Articles tagged with Breast Cancer
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Researchers at Scripps Research Institute have identified a mechanism controlling tumor aggressiveness and developed a simple treatment that inhibits cancer progression. In mice, the treatment prolongs life when tested with drugs already used for other conditions.
Research from Boston University School of Medicine found that alcohol consumption is a major contributor to cancer deaths and years of potential life lost in the US. The study showed that reducing alcohol consumption can be an effective cancer prevention strategy.
Researchers have identified at least four disease subtypes within triple-negative breast cancers, highlighting the need for targeted therapies that target individual biomarkers. The Basal-like subtype is the majority of TN patients, and therapies targeting its unique biology are crucial for therapeutic progress.
Researchers at Weill Cornell Medicine found that a copper-depletion compound, tetrathiomolybdate (TM), prevents cancer recurrence and metastasis progression. The study's findings are promising for high-risk triple-negative breast cancer patients with no current visible breast cancer.
Breast cancer stem cells drive tumor progression and recurrence, making current treatments ineffective. Zolkiewska's research focuses on ADAM12, a promising marker that can help identify and target these cells for more effective treatments.
European women are at risk of dying from lung cancer, which is expected to overtake breast cancer as the main cause of death. According to research, lung cancer deaths have increased by 7% since 2009, while breast cancer deaths have declined steadily.
A study found that genetic testing revealed high-risk mutations in individuals but prompted them to take positive steps, including follow-up visits with a doctor and discussions with family members. The test results also led to a 'cascade effect' where relatives were subsequently tested and discovered they too had the mutation.
A Wayne State University researcher has identified characteristics in benign breast disease associated with future cancer risk in African-American women. The study found that women with proliferative breast disease with atypia were three times as likely to develop breast cancer.
Researchers at Karolinska Institutet discovered that a deficiency in the endoglin protein weakens tumor blood vessels, allowing cancer cells to spread more easily. This finding suggests that strengthening blood vessel protective function may prevent cancer spread.
Studies reveal that blocking TGF-β can prevent tumor recurrence in mice with triple negative breast cancer. Additionally, targeting specific subsets of immune cells, such as CD8+ regulatory T-cells, may provide a new approach to treating rheumatoid arthritis.
A meta-analysis of 12 studies involving 116,000 participants found no evidence of an association between job strain and overall cancer risk. Stress can cause chronic inflammation, leading to unhealthy behaviors such as smoking and excessive alcohol consumption.
A large-scale study found that abnormal microRNA levels can be used to classify triple-negative breast cancer into four subtypes. The findings could lead to more effective therapies and personalized treatments for individual patients.
Researchers at the University of Minnesota have identified an enzyme called APOBEC3B as a key player in causing DNA mutations found in most breast cancers. The discovery may lead to new diagnostic methods and treatments that can prevent or block these harmful mutations, offering hope for improved breast cancer outcomes.
A new report from the American Cancer Society finds that cancer death rates are narrowing for African Americans, with nearly 200,000 deaths avoided since 1990. However, racial disparities remain for certain cancers, including colorectal and female breast cancer, highlighting the need for improved access to healthcare and screening.
A UCSF study of over 140,000 women aged 66-89 found that biennial screening led to fewer false positives and no increased risk of late-stage breast cancer. The study suggests life expectancy and co-existing illnesses should be considered when making cancer screening recommendations for older women.
A team of researchers found that specific acetylation marks on histone H4 determine the balance between two proteins, BRCA1 and 53BP1, controlling DNA repair mechanisms. This balance affects a cell's ability to repair breaks and respond to chemotherapy.
Researchers found that breast cancer tissue has a mix of stiff and soft zones, whereas healthy tissue has uniform stiffness. This discovery may help improve breast cancer diagnosis and therapy by identifying potential for cancer spread. The study used advanced microscopy techniques to analyze tissue properties at the nanoscale.
Researchers at Moffitt Cancer Center have developed an automated method to estimate mammographic breast density, a major risk factor for breast cancer. The new approach assesses the variation in grayscale values in mammograms, providing a viable, automated mammographic density measure that can be used in clinical settings.
Researchers have discovered a novel approach to fighting inflammatory breast cancer using quantum dots that deliver Vitamin D3, inhibiting invasion and migration of cancer cells. The therapy has shown promise in targeting tumor sites and visualizing the delivery of calcitriol through lymph systems.
Researchers at Walter and Eliza Hall Institute identify how pregnancy hormones alter DNA tags, controlling gene expression in breast cells. This discovery reveals a potential link between hormonal regulation and breast cancer risk, highlighting the importance of epigenome modifications.
