Articles tagged with Breast Cancer
Researchers from Cytori Therapeutics published a study demonstrating that cell-enriched autologous fat grafts have significantly higher quality and improved blood vessel density compared to traditional grafts. The results show a two-fold increase in long-term retention of cell-enriched grafts.
The study found that disrupting TGFβ signaling leads to the re-expression of silenced genes, reversing tumorigenic properties and putting brakes on cancer progression. This discovery may pave the way for new therapeutic strategies targeting the Smad signaling pathway.
Researchers at Dana-Farber Cancer Institute discovered a gene activity signature predicting high cancer recurrence risk in breast tumors treated with chemotherapy drugs. The study suggests that these tumors may still be vulnerable to other types of chemotherapy agents.
Researchers at University of Florida have developed a tiny new sensor that can detect glucose levels in the breath and pH levels, offering a potential solution for non-invasive diagnosis and treatment. The sensor is made from widely used technology already in cell phones and other devices, making it inexpensive to produce.
A study by researchers at Tufts University School of Medicine identifies two populations of progenitor cells that propose a new model for breast cell differentiation. One population appears to be the cell of origin for luminal-like breast cancer, which is sensitive to hormones and tends to grow more slowly.
Researchers at OU Health Sciences Center have developed a new treatment that kills large breast cancer tumors and reduces the need for mastectomies by almost 90 percent. The treatment, called Focused Microwave Thermotherapy, uses microwave technology to kill cancer cells, allowing women to save their breast tissue.
Researchers found that tumor-associated macrophages produce high levels of proteases cathepsin B and S, enhancing tumor growth and invasion. Interleukin-4 stimulation by tumors stimulates increased Cts B and S activity, providing a potential therapeutic target.
A new report investigates the cognitive biases that lead people to misidentify common objects, such as guns or tumors. The researchers suggest retraining individuals in these professions through simulated searches to improve their accuracy.
Researchers found a significant correlation between mammography center availability and breast cancer mortality rates, with lower rates in counties with more facilities. Mammography availability was linked to a decrease in breast cancer mortality rates, suggesting that increasing access to these services can lead to better outcomes.
A new 21-gene test is helping doctors and patients make informed treatment decisions by predicting whether chemotherapy is necessary for early-stage breast cancer. The test, which examines tumor gene activity, has led to changes in treatment recommendations in 31.5% of cases, with most changes favoring avoidance of chemotherapy.
Researchers block COUP-TFII to suppress tumor blood vessel growth and tumor formation. This discovery identifies a new pathway for fighting tumors and offers hope for developing new treatments, including antagonists that can intervene to halt tumor growth.
A new study from the University of Michigan Comprehensive Cancer Center found that most breast cancer surgeons' practices do not meet quality care standards. Only about one-third of surgeons reported offering patient education resources and connecting patients with peers.
Scientists at the University of Nottingham have discovered that genetic rogue elements in 'junk DNA' are more common in breast cancer cells. The elements, produced by DNA sequences called LINE-1, can sabotage normal cell function and may play a role in cancer progression.
A U-M study reveals that a specific receptor, CXCR1, triggers growth of breast cancer stem cells in response to inflammation and tissue damage. Researchers found that blocking this receptor using an existing anti-inflammatory drug repertaxin kills breast cancer stem cells and prevents metastasis in mice.
A recent study identifies CXCR1 as a crucial protein in targeting human breast cancer stem cells. Inhibiting this protein selectively depletes the cancer stem cell population, leading to reduced tumor growth and metastasis. The findings suggest that strategies targeting CXCR1 may offer a promising approach for treating breast cancer.
The new SBI and ACR recommendations suggest that breast cancer screening should begin at age 40, with annual screening recommended for average-risk patients. High-risk patients may start screening as early as age 30. The guidelines aim to reduce mortality rates from breast cancer through earlier detection.
A study published in the Journal of Oncology found that acupuncture is as effective as drug therapy in reducing hot flashes and improving energy and clarity of thought in breast cancer patients. Acupuncture also showed benefits for sex drive and overall sense of well-being, with minimal side effects.
A new study reveals that self-seeding allows circulating tumor cells to return to their primary tumor and promote local growth while increasing potential for distant metastases. The research identifies key genes responsible for this process, which may lead to targeted therapies to slow or prevent tumor progression.
Researchers characterised genomic rearrangements in 24 breast cancers, revealing diverse patterns of disruption and defective DNA repair mechanisms. These findings have significant implications for tumour classification and the development of targeted therapies.
A study found that only 51.6% of eligible women completed a screening MRI, with claustrophobia as the primary reason for nonparticipation. Alternative methods like ultrasound may be considered for high-risk women who cannot undergo MRI screening.
