Articles tagged with Breast Cancer
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Researchers found elevated EGFR levels in blood of women with breast cancer 17 months prior to diagnosis, increasing risk by 2.9-fold. This marker shows promise as an early detection biomarker for breast cancer.
A prospective cohort study found that mid-life increase in body mass index (BMI) significantly increases the risk of postmenopausal breast cancer. Women who gained 5 kg/m2 or more between age 20 and study entry had a nearly twofold increased risk, with independent contributions from BMI gain before and after menopause.
Researchers at Fox Chase Cancer Center have identified NEDD9 as a key molecular player in the formation of HER2-driven breast tumors. The study shows that mice with the Nedd9 gene are more likely to develop tumors over an 18-month period, highlighting the protein's potential as a biomarker.
Researchers found that high levels of transforming growth factor beta 1 (TGF-β1) in breast cells may indicate atypical hyperplasia, a potentially precancerous condition. The study suggests that TGF-β1 could be part of a panel of genes and proteins used to identify women at risk of developing breast cancer.
Researchers at Georgetown Lombardi Comprehensive Cancer Center found that a high-fat diet during pregnancy increases breast cancer risk not only in daughters but also in their female and male offspring's daughters. The study suggests that pregnant mothers should eat well-balanced diets to potentially reduce the risk of breast cancer in...
Research reveals higher breast cancer rates among Latinas due to early diagnosis and poorer outcomes. Studies also show significant disparities in healthcare access and knowledge about screening practices among Mexican and Latina women living in the US.
Researchers found that vitamin supplements reduced breast cancer risk by about 30 percent, while calcium supplements reduced it by 40 percent. Calcium supplements lost their protective effect once DNA repair capacity was accounted for.
Researchers at Stanford University School of Medicine have identified a new genetic marker, called HOTAIR, that is significantly more prevalent in aggressive breast cancer cases. High levels of HOTAIR expression are associated with increased risk of metastasis and poorer survival rates for women with breast cancer.
Researchers at Washington University School of Medicine sequenced a patient's genome and that of her breast tumor and brain metastasis, identifying 20 genetic changes linked to the deadly spread. The study suggests that sequencing entire genomes can reveal clues to tumor progression and metastasis, paving the way for new drug targets.
Researchers discovered that larger body types at age seven were associated with a decreased risk of postmenopausal breast cancer. The study found that leaner girls had an increased risk of breast cancer, while larger bodies were protective against estrogen receptor negative tumours.
A new technique using tissue from below-the-waist 'love handles' improves cosmetic breast reconstruction in slim, athletic cancer patients. The method is less complicated than other options for surgeons and turns out to be effective in all 12 patients who underwent the procedure.
A study published in Pediatrics found that adolescent drinking increases the risk of benign breast disease, a precursor to breast cancer. The study, which followed over 6,900 girls aged 9-15, showed that girls who drank more frequently had higher rates of benign breast disease.
An international team of researchers has discovered a four-protein complex that promotes breast cancer metastasis. The complex, involving Myc, Skp2, Miz1, and p300, is a key regulator of RhoA gene expression. Targeting this complex could lead to the development of new drugs to thwart breast cancer migration and invasion.
A global study of nearly 10,000 women with early breast cancer found significant variations in treatment approaches across nine countries. Women with T1 tumours were more likely to receive breast-conserving surgery, while those with T2 tumours underwent mastectomies at varying rates.
Researchers discovered breast stem cells are exquisitely sensitive to oestrogen and progesterone, a finding that explains decades of evidence linking breast cancer risk to exposure to female hormones. The discovery also revealed the RANK ligand pathway is responsible for indirect control of breast stem cells in pregnancy.
Researchers discovered a peptide called iRGD that co-administers drugs to tumors, increasing treatment efficacy and reducing side effects. The peptide has been shown to enhance the therapeutic effect of anti-cancer drugs without creating new chemical entities.
Researchers at UC Davis Cancer Center found that African-American women with advanced breast cancer have poorer survival rates than white and Hispanic counterparts, regardless of radiation therapy. Despite lower radiation therapy rates, black patients did not benefit from the treatment.
A recent study published in the Journal of Clinical Oncology found that women with breast cancer before age 55 who carry an inherited mutation in BRCA1 or BRCA2 are four times more likely to develop cancer in the breast opposite their initial tumor. The study revealed a higher risk of contralateral breast cancer among younger women wit...
Childhood cancer survivors may experience a 10-year reduction in life expectancy due to late effects of treatment, according to researchers. Furthermore, social connections play a significant role in shaping alcohol consumption rates, with individuals influenced by friends and acquaintances' drinking habits.
