Articles tagged with Breast Cancer
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EMBL scientists have founded a start-up company called Elara Pharmaceuticals GmbH to develop new anti-cancer drugs. The company will take promising small molecule leads from EMBL's Chemical Biology Core Facility and further develop them for evaluation in animal models of various types of cancer.
Researchers identified a number of activity patterns in genes that make tumors biologically different, providing valuable information for treatment decisions. Four out of five predictors showed significant agreement in their outcome predictions, indicating potential for personalized treatments.
DNA damage in stroma tissue may predict breast cancer risk, according to a recent study. The researchers found that specific DNA lesions were more common in women aged 33-46, which corresponds with the rise in breast cancer incidence during this age group.
The study found that CAD increased cancer detection by 13.3% in screening-detected cancers and 14.2% for ductal carcinoma in situ (DCIS).CAD also improved recall rates and reduced false negatives, with the greatest impact on symptomatic patients.
Research published in The Lancet Oncology reveals anastrozole has fewer adverse effects and withdrawals compared to tamoxifen. Anastrozole showed a significantly better risk-benefit profile, particularly at 1-2 years of treatment.
A study of over 9,000 Danish residents found that a specific variation in the CHEK2 gene triples a woman's risk of developing breast cancer in her lifetime. Women with this mutation are three times as likely to develop breast cancer as those without it.
Researchers develop computer approach to precisely target breast tumors with electron and x-ray beams, reducing collateral skin damage. The technique helps send accurately targeted doses for 78 patients, providing benefits for shallow tumor treatments in the breast, chest wall, and head-and-neck region.
Researchers found a discrepancy in reported maternal vs paternal relatives with breast cancer, suggesting under-reporting on the paternal side. This could lead to inaccurate family history and missed screenings for breast cancer.
Women taking estrogen and testosterone therapy may have a higher risk of developing breast cancer compared to those not using hormone therapy. The study found that women on long-term use of estrogen plus testosterone had a 77% increased risk of breast cancer.
Researchers found that tamoxifen does not significantly reduce mortality in women at lower risk of breast cancer. For high-risk women, taking tamoxifen can be expensive with a $1.3 million price tag per year of life saved in the US market.
A new study finds that tamoxifen has little impact on mortality rates for most high-risk women, with life expectancy improving only at higher breast cancer risks. The high cost of tamoxifen further reduces its utility as a cancer prevention drug in the US.
A study found that cancer patients who used information services and online support groups experienced improved learning outcomes. The analysis revealed that interactive services also predicted improved learning outcomes, while interacting with an online expert did not contribute to benefits.
Researchers discovered that breast stem cells lack receptors for female hormones oestrogen and progesterone, resembling the aggressive 'basal' subtype of breast cancer. The findings support speculation that breast stem cells may give rise to basal tumours, which are more common in BRCA1 carriers.
Researchers have developed a non-invasive method to detect bladder cancer using DNA found in urine, while a study suggests high pesticide exposure increases the risk of liver cancer. Additionally, a growth factor has been found to inhibit lung tumor metastasis by stopping blood vessel growth and breaking down specific proteins.
A study has identified a new role for the breast cancer susceptibility gene BRCA1 in regulating intercellular signaling and tumor suppression. Researchers found that BRCA1 promotes survival of neighboring blood vessel cells and formation of capillary-like structures, contributing to accelerated tumor growth.
Researchers developed a gene screening method that can detect breast cancer with high accuracy, spotting 15 out of 21 samples positive for cancer. The test uses methylation-specific PCR to identify abnormal levels of chemical tags in DNA, which can be missed by pathologists' naked eye.
Researchers at Ohio State University found that interleukin 21 boosts natural killer cell activity, attacking and destroying Herceptin-coated breast cancer cells. This could lead to increased patient response rates with the existing drug.
A recent study published in JAMA Network found that weight gain since early adulthood is associated with an increased risk of breast cancer in postmenopausal women. Women who gained 55 pounds or more after age 18 were at a 45% increased risk, while those who lost 22 pounds or more and maintained their weight had a 57% lower risk.
A study published in JAMA found that women who smoke are more susceptible to lung cancer than men, with a higher rate of diagnosis. However, women tend to survive longer after diagnosis than men, with better survival rates for all major histological types of lung cancer.
Scientists create 'chemically programmed antibody' by linking small molecules and antibodies, enhancing therapeutic efficacy against breast cancer metastasis. The approach has potential for treating multiple types of cancers, increasing effectiveness of existing therapies.
Researchers are testing a new drug combination that targets male-specific hormone levels to slow the progression of male breast cancer. The treatment, which involves anastrozole and goserelin, aims to lower overall estrogen levels in men, limiting breast tumor growth.
