Articles tagged with Breast Cancer
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Researchers at Michigan State University are studying the E2F family of transcription factors in relation to HER2 breast cancer. By understanding how these genes control tumor growth and spread, they hope to develop more effective treatments.
Researchers at MGH have identified components responsible for therapy-blocking solid stress and suggest therapeutic strategies. By measuring solid stress in tumor tissues, they found that inhibition of fibroblast growth can reduce solid stress and open up compressed blood vessels, improving treatment outcomes.
Researchers at Thomas Jefferson University found that decorin, a naturally occurring substance, induces tumor suppressor genes in the surrounding tissue of triple negative breast cancer tumors. This breakthrough may lead to improved therapeutics for metastatic breast cancer.
A new study analyzing 82 movies with cancer storylines found that characters' chances of survival were often misrepresented. Researchers suggest that Hollywood films should tackle the realities of cancer diagnosis and treatment to raise awareness among patients and healthcare professionals.
Researchers found that women with luminal A tumors, considered the least aggressive subtype, were at risk of death from breast cancer more than 10 years after diagnosis. The study highlights the importance of considering molecular subtypes in determining treatment options for women with breast cancer.
A meta-analysis found a detectable increase in the risk of oral cavity and pharynx, esophagus, and female breast cancers associated with light drinking. However, no association was found with colorectum, liver, and larynx cancers.
Recent breast cancer research at ESMO 2012 emphasizes the importance of avoiding weight gain after treatment to reduce recurrence risk. Additionally, studies focus on the correlation between body mass index and prognosis, as well as lung cancer in never-smoking women, highlighting hormonal factors and high incidence of EGFR mutation.
Researchers found that PARP inhibitors are sensitive to HER2-positive breast cancer cells, even without a DNA repair defect. The study suggests that inhibition of NF-kB signaling may be a cause of this sensitivity, paving the way for further research and potential broadened clinical application.
Researchers at Cleveland Clinic have found that vitamin E may reduce cancer risk in individuals with Cowden Syndrome, a genetic disorder that increases the risk of breast and thyroid cancers. Vitamin E's antioxidant properties may help prevent cellular damage caused by mutations in succinate dehydrogenase genes.
Researchers at UC Davis discovered that early-life diet and metabolic changes can stimulate breast growth and increase the risk of breast cancer, independent of estrogen levels. The study used mice with a diet supplemented with CLA to mimic metabolic syndrome, which was found to increase mammary duct growth and tumor formation.
Research reveals that tumor hypoxia drives aggressive behavior and poorer prognosis in various cancers. CD24 overexpression is linked to tumor growth and metastasis, making it a potential therapeutic target.
A major review of European breast cancer screening services found that the benefits outweigh the harms, with seven to nine lives saved for every 1,000 women screened. The review also noted that four cases of over-diagnosis occur for every 1,000 women screened, which can cause stress and anxiety.
The 2012 Breast Cancer Symposium presents four major studies on the treatment of early breast cancer, confirming which patient populations benefit from screening interventions and surgical procedures. The research aims to improve treatment decisions and maximize benefits for patients.
Researchers at Berkeley Lab identify protein FAM83A as a key player in breast cancer's resistance to widely used cancer therapy EGFR-TKIs. The discovery may provide new insights into the mechanisms behind this resistance and pave the way for novel therapeutic targets.
Research finds epigenetic alterations can transmit increased breast cancer risk to subsequent generations without genetic mutation. High-fat diets and excess estrogen during pregnancy may increase cancer risk in offspring.
Studies find extended office hours reduce health expenditures and improve breast cancer outcomes for Medicare beneficiaries. Additionally, research on adult cancer survivors reveals the need for primary care engagement in follow-up care, while a team-based model of primary care offers potential solutions to excessive patient panel sizes.
Breast cancer cells spread to surrounding lymph nodes through invasion into lymph vessels. Johns Hopkins researchers discover protein HIF-1 triggers this process by stimulating the growth of new blood vessels and activating genes involved in lymph vessel formation.
A study found that women with breast cancer are at risk of severe pain after surgery, especially those with chronic pain or low psychological state. The research suggests using factors like pre-operative pain and psychology as indicators for extra pain relief support.
Researchers found that high F-18-FDG uptake in axillary lymph nodes before treatment can predict disease-free survival in invasive ductal breast cancer patients. A nodal SUVmax of 2.8 was identified as the optimal cutoff for predicting disease-free survival.
A new method uncovered a way cancer cells use HER3 to drive tumor progression despite treatment with HER1 and HER2 inhibitors. Researchers found HER3 could be up to 10 times more effective than HER2 in recruiting accessory proteins that promote cancer growth and metastasis.