Researchers from the University of Gothenburg found that women with a known Western Swedish mutation in the BRCA1 gene have an increased risk of developing ovarian cancer. The study suggests that women without this mutation do not face an elevated risk, and provides clarity for targeted screenings.
A study published in Value in Health suggests that extending breast cancer screening to younger women could lead to better health programs and a more balanced approach to fighting the disease. The research found that screening only older women increases unfair disparities in life expectancy, quality of life, and disease incidence.
Research finds that occupational exposure to synthetic fibers and petroleum products before mid-30s may treble the risk of developing breast cancer after menopause. Women exposed to these chemicals have a seven-fold increased risk, with risks magnified by each additional decade of exposure.
Researchers at St. Jude Children's Research Hospital have identified a new class of compounds targeting the MDMX protein, implicated in promoting various cancers, including retinoblastoma. The compound, SJ-172550, has shown promise in killing cancer cells by binding to the protein and allowing p53 to function normally.
A new study from the University of Michigan found that mastectomy patients are less likely to receive radiation therapy than those who had lumpectomy. Despite medical guidelines recommending radiation after mastectomy for certain patients, only 78% received it, compared to 95% of lumpectomy patients.
A new study at the University of Illinois Chicago found that women who have given birth may be at increased risk for breast cancer due to inflammatory-related genes in their breast tissue. The researchers discovered a protective effect of pregnancy on breast cancer risk, suggesting a balance between high-risk inflammatory and protectiv...
Two new studies shed light on treatment options for women carrying BRCA1 and BRCA2 genetic mutations, which predispose them to breast cancer. Prophylactic mastectomy was found to have little impact on disease-free or overall survival, while breast conserving therapy with chemotherapy reduced recurrence rates in the breast.
The median survival time for metastatic breast cancer patients increased steadily over 25 years, with improved outcomes for those with grade III tumours. Targeted therapies, particularly trastuzumab, have contributed to these advancements, offering new hope for patients with aggressive forms of the disease.
The study found that PARP expression is present in all breast cancer subtypes and correlates with a total response to chemotherapy. Tumors with high PARP levels showed a significant improvement in overall survival.
A multi-centre study found that specific lymph node radiotherapy is well-tolerated in early breast cancer patients after mastectomy or breast conserving surgery. The treatment showed no increased toxicity to the heart at three years follow-up, and estimated overall survival rates of 79%.
Researchers found that beta-blocker treatment reduced metastasis and improved survival in breast cancer patients, with a 71% reduced risk of death compared to other groups. The study suggests that beta-blockers may slow down tumour growth and target patients at high risk of secondary cancers.
A recent meta-analysis of 14 trials found that pregnancy after breast cancer diagnosis reduces the risk of death by 42%. The study suggests that hormonal changes during pregnancy may have an inhibitory effect on breast cancer cells, and that foetal antigens may also play a role in reducing the risk of recurrence. The findings support t...
Researchers identified CEP17 as a highly significant indicator of response to anthracycline treatment in breast cancer patients. Patients with CEP17 were approximately two-thirds more likely to survive and experience recurrence-free survival compared to those without the biomarker.
New research suggests that pregnant women with breast cancer can be treated with chemotherapy without endangering the health of their unborn baby. The study found that babies exposed to chemotherapy during pregnancy were born slightly lighter but otherwise had similar outcomes as those not exposed to chemotherapy.
A preclinical model of human prostate cancer mimics primary tumors' genetic behavior, offering a platform for biomarker and drug discovery. High expression levels of delta-like ligand 4 in breast cancer predict poor prognosis.
Women diagnosed with breast cancer after pregnancy are 48% more likely to die than others, but risk is similar if cancer is diagnosed during pregnancy. Further investigation is needed to understand the relationship between cumulative pregnancy effects and breast cancer prognosis.
Researchers found that women who have been diagnosed with breast cancer tend to overestimate their risk of developing cancer in the other breast. After counseling and a 12-month delay, most patients reconsidered and opted against prophylactic surgery.
Research suggests locoregional recurrence after long disease-free interval is associated with distant disease rather than cause. Patients with recurrence have four times higher risk of metastases and eight times higher risk of dying compared to those without recurrence.
Patients with metastatic breast cancer expect to prolong life by at least a year over current therapies, whereas doctors consider four to six months of additional survival significant. Thorough discussion of treatment goals is essential for both groups.
The largest European study on socioeconomic status and breast cancer survival found that women from poorer backgrounds had worse outcomes, even after adjusting for tumor size and stage. Women from the poorest backgrounds were a fifth more likely to die within ten years of diagnosis than those from the wealthiest backgrounds.
