Articles tagged with Breast Cancer
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Researchers found a short overnight fast was associated with a 36% higher risk of breast cancer recurrence and 21% higher probability of death. Prolonging overnight fasting intervals may be a simple strategy for reducing breast cancer risk, according to the study.
A new tool, IMPACT, interprets whole-exome sequencing data to identify candidate genes linked to cancer and recommends FDA-approved targeted treatments. The tool has been validated in patients with EGFR-mutated non-small cell lung cancer and melanoma, showing its potential to accelerate precision medicine.
Researchers found that cancer stem cells multiply through the same mechanism used by embryonic stem cells, encouraged by low oxygen levels. The discovery could offer a path to targeting cancer stem cells and reducing their threat in human cancer.
Researchers at NIST have developed a widely useful standard for breast cancer MRI, mimicking human tissue to test imaging systems. The phantom supports quantitative MRI and is used in clinical trials, enabling accurate images for diagnosis, staging, and treatment monitoring.
The new guideline provides recommendations for key areas of clinical follow-up care for head and neck cancer survivors, including surveillance for recurrence, screening for second primary cancers, and assessment of physical and psychosocial effects. It aims to improve care and health outcomes for this growing population.
African American patients are less likely to receive a common genomic test that predicts the seriousness of early-stage breast cancer. The study found higher scores among African Americans, indicating an increased likelihood of aggressive tumor biology benefiting from chemotherapy.
A study found that pathologists agree on invasive breast cancer diagnoses but not on non-invasive lesions like DCIS and atypia. Women with borderline findings may benefit from revised guidelines for clinical treatment and management.
The new WHO Model List of Essential Medicines includes tumour-specific indications for 46 essential medicines, empowering oncologists to demand quality care. The list aims to reduce disparities in survival outcomes and bring cancer care to developing worlds.
Scientists have identified a new gene, GT198, that causes breast cancer and can be used to diagnose the disease early. The gene is normally regulated by estrogen but becomes mutated when it causes rapid growth of cancer cells.
Researchers at Scripps Florida aim to block breast cancer growth by targeting a specific microRNA that adapts cancer cells to low oxygen environments. Inhibiting this microRNA increases the sensitivity of cancer cells to death and makes them more vulnerable to chemotherapy.
Researchers identified a new subtype of muscle-invasive bladder cancer that resembles some forms of breast cancer, characterized by low levels of the tight junction protein claudin. These claudin-low tumors express high levels of immune-related genes but also show a strong signature of immunosuppression.
A new breast cancer staging system, Neo-Bioscore, incorporates HER2 status to provide more precise prognostic stratification of all breast cancer subtypes. The system improves prognosis and identifies patients in greatest need of additional therapy.
Researchers developed an antibody against KCNK9, a cellular gateway that suppresses lung tumor cell growth and breast cancer metastasis. The antibody reduced tumor growth by up to 70% and slowed metastases in mice.
Researchers have developed a pill that can selectively target cancer cells, providing clearer images and reducing the risk of false positives. The oral agent uses near-infrared light to bind to tumors, allowing for more accurate diagnoses and potentially leading to improved treatment outcomes.
A new study from MIT reveals how cancer cells take their first steps towards metastasis by remodeling their environment, enabling them to migrate into blood vessels. High levels of the Mena protein, MenaINV, are correlated with metastasis and earlier deaths among breast cancer patients.
A new study finds that CDK4/6 inhibitor abemaciclib can restore sensitivity to HER2-targeted treatments in breast cancer cells, overcoming drug resistance. The agent's effectiveness was confirmed in mouse models and paves the way for a clinical trial.
A University of Houston researcher has discovered a link between alcohol and breast cancer, finding that alcohol enhances the actions of estrogen in driving breast cancer cell growth. The study also found that alcohol weakens the effectiveness of a cancer drug called Tamoxifen.
A new study found that a 21-gene test can identify patients with early breast cancer who can be spared chemotherapy and still survive five years after diagnosis. The trial showed a 94% disease-free survival rate among low-risk patients treated with hormone therapy alone.
New research from Brigham and Women's Hospital finds that contralateral prophylactic mastectomy has more than tripled from 2002 to 2012, despite evidence suggesting no survival benefit over breast conservation. The majority of women undergoing CPM are at low risk for developing breast cancer in the unaffected breast.
A new study has revealed significant biological differences between male and female breast cancers, shedding light on why male patients often receive delayed diagnoses. Researchers hope this knowledge will enable better treatment choices for Male BC patients, including the use of chemotherapy and targeted agents.
