Articles tagged with Breast Cancer
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A study published in The New England Journal of Medicine found that adding goserelin to chemotherapy regimens can significantly reduce the risk of early menopause and improve fertility in young breast cancer patients. Women who took goserelin had a higher pregnancy rate and were more likely to deliver healthy babies.
Women treated with goserelin during chemotherapy experienced an 8% ovarian failure rate compared to 22% for the control group. Goserelin also improved pregnancy rates by 21% within 5 years post-treatment.
A new study uses MR spectroscopy to identify biochemical changes associated with precancerous breast tissue in women with BRCA gene mutations. The technique shows promise for detecting cancer at an early stage, potentially allowing for more targeted treatments and preventive measures.
The debate surrounding breast cancer overdiagnosis has led to inconsistent estimates, with some suggesting up to 50% of diagnosed cancers may be overdiagnosed. Experts argue that achieving consensus is crucial for providing balanced and uncontested information to women.
Researchers developed a test to identify women with triple-negative breast cancer, a form of disease difficult to treat. The test assesses gene activity in breast cancer cells, finding those resembling adult stem cells are more likely to spread and recur.
A UK survey found that people's willingness to accept overdetection in cancer screening varies greatly, depending on the level of benefit and perceived harms. The study revealed that up to 14% would accept overdetection in the entire population, with median acceptability ranging from 113 to 150 cases.
A Mayo Clinic study found that US women's awareness of breast density varies significantly by race, ethnicity, household income, education level, and healthcare experiences. More than half of women reported having heard of breast density, but only 53% knew it was associated with cancer risk.
Australian researchers identified MCL-1 as a critical regulator of breast development and milk production in the mammary gland. This discovery highlights the importance of MCL-1 for all stages of breast development and lactation.
Researchers developed a new test analyzing 'immune hotspots' to predict breast cancer survival. The test uses statistical software to track the immune system's reaction to tumors, identifying those who need intensive treatment.
The study, which analyzed data from the National Cancer Data Base, found that 59% of women who received pre-surgery chemotherapy had breast conservation therapy. Women with larger tumors were also more likely to opt for pre-surgery chemotherapy and lumpectomy versus mastectomy.
The use of ultrasound for supplemental breast cancer screening is hindered by the lack of intensive training programs for physicians and interpreters. This limitation is attributed to MRI's restricted use due to pacemaker and claustrophobia concerns, making it an alternative option.
A Northwestern University study found that community navigators can significantly improve healthcare outcomes for low-income, uninsured Spanish-speaking women. Despite facing numerous barriers, patients in the navigation program had shorter follow-up times and did not experience delayed diagnoses compared to English-speaking counterparts.
Researchers found that a regional anesthetic technique, called ultrasound-guided paravertebral blocks, can significantly reduce chronic post-operative pain in women after mastectomies. The study showed that these nerve blocks most reduced neuropathic pain, which affects sensation and is the most common form of chronic pain.
A new study published in Molecular Cancer Therapeutics shows that a low percentage of androgen-receptor-positive cells in triple-negative breast cancer cells can benefit from anti-androgen therapies. This finding may lead to a larger pool of patients eligible for targeted cancer therapy.
Filipinos who move to Canada are diagnosed with breast cancer at a younger age than women from other parts of East Asia or Caucasians. They are also more likely to be diagnosed with a more aggressive form of cancer and undergo mastectomies.
A recent study published in the Journal of Clinical Oncology found that household net worth, rather than just income, plays a significant role in determining breast cancer patients' ability to afford treatment. The study suggests that physicians and health insurers need to consider this economic variable to ensure equitable care.
Fox Chase Cancer Center has received a one-year grant from the National Breast Cancer Foundation to provide mammography screening and navigation services to underserved women. The program aims to increase access to care by bringing cancer screening into community settings via its mobile unit.
A study found that most UK women (85%) would back the idea of more frequent breast screening if they are at higher genetic risk of developing breast cancer. Women at lower genetic risk were less supportive, but still willing to participate in screening with proper information and support.
The phase II study results indicate that palbociclib can extend disease control and produce tumor shrinkage in ER+ breast cancer patients. Researchers observed significantly longer progression-free survival in hormone receptor-positive patients compared to those with HR-negative breast cancer.
Researchers at MD Anderson Cancer Center found that targeting pericytes and angiopoietin-2 signaling may reduce breast cancer tumor growth and metastasis. The study suggests a potential new therapeutic approach for metastatic breast cancer.
A new study found that women who understand the risks of over-detection and over-diagnosis associated with mammography screening are less likely to have a breast screening test. The Lancet study suggests that clear decision support materials can help women make more informed decisions about their screening choices.