Young women with breast cancer are concerned about their fertility, with treatments like chemotherapy and hormonal therapy affecting egg production. Fertility preservation options, such as egg freezing or ovarian tissue transplantation, can help alleviate these concerns.
Researchers developed a strategy to overcome the issue, highlighting the importance of communication between healthcare providers. The study showed that changing drug therapy at an early stage can help patients get the full benefit of tamoxifen treatment, leading to improved breast cancer efficacy.
Researchers at Lombardi Comprehensive Cancer Center are working on a five-year $7.5 million grant to understand the role of the estrogen receptor in breast cells, aiming to develop more advanced and targeted therapies for ER+ breast cancer cases. The project involves collaborative research with Virginia Tech and Fox Chase Cancer Center.
African American patients with similar treatment settings as white counterparts show reduced mortality rates, highlighting the impact of institutional factors on cancer outcomes. The study suggests that where patients receive care may partly explain observed racial disparities.
Women with rare ATM gene mutations and radiation exposure may be at higher risk for a second breast cancer in the opposite breast. Researchers found a statistically significant increase in contralateral breast cancer among women with deleterious missense variants and radiation exposure.
Studies reveal significant health disparities among Asian Americans, Native Hawaiians, and Pacific Islanders, with culturally appropriate care shown to reduce cancer rates and heart disease. Immigrant women face high risk of death from breast cancer, while obesity and high blood pressure are major concerns for Native Hawaiians.
A content analysis found that media reports tend to focus on aggressive treatments and survival rates, neglecting discussions of death, palliative care, and adverse events. This study highlights the need for a more balanced approach in cancer news coverage.
A study found that case management in the National Breast and Cervical Cancer Early Detection Program reduced delays in diagnosis among low-income women by 45% between 1998 and 2007. Free treatment also showed no significant impact on diagnostic or treatment delays.
Researchers successfully froze breast cancer in patients who refused surgery, with no localized treatment recurrences seen for up to five years and no significant complications noted. The study used image-guided, multiprobe cryotherapy, which provided safe and effective breast conservation with minimal discomfort.
A new study found that breast cancers detected through palpable lumps, not mammography, were more common in women who didn't undergo annual screening. The researchers also found that clinical breast examination and breast self-examination played a crucial role in detecting breast cancer.
A new clinical trial at the Virginia G. Piper Cancer Center uses molecular profiling to identify specific treatments for refractory breast cancer. The trial aims to keep cancer under control for longer periods and potentially shrink tumors.
A recent study has found that breast cancer is affecting premenopausal women in Iraq, with a significant proportion presenting with advanced stage cancer. The study also highlights the importance of early detection and treatment, as only 32% of women detected a lump on self-examination sought medical advice within the first month.
Researcher Dolores Takemoto found a correlation between protein Coonexin46 and hypoxia, leading to potential treatments for retinoblastoma and breast cancer. Her study suggests that siRNA medication could prevent tumor growth by suppressing Cx46.
Postmenopausal women, especially those over 70, have a higher prevalence of cancer detected in the undiagnosed breast with MRI compared to premenopausal women. Detecting and treating both breasts at the same time may save costs and reduce patient stress.
A new study found that one in three early-stage breast cancer patients felt they didn't fully understand their genomic test result discussions, while a quarter experienced distress. The study suggests there is room for improvement in communicating cancer recurrence risks and treatment decisions with patients.
Breast cancer patients with early-stage disease and one lymph node metastasis have a low risk of recurrence without post-mastectomy radiation. Researchers found no significant difference in the 10-year risk of recurrence between women with lymph node spread and those without, highlighting the need for individualized treatment approaches.
A study of over 18,000 women aged 65 and older with breast cancer found that delaying radiation treatment after surgery increased local recurrence risk. The risk rose incrementally by day, with a 19% increase at longer intervals.
A combination of Herceptin and Tykerb significantly inhibits tumor growth in gastric cancers with HER2 amplification, providing a new treatment option for tens of thousands of patients worldwide.
A large study of nearly 6,000 Wisconsin women found that bisphosphonate drug use for more than two years was associated with a nearly 40% reduction in breast cancer risk. The protective effect was observed only among non-obese women.
A new study from Michigan Medicine found that freezing breast tumors using cryoablation kills the cancer and generates an immune response that helps stop its spread, leading to improved survival rates. The rapid freezing technique appears to be more effective than slower techniques in killing metastases and improving survival.
A new imaging technique combines ultrasound and specially modified contrast agents to detect cancer at the molecular level, allowing for early detection and potentially saving lives. The technique uses microbubbles paired with a peptide that binds to tumor vessel cells, enabling visualization of tumor activity.