Articles tagged with Breast Cancer
A University of Oklahoma research team, led by Hong Liu, has been awarded a $3 million grant to develop an innovative X-ray technique for enhanced breast cancer detection. This technique aims to reduce radiation dose and improve accuracy in diagnosis.
Researchers have developed an experimental drug, BHPI, that rapidly shrinks most tumors in a mouse model of human breast cancer. The drug works by hyperactivating the unfolded protein response pathway, driving cancer cells from using it for protection into making it a lethal pathway.
Breast tumors trick immune cells to produce neutrophils that block T-cell action, allowing cancer to spread. Anti-IL17 drugs already exist for inflammatory diseases, offering potential treatment for metastatic breast cancer.
A recent Loyola University Health System study found that breast ultrasound examinations can eliminate the need for biopsy in many cases. The study concluded that if breast masses meet certain criteria, biopsies may be unnecessary.
Australian researchers found a gene ID4 driving the most aggressive form of triple-negative breast cancer. The discovery shows that switching off ID4 may 'tame' these cancers, making them more responsive to existing treatments. Researchers plan to further study how to block the gene and test its potential in mice and humans.
A study of 2.7 million US breast cancer patients found that surgeons are increasingly removing only the 'gatekeeper' lymph nodes, rather than all underarm lymph nodes, when a biopsy shows cancer. This shift is attributed to the lower risks for patients who undergo sentinel lymph node biopsy alone.
Dr. Mitchell Gail recognized for pioneering statistical work in cancer research, including breast cancer risk prediction models. His research has led to the development of widely used tools like the NCI's Breast Cancer Risk Assessment Tool.
A new study by Women's College Hospital found that women with diabetes are more likely to be diagnosed with advanced stage breast cancer. The study analyzed data from over 38,000 women and found that those with diabetes were 14% more likely to present with Stage II or III breast cancer.
A new study finds that providing women with stress management skills during breast cancer treatment can lead to improved mood and quality of life many years later. Women who received the intervention had persistently less depressive symptoms and better quality of life up to 15 years post-treatment.
A new study by the University of Miami found that women who received stress management training during breast cancer treatment experienced improved mood and quality of life for up to 15 years. The study suggests that early stress management can have long-term benefits for psychosocial health.
Researchers found that MED15 overexpression is associated with higher mortality rates in HNSCC patients with cancer recurrence, particularly in oral cavity/oropharyngeal tumors. MED15 may serve as a prognostic marker for HNSCC recurrence and as a therapeutic target in HNSCC patients suffering from recurrences.
Researchers at the University of Otago have identified key genetic mutations underlying deadly hereditary stomach and lobular breast cancers. The team found that these mutations also create vulnerabilities in cancer cells, making them susceptible to existing drug therapies targeting other cellular mechanisms.
A Cancer Research UK study found that text message reminders increased breast cancer screening attendance by 20% among women aged 47-53. The trial, which sent text messages to over 450 women, showed that 72% of those who received the reminders attended their appointments compared to 60% of those who did not.
A Dartmouth investigator found an mHealth app acceptable to diverse and low-income women for breast health risk assessment. The study showed that 11 of the 15 participants preferred using the mobile health device over a paper tool.
A study published in Nature Structural & Molecular Biology reveals that human DNA polymerase theta may be a promising drug therapy target for inhibiting breast cancer. The researchers used X-ray crystallography to determine the first crystal structures of POLQ, providing insights into its role in DNA repair and genomic instability.
Researchers found that exercise significantly improved blood vessel formation around tumors, leading to better oxygenation and reduced tumor growth. Exercise also enhanced the efficacy of chemotherapy drugs, shrinking tumors more effectively than sedentary animals.
A large cohort study found no association between dietary dioxin exposure and breast cancer risk in post-menopausal women, contradicting previous studies on environmental contact with dioxins. Higher dioxin intake was linked to a decreased risk of hormone-independent breast cancer.
Researchers discovered that Shp2 blocks protection program senescence, boosting tumor growth in breast cancer. Senescent cells secrete messenger molecules to trigger the immune system's defense against cancer.
Research shows exercise slows tumor growth and improves blood vessel perfusion, leading to reduced hypoxia and better response to chemotherapy. Exercise combined with chemotherapy results in slower tumor growth compared to sedentary mice or those treated with the drug alone.
A Swiss Institute of Bioinformatics-led trial demonstrates the potential of mathematical modelisation and experimentation in treating breast cancer. By combining clinical and experimental oncology with modelisation, researchers identified mechanisms that enable tumour cells to shape monocyte activities for their advantage.
