Articles tagged with Breast Cancer
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Researchers demonstrate that a combination of epigenetic drugs can reactivate the expression of over 1,000 genes in primary tumours of breast cancer patients. These reactivated genes play crucial roles in cell proliferation, differentiation, and immune recognition, suggesting increased anti-tumour effects.
A study found that viewing prior mammograms alongside current mammograms significantly improves radiologist performance and reduces unnecessary recalls. The use of prior mammograms recorded on film in comparison with digital mammograms poses a challenge, but limiting their availability may balance medical benefits with effort.
The GeneSearch Breast Lymph Node assay has been shown to have higher sensitivity and specificity in detecting breast cancer metastases compared to traditional intra-operative tests. The test's accuracy enables surgeons to make more informed treatment decisions and potentially reduce the need for second surgeries.
Researchers found that breast cancer in men is rare and can often be detected on physical examination. In most cases, a mammogram is not necessary for confirming gynecomastia diagnosis.
A randomized, phase III trial found that reducing dietary fat intake to 15% of total calories may prolong relapse-free survival in women with early-stage breast cancer. The study reported a 24% lower risk of relapse in the intervention group compared to the control group.
Researchers at Mayo Clinic have developed a new gamma camera technique that can detect breast tumors as tiny as one-fifth of an inch in diameter with 88% accuracy. The device is sensitive enough to identify small cancers that were not found by mammography, and may be more comfortable for women due to less pressure needed during imaging.
A new study demonstrates the effectiveness of Pfizer's Aromasin for early breast cancer treatment, with improved relapse-free survival and disease-free survival rates. The B-33 trial found that Aromasin was well-tolerated and showed a significant improvement in patients who received it after five years of tamoxifen.
A new report by Breast Cancer Action analyzes 612 women's responses to an online survey, finding nearly all reported side effects and 30% discontinued use due to intolerable side effects. The most common side effects included hot flashes, bone pain, and insomnia.
Scientists have discovered two protein biomarkers associated with breast cancer spread, which could help predict patient outcomes and guide treatment decisions. The study found that overexpression of one protein and underexpression of another were highly accurate in identifying patients at risk of metastasis.
Researchers developed genomic tests to predict breast cancer response to chemotherapy and hormonal therapy, with promising results in clinical trials. The tests showed high accuracy in predicting treatment response and patient outcomes, offering new hope for personalized treatment planning.
A Phase II trial found that 86% of patients with inflammatory breast cancer responded to lapatinib-chemotherapy, offering new hope for treatment. The study also showed that 25-30% of patients responded within two weeks of treatment alone.
A Phase III study found that combining Herceptin with chemotherapy significantly improves disease-free survival in women with early stage breast cancer and reduces the risk of heart damage. The study showed a five-fold decrease in significant heart toxicities compared to those who received Adriamycin.
A new analysis suggests that the decline in breast cancer incidence between 2002 and 2003 was largely due to the reduction of hormone replacement therapy (HRT) use. The study found a 7% relative decline in breast cancer cases, with an absolute decline of about 14,000 fewer women diagnosed in 2003 compared to 2002.
The TEACH study is a Phase III trial investigating the experimental drug Tykerb in patients with early-stage, HER2-positive breast cancer who have not been treated with Herceptin. The trial aims to determine whether Tykerb can benefit women several years after their initial diagnosis of breast cancer.
A monoclonal antibody JAA-F11 has been shown to extend the survival of mice with human breast-cancer tumors and inhibit their spread to the lungs, a result attributed to its ability to block adhesion and growth stages of cancer cells.
Women with higher physical activity levels have a lower risk of developing breast cancer, especially for estrogen receptor-positive/progesterone receptor-negative tumors. Physical activity reduces body fat, leading to lower estrogen levels and potentially decreasing ER+/PR+ tumors.
Researchers at Cornell University discovered a mutant mouse with increased genomic instability, leading to mammary tumors. The study suggests that impaired DNA replication genes may contribute to breast cancer.
Researchers discovered that changes in expression of one component of the TGF-beta receptor, T-beta-RIII, might provide a mechanism for the distinct effects of TGF-beta at different stages of breast cancer. Additionally, analysis of RB functionality could help clinicians determine the most effective therapy for their patients.
Research suggests that T-beta-RIII can suppress breast cancer progression by blocking TGF-beta signaling. Low levels of T-beta-RIII are associated with decreased recurrence-free survival in patients with breast cancer.
Researchers discovered a new biomarker that predicts which tumors will resist anti-estrogen therapy, potentially improving treatment outcomes for breast cancer patients. The study found that disrupted retinoblastoma tumor suppressor pathway can lead to resistance to these therapies.