A clinical trial found that approximately a quarter of women with HER2 positive breast cancer who received combination treatment experienced significant tumor shrinkage or disappearance within 11 days. This discovery offers the possibility of tailoring treatment for each woman, potentially reducing the need for chemotherapy.
New research analyzed data from over 68,000 women with breast cancer registered in England between 2006-2013. The study found that average age at diagnosis was lower in both South Asian and Black women than in White women. Ethnic minority women may still face larger tumours and more aggressive features despite younger age.
A new study found that a specific gene variant can speed up the metabolism of drugs in cancer patients, leading to poorer outcomes. This variant affects the CYP3A7 enzyme, which breaks down hormones and medications, potentially reducing their effectiveness.
Breast cancer is more aggressive and common in obese women due to peritumoral fat facilitating the expansion of cancer stem cells. Researchers found that interactions between tumor cells and immature adipocytes increase cytokine secretion, leading to increased CSCs and metastasis.
Adding tomosynthesis or ultrasound scans to standard mammograms detects more breast cancers in women with dense breasts. These imaging technologies picked up an extra 24 cancers, improving detection rates.
A new trial found that full-dose radiotherapy to the whole breast is not necessary for women with low-risk early breast cancer. The study showed very low rates of local recurrence and minimal side effects across all treatment groups, suggesting that partial breast radiotherapy may be sufficient for many patients.
Researchers found that dose-dense adjuvant chemotherapy significantly improved overall survival after ten years by nearly a third compared to standard interval regimens. Dose-dense chemotherapy was not associated with an increased risk of treatment-induced amenorrhea, and it seemed effective irrespective of hormone receptor status.
A CWRU researcher is using plant viruses to detect and treat aggressive prostate and breast cancers. The lab will customize tobacco mosaic virus to target biomarkers of prostate cancer and deliver chemotherapy deep into breast tumor tissue.
A large-scale study found no link between physical activity and breast density, contradicting previous findings. Women with high breast density are still at a higher risk of developing breast cancer, but lifestyle changes such as a healthy diet can lower their risk.
A study of 5,644 women found that diabetes treatment decreases mammographic density, while insulin use increases it. The researchers also urge women with and without diabetes to adopt simple lifestyle changes to reduce breast cancer risk.
Researchers have identified a genetic mutation associated with a high risk of breast cancer in the Chinese ethnic population. The RECQL mutation was found to be present in 0.54% of Southern Chinese women, suggesting it may be an important factor in genetic screening for women with a family history of breast cancer.
A study of 300 women with early stage breast cancer found that a high white blood cell ratio is associated with an increased risk of disease recurrence. Women with low NLR fared better at subsequent check-ups, with higher survival rates compared to those with high NLR.
A recent study found that women who underwent a double mastectomy showed little improvement in quality of life compared to those who had a single mastectomy. However, breast reconstruction was found to have a significant positive impact on psychosocial well-being and breast satisfaction.
Researchers at the University of Texas Health Science Center have discovered that BRCA1 serves as a limiter on a gene called COBRA1, regulating breast cell growth. This finding provides new insights into how BRCA1 mutations increase breast cancer risk in women.
A recent study shows that cancer cells work together with surrounding healthy cells to build new blood vessels, promoting tumor growth. Researchers found that collagen production is increased by a specific type of transfer RNA, allowing tumors to acquire the necessary resources to grow and spread.
Regular low-dose aspirin use for at least six years was associated with a modestly reduced overall risk for cancer, primarily due to a lower risk for gastrointestinal tract cancer. The study found that regular aspirin use may complement CRC screening and have an absolute benefit regardless of endoscopy status.
EPFL scientists have developed an animal model for estrogen receptor-positive breast cancer that faithfully captures the disease. The new model has been tested on human breast tissue in a pre-clinical context, providing crucial factors such as hormone action and molecular responses to therapies.
A study of 166 breast cancer patients found that 82.5% exhibited symptoms of PTSD following diagnosis, with more than half continuing to display symptoms one year later. The severity of psychological impact was underscored by the fact that some patients rated having breast cancer as their most severe traumatic event.
A new study published in Cancer Causes & Control found that Latinas who consume processed meats like bacon and sausage have an increased risk of breast cancer. The study also suggests that tuna consumption is associated with breast cancer risk in white women, but not significantly so among Latinas.
A Stanford study found that vitamin D deficiency in mice leads to faster-growing and more aggressive breast cancer tumors. Researchers also identified a direct link between vitamin D levels and the expression of the ID1 gene, which plays a role in tumor growth and metastasis.
