Articles tagged with Breast Cancer
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A study found that combining annual mammography with screening ultrasound in women at high risk for breast cancer and dense breasts resulted in a higher detection rate of incident breast cancers. Supplemental MRI further increased cancer detection, adding 14.7 cases per 1,000 women.
Researchers at Thomas Jefferson University found that eliminating the 'good cholesterol' receptor SR-BI can decrease breast cancer cell growth and tumor formation in mice. This study suggests a potential new approach to fighting breast cancer, with further research needed to fully characterize its role.
Researchers found that between 15% and 25% of breast cancer cases are overdiagnosed due to routine mammography screening. This can lead to unnecessary treatments and stress for women, with only a small reduction in mortality rates.
A clinical trial involving 14 TNBC tumors explores the use of whole-genome sequencing to identify potential treatment options. The study aims to advance personalized medicine and guide treatment for individual patients.
A new study in animal models found that women with breast cancer who began eating soy as an adult may develop a tumor more resistant to treatment. The research suggests that stopping soy intake if diagnosed with breast cancer could be beneficial.
A new study in Annals of Internal Medicine reveals that mammography screening may lead to overdiagnosis of breast cancer, potentially causing unnecessary anxiety and altered quality of life. Meanwhile, an international network of experts proposes minimum standards for guideline development to ensure high-quality evidence-based care. Ad...
A survey of mothers tested for hereditary breast cancer risk genes and their partners found unmet needs in making well-informed decisions about family communication. Genetic counseling should provide assistance to parents in disclosing risk information to children, the article proposes.
Researchers created transgenic mice with light-emitting lymphatic vessels to study tumor cell dissemination. The technique detects lymph node invasion by tumor cells, providing a unique tool for studying inflammation and metastasis.
A new study found that a protein called SIX1 plays a critical role in early stage metastasis, especially lymphatic metastasis, in breast cancer. The study identified the SIX1-VEGF-C pathway as an important signaling pathway involved in breast cancer metastasis.
A new study by Georgetown Lombardi Comprehensive Cancer Center finds that using a c-Src inhibitor like PP2 in combination with estrogen may cancel out the benefits of estrogen therapy. Instead, a c-Src inhibitor alone may offer an alternative treatment option for breast cancer patients whose tumors no longer respond to tamoxifen or aro...
Researchers found four proteins dysregulated by the PI3K/mTOR pathway associated with poor survival in hormone receptor-positive breast cancer. These findings suggest potential new prognostic factors and therapeutic targets for treatment.
A study by University of North Carolina at Charlotte researchers confirms the connection between metastatic breast cancer and autoimmune arthritis. Mast cells play a critical role in facilitating breast cancer metastasis, with SCF/Kit signaling inducing mast cell differentiation in arthritic conditions. This finding suggests a potentia...
Researchers found that patients with high levels of Aurora-A protein had shorter survival after surgery compared to those with normal levels. This suggests Aurora-A plays a role in head and neck cancer development and could serve as a new treatment target.
The University of Arizona has received a $2 million grant from the National Institutes of Health to develop an innovative magnetic resonance imaging method for measuring pH levels in tumors. This technique aims to personalize cancer treatments, such as baking soda therapy, and predict their effectiveness before treatment begins.
A new study identified a key mechanism driving breast cancer invasion and linked it to ErbB2 amplification and cathepsin expression. This research offers insights into the molecular basis of ErbB2-induced malignancy and potential therapeutic targets for treatment-resistant forms.
Researchers have identified a new breast cancer risk gene, XRCC2, using advanced genetic sequencing technology. The gene's mutations explain a proportion of breast cancers that run in families with no known genetic cause, particularly those diagnosed at an early age.
A new breast cancer susceptibility gene, XRCC2, has been discovered by researchers at the University of Utah Health. The study found that mutations in this gene increase breast cancer risk, providing a new target for chemotherapy and improving diagnostic accuracy.
Breast cancer patients treated with IMRT had lower incidence of acute and chronic toxicities compared to standard WBI. Larger breasted women also benefited from reduced toxicities with IMRT.
A new blood test has been developed to detect breast cancer recurrence up to 11-12 months before current tests, using a combination of biomarkers and mass spectrometry. The test shows promise for improving therapy outcomes by enabling earlier detection and treatment.
Researchers at the University of Alberta discovered that some breast cancer tumors with weak 'survival' systems responded better to taxane chemotherapy than those with strong survival systems. This finding could lead to new strategies for identifying patients who may not respond to this common treatment.
