Articles tagged with Breast Cancer
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Researchers have identified a new prognostic factor in breast cancer patients, predicting early disease recurrence, metastasis, and patient survival. The absence of caveolin-1 in the stroma is strongly associated with more aggressive disease and reduced progression-free survival.
The IMPAKT Breast Cancer Conference is a groundbreaking collaboration between the European Society for Medical Oncology and Susan G. Komen for the Cure to accelerate breast cancer research. The conference aims to bring together world leaders in translational research to discuss cutting-edge treatments.
A study published in the American Journal of Roentgenology found that 3T MRI detected 66 malignant lesions, while mammography detected 54 and sonography detected 57. This suggests that 3T MRI is an important tool for early breast cancer detection and more accurate disease evaluation.
A novel gene called DEAR1 is associated with increased risk of local recurrence in young women with breast cancer. The discovery could lead to a new prognostic marker and guide treatment decisions.
A new gene called DEAR1 has been found to be genetically altered in breast tumors and may provide a new prognostic marker for breast cancer patients, particularly those with early-onset cancer. The research suggests that DEAR1-negative staining could help identify young women at high risk of cancer recurrence.
New research highlights large disparities in breast cancer care and treatment for African-American women, with a significantly lower five-year survival rate compared to Caucasian women. Socioeconomic barriers also hinder access to advanced treatments.
Richard Junghans, MD, has been awarded a $5.9 million grant from the Department of Defense Breast Cancer Research Program to research gene therapy techniques to modify patients' T cells and create 'designer T cells' to fight breast cancer.
A Michigan State University researcher has discovered a key hormone found in fat tissue that promotes tumor growth and cancer progression. Abdominal fat is associated with the greatest risk for cancer, particularly breast, colon, and endometrial cancers.
A brief intervention program boosted the number of women performing breast self-exams by tenfold, with 59% participating in adequate exams after one year. The program's success highlights the potential for simple interventions to improve health behaviors.
A study by Japanese researchers found that a molecule called M-CSF can be used to block the formation of new blood vessels in tumors, suppressing growth even after treatment is stopped. This approach differs from existing VEGF-based treatments, which have been shown to have limited long-term effects.
Researchers propose trial designs to investigate the impact of physical activity and weight control on breast cancer risk, with potential causal relationships. Clusterin is identified as a tumor suppressor gene in mouse models of neuroblastoma, where its expression affects tumor growth and metastasis.
Research found that women with tumors carrying TOP2A gene alterations had better outcomes when treated with anthracycline-based regimens, similar to those seen in HER2-positive tumors. The study suggests that TOP2A gene alteration is associated with increased benefit from anthracycline therapy.
Researchers have discovered a way to trigger an improved immune response to cancer using a combination of interleukin-7 and a viral vaccine. The new approach shows promise in treating cancer, potentially sparing patients from toxic therapies.
In a phase II study, lapatinib demonstrated efficacy in treating patients with inflammatory breast cancer, with 49% experiencing a partial response to the treatment. The median overall survival for responding patients was 18.4 months, significantly longer than non-responders.
A new report reveals a significant increase in the number of people diagnosed with cancer in Ireland, but also shows that survival rates are rising for certain types of cancer. The report highlights the importance of prevention and early detection in reducing the burden of cancer.
A new imaging technique called breast elastography enables accurate diagnoses of breast cancer by analyzing tissue stiffness. This study found that breast elastography outperformed conventional ultrasound in diagnosing breast cancers, reducing unnecessary biopsies and patient anxiety.
A study from the Medical College of Wisconsin found that the removal of more than five lymph nodes and presence of cancer in the lymph nodes are key factors linked to lymphedema. The study suggests that all women undergoing axillary surgery should be counseled on their risk for lymphedema.
A new MR procedure using diffusion-weighted imaging (DWI) can correctly identify 50 of 60 malignant lesions and 23 of 25 benign lesions, potentially reducing false-positive rates. This technique may help save women from unnecessary breast biopsies by characterizing benign from malignant lesions.
A new computer algorithm assesses mammographic breast density by automatically segmenting breast tissue from background, removing muscle, and using region growing to determine dense areas. This method provides objective and accurate recommendations on further imaging or monitoring, reducing variability among radiologists.
Researchers at Georgetown University Medical Center found that hormone levels in blood do not accurately reflect breast cancer risk. The study suggests that measuring hormones in blood may give a false impression of breast cancer risk and an imprecise picture of how these hormones affect breast cancer development.
