Articles tagged with Breast Cancer
Researchers found that irradiation of breast fat triggers an inflammatory response, protecting remaining cancer cells and allowing tumors to grow. Agents that block inflammation could improve radiotherapy effectiveness, potentially revolutionizing breast cancer treatment.
Researchers at Walter and Eliza Hall Institute have found a new way to use immunotherapy to treat triple negative breast cancers arising in women with BRCA1 mutations. The combination of two immunotherapy drugs effectively controls tumour growth and improves survival rates in laboratory models.
Research found that slow-growing breast cancers with favorable biologic factors have an excellent prognosis, often outliving patients. The study suggests that large, aggressive tumors are more likely to cause harm and should be prioritized for screening.
Scientists from Griffith University and partners have engineered a new tool to detect cancer by recognizing an unusual sugar present on tumor cells. The innovation utilizes the E. coli toxin, which binds to Neu5Gc, a substance produced by tumor cells.
A study published in the New England Journal of Medicine found that wealthier individuals are more likely to receive cancer diagnoses due to increased testing. However, mortality rates from these cancers have been decreasing, largely due to improved treatments. The authors suggest alternative payment models and reduced financial confli...
A research team from IDIBELL has characterized the complete epigenomes of the most frequent tumors, including those of colon, lung and breast cancer. The study reveals that anti-cancer genes slow down their activity in cancer-affected organs, but also identifies alterations in distant chromosomal regions.
Researchers have discovered a novel mechanism behind treatment resistance in brain metastatic breast cancers, and a potential treatment strategy that may overcome this resistance. Targeting the Human Epidermal Growth Factor Receptor 3 (HER3) protein has been shown to significantly slow tumor growth and improve survival.
A phase III clinical trial suggests that adding pertuzumab to standard trastuzumab treatment after surgery may help reduce the risk of invasive breast cancer by 19% in patients with HER2-positive disease. The benefit is most pronounced in women with node-positive and hormone receptor-negative breast cancer.
A new computer-aided diagnostic technique uses cutting-edge imaging technology and artificial intelligence to differentiate between benign and malignant tissues. The technique achieved a classification accuracy of over 90%, reducing the need for second breast cancer surgeries.
A population-based study found that a 2014 consensus statement endorsing minimal negative margins led to decreased reoperations and increased rates of breast-conserving surgery. Final surgical treatment rates also shifted towards mastectomy, resulting in overtreatment reduction.
In a phase III clinical trial, olaparib reduced cancer progression by 42%, delaying it by 3 months compared to standard chemotherapy. Tumors shrunk in about 60% of patients who received olaparib.
A retrospective study of 1,200 women found that pregnancy after breast cancer diagnosis did not increase the risk of cancer recurrence and death. However, survivors with estrogen receptor-positive tumors may want to consider their personal risk for recurrence when deciding how long to wait before becoming pregnant.
A new genomic sequencing approach detected circulating tumor DNA at a high rate in 89% of patients, identifying genetic changes that can be matched to targeted therapies. The study found 73% of genetic changes in tumor samples were also detected in blood samples.
A large study of over 1,200 women found that pregnancy after breast cancer diagnosis does not increase the chance of cancer recurrence or death. The findings confirm that women with ER-positive cancer can safely become pregnant without increasing their risk of recurrence.
A phase II randomized clinical trial found that the Conquer Fear psychological intervention significantly reduced fear of cancer recurrence in survivors. The intervention lowered general anxiety, cancer-specific distress, and improved quality of life compared to relaxation training.
The immunotherapy drug pembrolizumab has been shown to shrink tumors in patients with metastatic triple negative breast cancer, regardless of prior treatment. In a Phase II clinical trial, the drug demonstrated activity in both PD-L1-positive and -negative tumors.
Researchers have developed a new technique using Cerenkov luminescence imaging (CLI) to assess tumor margins during breast tumor surgery. This method combines optical and molecular imaging, providing high-resolution images of the tumor and surrounding tissue.
Researchers found that radiation therapy can improve the delivery of cancer nanomedicines up to 600% by attracting macrophages to tumor blood vessels, leading to increased nanoparticle uptake. This combination strategy shows promise for enhanced treatment efficacy and could be tested in clinical trials quickly.
Researchers found a link between isolated white communities and late-stage breast cancer diagnoses, with one-third of new patients diagnosed at a late stage in the US. Concerted public health efforts may explain lower risk disparities in black and Hispanic neighborhoods.
Researchers found that combining pembrolizumab with epacadostat improved pathological complete response rates in patients with triple-negative breast cancer. The treatment also showed promising responses in other cancers, such as non-small cell lung cancer and squamous cell head and neck cancer.
