Articles tagged with Breast Cancer
Researchers found that breast cancer survivors with higher self-efficacy scores were 10% more likely to be physically active six months after the intervention. Behavioral skills such as self-confidence and motivation can be taught, enabling women to overcome exercise-related barriers.
Professor Sidney Fu is studying small RNA biomarkers to develop a blood test for detecting early-stage breast cancer. His research aims to identify patients who will not benefit from aggressive treatments, saving them from unnecessary trauma and stress.
Army surgeons have presented two studies highlighting the potential of a cancer vaccine in improving survival rates. The first study showed that breast cancer survivors who received a HER2 peptide vaccine had a higher likelihood of surviving disease-free compared to those without the treatment. In contrast, patients with Crohn's Diseas...
Researchers found that a memory training program improved memory performance, while a computer-based program called Insight improved both memory and information processing speed. The study suggests these programs may help alleviate symptoms such as depression, anxiety, and fatigue in breast cancer survivors.
Research identifies NF1 as a driver in more than 25% of non-inheritable breast cancers, associated with increased Ras activity and decreased NF1 levels. This finding may guide clinicians to targeted treatments for patients with NF1 mutations.
A novel MRI technique using diffusion-weighted imaging (DWI) successfully characterizes 46% of non-malignant breast lesions as benign, reducing false-positive findings and preventable biopsies. DWI differentiates high-risk lesions requiring additional workup from other non-malignant subtypes.
Researchers at Wake Forest University have designed a targeted therapy that delivers a sneak attack on breast cancer cells, similar to a Trojan horse. The new platinum-based molecule has shown promising results in treating non-small cell lung cancer and pancreatic cancer, with potential applications for breast cancer treatment.
A new study from the Netherlands found that digital mammography improves breast cancer screening detection rates, particularly for high-grade lesions. While there was a slight increase in clinically insignificant disease diagnoses, the benefits of digital mammography outweighed the risks.
Researchers have found that one year of treatment with trastuzumab is as good as two years of treatment, improving outcomes and reducing the risk of disease recurrence. This conclusion comes from the HERA trial, which involved over 5100 women with early HER2-positive breast cancer.
A new study published in the Journal of American College of Surgeons found that needle biopsies can lead to improved treatment outcomes for women diagnosed with breast cancer. Patients who underwent needle biopsies were more likely to have adequate tumor excision and lymph node assessment compared to those who received open biopsies.
Using biological markers can increase the success rate of new breast cancer drugs. A study found that the use of biomarkers such as HER2 resulted in a 23% success rate, compared to 15%, with significant cost savings.
Researchers explored AMP-activated protein kinase's role in Drosophila energy homeostasis and tissue-specific gene expression in Arabidopsis. Cellular memory of stress resistance was also studied in Saccharomyces cerevisiae, revealing a multifaceted response mechanism.
Researchers are developing a simple blood test to detect early signs of breast cancer, which could improve treatment and detection rates. The study aims to identify DNA markers consistent with cancer in blood samples from women attending breast screening clinics.
Researchers have discovered a new vaccinia virus that targets triple-negative breast cancer cells, achieving over 90% cell kill and extensive tumor destruction. The virus also inhibits tumor blood vessel growth, offering a potential targeted therapy for this deadly form of breast cancer.
A large-scale trial has successfully tested whole-genome cancer testing to identify targeted therapies for patients with metastatic breast cancer. The study found that around 20% of patients had rare and unexpected genomic alterations, highlighting the need for whole-genome approaches.
New research reveals that women with HER2 positive breast cancer that is also hormone (estrogen and progesterone) receptor negative have an increased risk of early death and less likely to recur in bone compared to those with hormone-sensitive cancer. The study suggests HR status defines two different subsets of HER2 positive cancers.
Studies presented at ESMO 2012 Congress reveal that a large proportion of people overestimate the cancer risk attributable to genetics and underestimate the risks associated with obesity, alcohol, and sunlight exposure. Increasing awareness of primary cancer prevention is crucial to reduce incidence rates.
Research reveals activation of PI3K-Akt signaling pathway induces mammary gland cells to produce prolactin, triggering Stat5 activation and milk production. Prolactin's role in human breast cancer is reevaluated, with potential implications for treatment.
A new study suggests that not enough women with breast cancer are being offered the chance to undergo treatments that may conserve their breasts. Despite high response rates to neoadjuvant therapy, only around 40% of patients receive breast-conserving surgery. The studies call for a clear consensus on the role of breast conserving surg...
A new optical imaging technology, developed at Tufts University School of Engineering, uses near infrared light to scan breast tissue and can identify water, fats, and oxygen-rich and oxygen-poor tissue. This non-invasive technique could complement standard mammography, particularly for women with dense breast tissue.
