Articles tagged with Breast Cancer
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A randomized trial found that telephone-based weight loss advice reduced breast cancer recurrence risk by lowering weight and inflammation. Postmenopausal women with breast cancer who received lifestyle coaching via phone achieved comparable sustained weight loss to in-person consultations.
A study of over 59,000 patients found that 3D digital breast tomosynthesis increased overall cancer detection by 28.6% and invasive cancer detection by 43.8%. The technology also reduced recall rates in community-based radiology practice.
Researchers at the University of Missouri have discovered a potential cholesterol-lowering drug that can also halt the progression of breast cancer and kill cancerous cells. The compound targets the production of cholesterol in cancer cells, leading to cell death.
A recent study found that most elderly women with non-metastatic breast cancer comply with hormone therapy recommendations. However, non-white women were more likely to discontinue treatment, highlighting a need for targeted interventions.
Researchers at Georgetown University Medical Center found that combining tamoxifen with hydroxychloroquine reverses resistance to the breast cancer drug in mice. The study's findings provide a promising new treatment option for women with advanced estrogen receptor-positive breast cancer.
A new study found that women with breast cancer who test positive for BRCA mutations are more likely to change their surgical plan, typically opting for a double mastectomy and sometimes ovary removal. Genetic testing before surgery can significantly impact treatment decisions, but may not necessarily delay surgery.
A class of leukemia drug has been found to stimulate immunity against multiple cancer types. Inhibiting the p110δ enzyme helps boost the body's immune system to kill tumor cells.
The Journal of Medical Imaging has launched with freely accessible articles on new research in cancer diagnosis, image quality assessment, and other topics. The journal covers fundamental and translational research in medical imaging, spanning physics, tomographic reconstruction algorithms, computer-aided diagnosis, and more.
Researchers found an association between decreased carbohydrate intake and reduced breast cancer recurrence among women whose tumor tissue is positive for the IGF-1 receptor. The study suggests that personalized diets based on molecular characteristics of primary tumors may be possible, but further research is needed.
A US-based study of 88,803 premenopausal women found a significant association between high red meat intake and increased breast cancer risk. Replacing red meat with a combination of legumes, poultry, nuts, and fish was linked to a lower risk of breast cancer.
Researchers analyzed the impact of mammography on breast cancer rates and found a significant decrease in late-stage diagnoses. The study attributed this decline to successful screening programs, which led to increased detection of early-stage cancers.
Two studies published in PLOS Medicine found a link between moles and increased breast cancer risk. Women with more moles were more likely to develop breast cancer, particularly postmenopausal women. The findings suggest that nevi may be affected by hormone levels, which could be used as a marker for breast cancer risk.
Researchers at MedStar Washington Hospital Center found that African-American women are more likely to be diagnosed with biologically less favorable subtypes of breast cancer. Genomic profiling identified specific molecular subtypes associated with a higher risk of recurrence.
Breast cancer patients often do not meet national physical activity guidelines after diagnosis, with African-American women being less likely to do so. A study found that only 35% of survivors met guidelines post-diagnosis, with a significant decrease in activity six months after diagnosis.
A new molecular breast imaging protocol using a higher dose of Tc-99m filtered sulfur colloid has been shown to improve the detection of advanced breast cancer. Imaging performed the day prior to surgery was more sensitive than imaging on the day of surgery, detecting 76% versus 49% of cases with metastasized lymph nodes.
A new antibody-based molecular imaging agent has been developed to target the HER3 receptor in breast cancer, which may lead to better diagnosis and treatment of high-risk cases. This approach could also help identify patients who would benefit from additional therapies.
A recent MSU study has discovered that many preclinical models of human breast cancer can replicate several key characteristics, particularly at the gene level. The researchers analyzed 1,172 mouse mammary tumor samples from 26 different models and found that most human breast cancers can be represented by one specific strain of mice.
As women age, their breast cells lose responsiveness to their surroundings, leading to increased tumor growth and higher risk of breast cancer. Researchers at Berkeley Lab discovered that multipotent progenitor cells, responsible for maintaining healthy tissue, fail to perceive differentiation cues as they age.
Researchers have identified four new genes that increase familial breast cancer risk, with RINT1 also linked to a broad spectrum of gastrointestinal and gynecological cancers. The study has significantly expanded the panel of genes known to account for increased breast cancer occurrence within families.
A Kaiser Permanente study published in the Journal of Clinical Oncology found that patients with small HER2+ breast cancer tumors (<0.5 cm) had a high survival rate without distant recurrence, even without treatment. For larger tumors (0.6-1 cm), the risk was slightly lower but still remained low.
