for average-risk women, recommending mammography every other year beginning at age 50. The guidelines take into account the potential harms of overdiagnosis and overtreatment associated with annual or biennial screening.
The American College of Physicians recommends that average-risk women between 50 and 74 years old undergo breast cancer screening with mammography every other year, as this approach balances benefits and harms. This strategy reduces false-positive findings and overtreatment, while minimizing radiation exposure and related risks.
A study found that breast cancer patients who don't respond to targeted therapy have distinct patterns of epigenetic modifications compared to those who do respond. The researchers identified 879 genes with higher methylation levels in resistant patients, suggesting potential targets for new treatments.
Scientists discovered a set of genes expressed in high levels in breast cancer tumors linked to aggressive types and shorter patient survival. The findings offer clues for diagnosis, prognosis, and potential drug discovery.
A clinical study demonstrated the safety and efficacy of high-dose stereotactic body radiotherapy (SBRT) for patients with centrally located non-small cell lung cancer. The treatment resulted in high tumor control rates, comparable to those seen in patients with peripheral tumors.
Researchers developed a new method to predict tumor growth rates using progression-free survival plots, reducing errors found in current methods. This improvement enables clinicians to schedule optimal screenings and set effective dosing regimens.
A retrospective cohort study found that surgery was associated with a 44% increased chance of survival for women with HER2+ stage 4 breast cancer, especially those with Medicare or private insurance. The study also revealed disparities in healthcare access and outcomes due to race and socioeconomic factors.
Professor Jonas Bergh is recognized for his work on breast cancer biology, including tailored treatments and the impact of chemotherapy. He has made significant contributions to primary breast cancer treatment through his involvement in clinical trials and research collaborations.
Salk scientists discovered a new mechanism of action for the CDK12 protein, revealing its role in regulating gene expression and cell division. This finding suggests that targeting CDK12 could be an effective way to kill cancer cells and improve treatment outcomes.
Researchers at the University of California, Riverside found that surgery is associated with a 44% increased chance of survival for patients with HER2-positive stage 4 breast cancer. The study suggests that surgery should be considered as part of treatment, particularly for women with Medicare or private insurance.
A new study found that 3D mammography improves breast cancer detection in older women, with lower false-positive rates and higher positive predictive values. The results suggest that guidelines for screening in this age group should be based on individual preferences and health status.
Scientists have found that successful removal of breast cancer tumors triggers a strong immune response, which clears disseminated tumor cells from lymph nodes and organs. In contrast, leaving behind primary tumor cells supports tumor growth and metastasis.
A prototype wearable device can continuously collect live cancer cells directly from a patient's blood, offering a biopsy alternative. This innovation could help doctors diagnose and treat cancer more effectively by providing better information for planning treatments.
The D.C. Council has passed the Breast Density Screening and Notification Act, requiring women with dense breast tissue to be informed and receive additional screenings. This legislation aims to reduce deaths from breast cancer by promoting early detection among high-risk groups.
A mesothelin-targeted CAR T-cell therapy demonstrated antitumor activity and acceptable toxicity in a phase I clinical trial for patients with malignant pleural disease. The therapy showed significant tumor regression and reduced mesothelin-related peptide levels in the blood.
Researchers found that obesity at older ages is linked to worse outcomes, with higher tumor growth in obese mice compared to lean mice. They also discovered a connection between leptin, a biological signal released by fat tissue, and increased numbers of tumor-initiating cells.
Researchers have discovered a correlation between estrogen byproducts and survival rates for women with breast cancer, with higher levels of the "good" metabolite associated with reduced mortality. The study suggests that measuring these byproducts may help predict prognosis after breast cancer diagnosis.
Researchers presented studies on the clinical utility of liquid biopsy powered by ddPCR technology to measure blood-based tumor biomarkers in a reproducible way. Studies demonstrated correlations between ctDNA mutations and response to abemaciclib in breast cancer patients and found potential as a predictor for surgery success in malig...