A new study suggests a link between abdominal obesity and an increased risk of colon cancer, with waist circumference and waist-to-hip ratio being key factors. Additionally, incidence rates of ocular non-Hodgkin lymphoma have been rising rapidly, with no signs of slowing down.
The Lancet highlights the case of CancerBACUP, a UK charity that accepted funding from drug manufacturer for trastuzumab, yet failed to disclose this in press releases. The charity's failure undermines its credibility and raises questions about its true interests.
Surgeons at UT Southwestern Medical Center have recorded some of the most successful patient outcomes nationally for patients with rare and complex type of kidney tumors. The five-year survival rate was among the highest, while one-year survival rate is 78 percent.
Research reveals that women genetically predisposed to breast cancer may be more susceptible to low-dose ionizing radiation, such as chest X-rays. Women with BRCA1/2 mutations who reported ever having a chest X-ray were found to be 54% more likely to develop breast cancer than those who had never undergone the procedure.
A new study reveals that older American women, particularly those from minority groups, receive significantly lower rates of mammogram screening than previously reported based on self-reported data. The study analyzed national Medicare data and found that the rate of screening among non-white women is substantially lower than that for ...
A new study finds that high cadmium levels may increase breast cancer risk, while silibinin has been shown to inhibit lung tumor blood vessel formation. Additionally, researchers have identified a potential anticancer compound in milk thistle and explored the role of KGF and FGFR2b in cancer treatment.
A genetic variant of BARD1 has been found to be associated with an increased risk of breast cancer, particularly in women who carry the BRCA2 mutation. The study suggests that inheriting this allele may increase a woman's breast cancer risk, but for most women, the risk is only slight.
Researchers reviewed data from 156 patients with inflammatory breast cancer and found that a standard combination of therapies did not significantly increase survival rates. The study highlights the need for further research to identify subsets of patients who may benefit from alternative treatment approaches.
Combination therapy with a monoclonal antibody (CLTA4 blockade) and a vaccine (Gvax) leads to increased infiltration of CD8+ T effector cells into tumors, resulting in tumor rejection. Chronic exposure to this therapy does not deplete regulatory T cells, preserving their immune-modulating function.
CS-Keys, a new company formed by Indiana University faculty, is developing an early diagnostic tool for breast cancer using a biomarker that distinguishes healthy cells from cancerous cells. The technology has the potential to improve diagnosis and treatment outcomes, making it easier to detect cancer in its earliest stages.
A University of Manchester team has discovered a protein potentially involved in the spread of tumors. The researchers believe their findings could lead to new approaches to treating breast cancer by blocking the protein's actions.
A new study has discovered a novel estrogen receptor that differs significantly from existing receptors, with potential implications for anti-estrogen breast cancer therapy. The receptor, hER-?36, is predominantly localized on the cell plasma membrane and stimulates cell growth through the MAPK/ERK signaling pathway.
Researchers have discovered gene SLIRP with the potential to shut down oestrogen in breast cancer cells and testosterone in prostate cancer cells, depending on the cancers' survival. This breakthrough could lead to the development of 'smart' drugs that target specific genes, potentially reducing side effects and improving survival rates.
The Vera Bradley Foundation has donated $6.8M to the IU Breast Cancer Research Program, supporting groundbreaking research and improving treatment outcomes for patients. The gift is the foundation's 13th major donation to IU School of Medicine and marks a continued commitment to finding a cure for breast cancer.
Researchers discovered that overexpressing a gene called uPA in mammary cancer cells can delay tumor progression and inhibit the formation of new blood vessels, leading to slower tumor growth. The study also suggests that uPA expression may have anti-cancer effects by reducing angiogenesis and proliferation.
A study found that pre-menopausal African American women are more likely to have the basal-like breast cancer subtype, which is more aggressive and lacks targeted treatment options. The researchers also noted a higher mortality rate among younger African American women with this subtype.
A 10-year study by U-M researchers found that women with BRCA1 or BRCA2 gene mutations who underwent breast-conserving surgery and hormonal treatment had lower rates of breast cancer recurrence. Tamoxifen reduced the risk of same-breast recurrence by 58 percent, while oophorectomy lowered the risk even further.
The SUPREMO trial will investigate the benefits of postoperative radiotherapy after mastectomy in women at intermediate risk of breast cancer recurrence. The study aims to identify a molecular signature that can refine selection for radiotherapy and explore its impact on quality of life.
A recent study found that breast cancer in younger black women is more likely to be an aggressive variety, with a high frequency of basal-like subtype. The study suggests that this could contribute to the higher mortality rate among young black women with breast cancer.
