Articles tagged with Breast Cancer
A review of 21 National Comprehensive Cancer Network member institutions found that only four provided nutritional guidelines, while many linked to external sites with inconsistent information. The analysis highlights the need for evidence-based, standardized guidelines on dietary recommendations for cancer patients.
Researchers at Moffitt Cancer Center have developed a small molecule, S31-1757, that inhibits the ability of STAT3 to cause malignancy. This development could impact the treatment of several tumor types, including breast, lung, prostate and others that depend on STAT3 for survival.
Researchers from Scripps Research Institute have identified a class of compounds that can modify cell signaling activity, including anti-inflammatory effects, which could lead to innovative treatments for breast cancer. The study focuses on compounds interacting with the estrogen receptor-α, a key target in breast cancer treatment.
The study found that many young black women with BRCA mutations do not receive genetic counseling or testing, despite meeting national guidelines. This may represent a missed clinical opportunity to reduce breast cancer incidence and mortality.
A new imaging dye has been shown to effectively detect and map cancers in lymph nodes, improving staging accuracy. The radioactive dye successfully identified cancerous lymph nodes, detecting 94% of malignancies compared to the standard blue dye's 76%.
Researchers identified a set of genes associated with lipid metabolism that may help identify women at risk for hormone receptor-negative breast cancer. These genes were found to be overexpressed in the unaffected breasts of women with estrogen receptor-negative disease.
A new study involving over 900,000 women found that biennial mammograms are as effective as yearly exams in detecting breast cancer and reducing false positives. For women with dense breasts, screening every two years decreases the risk of false-positive results by about a third.
Researchers have discovered a set of genes that can predict which women are at high risk for estrogen-sensitive breast cancer, making it possible to identify potential beneficiaries of preventive drugs. The study identifies 13 genes associated with lipid or fat metabolism in women with hormone receptor-negative breast cancer.
A new study published in JAMA Internal Medicine found that biennial mammography screening for women aged 50-74 does not increase the risk of advanced breast cancer, but rather reduces the risk of false-positive results. For women under 50 with extremely dense breasts, annual screening may be necessary to decrease the risk of advanced d...
A recent study published in the Journal of Family Planning and Reproductive Health Care analyzed data from three major studies on hormone replacement therapy (HRT) and found no clear evidence linking its decline to a decrease in breast cancer rates. The authors point out methodological flaws in the original studies, including detection...
A recent study published in the Journal of the National Cancer Institute found that consuming high-fat dairy products following breast cancer diagnosis increases the risk of dying from the disease. The study tracked over 1,800 women and found an association between high-fat dairy intake and poorer breast cancer survival.
Research published in Occupational and Environmental Medicine found that night shift workers have a higher risk of developing ovarian cancer. Women who identified as 'owls' had a lower risk compared to those who were 'larks'. The study, based on data from over 1,100 women, suggests that melatonin may play a role in the increased risk.
A study published in the Journal of the National Cancer Institute found that Medicare spending for advanced cancer patients does not correlate with survival rates. Despite significant regional differences in spending, researchers discovered a strong link between higher spending and more frequent hospital visits.
The EPSRC is investing £12.2 million in 15 research projects that aim to improve the diagnosis and treatment of serious illnesses, including Alzheimer's and cancer, as well as enhance patient outcomes and quality of life for severely disabled individuals.
Researchers found African-Americans have a 1.4-fold greater risk for heart failure compared to their white counterparts after breast cancer treatment. The study also highlights the importance of closer monitoring and pretreatment with cardioprotective drugs.
Researchers at Vall d'Hebron Institute of Oncology have successfully eliminated mouse lung tumors by inhibiting the Myc protein, a key regulator of gene expression and cell growth. The study confirms that Myc-targeted therapy is a safe and effective option for treating various types of cancer, with no signs of resistance or side effects.
The Endocrine Society issues a position statement on estradiol measurement, highlighting the need for accurate testing to diagnose conditions like breast cancer, osteoporosis, and infertility. The organization calls for a universally recognized estradiol standard and new methods capable of measuring small concentrations.
A large US study has found that living in high-poverty areas or being uninsured significantly increase the risk of being diagnosed with breast cancer at a later stage. The study's findings highlight the importance of addressing health insurance coverage and poverty levels as key predictors of late-stage breast cancer diagnosis.
The UK's pace of decline in premature mortality has fallen behind the average of other European countries and EU15+ nations over the past 20 years. The country struggles with disabling conditions such as back and neck pain, depression, and drug use, leading to more chronic disability than ever before.
A study of over 1,100 women found that nearly a quarter developed post-traumatic stress disorder (PTSD) symptoms within two to three months after breast cancer diagnosis. Younger women and those from Asian and black backgrounds were at higher risk.
