Articles tagged with Breast Cancer
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Research suggests that automated breast density measurement can predict breast cancer risk in younger women, with changes in breast density over time playing a significant role. Women under 50 are at high risk for density-associated breast cancer, and earlier mammogram screenings may be beneficial for those with denser breasts.
A large screening study found that 3D mammography increased breast cancer detection by 22% and reduced recall rates. The technology improved the accuracy of suspicious findings, leading to a 46% increase in positive predictive value.
A new receptor, similar to those for endorphins or morphine, has been discovered to play a crucial role in the body's response to sepsis. Blocking this receptor may help reduce inflammation and improve outcomes for critically ill patients suffering from sepsis.
Digital breast tomosynthesis (DBT) led to reduced recall rates and an increase in cancer detection compared to digital mammography. The study found that DBT decreased the average recall rate by 1.62% and increased the cancer detection rate by 21.5%.
A special issue of the Journal of the American College of Radiology addresses imaging-based screening and radiology's role in preventive medicine. The issue explores breast density legislation, digital breast tomosynthesis, lung cancer screening, and CT colonography reimbursement, highlighting both benefits and controversies.
A computer algorithm predicts breast cancer type with 93% accuracy by identifying three genes involved in estrogen signaling. The technique has the potential to replace traditional lab tests, potentially becoming more affordable and accessible in the future.
Researchers found that high cholesterol's metabolite, 27HC, mimics estrogen to drive breast cancer growth. Statins appear to reduce this effect, suggesting a link between dietary changes and breast cancer prevention. Human breast tumors express the enzyme making 27HC, which can promote tumor growth.
Researchers at MD Anderson Cancer Center have identified USP13, an enzyme that stabilizes the tumor-suppressor protein PTEN, preventing its destruction by the cell's proteasome machinery. This discovery provides a new avenue for treating cancers with low levels of PTEN.
Research suggests that women who test negative for BRCA2 mutations but have a family history are still at higher risk of developing breast cancer, with a fourfold increased risk compared to the general population. The study found that genetic factors other than BRCA-related genes may contribute to this increased risk.
A high-fat diet starting at puberty accelerates breast cancer development and alters immune cells, leading to precancerous lesions. This type of diet may also produce a distinct gene signature consistent with basal-like breast cancers, which have a worse prognosis.
Researchers at UNC School of Medicine have identified Engrailed 1 as a protein overexpressed in basal-like carcinomas, which can lead to chemotherapy resistance. A synthetic peptide designed by Adriana Beltran and colleagues can disrupt Engrailed 1's function, causing rapid cell death.
Researchers identified epigenetic alterations associated with the aging process in disease-free breast tissues, which are further altered in breast tumors. These changes may contribute to the development of breast cancer by increasing cancer risk.
A new study by MU researchers recommends that women on hormone replacement therapy with progestin avoid ingesting pure apigenin as a supplement. Apigenin, found in celery and other plants, can increase the incidence of breast cancer tumors when combined with synthetic hormones.
A large national study found that breast MRI screenings nearly tripled from 2005 to 2009, with a notable increase in high-risk women. Despite this progress, the study highlights areas for improvement in the use of breast MRI for risk-based screening.
A recent study published in Breast Cancer Research and Treatment found obesity to be a major risk factor for developing basal-like breast cancer in women. Researchers at the University of North Carolina discovered that obesity alters the cellular microenvironment of mammary glands, promoting the growth of basal-like tumors.
Two studies on breast MRI usage found a significant increase in its use for diagnostic evaluations and screenings, particularly among high-risk women. The studies also revealed disparities in the use of breast MRI, with some groups receiving more frequent screening than others.
Researchers discovered mutations in immunity genes in every breast cancer analyzed, suggesting an important role of immune system mutations in breast cancer development. The study's findings could lead to targeted prevention and therapy using vaccines or antiviral drugs.
Researchers at Houston Methodist have developed a technology that can detect breast cancer biomarkers in blood samples, potentially leading to early diagnosis. The technology uses carboxypeptidase N enzyme to separate and detect peptides created by the enzyme in blood serum proteins.
A new USC study found that the protein Lkb1 promotes orderly skeletal growth and prevents skeletal tumors by controlling the progression of immature cartilage cells. This discovery sheds light on how this protein helps keep people organized, with implications for understanding human diseases such as cancer and diabetes.
Researchers found that simple compression bandages are as effective as expensive daily lymphatic massages in treating breast cancer-related arm swelling, known as lymphedema. The study followed over 100 women with breast cancer and found no difference between the two treatments.