A Stanford study shows a single antibody can shrink human tumors in mice by blocking a protein flag on cancer cells. The treatment achieved dramatic responses in various types of cancers, including breast, ovarian, colon, bladder, and prostate cancers.
A new study reveals that only four percent of young women with cancer preserve their fertility during treatments. Women from specific socio-demographic groups are more likely to receive counseling and take action.
Percutaneous cryoablation, an interventional radiology procedure, uses tiny probes to freeze and destroy tumors in metastatic breast cancer. The treatment has been shown to provide a valuable alternative to other therapies with minimal side effects and reduced recovery time.
A randomised controlled trial found ultrasound-guided surgery excises all cancerous tissue with minimal healthy tissue removal, reducing re-excisions and radiotherapy. The technique enables precise tumour localisation and assessment of surgical margins.
A new study found that overweight and obese women are at higher risk of breast cancer recurrence, regardless of chemotherapy dosage. The study, which analyzed data from 1909 patients, suggests that lifestyle factors can influence cancer prognosis.
Researchers have developed a breast implant with a 'bed-of-nails' surface at the nanoscale that reduces cancer cell growth and promotes healthy endothelial breast cells. The implant's unique surface features deter cancerous cells from dwelling and thriving, offering a promising alternative to traditional treatments.
A national clinical trial found that preoperative aromatase inhibitors enabled postmenopausal women with estrogen receptor-positive breast cancer to have lumpectomy instead of mastectomy. The treatment increased the likelihood of breast-conserving surgery, sparing women's breasts.
A phase III clinical trial found that the combination of everolimus and exemestane improved bone strength and reduced the chance of cancer spreading in the bone. The treatment also showed a lower rate of further tumour growth and more difficult metastases to occur.
Scientists have identified a genetic marker that predicts which breast and ovarian cancers will respond to platinum-based chemotherapies. The marker, found on chromosomes within cancer cells, flags tumors unable to repair DNA damage caused by platinum agents, offering new hope for aggressive triple-negative breast cancer patients.
Researchers found 22% of TNBC patients had the androgen receptor, which was linked to more aggressive cancer but not necessarily worse survival rates. The study suggests targeting the androgen receptor could be a new way to treat TNBC.
A 15-year follow-up of over 1000 DCIS patients found that radiotherapy reduced local recurrence risk by 50%, while improving survival for invasive recurrence cases. The study suggests a continuous protective effect of RT on DCIS recurrence in the long term.
A national survey of OB-GYNs found that most doctors do not routinely ask about sexual problems or satisfaction, and even fewer inquire about a patient's orientation. This omission can lead to missed opportunities for diagnosis and treatment, with women often suffering in silence due to fear or embarrassment.
Researchers found that cognitive behavioural therapy (CBT) and physical exercise can significantly reduce menopausal symptoms, such as hot flushes and vaginal dryness, in breast cancer patients undergoing treatment. The interventions also improved sexuality and physical functioning, with positive effects still apparent after six months.
A new genomic test has been shown to help doctors identify breast cancer patients who do not need adjuvant chemotherapy, reducing side effects and improving quality of life. The study found that patients classified as low risk by the test had a higher distant disease-free survival rate compared to those classified as high risk.
A Dutch study reveals that breast cancer screening and improved treatments together save a significant number of lives. The study found that adjuvant therapy reduced deaths by 13.9%, while two-yearly screening added another 15.7%. Combining both approaches resulted in a total reduction of 31.1% in breast cancer mortality.
A stress management program for breast cancer patients can alter tumor-promoting processes at the molecular level, facilitating better recovery during treatment. The study found that women who participated in the program had improved psychological adaptation and physiological changes indicating better recovery.
A 20-year breast cancer screening program in the Netherlands showed a significant drop in deaths from the disease, with a 31% reduction in deaths among women aged 55-79. The program also found limited harm from false positives and over-diagnosis, with only 2.8% of all breast cancers diagnosed being over-diagnosed.
A recent study suggests that MRI screening could be a cost-effective option for women with a familial risk of breast cancer, despite being expensive. The research found that adding MRI to standard mammography screening reduces deaths by 24% at a lower cost per year of life gained.
Research presented at the European Breast Cancer Conference found that women with denser breasts have a nearly double risk of local recurrence. The study, which involved 1,774 post-menopausal women, highlights the importance of considering breast density in treatment decisions and follow-up routines.
Researchers have identified obscurins as tumor suppressor genes in the breast, which are lost or mutated when cancer develops. This discovery holds promise for developing new tools to assess breast cancer risk and diagnose it at an early stage.