Researchers at Duke University Medical Center have identified a link between gene mutations in the IDH gene and the formation of benign cartilage tumors that can evolve into cancerous chondrosarcomas. The study provides insights into the potential development of new treatments using drugs designed to block IDH function.
Researchers estimated that by age 80, CDH1 mutation carriers have a 70% chance of developing gastric cancer and a 42% risk of breast cancer. The study provides more precise estimates for carriers of the CDH1 gene mutation, a cancer predisposing gene associated with hereditary diffuse gastric cancer.
New research suggests that cancer false alarms could lead to patients delaying symptom checks due to a lack of support. A systematic review found that over-reassurance and under-support can discourage patients from seeking help for new or recurrent symptoms.
A new commentary suggests that mandatory screening for women with dense breast tissue without careful analysis of benefits and risks is unwise. Education on the increased risk and other important factors can help healthcare providers guide recommendations for supplemental screening.
A Cancer Research UK study found that nine in 10 people think cancer screening is 'almost always a good idea', despite low uptake. The researchers highlight the need for clearer information on risks and benefits to encourage informed decision-making.
African American women are at higher risk of pre-menopausal breast cancer due to unique genetic mutations. The study found novel genomic segments shared among family members with breast cancer, supporting the hypothesis that specific genes may be unique to this population.
A recent study found that nearly a third of women with N2/N3 breast cancer did not receive post-mastectomy radiation therapy (PMRT), which is the standard of care for this patient group. The study evaluated over 57,000 cases and found that socioeconomic factors did not influence PMRT receipt.
A new study by Johns Hopkins researchers links the Notch cell signaling pathway to pilocytic astrocytoma, a common and slow-growing brain tumor in children. The study found that Notch was abnormally active in nearly all samples of PA brain tissue, suggesting it may be a therapeutic target for treatment.
A new report from the American Cancer Society finds that lung cancer has surpassed breast cancer as the leading cause of cancer death in females in developed countries. The tobacco epidemic in women is cited as a major factor contributing to this shift.
A worldwide study of 100,000 women has discovered two new genetic variants associated with an increased risk of breast cancer. The variants are specifically linked to the most common form of breast cancer, oestrogen receptor positive, providing important clues about its causes and potential leads for treatment discovery.
Researchers at UNC Chapel Hill have developed a device that can deliver chemotherapy drugs directly into tumor tissue, allowing for potential life-saving surgeries and increased life expectancy. The device uses electric fields to target poorly vascularized tumors, which are difficult to treat with standard IV chemotherapy drugs.
A new research by Dr Alessandra Ghigo found that inhibiting the activity of phosphoinositide 3-kinase gamma (PI3K?) protected mice with hypertension from developing heart failure. The study also showed that a PI3K? inhibitor could synergise with chemotherapy to delay tumour growth and prevent cardiotoxicity.
Researchers discovered clusters of gene-blocking microRNAs expressed only in oligometastatic cells, which can shut down specific genes involved in metastasis. These findings suggest microRNAs could provide a personalized biomarker to predict tumor aggressiveness and guide effective treatment.
A new study published in Journal of Clinical Oncology finds that ultrasound can help surgeons decide whether to remove only a few or all underarm lymph nodes from breast cancer patients who have received chemotherapy, reducing the risk of complications and saving healthcare costs.
A new study reveals distinct methylation patterns in primary biopsy breast cancer cells, indicating better or worse prognosis. This epigenetic signature can stratify triple-negative breast cancers into two sub-groups, allowing for more precise disease management and potential improved outcomes.
Researchers at Dartmouth's Norris Cotton Cancer Center have identified ERBB4 as a driver protein in breast cancers that have developed resistance to HER2 targeted therapies. The discovery suggests that anti-ERBB4 drugs could be highly beneficial for patients who no longer respond to first or second-line treatments.
Researchers at NYU Langone Health have discovered a new pathway to slow down tumor growth in cancers with BRCA1 and BRCA2 genetic mutations. By inhibiting the action of polymerase theta enzyme, cancer cell growth can be cut by more than half.
A UTSW study reveals a strong correlation between low levels of beclin 1 and both triple-negative breast cancer incidence and poor prognosis. Patients with low beclin 1 activity had a 67% increased risk of dying from breast cancer compared to those with higher levels.
Researchers at H. Lee Moffitt Cancer Center & Research Institute found that low levels of tristetraprolin (TTP) protein are associated with more aggressive tumors and poorer prognosis in breast and lung cancer patients. A network of 50 genes linked to TTP is present in various tumor types, suggesting potential therapeutic strategies.