A new study from NYU Langone Medical Center found that over 40% of low-risk prostate and breast cancer patients in certain US regions received inappropriate tests. The research suggests that regional culture and infrastructure play a significant role in the use of imaging tests, with some areas exhibiting more appropriate use than others.
Women with very low breast tissue density experience shorter disease-free survival and overall life expectancies compared to those with high-density breasts. A six-year follow-up study of 270 breast cancer patients found that lower breast tissue density is an independent poor prognostic factor for breast cancer.
A study published in JAMA Oncology found high rates of inappropriate imaging for both prostate cancer and breast cancer, suggesting that regional culture and infrastructure play a role in health care utilization patterns. The researchers estimated that 30% of healthcare resources in the US do not improve patient health.
The Wistar Institute has received a $1.1 million grant from the Jayne Koskinas Ted Giovanis Foundation to support the work of three scientists researching metastatic breast cancer. The researchers aim to develop novel targeted therapies by understanding the pathways essential to breast cancer cells.
A study by Sanford-Burnham Medical Research Institute identifies a protein called RNF5 that determines breast cancer response to paclitaxel, a chemotherapy drug. The researchers found that RNF5 causes degradation of glutamine carrier proteins, leading to sensitization of breast cancer tumors to death.
Scientists have identified 15 new genetic 'hot-spots' linked to an increased risk of breast cancer, with some women having multiple variations that double their risk and others being three times more likely to develop the disease. The discovery could help identify high-risk women and improve cancer screening and prevention.
A family history of prostate cancer in first-degree relatives increases breast cancer risk by 14%, according to a study of 78,171 women. Women with both breast and prostate cancer histories face an almost 2-fold increase in breast cancer risk
A new analysis of a large national database found that breast cancer survivors have an increased risk of developing thyroid cancer, especially within five years of their diagnosis. Women who received radiation therapy for breast cancer were more likely to develop aggressive thyroid cancer, but with smaller tumors and fewer treatments.
A study published in LGBT Health found that transgender veterans are at higher risk of developing breast cancer, with ten new cases identified. The study also highlights the importance of sensitively discussing screening methods with transgender individuals, regardless of hormone use.
The use of the 21-gene recurrence score assay increased from 1.1% to 10.1% among Medicare beneficiaries diagnosed with breast cancer between 2005 and 2009. The majority of tests were performed in patients with intermediate-risk disease, and rates of chemotherapy remained similar during this period.
A study published in The New England Journal of Medicine found that adding goserelin to chemotherapy regimens can significantly reduce the risk of early menopause and improve fertility in young breast cancer patients. Women who took goserelin had a higher pregnancy rate and were more likely to deliver healthy babies.
Women treated with goserelin during chemotherapy experienced an 8% ovarian failure rate compared to 22% for the control group. Goserelin also improved pregnancy rates by 21% within 5 years post-treatment.
A new study uses MR spectroscopy to identify biochemical changes associated with precancerous breast tissue in women with BRCA gene mutations. The technique shows promise for detecting cancer at an early stage, potentially allowing for more targeted treatments and preventive measures.
The debate surrounding breast cancer overdiagnosis has led to inconsistent estimates, with some suggesting up to 50% of diagnosed cancers may be overdiagnosed. Experts argue that achieving consensus is crucial for providing balanced and uncontested information to women.
Researchers developed a test to identify women with triple-negative breast cancer, a form of disease difficult to treat. The test assesses gene activity in breast cancer cells, finding those resembling adult stem cells are more likely to spread and recur.
A UK survey found that people's willingness to accept overdetection in cancer screening varies greatly, depending on the level of benefit and perceived harms. The study revealed that up to 14% would accept overdetection in the entire population, with median acceptability ranging from 113 to 150 cases.
A Mayo Clinic study found that US women's awareness of breast density varies significantly by race, ethnicity, household income, education level, and healthcare experiences. More than half of women reported having heard of breast density, but only 53% knew it was associated with cancer risk.
Australian researchers identified MCL-1 as a critical regulator of breast development and milk production in the mammary gland. This discovery highlights the importance of MCL-1 for all stages of breast development and lactation.
Researchers developed a new test analyzing 'immune hotspots' to predict breast cancer survival. The test uses statistical software to track the immune system's reaction to tumors, identifying those who need intensive treatment.
The study, which analyzed data from the National Cancer Data Base, found that 59% of women who received pre-surgery chemotherapy had breast conservation therapy. Women with larger tumors were also more likely to opt for pre-surgery chemotherapy and lumpectomy versus mastectomy.