A study of 160,000 women screened in their 40s compared to those in their 50s found little change in estimated overall survival. The authors conclude that the benefits of early detection may outweigh the risks of radiation-induced breast cancer, but the uncertainty remains too great to make a definitive recommendation.
Research shows pro-vitamin E, alpha-tocopheryl succinate, reduces tumour volume in experimental animals with high HER2 levels. The compound induces controlled cell death and has the potential to be an effective treatment for hard-to-treat breast cancers.
A recent study found that annual breast screening for women aged 40-49 years may not have a significant net benefit, with only a 17% decrease in breast cancer mortality. Additionally, the trial discovered a higher rate of false positive results among younger screened women compared to those over 50.
A University of Rochester study published in Obstetrics and Gynecology journal found that low doses of mifepristone shrink uterine fibroid tumors and greatly improve the quality of life in women who suffer from pain and heavy bleeding. The treatment resulted in a 135% improvement in quality of life for women taking mifepristone compare...
The 2004 influenza vaccine shortage had a significant impact on continuity of care, with flu vaccination rates dropping by over 50% in some areas. Additionally, studies found that improper antibiotic use can exacerbate sinusitis symptoms and that patients with sore throats often seek pain relief rather than antibiotics.
A new Italian risk model was found to be as accurate as a commonly used US model in predicting breast cancer diagnosis, suggesting the possibility of revising the model to include additional risk factors. Additionally, genetic variants have been linked to diarrhea when treated with certain cancer drugs, including gefitinib.
Researchers found that low p27 expression is associated with poor breast-cancer prognosis, particularly among women with hormone-receptor-positive tumors. High p27 expression was linked to a 6% improvement in 5-year survival rates compared to those with low p27 expression.
A study found that BRCA1 and BRCA2 mutations are more common in the general population than previously reported, increasing the risk of ovarian, breast, testicular, and pancreatic cancers. The study also showed that these mutations are associated with higher risks of specific types of cancer.
Research from the Flint Men's Health Study found that African-American men with prostate cancer were more likely to report a family history of both diseases among siblings. This increased risk was particularly notable for having a brother diagnosed with prostate cancer and a sister diagnosed with breast cancer, highlighting the importa...
UCI scientists discovered that mifepristone, a chemical compound used in abortion pills, can prevent breast tumor growth by inhibiting progesterone in breast tissue cells. This finding may lead to new prevention methods for women with a genetic predisposition to breast and ovarian cancers.
A study from Michigan Medicine found that over half of breast cancer patients who sought a second opinion received a change in their recommended treatment plan. Changes were often made based on reinterpreted imaging results or differing diagnoses, leading to new treatment recommendations.
A new minimally invasive approach to partial breast irradiation offers an additional treatment option for women with early-stage breast cancer. The procedure uses ultrasound to guide balloon catheter placement, reducing the risk of damaging healthy tissue and allowing for a shorter treatment regime.
The Cone Beam Breast Computed Tomography (CBBCT) scanner produces three-dimensional pictures of breast anatomy to distinguish benign lesions from tiny cancers. The pilot study showed promising results, with one case demonstrating a cancer that was hard to detect on a mammogram.
A study found that elderly women, those with public health insurance, and those who don't visit obstetricians regularly are less likely to receive clinical breast exams and mammogram recommendations. Regular clinical breast exams can detect breast cancer at an early stage, making them comparable to yearly mammograms.
A new ultrasound technique, elasticity imaging, has been found to correctly identify both cancerous and harmless breast lesions in nearly all cases. By gauging tissue movement, the non-invasive method can detect how soft or stiff an object is, reducing the need for invasive biopsies.
Researchers found significant regions of the brain associated with memory, analysis, and cognitive functions were smaller in breast cancer patients who received chemotherapy compared to those who did not. However, these structural changes were not sustained after three years.
Research suggests that higher body mass index (BMI) in early adulthood is associated with a reduced risk of breast cancer before menopause. This protective effect is not linked to ovulation problems, and the association persists even when adjusting for other factors such as family history and lifestyle habits.
A recent study published in The Lancet Oncology found that switching to anastrozole after 2-3 years of tamoxifen treatment significantly improves overall survival and reduces the risk of recurrence for postmenopausal women with hormone-sensitive early-stage breast cancer. The study analyzed data from three trials and used meta-analysis...
Researchers at Thomas Jefferson University have found that the protein fragment endorepellin blocks both skin and lung cancer tumors from progressing in animal models by preventing their ability to recruit new blood vessels. Endorepellin has surprisingly powerful effects on halting a cancer tumor's ability to move about and spread.