Research links BRCA1 gene mutations to lower ovarian response rates in women undergoing fertility preservation treatments for breast cancer. Women carrying the mutated gene are more likely to experience infertility due to decreased egg production.
Scientists have discovered a possible way to identify malignant breast tumors without invasive biopsies, using an agent called 64Cu-TP3805 that targets a specific biomarker called VPAC1. This method has the potential to significantly contribute to breast cancer management.
The Scripps Research Institute has been awarded $1.2 million to develop high-throughput screening tests that will help identify potential small molecule therapies for breast cancer and cardiovascular disease. The project aims to modulate the activity of the LRH-1 receptor, which plays a crucial role in hormone-driven breast cancer.
A new study found that DC-SCRIPT has prognostic value in breast cancer, regulating nuclear receptor activity and affecting tumor behavior. Lower DC-SCRIPT expression levels were associated with poorer outcomes in ER- and/or PR-positive tumors.
A new study by the University of Texas M. D. Anderson Cancer Center reveals racial disparities in radiation therapy rates for early stage breast cancer patients, with black women less likely to receive standard treatment. The study examined over 37,000 patients and found significant variations in radiation rates across different regions.
Using Herceptin with chemotherapy reduces the risk of cancer recurrence by 25% compared to using it after chemotherapy. This new standard of care may benefit up to 10,000 women worldwide each year.
A new hybrid agent, T-DM1, has shown promising results in a Phase 2 clinical trial for metastatic HER2-positive breast cancer. The compound shrunk tumors by 30% or more in 40% of women with confirmed HER2-positive cancers, and had a total clinical benefit rate of approximately 53%.
Researchers at M. D. Anderson Cancer Center identified an association between mucinous carcinoma and multiple undetected tumors, contrary to its long-considered favorable prognosis. The study suggests that these patients may need more treatment and additional screening.
A study presented at the CTRC-AACR San Antonio Breast Cancer Symposium found that anti-estrogen therapy for breast cancer patients reduced their risk of dying from lung cancer. The research involved 6,715 women diagnosed with breast cancer between 1980 and 2003.
A recent study found that black women with hormone receptor-positive breast cancer have worse disease-free and overall survival rates than women of other races. This disparity persists even after controlling for other factors such as medical care and comorbidities.
A new study presents a promising approach to re-sensitize breast cancer to standard therapy after it becomes resistant. The treatment combination of an aromatase inhibitor and sorafenib shows encouraging responses in 20% of post-menopausal women with metastatic breast cancer, offering a potential new treatment option.
Researchers found that combining targeted therapies lapatinib and trastuzumab significantly extends survival in HER2-positive breast cancer patients, with a median overall survival of 60.7 weeks compared to 41.4 weeks alone.
Researchers at the University of Texas M. D. Anderson Cancer Center have developed a novel detection method that can identify circulating tumor cells (CTCs) after they undergo epithelial-mesenchymal transition (EMT), rendering them undetectable by current methods.
Women with high BMI have poorer breast cancer prognosis, with increased risk of death and reduced treatment effectiveness. Researchers found that adjuvant treatment loses its effect more rapidly in obese patients.
A landmark study confirms that chemotherapy with tamoxifen improves survival rates for postmenopausal women with estrogen receptor-positive breast cancer. A second study identifies a subset of patients who may not benefit from chemotherapy despite being at higher risk, suggesting a potential need to reassess treatment guidelines.
A phase 3 trial found that adding chemotherapy to tamoxifen treatment significantly improves disease-free survival in postmenopausal women with node-positive breast cancer. The benefit is maximized when tamoxifen follows chemotherapy.
Researchers found that MRI coupled with mammography detected almost all cancers at an early stage in high-risk women, resulting in smaller cancer sizes and fewer advanced cases. This alternative screening method may convince healthcare providers to recommend yearly MRI and mammography over surgical removal of the breast.
Research found moderate to heavy alcohol consumption increased breast cancer recurrence risk by 1.3-fold, with wine being the most popular choice among drinkers. Postmenopausal and overweight participants were more susceptible to the effects of alcohol on recurrence.
A new study by the Kaiser Permanente Division of Research found that moderate alcohol consumption is associated with a 30% increased risk of breast cancer recurrence. Post-menopausal and overweight women may be most susceptible, regardless of type of alcohol consumed.
A landmark study by Dr. Kathy Albain of Loyola University Health System found that chemotherapy improves survival in postmenopausal breast cancer patients, while a multigene test can identify those who may not benefit from chemotherapy. The study established the standard of care for tamoxifen treatment in relation to chemotherapy.
