Articles tagged with Breast Cancer
A systematic evidence review found daily low-dose aspirin can prevent preeclampsia complications by 24% and preterm birth by 14%, with no identified harms. A new approach to breast cancer research suggests reevaluating mammography screening and focusing on prevention through lifestyle changes.
Researchers found that women who underwent radiotherapy for breast cancer have a small but significantly increased risk of developing a primary lung tumour. The risk increases with the amount of radiation absorbed by the tissue, with an estimated relative risk of 8.5% per delivered Gy to the lung.
In mice, obese fathers pass on their weight and gene expression changes to their daughters, increasing the risk of obesity and breast cancer later in life. This study provides evidence for a potential paternal link to cancer risk, challenging traditional research focus on maternal influences.
Researchers at UPMC Cancer Institute discover plant-derived compounds that selectively target breast cancer cells, inhibiting growth and inducing death. These findings offer potential new approaches to preventing and fighting breast cancer.
Researchers discovered two new genes, NEIL2 and OGG1, that modulate the risk of breast and ovarian cancer in women with high-risk mutations. The genes affect an alternative DNA repair pathway and may have implications for treatments like PARP inhibitors.
A study published in Cell Reports found that 90% of osteosarcomas, the most common childhood bone tumor, have mutations in the TP53 gene. This alteration helps explain why standard doses of radiation therapy are largely ineffective against these tumors.
Sanford-Burnham will present various cancer research findings at the AACR annual meeting, including novel methods of drug delivery and novel targets for breast, melanoma, and prostate cancers. Researchers will also discuss epigenetic mechanisms and cancer metastasis.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that women who took clomiphene citrate or gonadotropins for fertility treatment did not have an increased risk of breast cancer over 30 years. However, a small number of women had a higher risk after multiple cycles of these medications.
A landmark study found pathological complete response after neoadjuvant chemotherapy to be an independent predictor of favorable clinical outcomes in all molecular subtypes of breast cancer. The treatment administered, taxane or non-taxane, was also shown to impact event-free survival.
A comprehensive review suggests that mammography screening benefits are often exaggerated while harms are understated. The study's findings emphasize the need for individualized approach to breast cancer screening based on clinical factors and personal preferences.
A new study found that full-field digital mammography (FFDM) is associated with lower recall and biopsy rates than screen film mammography (SFM), reducing the number of unnecessary diagnostic workups. FFDM implementation led to lower false positive screening exams and fewer biopsies with benign outcomes.
A review of scientific literature suggests that routine mammograms for women over 75 may not be beneficial and could lead to unnecessary treatment. The authors conclude that doctors should consider life expectancy when making screening decisions for this age group.
Researchers identify two distinct types of cells responsible for different breast cancer subtypes, shedding light on the origins of breast cancer diversity. This breakthrough discovery has the potential to revolutionize personalized treatment for patients, reducing unnecessary treatments and improving outcomes.
Researchers developed a predictive tool that analyzes gene expression changes to predict patient survival. The tool, based on mouse studies, has shown promise in predicting treatment risk for early-stage breast cancer and certain lung cancers.
A new study found that adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors, including p16INK4a and ARF expression. These age-promoting effects may last for several years after treatment and even be permanent.
Researchers at Queen's University Belfast have discovered a link between high levels of oestrogen and DNA damage in breasts and ovaries, driving cancer in women with the BRCA1 mutation. This breakthrough could lead to alternative treatments to surgery, such as drugs that chemically reduce oestrogen production.
A faster and cheaper DNA sequencing technique, NGS, will improve care for patients with breast cancer by providing genetic mutation results before treatment begins. This may lead to more women opting for mastectomy instead of breast-conserving surgery, highlighting the need for close monitoring of at-risk patients.
UCSF researchers found that breast tissue stiffening in cancer development leads to tumor progression, triggering the production of a molecule associated with worse clinical outcomes. The discovery may lead to more accurate prognosis and new treatment strategies targeting structural changes in breast cancers.
Researchers discovered that breast cancer tumors can hijack patients' repressive gene regulatory machinery, permanently blocking cancer-killing genes. This allows the cancer to continue growing despite treatment with aromatase inhibitors, which block estrogen synthesis.
A Texas A&M AgriLife Research study found that peach extract inhibits breast cancer metastasis in mice by targeting metalloproteinases. Consuming two to three peaches per day may provide similar benefits for humans, according to the study published in the Journal of Nutritional Biochemistry.
A study by University of Michigan Comprehensive Cancer Center researchers found that 25% of breast cancer survivors reported financial decline after treatment. Racial disparities were also noted, with Spanish-speaking Latinas and Blacks being more likely to experience financial hardships.