A recent meta-analysis by researchers at Moffitt Cancer Center found that breast cancer patients who received chemotherapy had slight cognitive impairments in verbal and visuospatial abilities. The study suggests that these deficits can be managed through awareness and compensatory strategies, improving daily life for affected individu...
A new Cancer Research Network study estimates real-world use of anthracycline and trastuzumab in breast cancer patients, showing a higher risk of heart failure and cardiomyopathy compared to previous clinical trials. The study's findings highlight the importance of awareness about the risks associated with these chemotherapy drugs.
Researchers at Ohio State University Comprehensive Cancer Center have discovered how tamoxifen-resistant breast-cancer cells grow and proliferate. They suggest an experimental agent might offer a novel targeted therapy for these resistant tumors.
Studies reveal paradoxical roles of PML in regulating fat-burning metabolism and its impact on breast cancer cells, hematopoetic stem cell maintenance, and obesity. Enhanced cellular metabolism provides energy to breast cancer cells, while inhibition of fatty acid oxidation poses a risk to replenishment of HSCs.
A multidisciplinary team will recruit 1,500 breast cancer patients to examine the effects of exercise and physical fitness on survival and recovery. Researchers will assess physical activity, body composition, and biomarkers to better understand the optimal exercise prescription for fighting breast cancer.
A new study found that extra body fat increases the risk of breast cancer recurrence and death in women with hormone receptor-positive breast cancer. Obesity is linked to hormonal changes and inflammation that drive cancer spread and recurrence.
A recent study published in Breast Cancer Research and Treatment found a strong correlation between short sleep duration and worse recurrence scores in post-menopausal breast cancer patients. The research suggests that insufficient sleep may cause more aggressive tumors, but further research is needed to verify this association.
A WSU researcher has identified over 40 plant-based compounds that can turn on genes that slow the spread of cancer. The study highlights the potential role of diet and nutrition in controlling cancer's spread.
Researchers found that tamoxifen effectively suppresses gynecomastia and breast pain in men with prostate cancer. Treatment with tamoxifen was more successful than with aromatase inhibitors or radiotherapy in reducing breast symptoms.
A genetic variant associated with a six-fold higher risk of developing certain brain tumors has been identified by researchers at UCSF and Mayo Clinic. The study found that individuals carrying the 'G' version of the variant have slower-growing gliomas, which could lead to better surveillance, diagnosis, and treatment.
Research suggests that radiation therapy is not necessary for older women with low risk of breast cancer recurrence, according to a recent editorial published in the Journal of Clinical Oncology. The study found that patients over 70 years old with estrogen receptor-positive tumors did not show improved survival or quality of life with...
A new survey conducted by the American Society of Plastic Surgeons found that 89% of women want to see the results of breast reconstruction surgery before undergoing treatment for breast cancer. The ASPS is launching a campaign to educate women about their options and provide a platform for patients to share their experiences.
Researchers at Ohio State University discovered that combining two peptide agents with a low-dose chemotherapy drug can delay tumor onset and progression in breast cancer models. The treatments caused few side effects.
Researchers have validated a radiosensitivity molecular signature that can predict clinical outcomes in patients treated with radiation therapy for breast cancer. The technology, called RSI, identifies radiosensitivity and radioresistance, opening the door to biologically guided radiation therapy.
Professors Ian Tannock and Jean Yves Blay will receive the 2012 ESMO Awards for their contributions to medical oncology. The European Organisation for Research and Treatment of Cancer (EORTC) is recognized with the ESMO Lifetime Achievement Award.
Researchers found that pre-test genetic counseling decreases distress in before-surgery patients, while improving informed decision-making in after-surgery patients. Both groups showed increased cancer knowledge following the counseling.
Infants born to mothers who received chemotherapy during pregnancy had lower birth weights but no higher risk of birth defects or blood disorders. The study suggests that breast cancer treatment during pregnancy is possible and prioritizing full-term delivery may be crucial for minimizing risks.
A phase III study published in Clinical Cancer Research found that denosumab reduced skeletal-related events by 31% compared to zoledronic acid, while also maintaining health-related quality of life. Treatment with denosumab also showed fewer acute reactions and adverse events.
A new study published in Cancer found that radiation after lumpectomy significantly reduced the risk of needing a mastectomy in older women with early-stage breast cancer. Radiation was shown to be beneficial for patients with high-grade tumors, while those with non-high grade tumors did not derive as much benefit.
Researchers at Case Western Reserve University have identified a new oncogene, FAM83B, which contributes to the development of breast cancer. Elevated expression of this gene is associated with the more aggressive triple-negative subgroup, highlighting the need for new therapeutic options.
