Articles tagged with Breast Cancer
Studies suggest that population commitment, physician implication, and reassurance in screening can improve participation rates. A patient-centred approach in Australia improved screening participation by offering a combined cancer screening service. Additionally, nurse-led clinics can provide effective early diagnosis and prevention o...
A large study of over 1.4 million women found no increased risk of breast cancer associated with night shift work, including long-term shifts. The research combined data from multiple studies and provided new insights into the topic.
Researchers harness microRNA therapy to block movement of cancer cells from primary tumors, preventing fatal proliferation and metastasis. The study's results suggest a promising approach for human breast cancer treatment.
PharmaMar presents updated clinical trial data for its antitumoral compounds Yondelis and lurbinectedin, demonstrating efficacy in treating solid tumors such as breast, soft tissue sarcomas, and colorectal cancer. These findings support the potential of these molecules as treatments for various types of solid tumors.
Women with extremely high breast density are more likely to develop breast cancer, and current mammography technology may miss tumors. Researchers are working to improve breast cancer diagnosis and health outcomes for women through education and better utilization of screening methods.
A recent study published in npj Breast Cancer found that postmenopausal breast cancer patients taking tamoxifen have a lower risk of uterine cancer than expected. The study suggests that a normal ultrasound before treatment may provide additional reassurance for women concerned about endometrial side effects.
The Houston Methodist Research Institute has established a research center focused on the physics of cancer immunotherapy, exploring physiological changes during cancer progression. The CITO will combine cancer immunology, biotechnology, and transport oncophysics to reveal how immunotherapy works in cancer patients.
NRG-RTOG 0232 study found no significant difference in 5-year progression-free survival between external beam radiation therapy plus brachytherapy and brachytherapy alone. The treatment combination also resulted in fewer late genitourinary effects, mostly noted in the brachytherapy only arm.
Researchers found that inhibiting glucose-regulated protein 78 (GRP78) restores sensitivity to tamoxifen in resistant breast cancer. Silencing GRP78 toxically stresses breast cancer cells, leading to cell death. Adding tamoxifen to a GRP78 inhibitor offers an effective combination, enhancing the treatment's effectiveness.
A Phase III randomized trial comparing intensity modulated radiation therapy (IMRT) to standard RT found that patients treated with IMRT had better bowel and bladder functions scores and required fewer anti-diarrheal medications. Quality of life measures also showed less decline for patients treated with IMRT.
A new mobile app, TOLF, is being developed to assist breast cancer survivors in identifying and treating lymphedema through self-assessment tools, avatar videos for exercise guidance, and symptom management features. Researchers found that 90% of participants reported no problems using the system.
Researchers found that pharmacological and genetic RANK pathway inhibition significantly reduced recurrences and metastases in a mouse animal model of breast cancer. This suggests RANK inhibitors used in osteoporosis treatment may also be effective against breast cancer.
A new long-term analysis of prognostic factors among patients with breast cancer reveals that young age and ductal carcinoma in situ (DCIS) adjacent to invasive tumors are associated with increased ipsilateral breast tumor recurrence. High-grade invasive tumors also relapsed more frequently during the first five years.
An animal study suggests that resistance to tamoxifen therapy in some estrogen receptor positive breast cancers may originate from in utero exposure to endocrine disrupting chemicals. Researchers identified four genes linked to tamoxifen resistance and poor prognosis of breast cancer.
Researchers developed a computer program to automatically count the number of tubules in breast cancer tissue specimens, finding a correlation with Oncotype DX gene expression test risk scores. The study aims to provide an affordable and quick alternative to current genomic tests for predicting chemotherapy needs.
Research from the University of Sydney found that physical activity can decrease cancer and all-cause mortality risks in drinkers. The study found moderate to heavy drinking increased cancer risk, but regular exercise offset this risk.
Researchers at RIT and Rochester Regional Health are advancing thermal imaging techniques for detecting early-stage breast cancer. The collaboration aims to increase the accuracy of screening using a potentially safer and less invasive diagnostic tool.
Researchers identified nuclear transport genes, particularly XPO1, as key players in tamoxifen resistance. Combining tamoxifen with selinexor improves sensitivity and prevents tumor recurrence.
The European Society for Medical Oncology (ESMO) has awarded four distinguished recipients for their outstanding contributions to cancer treatment and research. Alberto Sobrero received the ESMO Award for his world-renowned research on gastrointestinal cancer, while Sir Richard Peto was recognized for his important contributions to bre...