A blood test developed by Kansas State University researchers can accurately detect the beginning stages of breast and non-small cell lung cancer. The test works by detecting increased enzyme activity in the body, with a 95% success rate in detecting cancer in participants.
A study of Jewish women who lived under Nazi control during World War Two found that those with severe hunger were five times more likely to develop breast cancer. Women aged seven or younger at the time had a three times higher risk of developing breast cancer than their older counterparts.
Near-infrared (NIR) spectral imaging has been shown to be highly predictive of flap outcome in breast reconstruction, detecting circulatory complications early on. This non-invasive method can provide real-time feedback to surgeons during surgery and post-operative period, improving patient outcomes.
A retrospective study found that regular mammography screening can help eliminate the disparity in breast cancer mortality between black and white women. Women screened regularly were more likely to have hormone receptor-positive breast cancers, suggesting early detection can blunt negative prognostic biological characteristics.
A new program aims to improve the quality of breast cancer treatment decisions by studying how patients and doctors make choices. The researchers will develop an online decision tool to help patients weigh options and risks, with the goal of reducing unnecessary side effects and improving patient outcomes.
The Cancer Genome Atlas study identifies four main breast cancer subtypes defined by PAM50, with diverse genetic and epigenetic alterations converging into these phenotypes. The study's findings advance understanding of breast cancer biology and support the use of PAM50 as a gold standard for categorizing breast cancer by subtype.
Researchers developed a new nanotechnology that detects micrometastases in mouse models of breast cancer, marking them for early diagnosis and treatment. The technology uses nanochains to target cancer cells with integrins, allowing doctors to guide surgery or deliver cancer-killing drugs directly to the cells before a tumor forms.
A team of researchers identified genetic causes of the most common form of breast cancer, Estrogen-Receptor positive Luminal A subtype, providing clues for new therapeutic targets. They also found a molecular similarity between basal-like breast cancers and high-grade serous ovarian tumors.
A study by NIH/National Cancer Institute reveals shared genomic features between high-grade serous ovarian cancer and one subtype of breast cancer. This similarity suggests that the two cancers share a common molecular origin, facilitating comparison of therapeutic data.
A recent study reveals that basal-like breast tumors and ovarian tumors have similar genetic origins, suggesting potential for shared treatments. The research found unique genetic signatures within each subtype, highlighting the need for personalized cancer therapies.
Researchers at Michigan State University are studying the E2F family of transcription factors in relation to HER2 breast cancer. By understanding how these genes control tumor growth and spread, they hope to develop more effective treatments.
Researchers at MGH have identified components responsible for therapy-blocking solid stress and suggest therapeutic strategies. By measuring solid stress in tumor tissues, they found that inhibition of fibroblast growth can reduce solid stress and open up compressed blood vessels, improving treatment outcomes.
Researchers at Thomas Jefferson University found that decorin, a naturally occurring substance, induces tumor suppressor genes in the surrounding tissue of triple negative breast cancer tumors. This breakthrough may lead to improved therapeutics for metastatic breast cancer.
A new study analyzing 82 movies with cancer storylines found that characters' chances of survival were often misrepresented. Researchers suggest that Hollywood films should tackle the realities of cancer diagnosis and treatment to raise awareness among patients and healthcare professionals.
Researchers found that women with luminal A tumors, considered the least aggressive subtype, were at risk of death from breast cancer more than 10 years after diagnosis. The study highlights the importance of considering molecular subtypes in determining treatment options for women with breast cancer.
A meta-analysis found a detectable increase in the risk of oral cavity and pharynx, esophagus, and female breast cancers associated with light drinking. However, no association was found with colorectum, liver, and larynx cancers.
Recent breast cancer research at ESMO 2012 emphasizes the importance of avoiding weight gain after treatment to reduce recurrence risk. Additionally, studies focus on the correlation between body mass index and prognosis, as well as lung cancer in never-smoking women, highlighting hormonal factors and high incidence of EGFR mutation.
Researchers found that PARP inhibitors are sensitive to HER2-positive breast cancer cells, even without a DNA repair defect. The study suggests that inhibition of NF-kB signaling may be a cause of this sensitivity, paving the way for further research and potential broadened clinical application.
Researchers at Cleveland Clinic have found that vitamin E may reduce cancer risk in individuals with Cowden Syndrome, a genetic disorder that increases the risk of breast and thyroid cancers. Vitamin E's antioxidant properties may help prevent cellular damage caused by mutations in succinate dehydrogenase genes.
Researchers at UC Davis discovered that early-life diet and metabolic changes can stimulate breast growth and increase the risk of breast cancer, independent of estrogen levels. The study used mice with a diet supplemented with CLA to mimic metabolic syndrome, which was found to increase mammary duct growth and tumor formation.
