Articles tagged with Breast Cancer
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Researchers at Michigan State University discovered melatonin suppresses breast cancer tumor growth, providing proof for the link between sleep deprivation and increased risk. The study showed that melatonin treatment significantly decreased mammosphere size when combined with estrogen or BPA.
Breast density and risk can inform decision to adjust mammogram screening frequency; average-risk women with lower breast density may safely extend screening interval to once every three years. Higher-risk women with dense breasts would reap greater benefit from annual screening, according to the American College of Physicians.
A new report by the Harvey L. Neiman Health Policy Institute proposes a bundled payment model for breast cancer screening, which could help reduce healthcare costs and improve patient adherence to screening guidelines. The model includes mammography and downstream diagnostic imaging services within a 364-day episode window.
Research reveals that hypoxia, or low oxygen levels, can cause epigenetic alterations leading to cancer growth. Normalizing oxygen supply inhibits these changes, suggesting new anti-cancer drug targets.
A new measurement standard, developed by NIST, has been used to evaluate the performance of next-generation DNA-sequencing technologies for evaluating gene variations associated with an increased risk of breast cancer. The HER2 Standard Reference Material demonstrates its value in increasing confidence in reporting HER2 amplification f...
A new study of nearly 2,000 patients found that women with a specific pattern of gene activity were three times more likely to die from their breast cancers within 10 years. The research identified two genes, F12 and STC2, which may play a key role in releasing cancer cells from the glue that holds them in place.
Researchers developed a new radiotracer that safely and effectively maps sentinel lymph nodes in breast cancer patients. The study demonstrated the tracer's ability to provide clear SLN imaging with high detection rates.
A new study reveals that chromosomal changes in breast cancer occur in short, punctuated 'bursts' at the earliest stages of tumor growth, contradicting the traditional gradual acquisition model. This finding has significant implications for diagnosis and treatment, suggesting a potential new approach to clinical management.
The USC Cancer Report Card highlights the decline of prostate and lung cancer among men, while stomach cancer is on the rise globally. Breast cancer risk increases for women, particularly Korean women, due to westernized lifestyles. The report also shows that many cancers are preventable and curable if caught early.
A new study has identified a high prevalence of estrogen receptor mutations in patients with metastatic breast cancer, which are linked to poorer outcomes. The research found that 29 percent of patients had a mutation in the estrogen receptor, leading to reduced overall survival rates.
A study led by Case Western Reserve University researchers has identified a gene, S100P, that may help tumors evade trastuzumab, a common breast cancer treatment. By blocking S100P, tumor cells became sensitive to the drug again.
The Independent Data Monitoring Committee approved PharmaMar's CORAIL study of PM1183 in patients with platinum-resistant ovarian cancer. The pivotal Phase III trial evaluates the efficacy of PM1183 compared to standard treatments.
Researchers at Tokyo Institute of Technology created a boron carrier system that uses albumin to target tumors, improving the delivery of boron in cancer treatment. The new system was tested on mice and showed promising results, with high concentrations of boron in tumors and low levels in healthy cells.
Researchers propose that natural selection favors strong anti-cancer protection in small, critical organs like the heart and brain. The study suggests that these organs are more resistant to tumor formation due to their smaller size and importance for human survival.
A study at Columbia University's Mailman School of Public Health found that obesity prevalence increased from 22% to 32% among cancer survivors between 1997 and 2014. Colorectal and breast cancer survivors, as well as non-Hispanic blacks, were particularly affected.
A study published in The BMJ found that higher total physical activity levels are strongly associated with a lower risk of five common chronic diseases. Most health gains occur at a level of 3000-4000 MET minutes a week, suggesting that current recommended minimum levels may not be sufficient to achieve larger reductions in risks.
Researchers found that treating human breast cancer tumors with estrogen-deprivation therapy changes the spectrum of mutations in the tumor population. This suggests using this information to improve cancer treatment. The study also discovered 'collision tumors' - separate tumors of different origin growing closely together, undiagnose...
A new study analyzes breast tumors before and after hormone-reduction therapy, revealing the genetic complexity of these tumors and their varying responses to estrogen-deprivation treatments. The findings suggest that analyzing a single sample is insufficient for understanding how a patient should be treated.
Researchers have identified key proteins involved in regulating gene expression in blood cells, which could lead to the development of more effective breast cancer treatments. The study's findings may also help explain how existing drugs work inside human cells.
A study led by Johns Hopkins pathologists found routine hormone receptor testing for noninvasive breast cancer through needle biopsies is unnecessary and wasteful, costing millions annually. This practice could save up to $35 million yearly.
