Articles tagged with Breast Cancer
A new study found that dense breast notifications are often poorly readable and understandable, creating uncertainty for women making decisions about supplemental screening. The study suggests that efforts should focus on enhancing the readability of these notifications to inform women accurately about their breast density status.
A study by Nancy R. Kressin and colleagues found that dense breast notifications sent to women after mammography contain poor readability and understandability, potentially exacerbating disparities in breast cancer screening. Only three states' notifications met the recommended readability level of grades 7-8 or above.
A review paper suggests that estrobolome disparities could help develop microbiome-based biomarkers for mitigating certain cancers. The gut bacterial genes capable of metabolizing estrogens play a crucial role in shaping systemic estrogen levels.
Sir Richard Peto, Bob Langer, and Alimuddin Zumla receive Honorary Doctor of Medicine degrees for groundbreaking work in epidemiology, biotechnology, and infectious diseases. Their achievements have transformed the pharmaceutical industry and improved human health worldwide.
A study published in JAMA Oncology found that aromatase inhibitors, used to treat breast cancer, do not increase the risk of fatal cardiovascular events. However, women taking these drugs had a higher risk of less serious cardiovascular events, such as abnormal heartbeats and pericarditis.
Breast cancer survivors undergoing anthracycline-based chemotherapy did not experience greater risk of lasting cognitive decline, according to a recent study. Neuropsychological tests revealed comparable cognitive function between groups up to seven years after treatment.
Researchers identified gene alterations that may explain treatment resistance in TNBC, suggesting a potential role for JAK2 inhibitors. The study found that JAK2 amplification was more frequent in chemotherapy-treated tumors and associated with poorer outcomes.
A study analyzing 727 articles found that 45% of media coverage about celebrity diagnoses mentioned double mastectomy. Meanwhile, the number of women undergoing double mastectomy at a Michigan hospital nearly five-fold during this time. The
A recent multi-centre study found that breast cancer patients undergoing treatment with trastuzumab-containing regimens are at significant risk of heart damage, regardless of age. The study suggests that younger patients should also be equally monitored for heart damage.
The I-SPY 2 trial shows that a combination of T-DM1 and pertuzumab before surgery can eradicate residual disease in more patients compared to paclitaxel plus trastuzumab. This new approach may improve outcomes for women with HER2-positive invasive breast cancer.
A new study finds that patients with advanced cancer often view palliative care as a stigma due to its association with death. Experts suggest that education and rebranding could help break down this stigma, promoting a more positive view of the service.
A low-fat diet for eight years improved breast cancer survival rates and reduced mortality in postmenopausal women. The study, conducted by the Women's Health Initiative, found that a sustained low-fat diet increased survival rates among women diagnosed with breast cancer.
Researchers have slowed glioblastoma tumor growth in mouse models using a high-fat, low-carbohydrate diet. The modified diet increased life expectancy by 50% and reduced tumor progression by a similar amount.
A multi-institution study found that nipple-sparing mastectomies are as effective as traditional mastectomy in preventing breast cancer in women with a genetic mutation called BRCA. The procedure, which preserves the nipple and surrounding skin, was found to be safe and effective in reducing breast cancer risk.
A randomized clinical trial found neratinib plus paclitaxel to delay central nervous system (CNS) metastases and reduce their frequency compared to trastuzumab plus paclitaxel in women with ERBB2-positive breast cancer. However, median progression-free survival was similar between the two groups.
Research from Lund University found that cartilage protein COMP is linked to breast cancer development and metastasis. Women with high levels of COMP experienced increased mortality rates, suggesting the protein may serve as an indicator of aggressive breast cancer.
Researchers at Sanford Research have created an animal model to study choroid plexus carcinoma, a pediatric brain tumor. The study identified a new genetic pathway and targeted the Sonic Hedgehog protein as a potential treatment.
Gloria Heppner's 1984 article "Tumor Heterogeneity" has stood the test of time, cited more than any other article in Cancer Research history. The article's longevity is attributed to its clarity and interpretation of data, making it a landmark in cancer research.
A large study of 43,313 women found that infertility and hormone treatment may be linked to higher breast density, a known risk factor for breast cancer. The association was strongest among women who had undergone controlled ovarian stimulation (COS), a common fertility treatment.
A study found that older black women are less likely to receive trastuzumab, a targeted drug improving survival by nearly 40%, than white women. Approximately half of women in the study did not receive any therapy, highlighting disparities in access to proven yet expensive treatment.