Research reveals that tumor hypoxia drives aggressive behavior and poorer prognosis in various cancers. CD24 overexpression is linked to tumor growth and metastasis, making it a potential therapeutic target.
A major review of European breast cancer screening services found that the benefits outweigh the harms, with seven to nine lives saved for every 1,000 women screened. The review also noted that four cases of over-diagnosis occur for every 1,000 women screened, which can cause stress and anxiety.
The 2012 Breast Cancer Symposium presents four major studies on the treatment of early breast cancer, confirming which patient populations benefit from screening interventions and surgical procedures. The research aims to improve treatment decisions and maximize benefits for patients.
Researchers at Berkeley Lab identify protein FAM83A as a key player in breast cancer's resistance to widely used cancer therapy EGFR-TKIs. The discovery may provide new insights into the mechanisms behind this resistance and pave the way for novel therapeutic targets.
Research finds epigenetic alterations can transmit increased breast cancer risk to subsequent generations without genetic mutation. High-fat diets and excess estrogen during pregnancy may increase cancer risk in offspring.
Studies find extended office hours reduce health expenditures and improve breast cancer outcomes for Medicare beneficiaries. Additionally, research on adult cancer survivors reveals the need for primary care engagement in follow-up care, while a team-based model of primary care offers potential solutions to excessive patient panel sizes.
Breast cancer cells spread to surrounding lymph nodes through invasion into lymph vessels. Johns Hopkins researchers discover protein HIF-1 triggers this process by stimulating the growth of new blood vessels and activating genes involved in lymph vessel formation.
A study found that women with breast cancer are at risk of severe pain after surgery, especially those with chronic pain or low psychological state. The research suggests using factors like pre-operative pain and psychology as indicators for extra pain relief support.
Researchers found that high F-18-FDG uptake in axillary lymph nodes before treatment can predict disease-free survival in invasive ductal breast cancer patients. A nodal SUVmax of 2.8 was identified as the optimal cutoff for predicting disease-free survival.
A new method uncovered a way cancer cells use HER3 to drive tumor progression despite treatment with HER1 and HER2 inhibitors. Researchers found HER3 could be up to 10 times more effective than HER2 in recruiting accessory proteins that promote cancer growth and metastasis.
A recent meta-analysis by researchers at Moffitt Cancer Center found that breast cancer patients who received chemotherapy had slight cognitive impairments in verbal and visuospatial abilities. The study suggests that these deficits can be managed through awareness and compensatory strategies, improving daily life for affected individu...
A new Cancer Research Network study estimates real-world use of anthracycline and trastuzumab in breast cancer patients, showing a higher risk of heart failure and cardiomyopathy compared to previous clinical trials. The study's findings highlight the importance of awareness about the risks associated with these chemotherapy drugs.
Researchers at Ohio State University Comprehensive Cancer Center have discovered how tamoxifen-resistant breast-cancer cells grow and proliferate. They suggest an experimental agent might offer a novel targeted therapy for these resistant tumors.
Studies reveal paradoxical roles of PML in regulating fat-burning metabolism and its impact on breast cancer cells, hematopoetic stem cell maintenance, and obesity. Enhanced cellular metabolism provides energy to breast cancer cells, while inhibition of fatty acid oxidation poses a risk to replenishment of HSCs.
A multidisciplinary team will recruit 1,500 breast cancer patients to examine the effects of exercise and physical fitness on survival and recovery. Researchers will assess physical activity, body composition, and biomarkers to better understand the optimal exercise prescription for fighting breast cancer.
A new study found that extra body fat increases the risk of breast cancer recurrence and death in women with hormone receptor-positive breast cancer. Obesity is linked to hormonal changes and inflammation that drive cancer spread and recurrence.
A recent study published in Breast Cancer Research and Treatment found a strong correlation between short sleep duration and worse recurrence scores in post-menopausal breast cancer patients. The research suggests that insufficient sleep may cause more aggressive tumors, but further research is needed to verify this association.
A WSU researcher has identified over 40 plant-based compounds that can turn on genes that slow the spread of cancer. The study highlights the potential role of diet and nutrition in controlling cancer's spread.
Researchers found that tamoxifen effectively suppresses gynecomastia and breast pain in men with prostate cancer. Treatment with tamoxifen was more successful than with aromatase inhibitors or radiotherapy in reducing breast symptoms.
A genetic variant associated with a six-fold higher risk of developing certain brain tumors has been identified by researchers at UCSF and Mayo Clinic. The study found that individuals carrying the 'G' version of the variant have slower-growing gliomas, which could lead to better surveillance, diagnosis, and treatment.