Researchers at NYU College of Nursing have developed a new method to detect breast cancer-related lymphedema using Bioelectrical Impedance Analysis (BIA) ratios. The study found that BIA ratios can accurately identify lymphedema in breast cancer survivors, allowing for earlier treatment and better outcomes.
Researchers found that modulating the hormonal environment makes endometrial cancers more sensitive to PARP inhibitors. In high estrogen environments, tumors did not respond to the therapy due to increased DNA repair capabilities.
Researchers found that women with fewer financial resources are more likely to delay seeking medical attention for breast abnormalities, leading to potential delays in diagnosis and treatment. The study suggests that reducing copays and other 'hidden' costs may improve timeliness of diagnosis in this population.
A new '1-stop' radiotherapy technique has shown non-inferiority to traditional treatment in reducing breast cancer recurrence. The TARGIT trial found a single dose of targeted radiation during or soon after surgery reduced local recurrence risk by 80% compared to standard radiotherapy.
Researchers at UT Southwestern have found that a cholesterol metabolite called 27-hydroxycholesterol promotes tumor growth in estrogen-receptor positive breast cancers. The discovery may explain why endocrine-based therapies are often unsuccessful, providing a new target for therapy.
The EORTC study found that baseline recorded health-related quality of life parameters provided additional prognostic information for survival in eleven types of cancer, including brain, breast, and colorectal cancers. The specific health-related quality of life parameters found to be predictive for survival varied by cancer site.
Researchers have developed an algorithmic approach to analyzing breast cancer screening data, enabling more precise detection of malignant tumors. The machine learning method reduces false positives and unnecessary interventions, improving patient outcomes.
A study found that six patients with estrogen receptor-positive breast cancer developed mutations in the estrogen receptor after taking anti-estrogen therapies, leading to treatment resistance. The discovery sheds light on why patients become resistant to hormonal therapy and offers new insights into developing targeted treatments.
Researchers are developing computer-aided diagnosis methods for mammograms, ultrasounds, and MRIs to identify specific tumor characteristics. This technique may also help identify genes that influence the risk of disease.
A new study found that obesity is the largest predictor of earlier onset puberty in girls, with white girls experiencing breast development at a median age of 9.7 years. The study suggests that greater obesity may be the cause of this phenomenon, highlighting potential psychosocial and biologic outcomes for affected girls.
A new study found that pregnant rats exposed to an obesity-linked hormone during pregnancy lost their reduced breast cancer risk after birth. Researchers believe this may be related to gene changes in healthy breast cells.
A study of 48 patients found higher coronary risks associated with left-sided radiation and supine body position. Targeting baseline cardiac risk factors may reduce radiotherapy-induced heart disease risks.
A new study found that women experiencing breast cancer often experience positive outcomes, including enhanced interpersonal relationships, increased appreciation for life, and greater spirituality. Increased social support was also linked to more post-traumatic growth in these women.
Researchers identified a link between rare RINT1 gene variants and increased risk of early onset breast cancer. The study found that these variants may also predispose individuals to other types of tumors, highlighting the potential for RINT1 to play a broader role in cancer susceptibility.
McGill University has made its online game Phylo available globally to connect thousands of scientists with hundreds of thousands of gamer-citizens scientists. Players have already contributed over 4,000 puzzle solutions based on genomic data.
Researchers used a genomic sequencing approach to evaluate all 24 genes implicated in breast cancer in women with normal BRCA genes. The study found that over 25% of these patients carried cancer-predisposing mutations in genes other than BRCA1 or BRCA2.
Researchers at the University of Twente in the Netherlands have developed a new imaging tool called the photoacoustic mammoscope, which uses a combination of infrared light and ultrasound to create a 3-D map of the breast. The device has shown promise in detecting breast cancer early, when it is most treatable.
Researchers have developed a new Trojan-horse approach using stealth nanoparticles to sneak into tumor cells, lower their defenses and attack them with drugs. The nanoparticles showed significantly enhanced therapeutic effects and shrunk tumors by 8-fold in mice, offering a potential strategy to treat aggressive breast cancer.
A simple blood test detecting epigenetic alterations may reveal the earliest signs of pancreatic cancer, a disease with nearly always fatal outcomes. The test's sensitivity and specificity are 97% and 85%, respectively, offering a promising step towards reducing mortality from this cancer.
A study by researchers from the Mount Sinai Hospital found that nearly 80% of women who contacted a patient assistance program had their needs met, compared to just 35% of those who did not. Most patients utilized programs for information about adjuvant therapies, psychosocial support, and overcoming practical/financial obstacles.