A study published in Plastic and Reconstructive Surgery finds that round and shaped silicone implants have similar patient-reported outcomes in breast reconstruction, with few significant differences in quality of life. The researchers evaluated 65 women receiving round implants and 63 receiving shaped implants, finding average scores ...
Swedish scientists developed theranostic nanoparticles that can deliver chemotherapy to breast cancer cells while being detectable in MR scanners. The particles are biodegradable and show no toxicity, making them a potential tool against cancer.
A groundbreaking UK study found that aggressive triple-negative breast cancer cells lack the enzyme FBP1, leading to a glucose anabolic pathway that 'feeds' the cancer. This metabolic switch enables tumor cells to survive in low-oxygen environments, making it a promising target for new treatments.
A recent study found a small but statistically significant increase in the incidence of advanced breast cancer among young women aged 25-39 years, without a corresponding increase in older women. This trend is concerning due to the poor prognosis and lower survival rates associated with younger patients.
Women with Lynch Syndrome have a 50-60% lifetime risk of developing colorectal cancer, but an 11% risk of breast cancer, 11% risk of kidney cancer, and 9% risk of bladder cancer. This study expands the spectrum of cancers associated with Lynch Syndrome.
A new University of Michigan study found that the protein HER2 plays a role even in breast cancers traditionally classified as HER2-negative. The research suggests that the drug Herceptin may have a greater impact on treating breast cancer and preventing its spread, particularly when given early to prevent tumor recurrence.
A new study found that 75% of women who had arm node removal surgery worried about getting lymphedema, despite only 19% developing it. Most patients adopted multiple risk-reducing behaviors, which were not supported by data.
A UNC-led team has identified four molecular classes of head and neck squamous cell carcinoma (HNSCC), a disease with limited information on its molecular profile. The study confirms the presence of these subtypes and demonstrates their clinical relevance, paving the way for targeted therapies.
A study published in The Journal of Nutritional Biochemistry found that a lifelong diet rich in omega-3 fatty acids can inhibit the growth of breast cancer tumours. Mice producing omega-3s developed only two-thirds as many tumours and had 30-per-cent smaller tumours compared to control mice.
A new study found that a commonly used breast cancer risk prediction model developed for African Americans tends to underestimate risk in certain subgroups, particularly those who first gave birth at an older age. The researchers conclude that a better risk model is needed for estrogen receptor-negative breast cancer, a subtype disprop...
Researchers at Scripps Research Institute have identified a mechanism controlling tumor aggressiveness and developed a simple treatment that inhibits cancer progression. In mice, the treatment prolongs life when tested with drugs already used for other conditions.
Research from Boston University School of Medicine found that alcohol consumption is a major contributor to cancer deaths and years of potential life lost in the US. The study showed that reducing alcohol consumption can be an effective cancer prevention strategy.
Researchers have identified at least four disease subtypes within triple-negative breast cancers, highlighting the need for targeted therapies that target individual biomarkers. The Basal-like subtype is the majority of TN patients, and therapies targeting its unique biology are crucial for therapeutic progress.
Researchers at Weill Cornell Medicine found that a copper-depletion compound, tetrathiomolybdate (TM), prevents cancer recurrence and metastasis progression. The study's findings are promising for high-risk triple-negative breast cancer patients with no current visible breast cancer.
Breast cancer stem cells drive tumor progression and recurrence, making current treatments ineffective. Zolkiewska's research focuses on ADAM12, a promising marker that can help identify and target these cells for more effective treatments.
European women are at risk of dying from lung cancer, which is expected to overtake breast cancer as the main cause of death. According to research, lung cancer deaths have increased by 7% since 2009, while breast cancer deaths have declined steadily.
A study found that genetic testing revealed high-risk mutations in individuals but prompted them to take positive steps, including follow-up visits with a doctor and discussions with family members. The test results also led to a 'cascade effect' where relatives were subsequently tested and discovered they too had the mutation.
A Wayne State University researcher has identified characteristics in benign breast disease associated with future cancer risk in African-American women. The study found that women with proliferative breast disease with atypia were three times as likely to develop breast cancer.
Researchers at Karolinska Institutet discovered that a deficiency in the endoglin protein weakens tumor blood vessels, allowing cancer cells to spread more easily. This finding suggests that strengthening blood vessel protective function may prevent cancer spread.
Studies reveal that blocking TGF-β can prevent tumor recurrence in mice with triple negative breast cancer. Additionally, targeting specific subsets of immune cells, such as CD8+ regulatory T-cells, may provide a new approach to treating rheumatoid arthritis.
