Articles tagged with Breast Cancer
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A meta-analysis found that sustained oral contraceptive use prior to pregnancy increases a woman's risk of developing breast cancer. Premenopausal women who used oral contraceptives before having children are at a significantly increased risk of breast cancer, with a 44% higher risk compared to those who did not use them.
Researchers at the University of Pittsburgh are exploring the use of fat-derived stem cells for breast reconstruction, aiming to create durable replacement soft tissue. The study, led by Dr. J. Peter Rubin, may provide a safer option for breast cancer patients, avoiding invasive surgery and potential risks.
A recent study challenges the long-held link between Ashkenazi Jewish ethnicity and increased risk for hereditary breast cancer. The research highlights methodological flaws and unintended consequences, including disparities in access to care and stigmatization. For non-Ashkenazi Jewish women, similar prevalence studies are lacking.
African-American women with breast cancer had lower survival rates and larger, later-stage tumors compared to Hispanic and Caucasian women. Research suggests intrinsic biological differences in the disease contribute to these disparities.
A study found that women with premenopausal breast cancer and 4+ positive lymph nodes may experience improved 10-year cancer-free survival with aromatase inhibitors. However, patients over 60 years old or those with advanced age, comorbidities, or fewer positive lymph nodes may not benefit from additional therapy.
A new study found that African-American patients with breast cancer have more aggressive tumors and poorer outcomes due to differences in tumor biology. The research controlled for healthcare access biases and found that African-American race was independently associated with poor survival rates.
A panel of genomic tests analyzes a cancerous tumor's molecular traits to determine the most effective chemotherapy, potentially saving lives and reducing toxic side effects. The tests show 80% accuracy in predicting which drugs will kill the tumor.
A study by University of Chicago researchers found that female rats with a more apprehensive temperament are more likely to develop mammary and pituitary tumors and die earlier. The findings suggest that looking at links between behavior traits and cancer in humans may be crucial for research on the development of cancer.
A large study published in Environmental Health journal reveals that IBM factory workers in the US are more likely to die from cancer than the general population. The study confirms previous findings and highlights clear health risks for computer factory workers worldwide.
A study found that elderly women with breast cancer are often under-staged, under-treated, and miss out on life-saving treatments. The researchers analyzed data from a tumor registry database and found that 70% of patients were in early stages of cancer but missed out on lymph node evaluation.
Researchers found lower vitamin D levels in women with advanced breast cancer compared to those in early stages. The study supports the idea that vitamin D may play a role in preventing breast cancer progression.
A new study from the University of Southern California found that post-menopausal women's hormone levels vary by ethnicity and race, potentially explaining differences in breast cancer rates. Native Hawaiians have a higher risk of breast cancer due to their high estrogen levels.
Women undergoing radiation treatment for breast cancer who engage in regular aerobic exercise show improved oxygen capacity and maintained red blood cell levels compared to those who do not exercise. Exercise significantly correlated with increased peak oxygen capacity and erythrocyte levels.
Significantly obese women may experience complications and lower satisfaction rates after breast reconstruction following mastectomy. A retrospective study found a high complication rate for morbidly obese patients with a BMI over 40.
A study presented at the American Society of Plastic Surgeons Annual Meeting found that approximately one-third of breast cancer patients are dissatisfied with their cosmetic result after undergoing a lumpectomy. Many patients consider reconstruction to improve their physical appearance.
Four inspirational patients - Lillie Shockney, Ashley McGrath, Susan Carlisle, and Marine Sergeant Oscar Canon - were honored with the Patients of Courage: Triumph Over Adversity awards for their courageous actions after undergoing life-altering reconstructive plastic surgery. The awards recognize their determination to help others des...
A new UCLA study shows that chemotherapy causes persistent changes in brain function, leading to cognitive symptoms like forgetfulness and confusion. PET scans reveal a link between chemo-brain symptoms and lower brain metabolism, suggesting that monitoring brain activity could help prevent these effects.
Researchers found that nearly all tumor cells in the bone marrow of early-stage breast cancer patients have a putative breast cancer stem cell phenotype, increasing the risk of disease progression. This study provides evidence that these stem cells may be responsible for metastases and has significant implications for cancer treatment.
A study pooled data from over 20 groups conducting breast cancer research, identifying 16 single nucleotide polymorphisms (SNPs) that may be linked to breast cancer risk. The authors found that five SNPs showed borderline statistical significance and could contribute to breast cancer incidence.
Research highlights the increased risk of suicide among breast cancer survivors for up to 30 years after diagnosis, as well as the association between hormone therapies and ovarian cancer risk. Additionally, high levels of circulating sex hormones may contribute to premenopausal breast cancer risk.
