Articles tagged with Breast Cancer
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A new study suggests that breast cancer patients require additional psychological support, particularly regarding concerns about their children. The research highlights the importance of addressing these worries to improve overall quality of life and rehabilitation outcomes.
Researchers have identified genetic markers that can predict late recurrence of ER+ breast cancer, allowing for personalized treatment decisions. Women with tumours highly sensitive to oestrogen may benefit from extended hormone therapy beyond five years.
New research finds that radiotherapy after mastectomy reduces recurrence and death rates for women with early breast cancer in 1-3 positive lymph nodes. The study, which analyzed data from 3786 women, shows a significant benefit of radiotherapy regardless of chemotherapy or hormonal therapy use.
Breast cancer is a significant global health issue, with over 1.6 million new cases diagnosed annually. The disease disproportionately affects low-income countries, where late-stage diagnosis and limited treatment options contribute to high mortality rates.
Researchers have discovered a feedback loop between IL-6 and microRNA-34a that promotes tumor cell mobility and metastasis. The loop involves the activation of STAT3, which represses miR-34a production and leads to increased tumor-promoting proteins.
Researchers have developed a new technology that uses 'nano-flares' to detect metastatic breast cancer cells in blood samples, which could lead to earlier diagnosis and improved treatment options. The technology has shown promising results in animal tests and is currently being experimented with human samples.
Using big data analytics, researchers can predict the type of breast, lung, or oropharyngeal cancers with high accuracy. This technology may enable doctors to use MRI scans to diagnose more aggressive cancers earlier, leading to faster treatment options and improved patient outcomes.
A new clinical test called NPI+ has been developed to improve breast cancer treatment by providing more detailed information about a patient's cancer type and behavior. This will help clinicians create a more personalized treatment plan, leading to improved outcomes and reduced costs.
Researchers at St. Michael's Hospital found that ultrasound-guided paravertebral blocks improved pain relief, reduced recovery room time, and enabled earlier discharge for breast cancer patients compared to general anesthesia. The study's lead author notes the benefits of this technique will also apply to cosmetic breast surgeries.
A team of scientists created wearable technology that helps surgeons visualize cancer cells by making them glow blue, reducing the need for follow-up surgeries and associated costs. The innovation uses a custom video display, head-mounted device, and targeted molecular agent to distinguish cancer cells from healthy tissue.
Breast cancer patients with high vitamin D levels are twice as likely to survive the disease. Vitamin D receptors prevent tumor growth and expansion, leading to better survival rates in patients with high serum levels.
A new study led by the University of South Florida found that molecular subtyping can better identify women at high risk of recurrence. The method classifies breast cancer tumors into four genetically-distinct categories, providing valuable information for personalized treatment decisions.
The University of Texas Medical Branch (UTMB) has received $3.2 million from the Cancer Prevention and Research Institute of Texas (CPRIT) to continue its collaborative cancer research program in Texas. CERCIT researchers are studying cancer treatment outcomes, access to care, and patient survival rates.
A study at Tufts University has identified the gene TAZ as a critical regulator of breast cell development and cancer. The research team found that TAZ helps to control whether breast cells behave like basal or luminal cells, which is important in understanding and treating certain types of aggressive breast cancer.
Researchers at UT Arlington found that exposure to BPA can increase HOTAIR expression in breast tissue and tumor cells, potentially contributing to breast cancer growth. The study's results suggest a link between BPA and tumor genesis in addition to tumor growth.
Research finds that chemotherapy induces epigenetic changes in breast cancer patients' blood cells, leading to inflammation and symptoms like fatigue. The study identifies eight sites of methylation altered by chemotherapy, correlating with increased inflammatory signaling proteins.
A new study from Aarhus University suggests that screening for breast cancer primarily detects indolent cancer cases, which would otherwise have been fatal. Despite detecting more early-stage cases, the number of advanced stages has remained virtually unchanged.
Research published in the Journal of Clinical Investigation reveals that DLC1 suppresses breast cancer bone metastasis by inhibiting PTHLH production and regulating TGF-\u00b1 signaling. Clinical samples also show a correlation between reduced DLC1, elevated PTHLH, and bone metastasis.
Researchers developed a comprehensive measurement method to visualize tumor cells and their interactions, providing insights into the heterogeneity of tumors. The new technique can simultaneously record 32 biomarkers and has the potential to pinpoint weak points in the control system, leading to more effective therapeutic approaches.
Women with breast cancer who practiced yoga during radiation therapy experienced improved ability to engage in daily activities, better general health, and regulation of cortisol levels. Yoga also helped find meaning in the illness experience, which declined over time for women in other groups.