Researchers identified a unique oscillating pattern of a key cancer gene that may contribute to disease progression and treatment resistance. The study found that simultaneous treatment with chemotherapy and targeted drugs can suppress tumor cell growth in both ER+/HER2- and HER2+ subpopulations.
Researchers at Thomas Jefferson University found that African American breast cancer survivors face unique challenges, including emotional and physical problems. The study suggests that addressing these issues can help reduce cancer disparities and improve health outcomes.
A new study found that breastfeeding for longer than 6 months is associated with reduced breast cancer-specific and overall survival among women treated for breast cancer. The study, published in Breastfeeding Medicine, confirms the long-term maternal health benefits of breastfeeding.
A new report from UC Davis Institute for Population Health Improvement highlights areas where increased cancer screening and control efforts can save lives. Effective screening tests exist for several cancers, yet many Californians remain under-screened, leading to late-stage diagnoses and reduced treatment success.
A nationwide study in England has collected data on 30-day mortality for patients with breast and lung cancer treated with chemotherapy, identifying factors such as age, general well-being, and NHS trusts with higher-than-expected rates of mortality. The study aims to improve patient care and inform clinical decision-making.
Researchers at Houston Methodist developed an AI software that reliably interprets mammograms to predict breast cancer risk. The software achieves 99% accuracy in 30 times human speed, reducing unnecessary biopsies and saving physician hours.
Researchers have discovered a potential new approach to treating triple negative breast cancer by targeting enhanced mitochondrial function. Mice studies showed that inhibiting mitochondrial protein translation could slow tumor growth, suggesting this strategy may be a successful treatment option.
A new study by Brigham and Women's Hospital investigators shows that trained radiologists can identify abnormal mammograms at better than chance levels when shown images for only half a second. The researchers found that finer details of breast tissue texture help radiologists make the correct diagnosis more frequently.
Researchers discovered that functional regulatory components outside of genes contribute to breast cancer development. Epigenetic changes identified as key drivers of the disease.
A new epigenetic test can diagnose the primary tumor responsible for metastasis in patients with Cancer of Unknown Primary (CUP), allowing for more specific treatments. This test, EPICUP, analyzes a patient's DNA to identify the type of cancer, resulting in improved survival rates.
Researchers found a mixture of HER2-positive and HER2-negative breast cancer cells in patients' blood samples, which can lead to tumor progression and resistance to treatment. Combining therapies targeting both populations may be effective in eliminating these cells.
CPRIT awards UT Southwestern Medical Center $9.6 million for various cancer research projects, including lung cancer treatment and prevention efforts. The funding will support research into how cancer cells grow, target breast cancer survivors with active living interventions.
Researchers at Michigan State University discovered melatonin suppresses breast cancer tumor growth, providing proof for the link between sleep deprivation and increased risk. The study showed that melatonin treatment significantly decreased mammosphere size when combined with estrogen or BPA.
Breast density and risk can inform decision to adjust mammogram screening frequency; average-risk women with lower breast density may safely extend screening interval to once every three years. Higher-risk women with dense breasts would reap greater benefit from annual screening, according to the American College of Physicians.
A new report by the Harvey L. Neiman Health Policy Institute proposes a bundled payment model for breast cancer screening, which could help reduce healthcare costs and improve patient adherence to screening guidelines. The model includes mammography and downstream diagnostic imaging services within a 364-day episode window.
Research reveals that hypoxia, or low oxygen levels, can cause epigenetic alterations leading to cancer growth. Normalizing oxygen supply inhibits these changes, suggesting new anti-cancer drug targets.
A new measurement standard, developed by NIST, has been used to evaluate the performance of next-generation DNA-sequencing technologies for evaluating gene variations associated with an increased risk of breast cancer. The HER2 Standard Reference Material demonstrates its value in increasing confidence in reporting HER2 amplification f...
A new study of nearly 2,000 patients found that women with a specific pattern of gene activity were three times more likely to die from their breast cancers within 10 years. The research identified two genes, F12 and STC2, which may play a key role in releasing cancer cells from the glue that holds them in place.
Researchers developed a new radiotracer that safely and effectively maps sentinel lymph nodes in breast cancer patients. The study demonstrated the tracer's ability to provide clear SLN imaging with high detection rates.
A new study reveals that chromosomal changes in breast cancer occur in short, punctuated 'bursts' at the earliest stages of tumor growth, contradicting the traditional gradual acquisition model. This finding has significant implications for diagnosis and treatment, suggesting a potential new approach to clinical management.