Older women with breast cancer often receive inadequate care due to ageism, despite being half of new patients each year. Researchers call for considering overall health and frailty in treatment decisions.
A synthetic vitamin E derivative, á-TEA, has been shown to inhibit the spread of aggressive mammary cancer in mice when mixed into their food. The study found a 4.8-fold reduction in tumors that spread to the lungs, suggesting potential use as a dietary supplement for treating human metastatic breast cancer.
Researchers at Dana-Farber Cancer Institute have created a complete map of the molecular 'control panels' that regulate cell growth in breast cancer driven by estrogen. The atlas contains thousands of previously unknown on/off switches, providing new insights into gene regulation and potential treatments.
A recent European survey of post-menopausal women with early breast cancer found that information needs are not being met, leading to low levels of patient involvement in treatment decisions. The survey revealed significant knowledge divides among patients, particularly older women and those with lower education levels.
The IU and Purdue Analytical Proteomics Team has been awarded a grant to develop standardized proteomics methodologies to discover proteins relevant to cancer. The team will work with cancer researchers and clinicians at the IU School of Medicine, as well as experts in statistical and computer analysis.
A recent study of medical audit data found that community mammography screening results surpassed performance recommendations nationwide. The study, which analyzed over 1.1 million women's screening exams, revealed a cancer detection rate of 4.8 per 1,000 women.
African-American women with advanced/recurrent endometrial cancer had worse disease presentation and lower survival rates compared to Caucasian women. After controlling for clinical features and treatment, African-Americans survived significantly fewer months, suggesting socioeconomic and cultural factors may influence disease outcome.
A study by University of Rochester researchers found that young age, extensive surgery, and severe post-operative pain are risk factors for developing chronic pain after breast cancer surgery. The study suggests that counseling and analgesic drugs immediately after surgery may help prevent long-term problems.
A team of Monash University scientists has identified two proteins, Smad3 and c-Myc, involved in stopping telomerase production. This discovery could lead to the development of anti-cancer agents that mimic these proteins.
A recent study published in the American Journal of Epidemiology found that women with breast implants have a 73% higher suicide rate compared to the general population. However, the study also revealed no increase in mortality risk among these women.
Researchers found that third-generation aromatase inhibitors increased the survival time for patients with advanced breast cancer. The meta-analysis suggests that these inhibitors should be used as an initial therapy for these patients.
A new test, OncoPlan, has been developed to predict which breast cancer patients are likely to benefit from chemotherapy. The test measures the levels of two proteins that play a role in cancer growth and survival.
A new study found that raloxifene significantly reduces breast cancer risk in postmenopausal women, with a 58% reduction for those without a family history and an 89% reduction for those with a family history. The researchers are puzzled by why protection seems greatest in genetically predisposed women.
A new technology can detect one malignant cell in a typical blood sample, enabling early adjustment of treatment to target spreading cancer. This diagnostic tool has a 97% specificity and may revolutionize the prevention of cancer death.
A study published in the American Cancer Society found that women with higher levels of physical activity before diagnosis had better five-year survival patterns compared to those with lower activity levels.
A new screening tool called the pedigree assessment tool (PAT) effectively identifies women at risk for hereditary breast cancer, outperforming another commonly used tool in assessing individual patient risk. The PAT was 100% sensitive in identifying high-risk patients with potential BRCA mutations.
A recent study by researchers at UCLA and the University of Oslo suggests that breast discomfort during hormone therapy may be an early warning sign for breast cancer. The findings indicate that women experiencing breast pain or tenderness while on hormone replacement therapy should consult their healthcare provider promptly.
Researchers at Johns Hopkins Kimmel Cancer Center have identified close to 200 mutated genes linked to breast and colon cancer. The genetic code reveals distinct pathways for the development of each cancer type, with some genes crucial for tumor formation. The findings provide a foundation for future comprehensive genetic studies.
V. Craig Jordan's research has led to breast cancer prevention drugs like tamoxifen and raloxifene; the new grant aims to develop a treatment model to reverse resistance to anti-estrogen therapy, facilitating access to new breast cancer therapeutic drugs.
A new gene signature of 70 genes linked to breast cancer was found to accurately predict patient outcomes, surpassing traditional risk classifiers. The study's results suggest that the 70-gene signature adds valuable prognostic information, which may lead to improved treatment decisions and reduced chemotherapy for eligible patients.
A study found that cyclin D1 gene overexpression is associated with better survival outcomes and increased sensitivity to the cancer-fighting drug bortezomib in breast cancer patients. This is because it suppresses the activity of another gene, STAT3, which promotes cell growth and prevents tumor cells from dying.