The use of ultrasound for supplemental breast cancer screening is hindered by the lack of intensive training programs for physicians and interpreters. This limitation is attributed to MRI's restricted use due to pacemaker and claustrophobia concerns, making it an alternative option.
A Northwestern University study found that community navigators can significantly improve healthcare outcomes for low-income, uninsured Spanish-speaking women. Despite facing numerous barriers, patients in the navigation program had shorter follow-up times and did not experience delayed diagnoses compared to English-speaking counterparts.
Researchers found that a regional anesthetic technique, called ultrasound-guided paravertebral blocks, can significantly reduce chronic post-operative pain in women after mastectomies. The study showed that these nerve blocks most reduced neuropathic pain, which affects sensation and is the most common form of chronic pain.
A new study published in Molecular Cancer Therapeutics shows that a low percentage of androgen-receptor-positive cells in triple-negative breast cancer cells can benefit from anti-androgen therapies. This finding may lead to a larger pool of patients eligible for targeted cancer therapy.
Filipinos who move to Canada are diagnosed with breast cancer at a younger age than women from other parts of East Asia or Caucasians. They are also more likely to be diagnosed with a more aggressive form of cancer and undergo mastectomies.
A recent study published in the Journal of Clinical Oncology found that household net worth, rather than just income, plays a significant role in determining breast cancer patients' ability to afford treatment. The study suggests that physicians and health insurers need to consider this economic variable to ensure equitable care.
Fox Chase Cancer Center has received a one-year grant from the National Breast Cancer Foundation to provide mammography screening and navigation services to underserved women. The program aims to increase access to care by bringing cancer screening into community settings via its mobile unit.
A study found that most UK women (85%) would back the idea of more frequent breast screening if they are at higher genetic risk of developing breast cancer. Women at lower genetic risk were less supportive, but still willing to participate in screening with proper information and support.
The phase II study results indicate that palbociclib can extend disease control and produce tumor shrinkage in ER+ breast cancer patients. Researchers observed significantly longer progression-free survival in hormone receptor-positive patients compared to those with HR-negative breast cancer.
Researchers at MD Anderson Cancer Center found that targeting pericytes and angiopoietin-2 signaling may reduce breast cancer tumor growth and metastasis. The study suggests a potential new therapeutic approach for metastatic breast cancer.
A new study found that women who understand the risks of over-detection and over-diagnosis associated with mammography screening are less likely to have a breast screening test. The Lancet study suggests that clear decision support materials can help women make more informed decisions about their screening choices.
Researchers at Duke University Medical Center have identified a link between gene mutations in the IDH gene and the formation of benign cartilage tumors that can evolve into cancerous chondrosarcomas. The study provides insights into the potential development of new treatments using drugs designed to block IDH function.
Researchers estimated that by age 80, CDH1 mutation carriers have a 70% chance of developing gastric cancer and a 42% risk of breast cancer. The study provides more precise estimates for carriers of the CDH1 gene mutation, a cancer predisposing gene associated with hereditary diffuse gastric cancer.
New research suggests that cancer false alarms could lead to patients delaying symptom checks due to a lack of support. A systematic review found that over-reassurance and under-support can discourage patients from seeking help for new or recurrent symptoms.
A new commentary suggests that mandatory screening for women with dense breast tissue without careful analysis of benefits and risks is unwise. Education on the increased risk and other important factors can help healthcare providers guide recommendations for supplemental screening.
A Cancer Research UK study found that nine in 10 people think cancer screening is 'almost always a good idea', despite low uptake. The researchers highlight the need for clearer information on risks and benefits to encourage informed decision-making.
African American women are at higher risk of pre-menopausal breast cancer due to unique genetic mutations. The study found novel genomic segments shared among family members with breast cancer, supporting the hypothesis that specific genes may be unique to this population.
A recent study found that nearly a third of women with N2/N3 breast cancer did not receive post-mastectomy radiation therapy (PMRT), which is the standard of care for this patient group. The study evaluated over 57,000 cases and found that socioeconomic factors did not influence PMRT receipt.
A new study by Johns Hopkins researchers links the Notch cell signaling pathway to pilocytic astrocytoma, a common and slow-growing brain tumor in children. The study found that Notch was abnormally active in nearly all samples of PA brain tissue, suggesting it may be a therapeutic target for treatment.
A new report from the American Cancer Society finds that lung cancer has surpassed breast cancer as the leading cause of cancer death in females in developed countries. The tobacco epidemic in women is cited as a major factor contributing to this shift.