Research suggests that sedentary behavior is not an independent risk factor for death among breast cancer survivors, contrary to previous suggestions. Regular moderate-to-vigorous intensity physical activity may reduce the risk of death in this population.
Researchers associate epithelial-mesenchymal transition (EMT) with breast cancer disease progression and treatment response. EMT was detected in breast cancer patient samples and found to oscillate between epithelial and mesenchymal states, influencing tumor spread and invasiveness.
A pioneering study published in The Lancet Oncology found that local volunteers increased early breast cancer detection rates in a low-income rural area. The study showed that 70% of women screened were diagnosed with benign lesions or successfully treated for breast cancer, significantly improving long-term survival chances.
A new study found that women with BRCA gene mutations tend to undergo menopause significantly sooner than other women, resulting in a shorter reproductive window. Heavy smokers with the mutation had an even earlier onset of menopause, sparking concerns about potential infertility risks.
A new analysis found that lumpectomy plus radiation provides better survival rates than mastectomy for early breast cancer, especially among women over 50 with hormone-sensitive tumors. This suggests that breast-conserving treatments are a viable option for many patients.
A new study finds that women treated with lumpectomy plus radiation have improved survival rates compared to those who underwent mastectomy, regardless of age or tumor type. The research suggests that less invasive surgery may be an effective alternative for treating early stage breast cancer.
A University of Central Florida professor has discovered a protein present in several types of cancer that could help prevent tumors from coming back. The protein, KLF8, appears to protect tumor cells from drugs and aid their regeneration.
GATA3 acts downstream to activate microRNA29b, which stops tumor cells from spreading by inhibiting genes involved in metastasis. The absence of GATA3 allows cancerous cells to break free and induce inflammation and new blood vessel formation.
Researchers develop SAPS algorithm to identify significant prognostic gene sets associated with patient survival, overcoming limitations of previous methods. The study found new prognostic signatures in breast and ovarian cancer subtypes, suggesting shared therapeutic targets and potential for improved diagnostics and treatments.
A study published in JNCI Journal of the National Cancer Institute found that median out-of-pocket costs for Canadian breast cancer patients were $1,002, with higher costs among more educated women and those living far from hospitals. Wage losses had a greater impact on family finances than out-of-pocket costs.
A meta-analysis of large randomised trials found no significant increase in cancer risk among those taking daily folic acid for 5 years or less. The study provides reassurance about the safety of folic acid intake, particularly in countries where fortification is mandatory.
A prospective study of 1,200 healthy women found that low serum vitamin D levels before diagnosis increased the risk of premenopausal breast cancer. Women with low vitamin D levels had approximately three times the risk of breast cancer as those in the highest vitamin D group.
A study of 20 cohort studies found that high fruit and vegetable intake was associated with a lower risk of estrogen receptor-negative (ER-) breast cancer. The results suggest that increasing vegetable consumption may help lower ER- breast cancer risk, which accounts for only 15-20% of breast cancers.
Researchers found that combining PI3K inhibitors with anti-HER2 therapy can prolong treatment effectiveness by targeting the PI3K pathway, which activates anti-death protein survivin. High levels of survivin correlate with resistance to therapy, suggesting its measurement could predict treatment outcomes.
Researchers have identified a link between SNPs associated with breast cancer risk and the binding affinity of pioneer factor FOXA1. The study found that most risk-associated SNPs modulate FOXA1 binding, which is crucial for chromatin opening and transcription factor recruitment.
Researchers at Saint Louis University have discovered a molecular pathway contributing to triple-negative breast cancer and identified vitamin D as a possible new therapy. They also found three biomarkers to identify patients who could benefit from treatment, which may lead to less toxic therapeutic strategies.
Large-scale genomic sequencing reveals two DNA mutations driving 15% of meningiomas, a type of slow-growing brain tumor. The findings suggest targeted therapies may provide an effective treatment option for these patients.
Researchers at LSUHSC have identified a new therapeutic target to block the function of Her2, a gene that promotes breast cancer progression and spread. The study also found that a novel protein called Nischarin regulates breast cancer cell migration and movement.
The American Cancer Society's annual report shows a 20% decrease in cancer mortality rates since 1991, with significant drops in lung, colorectal, breast, and prostate cancers. These declines are attributed to reductions in smoking and improvements in early detection and treatment.
A new study in Spain found that breast cancer mortality among women under 50 has decreased, but among those over 85, it has remained stable. The researchers suggest adapting preventative practices according to patient age to improve outcomes.
Researchers identified a genetic marker in over 300 women with breast cancer, finding that those with this marker were more likely to experience recurrence. This breakthrough could enable doctors to tailor treatment strategies for high-risk patients based on their unique genetic profiles.