Increased support for minority-focused research and community-based participatory research can improve understanding of chronic diseases across races and ethnicities. Policy recommendations include increasing non-white participant enrollment, educating healthcare providers, and funding research on gene-environment interactions.
A recent study by the Medical University of South Carolina found that African American women with lower socioeconomic status are at a higher risk of developing ovarian cancer. The study revealed a significant inverse association between SES and ovarian cancer risk, with women having a college degree or higher experiencing a 29% lower r...
Researchers at CSI Singapore found that inhibiting protein BMI1 can stop lung cancer growth. Low levels of C/EBPa protein result in poorer survival and high expression of BMI1.
Researchers at Mayo Clinic found bacterial DNA in breast tissue, even when sterile conditions are maintained. The team discovered significant differences in the breast tissue microbiome of women with and without cancer, suggesting a distinct role for the microbiome in breast cancer development.
The American Cancer Society's new guidelines modify mammography ages and emphasize patient involvement in decision-making. The shift aims to balance cancer detection with the high rate of false positives, which are approximately 19 times more likely than true positives.
Researchers found that patients with nonfunctional adrenal tumors have a significantly higher risk for developing diabetes compared to those without the condition. The study suggests that these tumors may warrant more clinical attention and should be considered an independent risk factor for diabetes.
Researchers found that African-American women were twice as likely to choose autologous breast reconstruction over implant-based reconstruction. The study of 2,500 women undergoing breast reconstruction suggests patient preferences may play a role in the disparity. Further research is needed to confirm findings and evaluate potential r...
New research suggests EBV infection may increase risk of developing breast cancer, particularly high-grade estrogen-receptor-negative disease. EBV binds to breast cells, causing them to take on stem cell characteristics and accelerating tumor formation.
A study from Michigan Medicine found that women who engaged on social media after a breast cancer diagnosis expressed more deliberation about their treatment decision and more satisfaction with the path they chose. However, the researchers also identified significant barriers to social media use among certain groups of patients.
A study found that women with Medicaid or Medicare had lower odds of receiving breast reconstruction compared to those with private insurance. Distance to the nearest plastic surgeon also predicted lower rates of reconstruction. The researchers highlight additional barriers to access beyond socioeconomic class, age, and race.
Researchers at University of Pittsburgh Cancer Institute found that tumor sampling techniques used with new breast cancer tests may lead to underestimation of risk. The study suggests that refining the sampling process is crucial to ensure accurate treatment plans for patients with more aggressive tumors.
A study of over 2,400 women with newly diagnosed breast cancer found that online communication is used to enhance decision making and care support, but barriers exist across age, race, and education levels.
Changes to HER2 testing guidelines have led to a doubling of HER2-positive breast cancers in women, resulting in additional testing and more women being labeled as HER2-positive. However, the effectiveness of targeted therapies like Herceptin is still uncertain, highlighting the need for accurate determination of HER2 status.
Researchers have identified BRCA1 mutations that predict treatment resistance in breast and ovarian cancers. Studies found that tumors with these mutations express a RING-deficient BRCA1 protein, leading to poor treatment responses.
Researchers at UMass Medical School developed a Salmonella 'nanobug' mimic to deliver the protein SipA, which naturally reduces a well-known drug-resistant molecule found in many types of cancer cells. The nanobug dramatically boosts tumor sensitivity to chemotherapeutic drugs, shrinking colon and breast cancer tumors in mice.
A study found that the dietary habits of rat fathers can influence their daughters' breast cancer risk, with high-fat diets increasing risk and vegetable fats reducing it. The researchers also discovered changes in microRNA and protein expression in male rats and their female offspring.
A study examined regional radiotherapy practice patterns for ductal carcinoma in situ (DCIS) and their effect on mastectomy use. Women living in areas with high radiotherapy rates were more likely to undergo mastectomy despite being eligible for breast-conserving surgery.
A new review of epidemiological evidence reveals a causal link between alcohol and cancer at seven sites: oropharynx, larynx, oesophagus, liver, colon, rectum, and female breast. The strongest evidence comes from meta-analyses and dose-response relationships.
Six Canadian innovations, including a low-cost drill system and an HIV self-test application, will receive $10 million in scale-up funding from Grand Challenges Canada. The projects aim to improve global health in developing countries by providing innovative solutions for diseases such as diarrhea, cervical cancer, and HIV.
Researchers found that replication fork protection is a major mechanism of drug resistance in BRCA1/2-mutant breast and ovarian cancers. Proteins such as PTIP, CHD4, and PARP1 promote destabilization of replication forks, making cells chemoresistant.