The German ICGC network will analyze 300 tumor samples of two childhood brain tumors, medulloblastoma and pylocytic astrocytoma. Researchers aim to identify cancer-specific changes and develop new treatment approaches with targeted drugs.
A large population-based study of 5,042 female breast cancer survivors in China found that moderate soy food intake is safe and associated with lower mortality and recurrence rates. The study suggests that women with breast cancer may benefit from consuming soy foods as part of their treatment plan.
Research shows that the majority of first mammograms in this study were for screening purposes, rather than evaluation of a breast problem. False positive rates from diagnostic mammograms varied widely between ethnic groups, raising concerns about the impact on women's future mammography use.
Researchers found a 3.3-fold increase in cancer risk among isolated rats with naturally occurring mammary tumors. Isolation and stress led to higher production of corticosterone, a stress hormone, and increased tumor growth. The study suggests a causal relationship between social interaction and disease.
Research at Yale University and the University of Chicago found that socially isolated female rats developed more tumors and more malignant types than their group-living counterparts. The study suggests a link between social isolation and cancer susceptibility, particularly in psychiatric disorders.
Researchers identified a critical pathway that stimulates Mdm2 production, binding to and extinguishing tumor suppressors like p53. Preventing Mdm2's destruction is crucial to preventing cancer from spreading within the body.
Charles M. Perou has been awarded the AACR's 2009 Outstanding Investigator Award for his groundbreaking research on breast cancer subtypes and racial disparities in diagnosis. His findings have led to a reevaluation of treatment approaches, with his work being incorporated into clinical practice worldwide.
Researchers have identified genes that switch their nuclear position in tumor cells, offering a potential new method of diagnosing cancer. The study found that eight genes consistently relocated in the nuclei of invasive breast cancer cells, allowing for accurate diagnosis with success rates similar to current clinical tests.
Researchers at the University of Michigan Comprehensive Cancer Center found that compounds derived from turmeric and pepper can decrease stem cells while having no effect on normal differentiated cells. This suggests a potential role for curcumin and piperine in preventing breast cancer by targeting stem cells.
Researchers found that only 3% of breast cancer decline is due to decreased hormone therapy use, while the remaining 4% remains unexplained. Additional studies are needed to determine the source of this unexpected decline in breast cancer cases.
Researchers use live imaging to study breast cancer cell spread, finding TGFb as the control switch. Single cells break away when TGFb is active, while clumps do so when inactive, limiting spread to local lymphatic system.
Researchers at Johns Hopkins Medicine have discovered a protein called Twist that accurately distinguishes stem cells driving aggressive breast cancer from other cancer cells. The protein's presence alone can flag a tumor cell as a breast cancer stem cell, suggesting new potential for early detection and treatment strategies.
Dr. Shiaw-Yih Lin's research focuses on the DNA damage response, exploring its crucial component replication stress response or RSR. His team aims to identify biomarkers for early detection of defective RSR and develop targeted nanoparticles for diagnosis and treatment.
A U-M study found that only 6% of high-risk women were likely to take tamoxifen, a drug proven to prevent breast cancer, due to concerns over side effects. The decision aid provided tailored information about the drug's risks and benefits, improving understanding but not changing behavior.
A clinical trial found annual ultrasound screening significantly improves early breast cancer detection in women with dense breasts, while MRI increases sensitivity but also false-positive findings. The study suggests annual ultrasound as a suitable alternative to expensive MRI for these women.
Two studies found targeted ultrasound effective in distinguishing between cancerous and benign masses in young women, reducing the need for biopsies and expensive diagnostic procedures. The procedure's low malignancy rates among women under 30 make it a safer alternative to surgery or needle biopsy.
A recent study suggests that mammography screening in young women with genetic or familial predisposition to breast cancer may increase their breast cancer risk. The study found that repeated exposure to low-dose radiation increases breast cancer risk among these women, particularly those under age 20 or with five or more exposures.
High urea levels in chronic kidney failure have been found to be toxic, leading researchers to suggest a potential new treatment strategy. Antioxidant therapy was shown to restore insulin sensitivity in mice with end-stage kidney disease. Similarly, targeting the molecular link Mdm2 may help prevent progression of late-stage metastatic...
A team of Wistar Institute researchers has identified a 29-gene signature in the blood that can indicate the presence of non-small cell lung cancer at its earliest stages. This discovery could lead to the development of a simple blood test for early-stage lung cancer detection, which would greatly improve treatment outcomes.
Increased Mdm2 expression drives more aggressive cancer characteristics in late-stage breast cancers. Targeting Mdm2 may help prevent progression of the disease.