Detecting circulating tumour cells in blood can provide information about breast cancer survival and help target treatment. Patients with high CTC counts have a higher risk of recurrence and death, while CTC detection may also become a target for future therapy.
New research shows that becoming pregnant after a diagnosis of estrogen receptor positive breast cancer does not increase the risk of recurrence. In fact, patients who become pregnant appear to survive longer than those who do not. The study also found no difference in disease-free survival between women with ER+ or ER- disease.
Researchers have discovered a new growth-driving protein, MYC, that drives the growth of aggressive triple-negative breast tumors. Blocking a cooperating protein, CDK, causes these tumors to regress in mice, offering a potential new target for treatment.
The RESTORE-2 trial found high rates of investigator and patient satisfaction with autologous adipose-derived regenerative cell (ADRC)-enriched fat grafting for breast reconstruction after cancer surgery. The procedure also showed improved breast contour and no local cancer recurrences or serious adverse events.
A recent review of large prospective cohort studies and WHI trials found that estrogen plus progestin increases breast cancer risk, while estrogen alone decreases risk in women with a previous hysterectomy. The study proposes that mammography screening differences may explain the observed effects.
New monoclonal antibody drugs are being tested in most tumor types, allowing them to bind to multiple targets and stimulate the immune response. Researchers have developed advanced antibody engineering techniques to create more effective treatments, including bispecific antibodies and conjugates with toxic payloads.
A recent study published in Cancer Research suggests that dietary cadmium may be associated with an increased risk of breast cancer. Women who consumed higher amounts of whole grain and vegetables had a lower risk of breast cancer compared to those exposed through other foods.
A recent study published in the Journal of The National Cancer Institute suggests that estrogen alone may reduce breast cancer risk, whereas estrogen plus progestin can increase it. The findings are based on data from two randomized clinical trials conducted as part of the Women's Health Initiative.
Researchers at Thomas Jefferson University have discovered a powerful new strategy for personalized anti-cancer therapy by linking biomarker MCT4 to tumor metabolism. High levels of MCT4 are correlated with poorer overall survival and increased risk of recurrence in patients with triple negative breast cancer.
A recent study found that Asian breast cancer patients suffer from memory loss, decision-making difficulties, and speech problems after chemotherapy treatment. To cope with these changes, many turned to mind stimulation activities such as mahjong and qi gong.
Researchers at the University of Kentucky have identified a key protein interaction that promotes metastasis in triple-negative breast cancer. Snail interacts with G9a to suppress E-cadherin expression, which is critical for cell adhesion and preventing tumor spread.
Researchers have identified a critical link in the signaling pathway that enables cancer cells to establish tumors in distant parts of the body. A new drug targeting this molecule may help prevent cancer from spreading, offering hope for improved treatment options.
Researchers at Rensselaer Polytechnic Institute found a previously unknown link between breast cancer cells and the stroma. Cadherin-23, a new molecule, helps connect cancerous tumor cells to healthy tissue, facilitating invasive growth.
A study found that bone marrow-derived progenitor cells promote liver regeneration in rats, improving our understanding of how liver tissue can regenerate following damage. Researchers also discovered a new determinant of human breast cancer metastasis, highlighting the potential for new therapeutics targeting this pathway.
A new study published in The Lancet Oncology found that estrogen-only form of menopausal hormone therapy continues to protect women from breast cancer, with a 23% reduced incidence and 63% lower mortality rate compared to placebo. The research followed over 7,500 women for nearly 12 years.
Breast imaging tests have been shown to be ineffective in improving patient outcomes and healthcare quality for women with breast pain. The study analyzed over 900 cases, revealing that these tests did not provide significant reassurance or diagnostic value.
Researchers at Purdue University have developed a new imaging technique to detect subtle changes in breast tissue, which may help determine a woman's risk of developing breast cancer. The technology uses vibrational spectral microscopy to identify early precancerous stages and study the impact of fatty acids on breast tissue.
Researchers will focus on inhibiting cancer cell metabolism by targeting Mct1 and Mct4 proteins, which transport lactic acid out of cancer cells. The goal is to develop broad-spectrum anti-cancer therapeutics for breast cancer and lymphoma.
Women who used estrogen-only hormone replacement therapy (HRT) are less likely to develop breast cancer and die from the disease compared to those who never used HRT. The study, based on data from over 7,500 women, found a 23% reduction in breast cancer incidence and a 63% reduction in deaths from the disease.
Scientists at Max Planck Institute for Heart and Lung Research found that blocking Plexin B1 can prevent the formation of breast cancer metastases in mice. The study suggests a new potential approach to improving prognosis for patients with aggressive breast cancer.