Scientists at Sanford-Burnham Medical Research Institute found a molecule that promotes tumor vessel maturation, which could improve the effectiveness of anti-cancer therapies. By boosting R-Ras activity, researchers aim to normalize blood vessel structure and function in tumors, enabling better drug delivery.
A recent study found that radiation therapy after lumpectomy can help prevent mastectomy in early-stage breast cancer patients, particularly those with high-grade tumors. The research, published in the Journal Cancer, contradicts current national treatment guidelines.
A new method of delivering trastuzumab via subcutaneous injection has been found to be as effective as traditional intravenous delivery, with similar pathologic complete response rates. This could simplify breast cancer treatment, saving time for patients and reducing hospital dependence.
A study by Lawson Research Institute suggests that breast cancer stem cells have a preference for specific organs, such as the lung and brain, when spreading to other sites. Researchers hope to uncover the underlying factors driving this phenomenon and potentially develop new strategies to target these aggressive cells.
A new sequencing approach using long-range PCR and Next Generation Sequencing has been developed to provide a more effective method of BRCA1/2 mutational analysis. The method was successfully tested on 12 familial breast cancer patients, identifying all expected variants with high accuracy.
New human-derived breast cancer models retain heterogeneity, allowing researchers to test drugs more accurately. These models can help identify unique features in individual tumors, enabling targeted treatment.
A study published in the Journal of the National Cancer Institute found that a plant-based compound called phenethyl isothiocyanate (PEITC) slowed breast cancer growth in mice. PEITC was shown to reduce mammary carcinoma lesions by 56.3% and suppress tumor progression.
Researchers found that HSF1 activates a transcriptional program distinct from heat shock, driving the development of aggressive cancer phenotypes in breast, lung, and colon cancers. The findings suggest HSF1 as a potential therapeutic target for treating multiple cancer types.
A recent study in Pakistan found limited awareness of breast cancer among most women, with many unaware of self-breast exams and clinical breast exams. However, willingness to address health issues was high, and the majority of general practitioners understood major risk factors and importance of early detection.
Spouses of breast cancer patients struggle to find hope and balance in their lives, with many turning to exercise, music, and hobbies to cope. The study suggests that men need specific support and resources tailored to their needs, such as online guides and practical advice, to help manage stress and improve quality of life.
A combination of anastrozole and fulvestrant extended the median survival time of women with Stage 4 hormone receptor-positive metastatic breast cancer. The treatment option showed a significant overall survival benefit, particularly exciting for patients who have not had a new treatment in over a decade.
The combination of anastrozole and fulvestrant improved overall survival and progression-free survival in postmenopausal women with hormone receptor-positive metastatic breast cancer. The study showed a six-month extended median survival time compared to anastrozole alone, and improved median time to disease progression.
A study published in the New England Journal of Medicine found that combining two drugs extended the lives of women with metastatic breast cancer by more than six months. The combination treatment produced even greater benefits among women who had not previously taken tamoxifen, significantly improving survival rates.
Scientists at Western University have identified Nodal as a promising new therapeutic target for advanced breast cancer. The protein promotes vascularization, providing nutrients and oxygen to tumors, and its expression is correlated with more blood vessels in the tumor.
A team of researchers used computational analysis to identify a new therapeutic strategy for treating drug-resistant breast cancer. The study found that disrupting glucose metabolism is an effective approach, targeting existing drugs like Lapatinib. This discovery may offer improved treatments for breast cancer patients.
Researchers at A*STAR's Institute of Molecular and Cell Biology have devised a fast and cost-saving way to uncover genetic changes associated with cancer. By studying fruit flies, they identified new 'cooperating' genes that work together to cause aggressive cancer.
Researchers found that breast cancer patients lacking the retinoblastoma tumor suppressor gene (RB) had a better pathological response to neoadjuvant chemotherapy. A prospective clinical trial has been initiated at the Kimmel Cancer Center to explore this finding further.
A study by University of Michigan researchers found that an inflammatory pathway involving Interleukin-6 drives resistance to Herceptin in HER2-positive breast cancers. Blocking this pathway with a drug improved the treatment's effectiveness, and also prevented cancer stem cells from forming.
A recent study from the University of Texas Medical Branch at Galveston found that delivering a high-birth-weight infant more than doubles a woman's breast cancer risk. The researchers suggest that this increased risk is due to an elevated hormonal environment during pregnancy, which creates a pro-carcinogenic effect.
A study published in the Journal of the National Cancer Institute found that breast cancer mortality rates in Swedish women aged 40-69 declined at a rate similar to the prescreening period, suggesting limited impact of mammography screening. Researchers note potential limitations, including obesity and population mobility biases.