The study shows that open-access BRCA testing to Ashkenazi women enables the identification of carriers who would otherwise have been missed. Carrying one of the mutations for the BRCA genes means that women affected have a 50-80% risk of developing breast cancer and a 20-50% risk for ovarian cancer.
Researchers at George Washington University found a co-occurrence of COMT and BRCA 1/2 variants in women who remained cancer-free, suggesting potential protective effects. Further research is needed to confirm the findings and explore the mechanisms behind this association.
A recent study led by Massachusetts General Hospital researchers has identified a novel mechanism behind the resistance of HER2-positive breast cancer metastases to treatment. The study found that overexpression of the HER3 gene contributes to this resistance, and combining anti-HER2 and anti-HER3 therapies can slow tumor growth.
A study at Fred Hutchinson Cancer Center found that asymptomatic women with early-stage breast cancer often undergo unnecessary advanced imaging and tests, which provide little medical benefit but may have harmful effects and increase financial burden. ASCO guidelines recommend against routine surveillance testing for these patients.
A new report by the American Institute for Cancer Research reveals that drinking just one glass of wine or other alcoholic drink a day increases breast cancer risk, while vigorous exercise decreases risk. The study also found links between diet and breast cancer risk, including non-starchy vegetables and dairy products.
A new blood test called Videssa Breast has shown high sensitivity and specificity for detecting breast cancer in women under age 50. The test can help reduce the use of breast biopsies by up to 67 percent, ruling out breast cancer with a positive predictive value of 25.2 percent.
Research published in the British Journal of Cancer found that carrying excess body fat can increase cancer risk, with waistline and hip measurements being key indicators. The study combined data from over 43,000 participants and found that adding just 11cm to the waistline increased obesity-related cancer risk by 13%.
A study analyzing 3,640,229 patients in the SEER database found that lung cancer diagnoses are associated with a nearly 420% higher suicide rate compared to the general population. The highest suicide risk was observed in lung cancer patients, particularly older individuals, widowed patients, and those with metastatic disease.
A recent study published in Nature Cell Biology identified a small RNA molecule, miR-199a, that helps maintain the activity of stem cells in both healthy and cancerous breast tissue. The microRNA promotes particularly deadly forms of breast cancer and inhibiting its effects could improve existing breast cancer therapies.
A new study estimates that more than 150,000 US women are currently living with distant metastatic breast cancer, a form of the disease that has spread to distant sites in the body. Despite poor prognosis, survival rates for women diagnosed with MBC at younger ages have been increasing significantly.
Researchers have identified the same access paths for two molecules to reach the active site of an enzyme involved in female hormone synthesis, leading to more selective and effective drug development. The study, published in the Journal of Physical Chemistry Letters, has implications for treating breast cancer.
Engineers at Caltech have developed a new microscopy technique that can analyze tumor tissue in real-time, reducing the need for follow-up surgeries. The technology, called photoacoustic microscopy, has the potential to revolutionize breast cancer treatment and could be available to surgeons within several years.
A study of over 48,000 stored tumor samples reveals that deficiencies in DNA repair mechanisms are common across various solid tumor types. The most commonly mutated genes were ATM, PTEN, BRCA2, BRCA1, and ATRX, which could lead to targeted therapies, including PARP inhibitors.
Researchers have developed a photoacoustic imaging technology that can produce detailed images of cells, allowing for more accurate assessment of tumor margins during surgery. The goal is to speed up the process and enable real-time feedback to surgeons, reducing the need for second surgeries.
An analysis of nearly 273,000 patients found a 1% increase in breast, lung, and colorectal cancers diagnosed at stage I between 2013 and 2014. This trend suggests that increased health insurance coverage may lead to better cancer outcomes.
A study published on Nature Communications reveals that breast cancer cells undergo a stiffening state prior to acquiring malignant features and becoming invasive. This discovery identifies a new signal in tumor cells that can be further explored when designing cancer-targeting therapies.
Researchers at EMBL found that residual breast cancer cells have specific traits that distinguish them from healthy cells and seem to cause relapse. The study suggests lipid metabolism as an exciting therapeutic target to reduce breast cancer recurrence.
A study found that offering fixed date and time for new appointments improved poor attendance rates in breast cancer screening, especially among women from lower socioeconomic backgrounds. The analysis suggested a cost-effective way to shift national participation trends.
Researchers discovered that residual tumor cells display alterations in fat metabolism and oxidative stress, which contribute to DNA damage and cancer relapse. Targeting metabolic pathways in these cells could potentially prevent recurrence.
A study published in Journal of Clinical Oncology reveals that tai chi is an effective treatment for insomnia in breast cancer survivors, improving sleep health, depressive symptoms, and fatigue. The slow-moving meditation practice works just as well as cognitive behavioral therapy and better than medication.