A meta-analysis of 12 studies involving 116,000 participants found no evidence of an association between job strain and overall cancer risk. Stress can cause chronic inflammation, leading to unhealthy behaviors such as smoking and excessive alcohol consumption.
A large-scale study found that abnormal microRNA levels can be used to classify triple-negative breast cancer into four subtypes. The findings could lead to more effective therapies and personalized treatments for individual patients.
Researchers at the University of Minnesota have identified an enzyme called APOBEC3B as a key player in causing DNA mutations found in most breast cancers. The discovery may lead to new diagnostic methods and treatments that can prevent or block these harmful mutations, offering hope for improved breast cancer outcomes.
A new report from the American Cancer Society finds that cancer death rates are narrowing for African Americans, with nearly 200,000 deaths avoided since 1990. However, racial disparities remain for certain cancers, including colorectal and female breast cancer, highlighting the need for improved access to healthcare and screening.
A UCSF study of over 140,000 women aged 66-89 found that biennial screening led to fewer false positives and no increased risk of late-stage breast cancer. The study suggests life expectancy and co-existing illnesses should be considered when making cancer screening recommendations for older women.
A team of researchers found that specific acetylation marks on histone H4 determine the balance between two proteins, BRCA1 and 53BP1, controlling DNA repair mechanisms. This balance affects a cell's ability to repair breaks and respond to chemotherapy.
Researchers found that breast cancer tissue has a mix of stiff and soft zones, whereas healthy tissue has uniform stiffness. This discovery may help improve breast cancer diagnosis and therapy by identifying potential for cancer spread. The study used advanced microscopy techniques to analyze tissue properties at the nanoscale.
Researchers at Moffitt Cancer Center have developed an automated method to estimate mammographic breast density, a major risk factor for breast cancer. The new approach assesses the variation in grayscale values in mammograms, providing a viable, automated mammographic density measure that can be used in clinical settings.
Researchers have discovered a novel approach to fighting inflammatory breast cancer using quantum dots that deliver Vitamin D3, inhibiting invasion and migration of cancer cells. The therapy has shown promise in targeting tumor sites and visualizing the delivery of calcitriol through lymph systems.
Researchers at Walter and Eliza Hall Institute identify how pregnancy hormones alter DNA tags, controlling gene expression in breast cells. This discovery reveals a potential link between hormonal regulation and breast cancer risk, highlighting the importance of epigenome modifications.
Research suggests that sedentary behavior is not an independent risk factor for death among breast cancer survivors, contrary to previous suggestions. Regular moderate-to-vigorous intensity physical activity may reduce the risk of death in this population.
Researchers associate epithelial-mesenchymal transition (EMT) with breast cancer disease progression and treatment response. EMT was detected in breast cancer patient samples and found to oscillate between epithelial and mesenchymal states, influencing tumor spread and invasiveness.
A pioneering study published in The Lancet Oncology found that local volunteers increased early breast cancer detection rates in a low-income rural area. The study showed that 70% of women screened were diagnosed with benign lesions or successfully treated for breast cancer, significantly improving long-term survival chances.
A new study found that women with BRCA gene mutations tend to undergo menopause significantly sooner than other women, resulting in a shorter reproductive window. Heavy smokers with the mutation had an even earlier onset of menopause, sparking concerns about potential infertility risks.
A new analysis found that lumpectomy plus radiation provides better survival rates than mastectomy for early breast cancer, especially among women over 50 with hormone-sensitive tumors. This suggests that breast-conserving treatments are a viable option for many patients.
A new study finds that women treated with lumpectomy plus radiation have improved survival rates compared to those who underwent mastectomy, regardless of age or tumor type. The research suggests that less invasive surgery may be an effective alternative for treating early stage breast cancer.
A University of Central Florida professor has discovered a protein present in several types of cancer that could help prevent tumors from coming back. The protein, KLF8, appears to protect tumor cells from drugs and aid their regeneration.
GATA3 acts downstream to activate microRNA29b, which stops tumor cells from spreading by inhibiting genes involved in metastasis. The absence of GATA3 allows cancerous cells to break free and induce inflammation and new blood vessel formation.
Researchers develop SAPS algorithm to identify significant prognostic gene sets associated with patient survival, overcoming limitations of previous methods. The study found new prognostic signatures in breast and ovarian cancer subtypes, suggesting shared therapeutic targets and potential for improved diagnostics and treatments.
A study published in JNCI Journal of the National Cancer Institute found that median out-of-pocket costs for Canadian breast cancer patients were $1,002, with higher costs among more educated women and those living far from hospitals. Wage losses had a greater impact on family finances than out-of-pocket costs.