A phase I clinical trial of the investigational PARP inhibitor BMN 673 has demonstrated high objective and clinical benefit response rates in patients with BRCA-related breast and ovarian cancers. The treatment showed significant efficacy, with 44% of patients experiencing an objective response and 72% having clinical benefit.
Novartis' LEE011 has demonstrated robust antitumor activity in preclinical trials, particularly when combined with other targeted therapies. The small-molecule inhibitor of cyclin-dependent kinases (CDK) 4/6 shows promise in treating melanoma and breast cancer resistant to BRAF and PIK3CA inhibitors.
A study by UCL researchers found that abnormal levels of female hormones are a possible explanation for why women with BRCA1/2 mutations develop breast and ovarian cancer. The research suggests that targeting these hormones could lead to new ways of preventing cancers in high-risk women.
Researchers discovered 127 genes that appear to drive the development of a range of tumors in the body across 12 major cancer types. The study found common links among genes in different cancers, as well as mutations exclusive to particular cancer types.
A new optical imaging technique can accurately differentiate between breast cancer subtypes and detect responses to treatment as early as two days after therapy administration. The technique, known as optical metabolic imaging (OMI), measures the metabolic activity in cancer cells and generates distinct signatures for different types o...
Researchers at Thomas Jefferson University found that an HDL receptor in breast cancer cells may be responsible for the increased risk and aggressiveness of breast cancer. Blocking this receptor could help treat the disease, according to Dr. Philippe Frank.
A study of postmenopausal women found that taking multivitamin/mineral supplements reduced the risk of dying from invasive breast cancer by 30%. The association persisted even after controlling for other factors, suggesting a potential cause-and-effect relationship.
A major study has disproven the theory of a viral cause for breast cancer and glioblastoma, with over seven billion DNA sequences analyzed. The research found no genetic traces of viruses in these forms of cancer, contradicting previous theories suggesting Epstein-Barr virus and cytomegalovirus involvement.
A new diagnostic test for detecting BRCA1 and BRCA2 mutations has been developed using second-generation sequencing technology. The test is as sensitive as standard methodology but has the potential to improve efficiency and productivity in genetic testing laboratories.
Contralateral prophylactic mastectomy (CPM) may not significantly increase life expectancy for women with early-stage breast cancer in one breast. A new decision-making model helps women weigh the benefits of CPM against its risks and potential impact on survival.
A Mayo Clinic-led study found that a less-invasive procedure called sentinel lymph node surgery successfully identified whether cancer remained in lymph nodes in 91% of patients with node-positive breast cancer who received chemotherapy before their surgery. The procedure removed only a few lymph nodes, reducing surgical complications.
Researchers have developed a technique for injecting therapeutics into the nipple to target breast cancer in its most common origin. This method could reduce side effects and enhance effective drug levels, making it a promising treatment option.
A new study links moderate physical activity to lower breast cancer risk in postmenopausal women. Women who engaged in regular activities such as walking had a 14% lower risk and those with higher activity levels had a 25% lower risk compared to inactive women.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that walking for at least seven hours a week reduced breast cancer risk by 14% in postmenopausal women. Women who engaged in vigorous physical activity daily had a 25% lower risk of breast cancer.
A study published in Cancer Cell identified a previously unknown vulnerability in triple-negative breast cancers, which can be effectively treated with an FDA-approved drug. The researcher found that targeting the cystine transporter xCT significantly inhibited tumor growth in mice and cell culture.
A massive data analysis has implicated dozens of mutations in breast and prostate cancer development, focusing on non-coding DNA elements. The study provides new insights into the causes and treatment of cancer.
Researchers have identified potential genetic variants in non-coding DNA regions that drive the development of various cancers. The new approach prioritizes these variants based on their predicted impact on human disease, offering a promising tool for finding disease-causing genetic mutations.
Group Health Research Institute received two PCORI awards to study the effectiveness of breast MRI compared to mammography for breast cancer surveillance. The institute also provides assistance to a new national data network, enhancing the nation's ability to conduct patient-centered comparative effectiveness research.
Losartan opens up collapsed tumor blood vessels, improving chemotherapy delivery and oxygenation. Combining losartan with standard treatments delays tumor growth and extends survival in animal models.
A conservative approach to removing lymph nodes during breast cancer surgery is associated with less harm and similar results to more radical procedures. The study found that avoiding axillary surgery can reduce complications and morbidity in patients.