The American Society of Clinical Oncology recognizes MD Anderson leaders Gabriel Hortobagyi, Waun Ki Hong, and John Mendelsohn for their significant contributions to cancer research. Mendelsohn is known for his discovery of the monoclonal antibody Erbitux, while Hong has made groundbreaking advances in treating head and neck cancers.
Scientists identified a new protein, hnRNPM, that plays a key role in reprogramming breast cancer cells to spread. Removing this protein significantly reduces the ability of breast cancer cells to metastasize to other organs.
The ALTTO trial showed that adding lapatinib to trastuzumab and chemotherapy did not improve patient outcome, while increasing toxicity. Researchers suggest standard adjuvant treatment should remain trastuzumab with chemotherapy for early stage HER2-positive breast cancer.
The number of cancer survivors in the US is expected to grow from 14.5 million to almost 19 million by 2024 due to an aging population and improved treatment outcomes. The majority of cancer survivors were diagnosed five or more years prior, with nearly half aged 70 or older.
Four phase III trials released findings on new chemotherapy regimens and targeted treatments for advanced cancers. The studies confirm the effectiveness of commonly used treatments and provide insights into optimal patient care.
Research identifies new ways to ease cancer therapy effects and enhance patient well-being, from fertility preservation techniques to earlier palliative care. Studies show improved survival rates and reduced side effects for certain treatments.
Researchers found that reducing the frequency of bisphosphonate treatment from monthly to every three months after one year was non-inferior to continuing monthly treatment in terms of efficacy. The study also showed a reduced risk of serious side effects, including kidney-related adverse events.
A new clinical trial found that adding goserelin to chemotherapy regimens for premenopausal women with early-stage breast cancer significantly reduced the risk of early menopause. The study also showed improved overall survival rates and a higher pregnancy rate in the goserelin group.
Myriad Genetics Inc. presented new data on its BRACAnalysis CDx and HRD tests, supporting their clinical efficacy in predicting platinum-based therapy response for triple negative breast cancer patients. The company also announced an early access launch of the HRD test in FY15.
The investigational agent DMOT4039A, a combination of chemotherapeutic agent and antibody, showed initial evidence of anti-cancer activity in a phase I clinical trial for pancreatic and ovarian cancers. The drug targets mesothelin-rich cancer cells, reducing the risk of off-target effects.
A pilot study found that a 12-month self-care program reduced lymphedema risk in 97% of breast cancer survivors by promoting lymph flow and optimizing body mass index (BMI). The Optimal Lymph Flow program empowered patients to take proactive steps, dispelling fear and anxiety.
A large clinical study found that MRI detected invasive breast tumours in female survivors of childhood Hodgkin lymphoma at very early stages. The study highlights the need for breast MRI screening from age 25 or eight years after chest radiation, as recommended by established guidelines.
Researchers used large population-based data to compare six common chemotherapy regimens, identifying those with the highest risk of hospitalization. The study found that TAC and AC+T were associated with high hospitalization rates in younger patients, while all regimens except ddAC+P had higher risks for older patients.
Researchers at IRB Barcelona have identified a new gene, RARRES3, that promotes breast cancer metastasis to the lung. The study reveals that loss of function of this gene enhances adhesion and differentiation in cancer cells, leading to increased malignant capacity.
The University of Houston will bolster its biomedical research capabilities with the recruitment of cancer imaging expert David Mayerich. Mayerich's work focuses on improving diagnosis and treatment through high-performance imaging and modeling of complex tumor structures.
Scientists have identified two genes, MLF2 and RPL39, that may affect the most lethal type of breast cancer. Suppressing these genes can reduce tumor formation and metastasis by interfering with blood vessel formation and recruitment.
Researchers found that calorie restriction decreased microRNA production, which promotes the extracellular matrix and prevents cancer cells from spreading. The study aims to test whether calorie restriction can improve outcomes for women with breast cancer in a clinical trial.
A team at Cold Spring Harbor Laboratory has validated a potentially powerful new approach to treating HER2-positive breast cancer by inhibiting the protein PTP1B. The discovery may lead to improved treatments for the disease, which affects one in four patients and is often resistant to existing therapies.
Researchers at SLU's Institute for Molecular Virology have discovered a small fragment of adenovirus that can repress HER2 cell growth and kill breast cancer cells. The discovery offers a promising new therapy for the deadly disease, which affects 20-30% of breast cancers.
Researchers have found chemical signals that enable breast cancer metastasis by recruiting normal cells from the host animal, providing a promising new direction for cancer treatment. Blocking these signals in mice with breast tumors significantly reduced their ability to spread.