A new model developed by scientists from Group Health and seven other health care organizations finds that breast density is a significant predictor of breast cancer risk, with women having highly dense breasts facing nearly four times the risk as those with fat-filled breasts. The study analyzed data from over 1 million women and iden...
Two new breast cancer risk models use breast density to predict individual risks, outperforming the existing Gail model. The models identify high breast density as a significant predictor of breast cancer, with some studies suggesting it may be as powerful a risk factor as age.
A new study shows that trained lay health advisers in rural communities can increase mammography screening rates among low-income and minority women. The intervention improved knowledge and beliefs about mammography screening, empowering women to schedule their own appointments.
A 55-gene expression profile identifies children at high risk of progressive metastatic neuroblastoma. Lay health advisors improve mammography use among low-income women. Cyclin D1 inhibits STAT3, slowing breast cancer tumor growth. Researchers identify CD95/CD95L as a molecular system involved in radiation-induced pneumonitis.
A new study shows MRI is better than MDCT for determining breast cancer's intraductal component, allowing surgeons to achieve a cancer-free surgical margin. MRI correctly identified 33 of 44 cases with an intraductal component, outperforming MDCT in sensitivity and underestimation accuracy.
Researchers successfully transformed normal immune cells into tumor fighters, demonstrating their ability to persist in the body and shrink large tumors in humans. The engineered cells were found to show signs of persistence in 15 of the 17 patients in the study, with two patients seeing significant tumor shrinkage.
Recent studies suggest that protein S14 plays a critical role in driving fat metabolism in breast cancer cells, making it a promising new target for cancer treatment. The protein is required for the activation of genes involved in fat production, and its removal can lead to cancer cell death.
A new imaging technique using whole-body positron emission tomography (PET) scans can accurately predict whether breast cancer has spread to the lymph nodes in the armpit prior to surgery. The scans were found to be 72% accurate in identifying cancers with metastases, making them a valuable tool for healthcare providers.
Researchers at Cedars-Sinai Medical Center developed new objective criteria to enhance the reliability of PET scans in detecting breast cancer metastasis. The criteria use a standardized uptake value (SUV) threshold of 2.3, which was found to accurately diagnose lymph node involvement with 100% specificity and positive predictive value.
Researchers at USC/Norris Comprehensive Cancer Center discovered a new biological marker in tumors that can indicate whether a woman's breast cancer will respond to chemotherapy. Women with high levels of GRP78 protein in their tumors are more likely to have cancer recurrence, but may benefit from additional taxane treatment.
A core needle biopsy sample gives a representative picture of gene expression in the entire tumor, according to a new study. The results show that biopsy samples have identical gene expression levels as surgical samples, but with four specific genes modified by the biopsy procedure.
A recent study suggests that young breast cancer patients who receive chemotherapy may experience a higher number of serious side effects than previously reported. These side effects result in significantly higher healthcare expenditures for the affected individuals.
A large NIH-supported study provides the clearest picture yet of the prevalence of BRCA1 and BRCA2 gene mutations in the US population. The researchers found that 2.4% of breast cancer patients had BRCA1 mutations, while African American women were more likely to have BRCA2 mutations.
A large population-based study found that 2.4% of breast-cancer cases carried BRCA1 mutations and 2.3% carried BRCA2 mutations, with variations in mutation rates among different racial and ethnic groups. The study also identified predictors of carrying these mutations, including family history and age at diagnosis.
Researchers found that younger women with breast cancer are at risk of experiencing more chemotherapy-related serious adverse effects, including fever, infection, and low blood cell counts. These adverse effects can lead to hospitalizations, emergency room visits, and increased healthcare costs.
Studies found that trastuzumab treatment can cause impaired heart function in 28% of women with advanced breast cancer, which may be reversible. Additionally, radiation therapy to the left side of the chest increases the risk of heart disease and coronary artery disease.
A study by Stefania Galletti and her team has identified a plant-based source of the anti-cancer compound glucobrassicin, which has shown effectiveness against breast cancer. The researchers found that wounding leaves can increase levels of glucobrassicin, highlighting its potential as a natural defense mechanism.
Researchers discovered that Herceptin is effective in treating breast cancer tumors with low or undetectable HER-2 levels but high HRG expression. Continuous production of HRG activates the HER-2 receptor, promoting tumor growth and proliferation.
A study by researchers at The Miriam Hospital and Brown Medical School found that breast cancer survivors who believed an unhealthy behavior contributed to their cancer were more likely to modify that behavior. The most robust relationship was found for changes in diet.