Scientists create vaccine that strengthens immune defences by multiplying cancer-repelling T cells, promising treatment for individualized cancer immunotherapy and potential application in autoimmune diseases. Laboratory tests conducted on tumours in mice show effectiveness of approach.
Researchers have developed an experimental combined drug therapy that dramatically shrinks tumours and prevents metastasis in mice by targeting the DNA repair capability of cancer cells. The treatment has few side-effects compared to traditional chemotherapy and is being tested in clinical trials.
Researchers from Marshall University found that consuming two ounces of walnuts daily for two weeks changes gene expression in confirmed breast cancers, slowing growth and reducing survival risk. The study involved 10 women with breast lumps, who were randomized to walnut or control groups.
Breast cancer cells are inherently changeable, morphing from one cell type to another at the molecular level. This feature may promote resistance to certain therapies. The research provides new insights into how cancer cells develop and evolve within tumours.
Researchers at UNIGE and UNIL discover clofazimine's efficacy in stopping triple negative breast cancer progression by blocking Wnt cell signaling pathway. The study highlights the need to re-examine existing drugs for potential targeted therapy.
Women with metastatic hormone receptor-positive breast cancer live longer when receiving fulvestrant and anastrozole compared to treatment with anastrozole alone. The combination therapy shows promise as a life-extending first line of treatment, particularly for women who received lower doses of fulvestrant.
A new study estimates the risk of cancer associated with moderate levels of alcohol consumption and compares it to the risk of smoking. The study found that drinking one bottle of wine per week is equivalent to smoking five cigarettes for men and ten cigarettes for women.
A mouse study suggests that time-restricted eating can delay the development of tumors and reduce tumor growth in obese mice with high-fat diets. The results imply that this intervention could be effective in preventing breast cancer.
A new animal study suggests that exposure to dim light at night may contribute to the spread of breast cancer to bones. Researchers created a mouse model of bone metastatic breast cancer and found that mice exposed to a light/dim light cycle had larger tumors and increased bone damage compared to those in a standard light/dark cycle.
Researchers developed a nano-bomb targeting POLR2A, a viable target for treating triple negative breast cancer. The nano-bomb kills only cancerous cells while leaving healthy cells alive.
A new study suggests that consuming thermally abused cooking oil may trigger genetic changes that promote the progression of late-stage breast cancer. Mice fed thermally abused oil developed more tumors and aggressive growth than those fed fresh soybean oil, highlighting a potential link between diet and cancer recurrence.
New state laws recommending supplemental screening tests for women with dense breast tissue resulted in modestly boosted cancer detection rates, specifically increased breast ultrasound and cancer detection rates
Researchers discovered BRCA1 protein helps neuroblastoma cells cope with stress by opening a side track for repair. This mechanism enables tumours to grow rapidly despite DNA damage.
Researchers developed dual-complementary liposomes loaded with doxorubicin to target ICAM1 and EGFR receptors, achieving 40% reduction in tumor growth and no lung metastasis development. The treatment showed significantly improved survival without liver or kidney toxicity.
A new study published in Radiology found that digital breast tomosynthesis (DBT) significantly reduces the number of women who undergo breast biopsy for non-cancerous lesions. DBT detected 142 cancers with a biopsy rate of 69%, while reducing false positive biopsies by 52%.
A new study found that digital mammography is associated with a lower likelihood of high-density breast tissue compared to digital breast tomosynthesis (DBT) or synthetic mammography. This could have implications for personalized screening and recommendations for supplemental screening.
Scientists at the University of Wisconsin-Madison have discovered an unexpected regulator of the p53 protein, which plays a crucial role in cancer development. The research team found that an enzyme called PIPK1-alpha and its lipid messenger, PIP2, drive the stability of mutant p53, leading to cancer progression.
Breast cancer death rates are predicted to fall in all EU countries except Poland, where they will rise by 2%. The burden of the disease is expected to increase due to an aging population. Lung cancer remains the biggest killer in both sexes, with a predicted decrease in men's death rates.