The USC Cancer Report Card highlights the decline of prostate and lung cancer among men, while stomach cancer is on the rise globally. Breast cancer risk increases for women, particularly Korean women, due to westernized lifestyles. The report also shows that many cancers are preventable and curable if caught early.
A new study has identified a high prevalence of estrogen receptor mutations in patients with metastatic breast cancer, which are linked to poorer outcomes. The research found that 29 percent of patients had a mutation in the estrogen receptor, leading to reduced overall survival rates.
A study led by Case Western Reserve University researchers has identified a gene, S100P, that may help tumors evade trastuzumab, a common breast cancer treatment. By blocking S100P, tumor cells became sensitive to the drug again.
The Independent Data Monitoring Committee approved PharmaMar's CORAIL study of PM1183 in patients with platinum-resistant ovarian cancer. The pivotal Phase III trial evaluates the efficacy of PM1183 compared to standard treatments.
Researchers at Tokyo Institute of Technology created a boron carrier system that uses albumin to target tumors, improving the delivery of boron in cancer treatment. The new system was tested on mice and showed promising results, with high concentrations of boron in tumors and low levels in healthy cells.
Researchers propose that natural selection favors strong anti-cancer protection in small, critical organs like the heart and brain. The study suggests that these organs are more resistant to tumor formation due to their smaller size and importance for human survival.
A study at Columbia University's Mailman School of Public Health found that obesity prevalence increased from 22% to 32% among cancer survivors between 1997 and 2014. Colorectal and breast cancer survivors, as well as non-Hispanic blacks, were particularly affected.
A study published in The BMJ found that higher total physical activity levels are strongly associated with a lower risk of five common chronic diseases. Most health gains occur at a level of 3000-4000 MET minutes a week, suggesting that current recommended minimum levels may not be sufficient to achieve larger reductions in risks.
Researchers found that treating human breast cancer tumors with estrogen-deprivation therapy changes the spectrum of mutations in the tumor population. This suggests using this information to improve cancer treatment. The study also discovered 'collision tumors' - separate tumors of different origin growing closely together, undiagnose...
A new study analyzes breast tumors before and after hormone-reduction therapy, revealing the genetic complexity of these tumors and their varying responses to estrogen-deprivation treatments. The findings suggest that analyzing a single sample is insufficient for understanding how a patient should be treated.
Researchers have identified key proteins involved in regulating gene expression in blood cells, which could lead to the development of more effective breast cancer treatments. The study's findings may also help explain how existing drugs work inside human cells.
A study led by Johns Hopkins pathologists found routine hormone receptor testing for noninvasive breast cancer through needle biopsies is unnecessary and wasteful, costing millions annually. This practice could save up to $35 million yearly.
Increased support for minority-focused research and community-based participatory research can improve understanding of chronic diseases across races and ethnicities. Policy recommendations include increasing non-white participant enrollment, educating healthcare providers, and funding research on gene-environment interactions.
A recent study by the Medical University of South Carolina found that African American women with lower socioeconomic status are at a higher risk of developing ovarian cancer. The study revealed a significant inverse association between SES and ovarian cancer risk, with women having a college degree or higher experiencing a 29% lower r...
Researchers at CSI Singapore found that inhibiting protein BMI1 can stop lung cancer growth. Low levels of C/EBPa protein result in poorer survival and high expression of BMI1.
Researchers at Mayo Clinic found bacterial DNA in breast tissue, even when sterile conditions are maintained. The team discovered significant differences in the breast tissue microbiome of women with and without cancer, suggesting a distinct role for the microbiome in breast cancer development.
The American Cancer Society's new guidelines modify mammography ages and emphasize patient involvement in decision-making. The shift aims to balance cancer detection with the high rate of false positives, which are approximately 19 times more likely than true positives.
Researchers found that patients with nonfunctional adrenal tumors have a significantly higher risk for developing diabetes compared to those without the condition. The study suggests that these tumors may warrant more clinical attention and should be considered an independent risk factor for diabetes.
Researchers found that African-American women were twice as likely to choose autologous breast reconstruction over implant-based reconstruction. The study of 2,500 women undergoing breast reconstruction suggests patient preferences may play a role in the disparity. Further research is needed to confirm findings and evaluate potential r...
New research suggests EBV infection may increase risk of developing breast cancer, particularly high-grade estrogen-receptor-negative disease. EBV binds to breast cells, causing them to take on stem cell characteristics and accelerating tumor formation.
A study from Michigan Medicine found that women who engaged on social media after a breast cancer diagnosis expressed more deliberation about their treatment decision and more satisfaction with the path they chose. However, the researchers also identified significant barriers to social media use among certain groups of patients.