A combination of palbociclib and fulvestrant delays cancer growth in around two thirds of women with advanced hormone-receptor-positive, HER2-negative breast cancer. The treatment allowed many patients to delay the start of chemotherapy.
A new treatment combination of palbociclib and fulvestrant has been shown to significantly extend progression-free survival in women with stage-4 breast cancer. The study found that patients treated with the combination experienced a prolonged disease control, which may translate to improved survival.
Researchers found that beta-blockers can decrease the invasive growth of aggressive breast cancer cells by blocking the beta2-adrenoceptor, a cell surface protein stimulated by adrenaline. This discovery suggests beta-blockers could be a useful adjuvant therapy for some aggressive breast cancers.
Researchers discovered novel genetic variants in a hormone receptor-positive male breast cancer patient, which led to a prolonged stable disease. The study provides new insights into the genomic landscape of male breast cancer and suggests potential benefits of combining treatments to block the PI3K/Akt/mTOR pathway.
Researchers found that early MRI screening can reduce breast cancer mortality in female survivors of childhood Hodgkin's lymphoma who received chest radiation. The study suggests that starting screening at age 25 with MRI can be more effective than mammography, but may lead to false positives.
Whitehead Institute researchers develop hydrogel scaffolds that support human mammary tissue growth from patient-derived cells, providing insights into normal breast development and cancer progression. The scaffold responds to hormones and allows for the study of gene perturbations.
A multicentre study found type 1 diabetes associated with higher cancer incidence, especially for cancers of the stomach, liver, pancreas, endometrium, ovary, and kidney. Women with type 1 diabetes had a smaller but still significant increased risk compared to men.
A study of 120,000 women found five genetic variants affecting breast cancer risk, which alter how cells respond to oestrogen. The variants are associated with changes in the expression of genes involved in oestrogen regulation, potentially leading to new breast cancer preventions.
A single dose of trastuzumab kick starts an immune response in certain HER2-positive breast cancers, with women having the highest rate of immune response being those with the HER2-enriched subtype. The immune-cell-activating properties of trastuzumab are likely related to the subtypes of breast cancer.
PharmaMar has initiated a Phase II clinical trial for its antitumor drug PM184, targeting hormone-receptor positive and HER2-negative breast cancer patients. The trial aims to evaluate the efficacy of PM184 on four-month progression-free survival and assess safety and pharmacological profiles.
A new study compared four types of abdominal flaps used in breast reconstruction, revealing that muscle-sparing techniques like DIEP and msf-TRAM reduce hernia risks and improve patient satisfaction. The study found these methods to have lower rates of fat necrosis and abdominal morbidity compared to traditional flaps.
A new report from the American Brain Tumor Association reveals that malignant brain tumors are the most common cause of cancer-related deaths in adolescents and young adults aged 15-39. The study, which analyzed data from 2008-2012, also found a shift towards high-grade tumors with increasing age.
Researchers found that omega-3 supplementation reduced breast density in postmenopausal women with a body mass index above 29, bordering on obesity. The study suggests that DHA alone may be preferentially protective in these individuals, offering an example of personalized approach to breast cancer prevention.
Researchers at H. Lee Moffitt Cancer Center develop adaptive therapy to keep resistant cells in check, prolonging survival without disease progression in mouse models of triple-negative and ER+ breast cancer. The approach is being tested in a clinical trial for prostate cancer patients.
Mayo Clinic researchers found that using frozen section analysis during lumpectomies can reduce the need for second operations by 95%, saving patients time and financial burdens. The study estimates annual cost savings of $90.9 million to payers and $1.8 million to providers.
The American Cancer Society report reveals progress in reducing cancer death rates among African-Americans, but racial disparities persist in breast and colorectal cancers. The study finds that disparities in access to care and screening contribute to these disparities.
A consensus meeting of experts has established a framework for classifying bladder cancers based on genetic mutations. This development aims to improve patient outcomes by stratifying patients according to their tumor characteristics and response to therapy.
Researchers at the University of Toronto have developed shape-shifting nanoparticles that can target and deliver cancer drugs to specific tumor types. The system uses modular particles attached to DNA sequences to gain access to diseased tissue, minimizing collateral damage.
A study published in JAMA Oncology found that 3D mammography improved cancer detection and reduced call backs over three years. Regularly scheduled 3D mammography imaging maintained these benefits, even after a patient's first screening.
Researchers have developed a new nanoparticle that kills tumor cells in the eye by mimicking an enzyme used by immune cells, extending survival of mice with advanced breast cancer. The treatment offers advantages such as producing toxins per hour and being activated by light.