Articles tagged with Breast Cancer
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Engineers at Caltech have developed a new microscopy technique that can analyze tumor tissue in real-time, reducing the need for follow-up surgeries. The technology, called photoacoustic microscopy, has the potential to revolutionize breast cancer treatment and could be available to surgeons within several years.
A study of over 48,000 stored tumor samples reveals that deficiencies in DNA repair mechanisms are common across various solid tumor types. The most commonly mutated genes were ATM, PTEN, BRCA2, BRCA1, and ATRX, which could lead to targeted therapies, including PARP inhibitors.
Researchers have developed a photoacoustic imaging technology that can produce detailed images of cells, allowing for more accurate assessment of tumor margins during surgery. The goal is to speed up the process and enable real-time feedback to surgeons, reducing the need for second surgeries.
An analysis of nearly 273,000 patients found a 1% increase in breast, lung, and colorectal cancers diagnosed at stage I between 2013 and 2014. This trend suggests that increased health insurance coverage may lead to better cancer outcomes.
A study published on Nature Communications reveals that breast cancer cells undergo a stiffening state prior to acquiring malignant features and becoming invasive. This discovery identifies a new signal in tumor cells that can be further explored when designing cancer-targeting therapies.
Researchers at EMBL found that residual breast cancer cells have specific traits that distinguish them from healthy cells and seem to cause relapse. The study suggests lipid metabolism as an exciting therapeutic target to reduce breast cancer recurrence.
A study found that offering fixed date and time for new appointments improved poor attendance rates in breast cancer screening, especially among women from lower socioeconomic backgrounds. The analysis suggested a cost-effective way to shift national participation trends.
Researchers discovered that residual tumor cells display alterations in fat metabolism and oxidative stress, which contribute to DNA damage and cancer relapse. Targeting metabolic pathways in these cells could potentially prevent recurrence.
A study published in Journal of Clinical Oncology reveals that tai chi is an effective treatment for insomnia in breast cancer survivors, improving sleep health, depressive symptoms, and fatigue. The slow-moving meditation practice works just as well as cognitive behavioral therapy and better than medication.
Researchers at UT Southwestern Medical Center developed a new technique for delivering stereotactic partial breast radiation, which was found to be as safe as traditional radiation while significantly reducing treatment time from six weeks to just five treatments delivered every other day. The study showed outstanding tumor control and...
A new study reveals an association between cumulative exposure to harmful environmental factors and cancer incidence across the United States. Counties with poor environmental quality demonstrated a higher incidence of cancer cases, with prostate and breast cancer showing strong links.
Researchers identified RIOK1 as a potential new target for cancer therapy that slows down disease progression by blocking its enzymatic activity. The study found that inhibiting RIOK1 can reduce the growth and aggressiveness of cancer cells, including those with mutated RAS proteins.
A German multisite study investigated the role of post-traumatic stress in cancer-related cognitive impairment. The findings suggest that psychological factors may contribute more importantly to cancer-related cognitive impairment than neurotoxic effects of treatment.
A large data set has revealed genetic variations that are more common in black women with breast cancer, which could lead to more personalized risk assessments and improved treatment outcomes. The study also found that black women were more likely to develop aggressive breast cancer subtypes.
A new report by RTI International highlights the significant treatment burden faced by younger women with breast cancer, who often receive more aggressive treatments and incur substantially higher costs. The study estimates that younger women cost $97,000 to treat annually, compared to $76,000 for older women.
A new study conducted at The Ohio State University Comprehensive Cancer Center found that more than half of breast cancer patients undergoing mastectomy lack necessary medical knowledge for high-quality decision-making about reconstructive surgery. Researchers emphasize the need for shared decision-making tools and patient-doctor commu...
A commentary and editorial in Reproductive BioMedicine Online argue that a registry of egg donors is needed to monitor long-term health risks, citing five case histories of women who developed breast cancer after donation. The authors highlight the lack of data on this topic and call for increased transparency about potential risks.
A Mayo Clinic research team has developed a new type of cancer-fighting nanoparticle that can shrink breast cancer tumors by up to 70-80% and prevent recurrence. The nanoparticles work by engaging the entire immune system to kill cancer cells, prompting the body to create its own memory system to minimize tumor recurrence.
A recent study published by City of Hope found that regular use of low-dose aspirin (81mg) reduces the risk of breast cancer in women. The study analyzed data from 57,164 participants in the California Teachers Study and found an overall 16% lower risk of breast cancer in women who took low-dose aspirin at least three times a week.
A large study of African-American women found that those who drank seven or more drinks per week were 33% more likely to develop breast cancer than moderate drinkers. The study suggests that black women may benefit from limiting alcohol to reduce their risk, similar to white women.