Researchers at GW Cancer Center discovered USP15 as a potential biomarker for treatments of breast and pancreatic cancers. The enzyme regulates homologous recombination repair and cancer cell response to PARP inhibitors.
Breast cancer researchers found that stress hormones increase glucocorticoid receptor activity in metastatic cells, leading to tumor heterogeneity and reduced chemotherapy effectiveness. Synthetic derivatives of stress hormones also decrease chemotherapy efficacy.
Scientists have developed a statistical tool to predict breast cancer recurrence and progression, using molecular patterns from nearly 2000 women. The research identified distinct clinical trajectories for different breast cancer subtypes, highlighting the importance of personalized treatment options.
Researchers at the University of Illinois have found that free fatty acids in the blood promote proliferation and growth of breast cancer cells in obese women. The study suggests a potential link between obesity and an increased risk of ER-positive breast cancer after menopause.
A study of over 64,000 women found that infertility is associated with a higher risk of developing cancer compared to non-fertile women. The absolute risk is very low at just 2%, but still significantly higher among infertile women.
Researchers at the University of North Carolina Health Care discovered the enzyme USP21 promotes basal-like breast cancer proliferation and is upregulated in patient tumors. Targeting USP21 may sensitize cancer cells to existing therapies.
PARP inhibitors have been found to enhance the immune response against cancer cells with DNA repair defects, suggesting a new approach to treating various types of cancer. This discovery could lead to increased effectiveness of immunotherapies and improved treatment outcomes for patients.
Research confirms that women with BRCA1 and BRCA2 mutations experience a decreased risk of breast cancer after multiple full-term pregnancies. The study found that breastfeeding also reduces breast cancer risk for these women. However, the timing of pregnancy appears to play a crucial role in determining the level of risk reduction.
A team of Australian and US researchers has identified a potential therapeutic drug target for aggressive breast cancers. The Oncomix method enabled them to 'zoom in' on genetic information from cancer patients and identify genes with distinct activity patterns, revealing five genes that promote tumour growth.
US breast cancer patients experience significant economic burdens due to treatment side effects like lymphedema. Patients advocate for policy changes and institutional adaptations to address these challenges. Recommendations include improved insurance coverage, expanded support services, and enhanced financial assistance.
Researchers have found a pair of old drugs that can disrupt disease-causing pathways in triple negative breast cancer. Metformin and heme, previously used to treat diabetes and porphyria, were tested in mice and produced encouraging results when combined.
A new study found that AI systems can perform as accurately as radiologists in detecting breast cancer in digital mammography screening. This breakthrough suggests that AI may be a viable alternative to current methods, which are labor-intensive and facing staff shortages.
Researchers at UPMC and the University of Pittsburgh School of Medicine discovered genetic flags in 17% of tumors indicating susceptibility to existing chemotherapy drugs. The study's findings could lead to personalized treatment approaches for pancreatic cancer patients, increasing survival rates.
A new study explores an episodic bundled payment model for breast cancer screening reflecting the widespread adoption of DBT. The analysis found that non-DBT approaches to bundled payment models remain viable, but higher DBT-inclusive prices highlight the need to explore societal costs more broadly.
A study comparing 3D digital breast tomosynthesis and 2D digital mammography screening found that DBT was associated with improved detection of invasive cancers, particularly among younger women. The findings suggest a potential benefit of DBT in reducing false positives and improving overall cancer detection rates.
A recent study published in Preventing Chronic Disease found that immigrant Asian American women are at a higher risk for breast cancer compared to their U.S.-born counterparts. The researchers discovered that those who had immigrated and lived in the U.S. for more than 50% of their lives were three times as likely to have breast cancer.
A study of 160 breast cancer survivors found that most reported four times more positive than negative thoughts about changes they experienced due to their illness. Patients who participated in a psychological intervention program reported even more positive life changes.