Researchers at Cold Spring Harbor Laboratory have found a means of inhibiting PTP1B, which plays a critical role in the development of tumors in HER2-positive breast cancer. The discovery leads to the inhibition of tumor growth and prevention of metastasis.
A new study from the University of Michigan found that about 70% of women with breast cancer who underwent a double mastectomy had very low risk of developing cancer in their healthy breast. However, many of these women were driven by fear of recurrence rather than medical necessity.
A study of 2,290 women with breast cancer found that while many consider or undergo contralateral prophylactic mastectomy (CPM) to prevent cancer in the other breast, most do not have a clinically significant risk. The procedure is often associated with genetic testing, family history, and higher education.
Scientists at the University of Utah have uncovered the early steps of totipotency in sperm precursors, revealing a four-gene code that enables these cells to become stem cells and mature into various cell types. The discovery sheds light on the process of fertilization and provides insights into cancer and epigenetic regulation.
Women who participated in a 5-week cognitive behavioral training program showed significant improvements in mood, emotional well-being, and stress management skills. The Relaxation Training group also reported reduced disruptions in social activities and increased confidence in using relaxation techniques.
Researchers found that patients with tumor cells in their blood after surgery had a higher risk of relapse and poorer survival rates. The presence and count of tumor cells also predicted disease-free survival, with those having 5 or more CTCs at higher risk of recurrent disease.
Researchers have developed a new X-ray phase-contrast mammography technique that provides high-contrast images of breast tissue. This technique helps distinguish between different types of microcalcifications and can aid in assigning them to malignant lesions, enabling non-invasive detection of premalignant lesions.
Researchers are testing whether therapy incorporating advanced genomic technology will provide better outcomes than current treatments for women with an aggressive form of breast cancer. The trial uses targeted DNA sequencing to identify specific treatment choices that improve survival rates.
Researchers at University Hospitals Cleveland Medical Center presented data showing that the presence of tumor-infiltrating lymphocytes before treatment can predict a positive response to platinum-based therapy in women with triple-negative breast cancer. This discovery could lead to more personalized treatment decisions and improved p...
A recent study found that large panel genetic testing for breast cancer mutations yields limited results, with only 2.5% of patients having clinically actionable mutations. The test revealed reportable variants in over 30% of patients, leaving clinicians struggling to interpret the findings and provide accurate guidance.
A meta-analysis of 44 studies found that breastfeeding, tubal ligation, and oral contraceptives are associated with reduced rates of ovarian cancer in BRCA1 mutation carriers. Smoking may raise the risk of breast cancer for patients with a BRCA2 mutation.
The University of Chicago Medicine Comprehensive Cancer Center has been awarded a five-year, $3.9-million grant to serve as a Lead Academic Participating Site for the National Clinical Trials Network. The new network aims to improve cancer clinical trials' speed and efficiency.
A nationwide dataset analysis found that black women are 1.84 times more likely to be diagnosed with triple-negative breast cancer, a subtype with poorer prognosis. Asian/Pacific Islander women were also more likely to be diagnosed with HER2-overexpressing breast cancer.
Researchers at Hebrew University of Jerusalem found Erbin acts as a brake against excessive heart muscle growth. The protein's damage leads to decreased function and severe growth, which may be targeted for cardiac gene therapy in heart failure and breast cancer patients.
Three NSU professors received patents for their innovative solutions: a novel cancer treatment called JFD that starves tumors, a surface modification technology for ceramic materials in dentistry, and a computer-based system to predict law school admissions. The patents demonstrate NSU's focus on developing novel products and services.
Researchers from the University of Notre Dame have uncovered a novel mechanism by which carcinoma-associated fibroblasts (CAFs) contribute to tumor progression. CAFs block cell death through insulin-like growth factor-binding proteins, highlighting potential therapeutic targets for slowing breast cancer metastasis. Further pre-clinical...
AURORA is a large international molecular screening programme for metastatic breast cancer aiming to improve understanding of the disease and its response to treatments. The study will analyze over 1300 patients' tissue and plasma samples, enabling scientists to identify genetic characteristics that predict treatment outcomes.
A retrospective chart review found that high-risk lesions were predominantly identified in screened patients, enabling the administration of chemoprevention and reducing the risk of subsequent breast cancer development. Supplemental screening MRI may also detect future mammographically occult malignancies in these patients.
The GW Cancer Institute has received a $100,000 grant from the Avon Foundation to support a patient navigator. The patient navigator will help remove barriers and coordinate access to care for over 1,000 patients with breast cancer in the Washington D.C. area.
A new study finds that higher sleep efficiency is associated with lower mortality in women with advanced breast cancer. Mean survival was 68.9 months for efficient sleepers compared to 33.2 months for those with poor sleep efficiency.