Breast cancer cells with low myoferlin levels are less likely to spread when the gene is silenced, according to a new study. The protein's effect on mechanical properties and gene activation also influences cancer cell behavior.
A study by Nadia Obi found that older women with higher BMI or those who received trastuzumab had an increased risk for hypertension, while low-weight patients were more likely to develop osteoporosis. Regular exercise and monitoring are recommended to prevent these conditions.
A large international study found that women with BRCA1 mutations who underwent preventive ovarian surgery before age 35 had a 77% reduction in total mortality risk. In contrast, women with BRCA2 mutations may delay this procedure until their 40s.
A randomized controlled trial found that cognitive behavioral therapy plus hypnosis significantly reduced fatigue in breast cancer patients during and after radiotherapy. The treatment group had less fatigue than 79% of control group patients at the end of radiotherapy, with benefits persisting for up to six months.
A study found that breast reconstruction rates have increased significantly since 1998, with a six-fold increase in bilateral mastectomies and three-quarters of women receiving reconstruction. However, radiation therapy is less likely to be followed by reconstruction, raising concerns about the impact on patient outcomes.
A study from Michigan Medicine and Georgia Regents University identified a protein that increases cancer stem cells in triple-negative breast cancer. The researchers found that blocking this inflammatory pathway with the drug bortezomib may reduce cancer stem cells and improve patient outcomes.
A study found tamoxifen, a breast cancer treatment, in three out of four samples of the bodybuilding supplement Esto Suppress. The product label suggested a dosage that may provide enough to treat gynaecomastia. Off-the-shelf supplements have been known to contain pharmacologically active substances, posing risks to users.
Researchers identified a key biological mechanism explaining why women with dense breast tissue are at greater risk of developing breast cancer. The study found that the JNK1 signaling pathway is activated to a greater extent in fibroblasts from high-density breast tissue, creating an inflammatory environment that drives tumor formation.
A new UK study found that targeting Twist, a nuclear protein accelerating epithelial-mesenchymal transition, may provide an effective approach for treating triple-negative breast cancer. The study showed that disrupting the interaction of Twist with BRD4 inhibited invasion and tumorigenicity in triple-negative breast cancer cells.
Researchers at UNC Lineberger Comprehensive Cancer Center found that bladder cancer subtypes are genetically similar to breast cancer subtypes. The study revealed two distinct genetic subtypes of invasive bladder cancer, basal-like and luminal, which share genetic similarities with breast cancer subtypes.
A recent study suggests that women with a BRCA gene mutation who undergo a double mastectomy have a significantly lower risk of death from breast cancer, with an estimated 48% reduction in mortality. This finding has implications for the treatment options available to young women with early-stage breast cancer and BRCA mutations.
A new study has strengthened the link between alcohol consumption and breast cancer development. Researchers found that a particular enzyme, CYP2E1, plays a role in controlling the growth of breast cancer cells.
A Canadian study of 89,000 women aged 40-59 found that annual breast screening did not reduce mortality from breast cancer beyond physical examination or usual care. The study also revealed that 22% of screen-detected cancers were over-diagnosed, with one over-diagnosed cancer for every 424 women screened.
A recent study published in Cancer journal found that smoking is significantly linked with an increased risk of estrogen receptor positive breast cancer among young women. Young women who have smoked a pack a day for 10 years or more experience a 60% higher risk of developing this type of breast cancer.
A TGen study has uncovered possible genetic origins of breast cancer that spreads to the brain, providing potential new methods of diagnosis and treatment. The study identified common genetic alterations linked to key mechanisms of cancer, such as cell proliferation and cell-cycle progression.
The new guideline aims to reduce unnecessary re-excision rates by identifying optimal margin widths that minimize ipsilateral breast tumor recurrence. Wider margin widths do not significantly lower the risk, and the choice of radiation technique should not depend on margin width.
A large-scale study of whole-genome testing has identified a unique treatment approach for women with advanced breast cancer, targeting genomic alterations in their tumors. The study found that around half of patients had targetable genomic alterations, and 39% had rare alterations, many of which no treatments currently exist.
Researchers at Clemson University are developing a new method of studying breast cancer cells by building 3D structures that mimic the complex behavior of cancer cells in human tissue. The 3D structures allow for the testing of various treatments and can be customized to represent different stages of cancer.
A new photon-counting technique improves cancer detection rates in digital mammography screening, particularly for ductal carcinoma in situ. The method reduces scattered radiation and noise, enabling lower doses and improved outcomes.
Scientists at the University of Veterinary Medicine in Vienna have created a model to investigate the role of STAT1 in various disease conditions. The genetically modified mice can produce an exact dose of protein, enabling researchers to examine the origins and course of many diseases.