Sandra Rieger, Ph.D., will investigate the molecular mechanisms underlying peripheral neuropathy caused by Taxol (paclitaxel) and explore potential treatments using MMP-inhibiting compounds. The grant aims to develop new drug therapies for this debilitating condition affecting millions of Americans.
A new paper by Kate Sweeny argues there's a positive side to worrying, with benefits including motivating preventive and protective behavior, recovery from traumatic events, and adaptive preparation and planning. Worrying the right amount can also motivate without paralyzing motivation, while serving as an emotional buffer.
Researchers have identified a genetic signature associated with resistance in triple negative breast cancer, which can be reversed after a period of treatment cessation. This discovery may lead to personalized chemotherapy strategies and improved treatment outcomes.
A recent study found that anger and guilt in cancer patients can inspire them to set new goals and engage in moderate-to-vigorous exercise. This motivation can counteract the negative effects of stress hormones on physical health. The research suggests that certain negative emotions can play a crucial role in directing adaptive health ...
The International Osteoporosis Foundation has released new position statement guidelines for managing aromatase-inhibitor related bone loss in breast cancer patients. The guidelines recommend regular assessment of fracture risk, calcium/vitamin D supplementation, and bone-directed therapy to prevent fractures and improve bone health.
A global understanding of breast cancer dissemination is crucial to improve treatment, and this study reveals that most metastases originate from a single precursor. Analyzing the genomic profile of metastases can help make therapeutic decisions, particularly for targeted treatments.
A new study published in Nature Genetics has identified 389 genetic signals linked to the timing of puberty, including associations with an increased risk of breast, ovary, and endometrial cancers in women, and prostate cancer in men. The research also suggests that earlier puberty timing may have negative effects on later health.
New methods for detecting breast cancer in young women using breastmilk, targeting G protein-coupled receptors to develop cancer drugs, and exploring the effects of dried plums on colon health offer promising approaches to combat cancer.
A study published in JAMA Surgery found that certain breast cancer patients who achieve pathologic complete response (pCR) after chemotherapy have a low risk of developing local metastases, making them candidates for less invasive treatment options. These patients may be able to avoid follow-up surgery, including axillary surgery.
A study published in Scientific Reports found that strawberry extract inhibited the proliferation of breast cancer cells in both in vitro and in vivo models. The extract reduced cell viability, blocked cell division, and inhibited migration, while also stimulating the expression of a gene that suppresses metastasis.
FAU researchers identified Zeb1 as a key factor that activates embryonic programme, leading to rapid dissemination and metastasis in pancreatic cancer. They also found that blocking Zeb1 reduces metastatic capacity in other tumour types.
A recent survey found that half of women with breast cancer who undergo genetic testing do not have high-risk mutations. This highlights the need for genetic counselors to help patients and physicians understand genetic test results. Many physicians surveyed in the study stated they manage patients with uncertain significance in the sa...
Researchers reprogram tumor blood vessels to block tumor growth and facilitate T cell arrival, improving cancer immunotherapy efficacy. A2V therapy inhibits metastasis and promotes anti-tumor immunity, which can be enhanced by PD-1 checkpoint blockade.
A new study found that language barriers, information overload, and cultural differences disadvantage some Latina breast cancer patients. However, no significant inequities were recorded in how doctors provide information. The research highlights the need for providers to be more culturally sensitive and patient-centered.
Recent guideline changes have led to disagreement among professional societies on best practices for mammography. Physician screening recommendations vary, with some recommending annual exams and others prioritizing biennial screenings.
A new study found that different breast cancer treatments have varying relative values based on complications and cost. Lumpectomy plus whole breast irradiation was the most commonly used treatment, while mastectomy plus reconstruction had nearly twice the complication risk and higher costs.
Scientists have discovered that cancer can commandeers immature immune cells, called MDSCs, to facilitate its spread. MDSCs are normally part of the immune system's anti-tumor response but, under the influence of tumor-secreted cytokines, they can help tumors grow and metastasize.
A new study found that surgeons' recommendations against contralateral prophylactic mastectomy (CPM) did not increase the likelihood of patients seeking a second opinion or receiving surgery from a different surgeon. In fact, many patients were satisfied with their treatment despite no discussion about CPM. The study surveyed 1,140 pat...
A large US study found that living in areas with high fine particle air pollution may increase the chance of dense breasts, a well-established breast cancer risk factor. Women with dense breasts were more likely exposed to high PM2.5 levels.