Researchers found that lymphocytes, a type of immune system cell, produce the inflammatory protein RANKL when breast cancer cells are present. This leads to increased lung metastases. Blocking RANKL can halt cancer progression and may be a potential target for drug therapy.
Innate Therapeutics' novel microparticle-based immune response modifier MIS416 significantly inhibited tumor growth and metastasis in lung and breast cancers. Administered as an adjunct to localized tumor irradiation, MIS416 demonstrated synergistic activity against recurrent lung tumors.
Preclinical studies highlight PS-targeting antibodies' ability to reverse immune suppressing effects of tumors, change tumor microenvironment, and mobilize immune cells. These findings suggest that PS-targeting antibodies facilitate a cytokine shift in the tumor environment, encouraging multiple types of immune system cells to mount an...
A study by Elaine Hardman found that walnut consumption can reduce breast tumor incidence in laboratory mice. Walnut consumption delayed tumors by at least three weeks, with molecular analysis showing increased omega-3 fatty acid intake contributing to the decline.
A study of 227 breast cancer patients found that those with greater depressive symptoms and lower emotional quality of life were less likely to exercise as part of their recovery. Despite initial increases, physical activity declined over time, suggesting the need for future interventions to support long-term engagement.
Researchers at University of Texas M. D. Anderson Cancer Center found that overexpressing PEA-15 in breast cancer grafts in mice resulted in nearly undetectable tumor levels after 35 days. This suggests PEA-15 as a new, important target for therapy.
Researchers at Fox Chase Cancer Center found that smaller doses of human chorionic gonadotropin (hCG) can prevent breast cancer in rats. The study suggests that even shorter exposure to hCG may offer protective benefits against the disease.
A new nanoparticle has been developed to deliver a tumor suppressor gene to cancer cells, restoring normal gene function and bypassing healthy tissue. This breakthrough method shows promise in reducing the probability of recurrent tumors.
Researchers found that brain metastases subvert astrocytes, tricking them into protecting tumors and resisting chemotherapy. Surgery is effective when tumor removal is done intact, reducing the risk of cancer spreading to the spinal fluid.
A large US-based study found that nearly 26% of women with breast cancer have p53 gene mutations, leading to poorer outcomes. Postmenopausal women with higher body mass index (BMI) were more likely to develop these high-grade tumors.
Researchers from Loyola University Health System warn that the surgical gel FloSeal may cause microcalcifications on mammograms after breast cancer surgery. The study highlights the need for caution when using FloSeal in lumpectomies to avoid misdiagnosis.
Researchers found racial disparities in cancer survival rates disappear when analyzing smaller geographic areas like neighborhoods. The study suggests that modifiable factors such as socioeconomic differences and access to medical care contribute to these disparities.
Researchers found SIRT1 curbs cell division by speeding up the destruction of the tumor promoter c-Myc, a key finding that may aid cancer treatment. This study supports previous research suggesting SIRT1's anti-cancer effects while also identifying its role in regulating c-Myc levels.
A recent study found a 188% increase in women with ductal carcinoma in situ (DCIS) undergoing contralateral prophylactic mastectomy (CPM) between 1998 and 2005. The surgery is typically recommended for women with invasive breast cancer, but not for those with DCIS, which has a 98-99% 10-year survival rate.
Researchers at the University of Texas M.D. Anderson Cancer Center have discovered a gene that helps protect PTEN, a major tumor-suppressor protein, from degradation in breast cancer. Rak's protective effect is linked to its ability to stabilize PTEN protein, preventing breast cancer development.
A computer-based model has been developed to aid radiologists in diagnosing breast cancer by analyzing mammogram images. The model was trained on 48,744 mammograms and found that it could detect 41 more cancers than routine practice, with potential benefits including reduced unnecessary biopsies.
Duke University researchers developed a light-based system to analyze tumor oxygen levels, helping oncologists choose effective treatments. The system uses diffuse reflectance spectroscopy and can provide immediate feedback during biopsies.
Researchers found that Muc4 promotes release of breast cancer cells from primary tumor, allowing them to survive and resist treatment. The study suggests that targeting Muc4 could lead to new treatments for breast and potentially other cancers.
Researchers at Caltech develop a targeted cancer therapy using a gallium corrole that can detect and eliminate breast cancer tumors in mice, with fewer side effects than traditional treatments. The therapy shows promise for treating aggressive HER2+ breast cancers with lower toxicity.
Three Editorials in The Lancet focus on inadequate conditions for US migrant detainees, the need for tailored disease-prevention programs, and the recent Danish decision to award compensation to breast cancer sufferers who worked night shifts. Pope Benedict XVI's comments on AIDS are also criticized for distorting scientific evidence.