A UK-based clinical trial is being conducted to explore the effectiveness of a holistic rehabilitation program for people with and beyond cancer. The study aims to address the lack of support for those living with cancer in the UK, who often experience physical and emotional challenges after treatment.
Drexel University researchers developed a strategy to overcome biological barriers in cancer medication delivery. By decorating nanovehicles with enzymes and adding an extra layer of polyethylene glycol, the particles can penetrate solid tumors more effectively, increasing antitumor efficacy.
A new study reveals that cancer cells can adapt to treatment by actively co-opting blood vessels from nearby tissues, leading to drug resistance. The researchers hope their findings will lead to the development of new therapies targeting vessel co-option, which could be particularly effective when used alongside existing treatments.
Researchers have identified a molecular marker in normal breast tissue that can predict a woman's risk of developing breast cancer. The study found that women with higher levels of the marker were five times more likely to develop cancer.
A metabolic pathway up-regulated in certain breast cancers promotes disease progression by activating the cell signaling protein Arf6, according to a recent study. Statin-like drugs may be effective treatments for patients whose tumors express high levels of Arf6 signaling proteins.
Researchers discovered that breast cancer cells require fatty acids from the extracellular environment to proliferate. LIPG enzyme is crucial for tumor growth, and its inhibition may lead to more efficient chemotherapy treatments.
Researchers investigate how changes in light exposure may contribute to breast cancer development. Extended periods of nighttime illumination disrupted normal cellular behaviors and gene expression, particularly in hormone-dependent tissues like the breast.
A Kaiser Permanente study found that Latina women who received 'Promotora' visits had nearly twice the screening rate of those who did not receive visits. The study showed a modest but significant increase in screening rates, with over 19% of participants completing a mammogram within a year.
A new hybrid molecule has been developed by NYU Tandon researchers that can carry and deliver anti-cancer drugs to malignant cells. The protein-gold nanoparticle composite enhances small-molecule loading, sustained release, and increased uptake in breast cancer cells.
A new study found that BPA directly affects the mammary gland of mouse embryos, potentially raising breast cancer risk. The research, presented at the Endocrine Society's annual meeting, suggests that exposure to endocrine disruptors like BPA in utero may be a key factor in increased breast cancer incidence.
A study found that short nightly fasts of less than 13 hours increased breast cancer recurrence risk, while longer fasts were associated with lower HbA1c levels and longer sleep duration. Prolonging nightly fasting may be a simple strategy to reduce chronic disease risks.
Researchers found a short overnight fast was associated with a 36% higher risk of breast cancer recurrence and 21% higher probability of death. Prolonging overnight fasting intervals may be a simple strategy for reducing breast cancer risk, according to the study.
A new tool, IMPACT, interprets whole-exome sequencing data to identify candidate genes linked to cancer and recommends FDA-approved targeted treatments. The tool has been validated in patients with EGFR-mutated non-small cell lung cancer and melanoma, showing its potential to accelerate precision medicine.
Researchers found that cancer stem cells multiply through the same mechanism used by embryonic stem cells, encouraged by low oxygen levels. The discovery could offer a path to targeting cancer stem cells and reducing their threat in human cancer.
Researchers at NIST have developed a widely useful standard for breast cancer MRI, mimicking human tissue to test imaging systems. The phantom supports quantitative MRI and is used in clinical trials, enabling accurate images for diagnosis, staging, and treatment monitoring.
The new guideline provides recommendations for key areas of clinical follow-up care for head and neck cancer survivors, including surveillance for recurrence, screening for second primary cancers, and assessment of physical and psychosocial effects. It aims to improve care and health outcomes for this growing population.
African American patients are less likely to receive a common genomic test that predicts the seriousness of early-stage breast cancer. The study found higher scores among African Americans, indicating an increased likelihood of aggressive tumor biology benefiting from chemotherapy.
A study found that pathologists agree on invasive breast cancer diagnoses but not on non-invasive lesions like DCIS and atypia. Women with borderline findings may benefit from revised guidelines for clinical treatment and management.
The new WHO Model List of Essential Medicines includes tumour-specific indications for 46 essential medicines, empowering oncologists to demand quality care. The list aims to reduce disparities in survival outcomes and bring cancer care to developing worlds.
Scientists have identified a new gene, GT198, that causes breast cancer and can be used to diagnose the disease early. The gene is normally regulated by estrogen but becomes mutated when it causes rapid growth of cancer cells.