A recent study published in Applied and Environmental Microbiology has identified a distinct population of microbes in the breast tissue, with Proteobacteria being the dominant phylum. The presence of beneficial bacteria like Lactobacillus and Bifidobacteria suggests a potential protective effect for both mother and child.
A new treatment option for metastatic breast cancer patients with liver metastases shows promise in slowing disease progression and improving quality of life. Yttrium-90 radioembolization was safe and provided disease stabilization in 98.5% of treated liver tumors, with many experiencing significant tumor shrinkage.
Researchers at Dartmouth's Norris Cotton Cancer Center have compiled a review of genetic-based testing in breast cancer diagnosis and treatment. Genomic testing enables personalized therapy, increasing precision and success rates for patients.
A gene previously unassociated with breast cancer plays a pivotal role in the growth and progression of triple negative breast cancer, a particularly deadly strain. Targeting XBP1 may offer a new approach to treating this disease.
A UK study found that approximately one third of women are at higher risk of developing breast cancer and may require more frequent mammograms. Women with dense breast tissue were 2.9-fold more likely to develop breast cancer, highlighting the importance of personalized screening frequency.
Research from The Netherlands found that extending national breast cancer screening programs to women aged 70 and over does not decrease advanced stage cancer detection, but rather increases early-stage tumors. This leads to a large proportion of women being over-treated and at risk from the harmful effects of treatment.
Breast cancer mortality rates in Europe have decreased from 1989 to 2010 due to improved treatments and enhanced access to care. However, notable variations between countries remain, with France showing a modest decrease despite devoting substantial resources to cancer care.
A meta-analysis of 37 studies found that regular physical activity reduces breast cancer risk by 12% compared to the least active women. The protective effect of exercise seems to be cancelled out in women taking hormone replacement therapy, but this trend may change as HRT use decreases.
Research finds that obese patients have a higher risk of cancer recurrence and metastasis after neoadjuvant chemotherapy. Diabetes also affects cancer outcomes, particularly in hormone receptor-positive tumours, increasing the risk of death from all causes by 49%.
A new study suggests that breast cancer patients require additional psychological support, particularly regarding concerns about their children. The research highlights the importance of addressing these worries to improve overall quality of life and rehabilitation outcomes.
Researchers have identified genetic markers that can predict late recurrence of ER+ breast cancer, allowing for personalized treatment decisions. Women with tumours highly sensitive to oestrogen may benefit from extended hormone therapy beyond five years.
New research finds that radiotherapy after mastectomy reduces recurrence and death rates for women with early breast cancer in 1-3 positive lymph nodes. The study, which analyzed data from 3786 women, shows a significant benefit of radiotherapy regardless of chemotherapy or hormonal therapy use.
Breast cancer is a significant global health issue, with over 1.6 million new cases diagnosed annually. The disease disproportionately affects low-income countries, where late-stage diagnosis and limited treatment options contribute to high mortality rates.
Researchers have discovered a feedback loop between IL-6 and microRNA-34a that promotes tumor cell mobility and metastasis. The loop involves the activation of STAT3, which represses miR-34a production and leads to increased tumor-promoting proteins.
Researchers have developed a new technology that uses 'nano-flares' to detect metastatic breast cancer cells in blood samples, which could lead to earlier diagnosis and improved treatment options. The technology has shown promising results in animal tests and is currently being experimented with human samples.
Using big data analytics, researchers can predict the type of breast, lung, or oropharyngeal cancers with high accuracy. This technology may enable doctors to use MRI scans to diagnose more aggressive cancers earlier, leading to faster treatment options and improved patient outcomes.
A new clinical test called NPI+ has been developed to improve breast cancer treatment by providing more detailed information about a patient's cancer type and behavior. This will help clinicians create a more personalized treatment plan, leading to improved outcomes and reduced costs.
Researchers at St. Michael's Hospital found that ultrasound-guided paravertebral blocks improved pain relief, reduced recovery room time, and enabled earlier discharge for breast cancer patients compared to general anesthesia. The study's lead author notes the benefits of this technique will also apply to cosmetic breast surgeries.
A team of scientists created wearable technology that helps surgeons visualize cancer cells by making them glow blue, reducing the need for follow-up surgeries and associated costs. The innovation uses a custom video display, head-mounted device, and targeted molecular agent to distinguish cancer cells from healthy tissue.
Breast cancer patients with high vitamin D levels are twice as likely to survive the disease. Vitamin D receptors prevent tumor growth and expansion, leading to better survival rates in patients with high serum levels.