Exercise has been found to reduce colon cancer risk in men who engage in moderate to vigorous exercise for a year. Aspirin consumption may also negate the harmful effects of eating flame-broiled meat, particularly among breast cancer survivors. Childbearing may also be linked to an increased lung cancer risk.
A new Mayo Clinic study reveals that normal aging of breast tissue reduces breast cancer risk, particularly in women who experience complete lobular regression. Women with complete involution have half the risk of developing breast cancer compared to those without.
A new study found that colon cancer patients with a body mass index of 35 kg/m² and higher had a significantly increased risk of cancer recurrence or death from colon cancer. Underweight patients, on the other hand, had a higher risk of death from non-colon cancer causes.
A systematic review found no consistent evidence linking dietary folate intake to breast cancer risk. The review also did not find a significant association between a common genetic variation in the MTHFR gene and breast cancer risk.
A significant association was found between higher red meat consumption and an increased risk of hormone receptor–positive breast cancer in premenopausal women. Women who consumed more than one and one-half servings of red meat per day had almost double the risk compared to those who ate three or fewer servings per week.
A recent study found that nearly half of newly diagnosed breast cancer patients exhibit clinically significant emotional distress, including symptoms of major depression and post-traumatic stress disorder. The most common sources of distress were related to the cancer diagnosis, treatment uncertainty, and physical problems.
Scientists discover plant-derived triterpenoids and rexinoid LG100268 significantly reduce tumor growth in mice, offering potential future chemoprevention methods. The compounds inhibit inflammation and induce apoptosis in human lung cancer cells, presenting a promising avenue for preventing lung cancer.
A study found that MammoSite Brachytherapy does not always deliver lower doses of radiation to the heart during treatment of left-sided breast cancers compared to IMRT. The researchers analyzed data from 101 women with left-sided breast tumors treated with IMRT and found that in some patients, IMRT confers less radiation to the heart.
A study found that women with more than four positive lymph nodes are four times more likely to develop lymphedema when treated with a boost, despite similar risks of nodal recurrences. The increased risk may outweigh the benefits of receiving an extra dose of radiation.
A new study found that a shortened radiation course for early-stage breast cancer is safe and effective, reducing treatment time by up to two weeks while maintaining similar side effects. Women reported mild pain and high satisfaction with cosmetic results.
A study found that African-American women, particularly younger ones, have a significantly higher incidence of breast cancer and die at a younger age than white women. Environmental factors such as hormone-mimicking compounds are suggested to contribute to these disparities.
A study found that women with disabilities are less likely to receive standard breast-conserving surgery and radiation therapy after diagnosis. Despite this, they have a 29% higher risk of dying from breast cancer, indicating the need for more accessible and equitable treatment options.
A new study found that women with disabilities are less likely to undergo breast-conserving surgery after a breast cancer diagnosis. In contrast, older adults with three or more chronic diseases may not benefit from colorectal cancer screening due to shortened life expectancy.
Researchers developed a formula that takes into account various risk factors, including age, cancer size and grade, and treatment options. The new computer tool helps doctors evaluate the potential benefit of additional radiation therapy for patients with early stage breast cancer.
A new radiation technique called intensity modulated radiation therapy (IMRT) significantly reduces painful skin burns in women with breast cancer. IMRT controls the intensity of each beam to spare nearby healthy tissue, minimizing radiation exposure and side effects.
Researchers have found that three popular laboratory breast cancer cell lines share a similar genetic profile with human breast tumors. This discovery provides evidence for the accuracy of laboratory cell line models and their potential to inform treatment outcomes.
A novel estrogen receptor, GPR30, is linked to breast tumor progression and increased tumor size. The receptor's expression was positively associated with tumor size and metastatic disease, suggesting it could influence treatment decisions for hormone therapy.
Researchers found that the caveolin-1 gene can protect against pre-cancerous development in breast cells and may be a potential target for preventing breast cancer. The study also suggests a crucial role of the tumor microenvironment in the cancerous process.
A recent study challenges the practice of using Ashkenazi Jewish ethnicity as a proxy for genetic differences in breast cancer research, citing methodological problems and unintended consequences. The study highlights disparities in access to care and potential stigmatization, introducing gaps in testing and treatment for other groups.
Researchers at Thomas Jefferson University found that a specific gene, Dachshund, helps predict breast cancer prognosis. The study showed that higher expression of this gene is associated with better patient outcomes.
Research suggests women testing negative for BRCA1 and BRCA2 genes are still at higher risk of breast and ovarian cancer. Regular screening from age 35/40 is recommended due to genetic modifier genes, increasing their risk by three times that of the general population.