A study of 19,158 women who underwent IVF treatment and 5,950 women starting other fertility treatments found no association between IVF and increased breast cancer risk. Women with 7 or more IVF cycles had a significantly decreased risk compared to those treated with 1-2 cycles.
A high-fat Mediterranean diet with no restrictions on fat intake may reduce the risk of breast cancer, diabetes, and cardiovascular events. The diet's monounsaturated-to-saturated fat ratio, fruit and vegetable intake, and moderate red wine consumption are key components that contribute to these benefits.
The Nurses' Health Study has made significant advances in risk prediction for cancer, while also guiding recommendations from the US Surgeon General on smoking's adverse health effects. The study's findings have led to changes in regulation, such as reduced heart disease and diabetes risk associated with trans fats.
Researchers from OVC at the University of Guelph discovered a new way to boost immune responses against cancer by injecting oncolytic viruses into the spleen, bypassing traditional vaccine limitations. This breakthrough could lead to safer and more targeted cancer treatments for various types of cancer.
A new York University study suggests that fat cells can promote breast cancer growth in obese individuals but prevent it in lean people. Exercise has been shown to counteract the life-threatening effects of obesity and even completely prevent breast cancer growth.
A Mayo Clinic study reveals a drug combination of TLR agonists and cyclophosphamide to effectively treat advanced and metastatic cancers in mice. The treatment promotes the destruction of cancer cells and activates immune responses without toxicity.
A new study found that an enriched hops extract activates a chemical pathway in cells that could help prevent breast cancer. The research discovered a compound called 6-prenylnarigenin (6-PN), which increased a detoxification pathway linked to a lower risk of breast cancer.
A new digital image analytics test will enable accurate prediction of which women with ER+ breast cancer require chemotherapy or hormonal therapy. The test aims to reduce costs and improve patient outcomes by providing results in a day.
Two independent studies in mice show that fasting or caloric restriction mimetics during chemotherapy increases the presence of cancer-killing T cells, reducing tumor mass over time. The research provides proof of concept for two potentially safe approaches to enhance chemotherapy.
A systematic review of 30 observational studies found that disruption of sensory nerves in the axilla during armpit lymph node surgery is associated with chronic pain. Younger age and radiation therapy are also risk factors for developing chronic post-surgical pain.
A systematic review of 30 studies found that axillary lymph node dissection increases the risk of chronic pain by 21%. Younger age, radiation therapy, and acute pain after surgery were also associated with chronic pain. The study calls for more research into risk factors and techniques to reduce pain.
A diagnosis of high cholesterol is associated with reduced mortality and improved survival in four common cancers: lung, breast, prostate, and bowel cancer. Statins are linked to lower risk of death, with significant reductions seen in all four types of cancer.
A new study by Northwestern University finds that moderate-to-vigorous physical activity is associated with improved subjective memory in breast cancer survivors. Higher levels of physical activity are linked to lower distress, less fatigue, and higher self-confidence, which in turn aids memory.
Researchers at The Wistar Institute have discovered a specific network of proteins present in the mitochondria of cancer cells that enables their ability to proliferate, migrate, and spread. By targeting this pathway, they believe it may be possible to develop new treatments for various types of tumors
Two groundbreaking studies published in New England Journal of Medicine found that patients with specific subtypes of breast cancer responded better to neratinib and veliparib combinations before surgery. These findings have led to the fast-tracking of experimental drugs for large-scale phase 3 trials.
A new study found that acupressure reduced persistent fatigue in women treated for breast cancer, improving sleep quality and overall quality of life. Two-thirds of participants achieved normal fatigue levels after six weeks of relaxing acupressure.
The NCI's largest-ever study of breast cancer genetics in black women aims to identify genetic factors contributing to racial disparities in breast cancer. The study will investigate inherited genetic variations and gene expression in tumor samples.
Researchers are seeking to understand why African-American women die at a higher rate and experience more aggressive breast tumors than white women. The new study aims to identify genetic variants related to breast cancer in African-American women, which may lead to better treatments and prevention.
A study found that women with early-stage breast cancer prioritize their own judgments over surgeon and partner input when making surgical decisions. The majority of women with mastectomies identified themselves as the most influential factor in their decision, while those with lumpectomies prioritized surgeons.
The research team will explore the biological and genetic underpinnings of breast cancer in African-American women, with a focus on identifying novel genes and gene pathways. The study aims to improve knowledge of breast cancer biology, particularly for this population.