A new study led by the University of South Florida found that molecular subtyping can better identify women at high risk of recurrence. The method classifies breast cancer tumors into four genetically-distinct categories, providing valuable information for personalized treatment decisions.
The University of Texas Medical Branch (UTMB) has received $3.2 million from the Cancer Prevention and Research Institute of Texas (CPRIT) to continue its collaborative cancer research program in Texas. CERCIT researchers are studying cancer treatment outcomes, access to care, and patient survival rates.
A study at Tufts University has identified the gene TAZ as a critical regulator of breast cell development and cancer. The research team found that TAZ helps to control whether breast cells behave like basal or luminal cells, which is important in understanding and treating certain types of aggressive breast cancer.
Researchers at UT Arlington found that exposure to BPA can increase HOTAIR expression in breast tissue and tumor cells, potentially contributing to breast cancer growth. The study's results suggest a link between BPA and tumor genesis in addition to tumor growth.
Research finds that chemotherapy induces epigenetic changes in breast cancer patients' blood cells, leading to inflammation and symptoms like fatigue. The study identifies eight sites of methylation altered by chemotherapy, correlating with increased inflammatory signaling proteins.
A new study from Aarhus University suggests that screening for breast cancer primarily detects indolent cancer cases, which would otherwise have been fatal. Despite detecting more early-stage cases, the number of advanced stages has remained virtually unchanged.
Research published in the Journal of Clinical Investigation reveals that DLC1 suppresses breast cancer bone metastasis by inhibiting PTHLH production and regulating TGF-\u00b1 signaling. Clinical samples also show a correlation between reduced DLC1, elevated PTHLH, and bone metastasis.
Researchers developed a comprehensive measurement method to visualize tumor cells and their interactions, providing insights into the heterogeneity of tumors. The new technique can simultaneously record 32 biomarkers and has the potential to pinpoint weak points in the control system, leading to more effective therapeutic approaches.
Women with breast cancer who practiced yoga during radiation therapy experienced improved ability to engage in daily activities, better general health, and regulation of cortisol levels. Yoga also helped find meaning in the illness experience, which declined over time for women in other groups.
Breast cancer cells with low myoferlin levels are less likely to spread when the gene is silenced, according to a new study. The protein's effect on mechanical properties and gene activation also influences cancer cell behavior.
A study by Nadia Obi found that older women with higher BMI or those who received trastuzumab had an increased risk for hypertension, while low-weight patients were more likely to develop osteoporosis. Regular exercise and monitoring are recommended to prevent these conditions.
A large international study found that women with BRCA1 mutations who underwent preventive ovarian surgery before age 35 had a 77% reduction in total mortality risk. In contrast, women with BRCA2 mutations may delay this procedure until their 40s.
A randomized controlled trial found that cognitive behavioral therapy plus hypnosis significantly reduced fatigue in breast cancer patients during and after radiotherapy. The treatment group had less fatigue than 79% of control group patients at the end of radiotherapy, with benefits persisting for up to six months.
A study found that breast reconstruction rates have increased significantly since 1998, with a six-fold increase in bilateral mastectomies and three-quarters of women receiving reconstruction. However, radiation therapy is less likely to be followed by reconstruction, raising concerns about the impact on patient outcomes.
A study from Michigan Medicine and Georgia Regents University identified a protein that increases cancer stem cells in triple-negative breast cancer. The researchers found that blocking this inflammatory pathway with the drug bortezomib may reduce cancer stem cells and improve patient outcomes.
A study found tamoxifen, a breast cancer treatment, in three out of four samples of the bodybuilding supplement Esto Suppress. The product label suggested a dosage that may provide enough to treat gynaecomastia. Off-the-shelf supplements have been known to contain pharmacologically active substances, posing risks to users.
Researchers identified a key biological mechanism explaining why women with dense breast tissue are at greater risk of developing breast cancer. The study found that the JNK1 signaling pathway is activated to a greater extent in fibroblasts from high-density breast tissue, creating an inflammatory environment that drives tumor formation.
A new UK study found that targeting Twist, a nuclear protein accelerating epithelial-mesenchymal transition, may provide an effective approach for treating triple-negative breast cancer. The study showed that disrupting the interaction of Twist with BRD4 inhibited invasion and tumorigenicity in triple-negative breast cancer cells.
Researchers at UNC Lineberger Comprehensive Cancer Center found that bladder cancer subtypes are genetically similar to breast cancer subtypes. The study revealed two distinct genetic subtypes of invasive bladder cancer, basal-like and luminal, which share genetic similarities with breast cancer subtypes.