A new study published in The Lancet Oncology found that older women with early-stage hormone-receptor positive breast cancers who receive hormone treatment and surgery can safely omit radiotherapy. This group of patients is at low risk of cancer recurrence, making radiotherapy unnecessary.
UC Davis researchers found that half of primary care physicians are unfamiliar with the law, and many don't feel comfortable discussing breast density with patients. The study suggests that increased physician education is needed to address this gap and improve patient outcomes.
A new study found that frequent consumption of sugary drinks is associated with an earlier onset of menstruation in girls. The researchers followed 5583 girls aged 9-14 years and found that those who drank more than 1.5 servings of sugary drinks per day had their first period 2.7 months earlier.
Defects in extrusion, a process that helps cells die when overcrowded, may be a common hallmark of invasive tumor types. FAK inhibitors rescued cell death rates to normal and eliminated large cell masses.
A new breast cancer risk prediction model developed by the Mayo Clinic has been shown to be more accurate than the current screening standard in predicting breast cancer risk. The model uses histologic features of biopsied breast tissue and individual patient demographic information, classifying breast cancer risk with a concordance st...
According to the study, death rates from lung cancer are predicted to exceed those for breast cancer among European women in 2015. The rate of cancer deaths is expected to decline overall, with notable exceptions such as lung and pancreatic cancer.
A new analysis found that women with breast cancer have poor knowledge about their illness, with minority patients less likely to know accurate information. The study highlights the need for patient education and provider awareness to improve informed treatment decisions and overall cancer care.
Researchers developed a breast cancer risk prediction model specifically for African-American women, using data from 55,000 women. The new model predicts higher risk and is expected to increase the number of African-American women invited to participate in prevention trials.
A University of Michigan study found that fans and consumers separate an athlete's immoral behavior from their athletic performance more easily. This led to a less severe backlash for Tiger Woods' extramarital affairs compared to Lance Armstrong's doping scandal.
Researchers used next-generation sequencing techniques to analyze archived tissue samples of phyllodes tumors, identifying two genes (EGFR and IGF1R) that were amplified in malignant tumors. The study also found the gene MED12 was frequently mutated in all classifications of phyllodes tumors.
Researchers at Scripps Research Institute discover a promising new treatment for aggressive breast and pancreatic cancers, using a synthetic compound called SR1848. The compound targets the LRH-1 protein, which is involved in hormone synthesis and cholesterol metabolism.
A study of nearly 375,000 US women with invasive breast cancer found that racial and ethnic groups had different rates of early-stage diagnosis and survival. Biological factors, such as tumor aggressiveness and metastatic potential, played a significant role in determining stage at diagnosis.
New research review highlights the link between cytokines and breast cancer, exploring topics such as cytokine-mediated blood vessel formation and immune evasion. The study suggests that cytokines may serve as prognostic factors for breast cancer patients.
Researchers suggest that the tumor microenvironment could play a significant role in cancer treatment and delivery of nanoparticle-based drugs. They found varying levels of drug delivery between two triple-negative breast cancer tumors, highlighting the importance of personalized medicine and better profiling of tumors.
Researchers have discovered a novel breast cancer gene called BCL11A that drives the development and progression of triple-negative breast cancer. The study found that BCL11A is active in approximately eight out of ten patients with basal-like breast cancer, and its activity is associated with a more advanced grade of tumour.
Researchers developed a culturally-based program that increased fruit and vegetable intake among Latina breast cancer survivors, leading to improved clinical outcomes and weight loss. The program's success has implications for other cancer survivors and larger populations.
Researchers at Huntsman Cancer Institute have developed a new tool to estimate prostate cancer risk based on family history, which can help clinicians decide whether a PSA test is appropriate. The study found that two-thirds of Utah men have some increased risk of developing prostate cancer due to their family history.
Researchers at Dartmouth Hitchcock's Norris Cotton Cancer Center developed a prognostic test for E2F4 in ER+ breast cancer, significantly predicting patient outcome regardless of treatment status. The test identifies patients who should receive aggressive follow-up treatment.
A phase 2 clinical trial found that a combination of lower-intensity chemotherapy and targeted drug trastuzumab significantly reduced the risk of cancer recurrence in women with small, HER2-positive breast tumors. After three years, 98.7% of participants were alive and free of invasive breast cancer.
Women undergoing left-side breast cancer radiation therapy can reduce heart exposure by holding their breath, resulting in a 90% disease-free survival rate and a median reduction of 62% in radiation dose. The breath-hold technique also shows a lower risk of ischemic heart disease after 8 years.