A study led by UCSF breast cancer expert Laura J. Esserman recommends biennial mammography screening for women aged 50-74 to save $4.3 billion in healthcare costs. This approach is equally effective as annual screening while reducing false positive results and improving women's well-being.
Researchers have discovered a potential cure for triple negative breast cancer using a vaccinia virus engineered to make cancer cells produce radioiodine. The discovery, published in The FASEB Journal, has shown promising results in laboratory experiments and offers new hope for treating deadly and resistant forms of cancer.
A study published in Cancer Prevention Research found that atypical ductal hyperplasia and atypical lobular hyperplasia have similar potential to develop into breast cancer. The study followed over 700 women with biopsy-confirmed atypia for an average of 12.5 years, finding that the ratio of breast cancer development was the same in bo...
Researchers at UNC School of Medicine have developed a new ultrasound imaging technique that can visualize tumors using a contrast agent composed of tiny bubbles paired with an antibody. This method improves resolution and tumor-detecting ability, potentially leading to lower costs and increased accessibility for cancer treatment.
A study found that routine screening mammography in women aged 40-49 leads to earlier diagnosis of smaller tumors and reduced chemotherapy use. The researchers concluded that annual screenings starting at age 40 saves lives by identifying breast cancers in initial stages.
Researchers have identified 32 genes with recurring defects in muscle-invasive bladder cancer, offering a roadmap for targeted treatments. The study also found frequent alterations in chromatin regulation and viral DNA involvement in bladder cancer development.
A study published in PLOS ONE found that melatonin may inhibit tumor growth and cell production, as well as block the formation of new blood vessels in ER-negative breast cancer models. The results suggest that melatonin has the potential as a therapeutic agent for breast cancer.
New research from Berkeley Lab and the National Runners' and Walkers' Health Study found that runners had a significantly lower risk of breast cancer mortality compared to walkers. Exceeding current exercise recommendations may provide greater protection, with runners experiencing a 40% reduction in risk per MET hour.
Researchers found that SGLT2 inhibitors improved muscle insulin sensitivity and lowered fasting plasma glucose levels in type 2 diabetes patients. However, the use of these inhibitors also resulted in an increase in endogenous glucose production and decreased insulin secretion.
Researchers at the University of Toronto have developed a method to assemble gold nanoparticles using DNA as a vehicle to deliver cancer medications or markers directly into cancerous tumors. The particles can be precisely engineered to target specific tumor types and stages.
Practicing yoga for three months can significantly reduce fatigue and lower inflammation in breast cancer survivors, according to new research. The study found that women who practiced yoga experienced a 57% reduction in fatigue and up to 20% lower inflammation compared to those who did not practice yoga.
Researchers discovered that breast stem cells and their 'daughters' have a much longer lifespan than previously thought, actively maintaining breast tissue throughout life. This finding has implications for identifying the cells of origin of breast cancers and developing new treatment strategies.
Researchers at Cardiff University have identified a compound that potently inhibits Bcl3 and completely halts the spread of metastatic tumors in mice. The development aims to create a therapeutic agent capable of blocking metastatic disease in breast cancer and various tumor types.
Researchers have made refinements to a technique combining MRI and near-infrared spectroscopy (NIRS) to improve image quality and accuracy in detecting breast cancer. The new design allows for increased coverage of the chest, providing improved visibility for 'hard-to-see' areas, and has shown promising results in clinical trials.
A study suggests that moderate doses of radiation therapy to the unaffected breast can kill premalignant cells and reduce the risk of second breast cancers. The treatment could prevent tens of thousands of cases, according to researchers at Columbia University Irving Medical Center.
The University of South Florida and FORCE have received a PCORI award to expand a health data network for hereditary breast and ovarian cancer research. The ABOUT Network will collect comprehensive clinical data, engage patients, and advance patient-centered studies.
Researchers developed a mathematical model to predict how tumors will behave and which treatments are most effective, focusing on genetic diversity within tumors. The study found that tumors with less genetic diversity are more likely to respond to treatment, providing new insights into personalized cancer care.
Researchers developed a tool to predict which direction a breast cancer tumor is most likely to go and how it will respond to chemotherapy. The study's findings reveal general rules, including genetic diversity within tumors and the importance of analyzing individual cells.
The Jackson Laboratory will receive a five-year, $7.5 million grant to develop new mouse models and tumor repository for cancer genomics research. The collaboration with Seoul National University aims to advance individualized cancer diagnosis and treatment.
A new study by University of Kentucky researchers identified four key barriers to cancer screening in Appalachian women, including embarrassment about Pap tests and lack of health insurance. These barriers contribute to higher mortality rates for invasive cervical cancer in the region, with a 67% increase compared to national averages.