A recent study has shown that trastuzumab reduces recurrence of HER-2 positive breast cancer by 50 percent and does not add complications to radiation treatment. The study was conducted on 1,460 patients who received radiation in the original N9831 group, with no significant difference in side effects.
A study by OHSU Cancer Institute physicians validates the reclassification of breast cancer stages, improving disease-free survival rates for patients previously diagnosed with Stage II and III. The revised classification system has been shown to increase 10-year survival rates for these patients, from 30-36%.
The study found that tamoxifen reduced the incidence of non-invasive breast cancer, but had no effect on invasive breast cancer risk. Raloxifene also reduced the risk of invasive breast cancer and was associated with lower thromboembolic events.
The study found a reduced risk of breast cancer among women taking calcium and vitamin D supplements, with a significant interaction between those using supplements and those not. The researchers suggest further analysis of vitamin D metabolites may help clarify the findings.
A study of 886 women with BRCA1 or BRCA2 genetic mutations found that prophylactic surgery reduced ovarian cancer incidence by 89% and breast cancer incidence by 47%. The results differ for BRCA1 and BRCA2 carriers, highlighting the need for tailored risk-reduction strategies.
Participating in a daily yoga program during breast cancer treatment has been shown to improve physical function, general health, and social functioning among women. The study also found significant reductions in sleep-related daytime dysfunction and fatigue, but no impact on depression or anxiety.
A survey of 228 women found that 33% initially misunderstood the results and 24% became more anxious after learning their status. However, 39% reported a decrease in anxiety, highlighting the need for clear communication about clinical trial results.
A study of 57 women with metastatic breast cancer found that low-income African-American women experienced higher levels of symptom distress and lower quality of life compared to other racial and economic groups. The researchers emphasize the need for tailored care approaches to improve outcomes for these patients.
Early breast cancer patients switching from tamoxifen to Aromasin experience a 17% lower chance of dying and a 25% lower risk of breast cancer recurrence. The study's findings also suggest long-term safety benefits, with no clinically meaningful changes in the side effect profile.
Researchers found a known Caveolin-1 gene mutation present in 19% of breast cancers fed by estrogen. They also discovered six new mutations associated with estrogen-driven breast cancers. The study suggests that Caveolin-1 mutations may play a role in the development of these cancers.
Using MR spectroscopy improves the detection of malignant breast lesions, reducing the need for biopsy procedures. The technology helps identify tumors with elevated choline compounds, which are a marker of an active tumor, and eliminates the need for biopsies to determine their composition.
A study found that breast MRI screening can be cost-effective for BRCA1 mutation carriers, particularly when mammography is insensitive. Adding annual MRI from ages 35-54 is cost-effective among all BRCA1 carriers and those with high-risk due to aggressive cancer types
Dr. Mary-Claire King has made significant contributions to the understanding of inherited breast cancer, discovering the BRCA1 gene that predisposes individuals to this widespread disease. Her work also explores human genetic diversity and evolution, as well as the application of genomics to human rights problems.
A new clinical trial called TAILORx aims to determine whether chemotherapy is necessary for women with early-stage breast cancer. The study will use OncotypeDXTM, a genetic test that estimates a patient's risk of recurrence and predicts treatment outcomes.
Researchers have developed a new integrated system that combines MRI and NIR imaging to quantify hemoglobin, water, and scattering values in breast tissue. This technique may help detect early tumor growth and characterize tumor stage by learning about its vascular and cellular makeup.
Researchers found that women who gained more than 60 pounds during adulthood were almost twice as likely to have ductal type tumors and more than 1.5 times more likely to have lobular type cancers. The risk for metastatic disease increased with weight gain, particularly among those who gained over 60 pounds.
A study of 8,724 elderly women found that radiation therapy reduced breast cancer recurrence and mastectomies. Patients aged 70-79 years in good health gained the most benefit from radiation therapy.
A new study found that postmenopausal women who use statins have the same risk of invasive breast cancer as those who do not. Hydrophobic statins were associated with an 18% decreased risk of breast cancer, but individual statin associations warrant further research.
A study of 403 premenopausal women with estrogen receptor-positive breast cancer found that increased Pak1 expression correlates with reduced sensitivity to tamoxifen therapy, leading to decreased survival rates. Researchers suggest targeting Pak1 as a potential strategy to improve treatment response in breast cancer.
A study of over 156,000 post-menopausal women found that taking hydrophobic statins was associated with a 18% decreased incidence of breast cancer. However, no association was found between statin use and breast cancer risk in general. Further research is needed to confirm this finding.