Researchers have developed a new method to diagnose cancer using ultrasound and microbubbles that can identify malignant tumors with high accuracy. The technique has shown promise in distinguishing between benign and malignant breast and ovarian tumors, potentially reducing unnecessary surgeries.
A study of over 3,000 childhood cancer survivors found that 12% carry germline mutations associated with increased cancer risk. Genetic screening is recommended for these patients to prevent future cancers and design personalized therapeutic approaches.
Scientists have identified a biomarker, SMARCE1, that distinguishes poorly invasive tumors from those likely to spread and metastasize in early-stage breast cancer. This discovery enables doctors to tailor therapies designed to match the behavior of each patient's cancer, improving treatment outcomes.
A demo version of a new Pathology Atlas will be presented on April 2-5 at AACR17, offering information on human gene expression levels and their relationship with cancer patients' clinical outcomes. The atlas provides analysis on nearly 8,000 cancer patients across various major cancers.
Researchers discovered that tumor blood vessels and the immune system interact, with immune cells promoting vessel normalization to improve anti-tumor therapies. This bidirectional regulation may lead to better cancer treatment outcomes when considering both vascular structure and immune response.
Exposure to BPS multiplies breast cancer cells, exhibiting estrogen-mimicking behavior, and may cause breast cancer to become more aggressive. The study confirms BPS as a potent endocrine disruptor.
Overall cancer death rates have decreased for 11 types of cancer in men and 13 in women between 2010-2014. Five-year survival improved significantly for prostate, kidney, non-Hodgkin lymphoma, and leukemia cancers.
Researchers found that cancer cells grew faster in fatty, obese tissue, suggesting the microenvironment surrounding cancer cells plays a crucial role in disease progression. Weight loss reversed changes to this microenvironment, correcting tumor growth, highlighting potential therapeutic targets for obesity-related cancers.
A study analyzing data from three national databases found significant racial gaps in immediate breast reconstruction (IBR) after mastectomy, with white patients having the highest rate of IBR. The disparities were similar among women with ductal carcinoma in situ (DCIS), and were up to 50% in California.
A study found nearly half of young breast cancer patients in five states undergo preventive mastectomy to remove the unaffected breast. The proportion of women receiving this procedure increased significantly between 2004 and 2012, particularly among those under 45, with regional variations across states.
A new imaging device developed by Modulated Imaging Inc. uses low-power LEDs to project light onto the breast, measuring absorption and scattering properties to quantify skin health. The device aims to predict acute and late skin damage effects from radiation therapy in breast cancer patients.
Researchers at Mayo Clinic have identified an interaction between focal adhesion kinase and myosin that drives the production of secreted cancer-promoting proteins. This discovery may lead to the development of new drugs to inhibit cancer progression by blocking this interaction.
Researchers developed a new method to design more effective breast cancer treatments by combining patient-derived xenografts and proteogenomic integration. This approach allows for the identification of potential targets for drugs and has shown promise in suppressing tumor growth in laboratory models.
Researchers analyzed proteins in breast tumors and found multiple protein targets that could respond to drugs, including PI3K inhibitors and mTOR inhibitors. The study also identified potential benefits for HER2 positive breast cancer patients if analysis of tumor proteins is taken into consideration.
Researchers found that over 60% of BRCA tests performed on unaffected women have increased since 2004, mainly driven by marketing efforts. However, study findings suggest that this trend may not lead to better diagnosis of those at risk, as many women without harmful mutations are still being tested.
A new study found that the proportion of women without a history of cancer who underwent BRCA testing rose sharply from 2004 to 2014. However, many high-risk patients remain unidentified, highlighting the need for effective testing strategies to maximize detection of mutation carriers.
Researchers discovered new genes that cooperate with PTEN to prevent cancer development in mice. The study also found potential drug targets for cancers with a faulty PTEN gene.
Scientists have found that two immune system molecules, interleukin 1 beta (IL1β) and tumor necrosis factor alpha (TNFα), may drive drug resistance in estrogen-driven breast cancers by modifying the shape of the estrogen receptor. This finding could lead to novel therapeutic approaches.
A new study funded by Cancer Research UK finds that smokers treated for breast cancer have significantly higher risks of developing lung cancer or heart attacks due to radiotherapy. The long-term risk of death from these conditions is around 5% for smokers, compared to 0.5% for non-smokers.
A new study by UCR psychology professor Megan Robbins found that using positive emotion words and balanced pronouns, such as
The ABC Global Alliance, led by ESO, has launched a call-to-action to improve and extend the lives of patients with advanced breast cancer by 2025. The initiative outlines key gaps and actionable imperatives across patient care, societal support, and scientific investment for mBC.