Researchers at Scripps Florida aim to block breast cancer growth by targeting a specific microRNA that adapts cancer cells to low oxygen environments. Inhibiting this microRNA increases the sensitivity of cancer cells to death and makes them more vulnerable to chemotherapy.
Researchers identified a new subtype of muscle-invasive bladder cancer that resembles some forms of breast cancer, characterized by low levels of the tight junction protein claudin. These claudin-low tumors express high levels of immune-related genes but also show a strong signature of immunosuppression.
A new breast cancer staging system, Neo-Bioscore, incorporates HER2 status to provide more precise prognostic stratification of all breast cancer subtypes. The system improves prognosis and identifies patients in greatest need of additional therapy.
Researchers developed an antibody against KCNK9, a cellular gateway that suppresses lung tumor cell growth and breast cancer metastasis. The antibody reduced tumor growth by up to 70% and slowed metastases in mice.
Researchers have developed a pill that can selectively target cancer cells, providing clearer images and reducing the risk of false positives. The oral agent uses near-infrared light to bind to tumors, allowing for more accurate diagnoses and potentially leading to improved treatment outcomes.
A new study from MIT reveals how cancer cells take their first steps towards metastasis by remodeling their environment, enabling them to migrate into blood vessels. High levels of the Mena protein, MenaINV, are correlated with metastasis and earlier deaths among breast cancer patients.
A new study finds that CDK4/6 inhibitor abemaciclib can restore sensitivity to HER2-targeted treatments in breast cancer cells, overcoming drug resistance. The agent's effectiveness was confirmed in mouse models and paves the way for a clinical trial.
A University of Houston researcher has discovered a link between alcohol and breast cancer, finding that alcohol enhances the actions of estrogen in driving breast cancer cell growth. The study also found that alcohol weakens the effectiveness of a cancer drug called Tamoxifen.
A new study found that a 21-gene test can identify patients with early breast cancer who can be spared chemotherapy and still survive five years after diagnosis. The trial showed a 94% disease-free survival rate among low-risk patients treated with hormone therapy alone.
New research from Brigham and Women's Hospital finds that contralateral prophylactic mastectomy has more than tripled from 2002 to 2012, despite evidence suggesting no survival benefit over breast conservation. The majority of women undergoing CPM are at low risk for developing breast cancer in the unaffected breast.
A new study has revealed significant biological differences between male and female breast cancers, shedding light on why male patients often receive delayed diagnoses. Researchers hope this knowledge will enable better treatment choices for Male BC patients, including the use of chemotherapy and targeted agents.
A clinical trial found that approximately a quarter of women with HER2 positive breast cancer who received combination treatment experienced significant tumor shrinkage or disappearance within 11 days. This discovery offers the possibility of tailoring treatment for each woman, potentially reducing the need for chemotherapy.
New research analyzed data from over 68,000 women with breast cancer registered in England between 2006-2013. The study found that average age at diagnosis was lower in both South Asian and Black women than in White women. Ethnic minority women may still face larger tumours and more aggressive features despite younger age.
A new study found that a specific gene variant can speed up the metabolism of drugs in cancer patients, leading to poorer outcomes. This variant affects the CYP3A7 enzyme, which breaks down hormones and medications, potentially reducing their effectiveness.
Breast cancer is more aggressive and common in obese women due to peritumoral fat facilitating the expansion of cancer stem cells. Researchers found that interactions between tumor cells and immature adipocytes increase cytokine secretion, leading to increased CSCs and metastasis.
Adding tomosynthesis or ultrasound scans to standard mammograms detects more breast cancers in women with dense breasts. These imaging technologies picked up an extra 24 cancers, improving detection rates.
A new trial found that full-dose radiotherapy to the whole breast is not necessary for women with low-risk early breast cancer. The study showed very low rates of local recurrence and minimal side effects across all treatment groups, suggesting that partial breast radiotherapy may be sufficient for many patients.
Researchers found that dose-dense adjuvant chemotherapy significantly improved overall survival after ten years by nearly a third compared to standard interval regimens. Dose-dense chemotherapy was not associated with an increased risk of treatment-induced amenorrhea, and it seemed effective irrespective of hormone receptor status.
A CWRU researcher is using plant viruses to detect and treat aggressive prostate and breast cancers. The lab will customize tobacco mosaic virus to target biomarkers of prostate cancer and deliver chemotherapy deep into breast tumor tissue.
A large-scale study found no link between physical activity and breast density, contradicting previous findings. Women with high breast density are still at a higher risk of developing breast cancer, but lifestyle changes such as a healthy diet can lower their risk.