Researchers have engineered a new version of the tumour-inhibiting protein VHL that can target hypoxic areas in tumours, reducing HIF levels and causing tumours to regress. This breakthrough has implications for treating various types of cancer, particularly those resistant to conventional therapies.
A study found that quality of life determines the use of coping strategies among younger women with breast cancer. Positive cognitive restructuring and seeking social support were common coping strategies.
A study found that black women are 3 times more likely to develop aggressive triple negative breast tumours compared to non-black women. The study also revealed that the prevalence of these tumours is not limited to pre-menopausal black women, but is also common in those diagnosed before or after age 50 and across all body mass indexes.
A new surgical technique, lymphaticovenular bypass, shows promise in reducing lymphedema fluid by up to 39% in breast cancer patients. The minimally invasive procedure is a viable option for managing the condition, which affects up to 30% of women after surgery and radiation therapy.
A new UCLA study analyzes data from the Surveillance and Epidemiology End Result (SEER) cancer registry and the National Health Interview Survey (NHIS), finding that African Americans are more likely to get cancer in the first place, contributing to a life expectancy disparity of 1.47 years for men and 0.91 years for women.
A recent study published in Annals of Oncology found that a biopsy of suspected recurrent breast cancer can lead to significant changes in treatment. In some cases, the biopsy showed that the woman did not have an advanced cancer, but a benign condition.
A new study from University of Pennsylvania School of Medicine identifies genes associated with the BRCA1 protein and their involvement in the DNA repair pathway. MERIT40, a previously unknown protein, was found to work with BRCA1-RAP80 complex to achieve DNA repair.
A recent study found that early detection of second breast cancers in women who have already had the disease can significantly improve their chances of survival. The research revealed that mammography was more sensitive than clinical examination for detecting second cancers, with a sensitivity of 86%. Early detection at an asymptomatic...
Researchers at the University of Nebraska Medical Center discovered that certain estrogen metabolites can damage DNA, initiating breast and prostate cancer. A new dietary supplement called Preventium combines natural compounds to block this mechanism, potentially reducing cancer risk.
Researchers have developed nanoscale probes that can pinpoint tumors and deliver drugs directly to cancer cells using antibodies and magnetic particles. These probes offer a promising approach for more precise cancer treatment, expanding the possibilities of MRI-based tracking and optical luminescence.
Research finds that obese women, especially white ones, are less likely to have undergone a recent mammography compared to normal weight women. The study highlights poor self-esteem, body image issues, and racial disparities in obesity-related body image as reasons for the disparity.
Systematic literature reviews and meta-analyses support the use of risk assessment models combined with breast density information to identify high-risk postmenopausal women. Lifestyle factors such as exercise, weight reduction, and reduced alcohol intake also show promise in reducing breast cancer risk.
A new study published in Cancer Epidemiology, Biomarkers and Prevention found that red wine had no effect on breast cancer risk. Women who consumed moderate amounts of alcohol had a higher risk of breast cancer, regardless of the type of drink.
Women with BRCA gene mutations strongly favor preventive mastectomy as the most effective way to reduce their risk and fears of developing breast cancer. The study found that over 80% of these women ultimately underwent the procedure, highlighting the significant impact of genetic testing on medical decision-making.
A study published in Cancer found that women with BRCA mutations are more likely to choose prophylactic mastectomies due to emotional worry and fear of developing the disease. The research suggests that clinicians should consider a patient's lifestyle and quality of life when counseling them about prophylactic mastectomies.
The grocery chain has increased its contribution to TGen by 37% over 2008, with the donation representing a significant boost to breast cancer research. The funds will be used to develop treatments and eventually find a cure for breast cancer.
African-American breast cancer patients with high blood pressure have a higher mortality rate than their white counterparts, controlling for age, tumor characteristics, and treatment. Hypertension accounts for approximately 30 percent of the survival disparity between the two groups.
A new technique called stereotactic body radiotherapy (SBRT) has been shown to significantly improve survival rates for early-stage lung cancer patients, with a median survival range of over 32 months. The treatment doubles the odds of surviving and can even cure at least half of the patients, offering hope without the need for surgery.
A UT nanoscientist has developed a targeted new delivery system for breast cancer drugs, aiming to increase the efficiency of drug delivery and reduce side effects. The innovative approach uses nanocarriers engineered to search out and release their payload at tumor sites.
A new guide from Northwestern University helps doctors navigate fertility preservation strategies for cancer patients. The guide aims to increase awareness and improve treatment options for adolescents and younger adults facing cancer diagnosis.