Researchers at UT Southwestern Medical Center developed a new technique for delivering stereotactic partial breast radiation, which was found to be as safe as traditional radiation while significantly reducing treatment time from six weeks to just five treatments delivered every other day. The study showed outstanding tumor control and...
A new study reveals an association between cumulative exposure to harmful environmental factors and cancer incidence across the United States. Counties with poor environmental quality demonstrated a higher incidence of cancer cases, with prostate and breast cancer showing strong links.
Researchers identified RIOK1 as a potential new target for cancer therapy that slows down disease progression by blocking its enzymatic activity. The study found that inhibiting RIOK1 can reduce the growth and aggressiveness of cancer cells, including those with mutated RAS proteins.
A German multisite study investigated the role of post-traumatic stress in cancer-related cognitive impairment. The findings suggest that psychological factors may contribute more importantly to cancer-related cognitive impairment than neurotoxic effects of treatment.
A large data set has revealed genetic variations that are more common in black women with breast cancer, which could lead to more personalized risk assessments and improved treatment outcomes. The study also found that black women were more likely to develop aggressive breast cancer subtypes.
A new report by RTI International highlights the significant treatment burden faced by younger women with breast cancer, who often receive more aggressive treatments and incur substantially higher costs. The study estimates that younger women cost $97,000 to treat annually, compared to $76,000 for older women.
A new study conducted at The Ohio State University Comprehensive Cancer Center found that more than half of breast cancer patients undergoing mastectomy lack necessary medical knowledge for high-quality decision-making about reconstructive surgery. Researchers emphasize the need for shared decision-making tools and patient-doctor commu...
A commentary and editorial in Reproductive BioMedicine Online argue that a registry of egg donors is needed to monitor long-term health risks, citing five case histories of women who developed breast cancer after donation. The authors highlight the lack of data on this topic and call for increased transparency about potential risks.
A Mayo Clinic research team has developed a new type of cancer-fighting nanoparticle that can shrink breast cancer tumors by up to 70-80% and prevent recurrence. The nanoparticles work by engaging the entire immune system to kill cancer cells, prompting the body to create its own memory system to minimize tumor recurrence.
A recent study published by City of Hope found that regular use of low-dose aspirin (81mg) reduces the risk of breast cancer in women. The study analyzed data from 57,164 participants in the California Teachers Study and found an overall 16% lower risk of breast cancer in women who took low-dose aspirin at least three times a week.
A large study of African-American women found that those who drank seven or more drinks per week were 33% more likely to develop breast cancer than moderate drinkers. The study suggests that black women may benefit from limiting alcohol to reduce their risk, similar to white women.
Sandra Rieger, Ph.D., will investigate the molecular mechanisms underlying peripheral neuropathy caused by Taxol (paclitaxel) and explore potential treatments using MMP-inhibiting compounds. The grant aims to develop new drug therapies for this debilitating condition affecting millions of Americans.
A new paper by Kate Sweeny argues there's a positive side to worrying, with benefits including motivating preventive and protective behavior, recovery from traumatic events, and adaptive preparation and planning. Worrying the right amount can also motivate without paralyzing motivation, while serving as an emotional buffer.
Researchers have identified a genetic signature associated with resistance in triple negative breast cancer, which can be reversed after a period of treatment cessation. This discovery may lead to personalized chemotherapy strategies and improved treatment outcomes.
A recent study found that anger and guilt in cancer patients can inspire them to set new goals and engage in moderate-to-vigorous exercise. This motivation can counteract the negative effects of stress hormones on physical health. The research suggests that certain negative emotions can play a crucial role in directing adaptive health ...
The International Osteoporosis Foundation has released new position statement guidelines for managing aromatase-inhibitor related bone loss in breast cancer patients. The guidelines recommend regular assessment of fracture risk, calcium/vitamin D supplementation, and bone-directed therapy to prevent fractures and improve bone health.
A global understanding of breast cancer dissemination is crucial to improve treatment, and this study reveals that most metastases originate from a single precursor. Analyzing the genomic profile of metastases can help make therapeutic decisions, particularly for targeted treatments.
A new study published in Nature Genetics has identified 389 genetic signals linked to the timing of puberty, including associations with an increased risk of breast, ovary, and endometrial cancers in women, and prostate cancer in men. The research also suggests that earlier puberty timing may have negative effects on later health.
New methods for detecting breast cancer in young women using breastmilk, targeting G protein-coupled receptors to develop cancer drugs, and exploring the effects of dried plums on colon health offer promising approaches to combat cancer.
A study published in JAMA Surgery found that certain breast cancer patients who achieve pathologic complete response (pCR) after chemotherapy have a low risk of developing local metastases, making them candidates for less invasive treatment options. These patients may be able to avoid follow-up surgery, including axillary surgery.