Researchers at IDIBELL-Bellvitge Biomedical Research Institute have developed a new method to diagnose hereditary breast and ovarian cancer syndrome based on mass sequencing of BRCA1 and BRCA2 genes. The new protocol has been shown to be highly sensitive and specific, reducing costs and time for obtaining results.
Fox Chase Cancer Center has received a grant to expand its community-based patient navigation services, which will help women with abnormal mammography results obtain follow-up care. The grant also supports 10 breast cancer education programs in the community and provides mammography screening services for under-insured women.
Researchers at Fox Chase Cancer Center found that the NEDD9 gene controls the growth of progenitor cells that give rise to tumors, suggesting a new approach to treating breast cancer. The study also identified a link between NEDD9 levels and sensitivity to certain drugs.
A Weill Cornell study reveals that a specific miRNA, miR-708, acts as a metastatic tumor inhibitor and can be restored to stop the spread of aggressive breast cancer. Synthetic miR-708 delivery has blocked metastatic outgrowth in mice, making it a promising therapeutic target.
Dr. Nicholas Navin's new approach to genetic analysis could help researchers understand and map the complex process of cancer evolution, ultimately blocking the spread of cancer to other organs. The project aims to identify important mutations in single tumor cells at various stages of cancer development.
Researchers at Duke University Medical Center have developed a way to deploy sickle-shaped red blood cells to fight cancer tumors by exploiting their ability to adhere to and block the blood vessels surrounding hypoxic tumors. The treatment causes tumor cell death through oxidative stress, resulting in delayed tumor growth.
A new study by Oregon State University researchers reveals that Hmong women often make their own health decisions, but in an environment where screening is not discussed. The study found higher rates of breast and cervical cancer screenings among the Hmong population compared to national averages.
A recent study published in The BMJ suggests that cancer screening for patients with a life expectancy of less than 10 years may not be beneficial. The researchers analyzed data from five breast and four colorectal cancer trials, finding that the benefits of screening often outweigh the risks. However, they also emphasize that individu...
A recent study published in JAMA Internal Medicine found that higher spending on breast cancer screenings does not result in improved outcomes for older women. The research team analyzed Medicare expenditures and screened female beneficiaries over two years, discovering substantial geographic variation in costs.
New research reveals that 18F-FDG PET/CT provides better prognostic information than conventional imaging, changing management for over 50% of patients. The study found that PET/CT accurately identified lesions in multiple areas, leading to revised staging and treatment plans.
A recent study found that tumor boards have a modest association with the types of treatments patients receive for certain cancers. For example, lung cancer and prostate cancer patients were more likely to receive higher-quality care when treated at hospitals with tumor boards. However, other types of cancer care remained unaffected by...
A recent study published in PLOS Biology has discovered the role of ELF5 in aggressive breast cancer subtypes and its potential to overcome anti-estrogen therapies. The research suggests that manipulating ELF5 levels could lead to new treatment strategies for breast cancer patients.
A new study reveals how a 'transcription factor' called ELF5 causes aggressive breast cancer to develop, making it resistant to oestrogen therapies. Researchers found that manipulating ELF5 levels could be a potential treatment option for this type of breast cancer.
A new study by researchers from the Mayo Clinic and Austrian Breast and Colorectal Cancer Study Group found that genetic differences in liver enzyme CYP2D6 play a key role in tamoxifen's effectiveness. Women with altered CYP2D6 enzyme activity had higher rates of breast cancer recurrence and death, while those with normal enzyme activi...
A nationwide prospective cohort study found that offspring of cancer patients diagnosed at older ages are still at higher risk of developing the same cancer. The study suggests a significant genetic component to familial risks, with increased risks observed for various cancers including non-Hodgkin lymphoma, breast, and prostate cancer.
A recent study by Vall d'Hebron Institute of Oncology has led to the redefinition of hormone-sensitive breast tumours, improving diagnosis and treatment outcomes. Gene expression analysis revealed discrepancies between histopathological data and molecular profiles, prompting a new definition that incorporates progesterone receptor levels.
A study by the University of Colorado Anschutz Medical Campus suggests that a healthy lifestyle during menopause, including diet and exercise, can lower breast cancer risk. In obese postmenopausal women, excess calories fuel tumor growth, but in lean counterparts, they are stored in healthy tissues.
Researchers identified ID proteins as regulators of glioma progression and potential therapeutic targets. In contrast, the loss of TREM-1 increased inflammation and worsened lung infection outcomes in mice. Additionally, breast cancer cells interact with stroma to drive metastasis through HIF-dependent signaling pathways.
Researchers identified miR-181a as a molecule linked to aggressive breast cancer forms. Elevated levels of miR-181a prevented metastasis and extended mouse lifespans in test models.