Articles tagged with Breast Cancer
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A study of postmenopausal women found that those taking estrogen for more than 20 years had a significantly increased risk of developing estrogen receptor-positive and progesterone receptor-positive breast cancers. The risk was strongest in those who used estrogen for longer periods.
Researchers investigated the association between genetic variants and breast cancer risk, as well as apolipoprotein E (apoE) plasma levels and cardiovascular mortality in older adults. The study found no link between CHEK2 gene variants and breast cancer risk, while high apoE levels were associated with increased cardiovascular mortali...
A survey of 397 women found that 16% believed their risk of breast cancer was 50% or higher, and most thought mammograms could detect all cancers. The study identified pain experience, emotional distress, anxiety, and satisfaction with healthcare as significant predictors of repeat mammography behavior.
A U-M study found that non-invasive ductal carcinoma in situ (DCIS) can be effectively treated with lumpectomy and radiation, with only 8% of women experiencing recurrence. Regular follow-up mammograms are a reliable way to detect any return of cancer.
Researchers found that inhibiting myosin light chain kinase with ML-7 induces cell suicide in breast and prostate cancer cells. Combination with etoposide treatment reduces tumor growth by 88.5% and 79.1%, offering new target for cancer therapies.
Fenretinide has been shown to reduce the risk of second breast cancers in young women, particularly those under 40. The study found a 38% reduction in second breast cancers in pre-menopausal women and halved the risk for women under 40.
A study published in the Journal of the National Cancer Institute found that sentinel lymph node biopsy resulted in better arm function, improved quality of life, and faster recovery times compared to standard axillary lymph node dissection. Women who underwent sentinel lymph node biopsy had a low recurrence rate and equivalent surviva...
Researchers have developed a technique using iron oxide nanoparticles to group together in cancerous tumors, creating masses detectable by MRI machines. This method has the potential to replace traditional treatments like radiation or chemotherapy with fewer side effects.
Researchers have identified a biological marker that predicts persistent fatigue in breast cancer survivors, attributed to inflammation. The biomarker combines immune response elements, including interleukin-6 receptor and T cells with CD69 protein.
Researchers at UCLA discovered that breast cancer survivors with persistent fatigue have higher levels of pro-inflammatory cytokine proteins in their blood. Behavioral interventions like tai chi and yoga may help alleviate the fatigue, which affects about a third of breast cancer survivors for years after treatment.
Researchers discovered that tumors producing high levels of lysyl oxidase (LOX) are more likely to spread and cause death. Blocking LOX production has promise as a new therapy for hypoxic tumors, with trials potentially starting within three years.
Researchers developed a chemotherapy gel that slowly releases doxorubicin to kill remaining cancer cells, eradicating tumors in mice. The treatment also reduces breast deformity by filling dimples and indentations after surgery.
Researchers used nano-sized particles injected into mice to improve ultrasound image quality, detecting nanoparticles in the liver. This technology aims to identify early-stage diseases like cancers at a cellular level.
A study of 797 breast cancer survivors found that only 33% received a mammogram each year over the five years after treatment. Regular mammography for breast cancer survivors declines steadily within five years of treatment, highlighting the need to increase awareness among healthcare providers and patients.
Researchers at Vanderbilt-Ingram Cancer Center found a decreased risk of breast cancer among women with breast implants. The study, which followed over 3,400 Swedish women for an average of 18 years, also showed an increased risk of lung cancer but attributed it to smoking habits.
Researchers found that cancer treatment effectiveness is independent of tumor type, and varying levels of specific proteins determine drug response. This study suggests a new approach to treating cancer by selecting therapies tailored for individual patients instead of one-size-fits-all approaches.
A new study finds that health care spending generates significant health benefits, with a return on investment of $1.55 to $1.94 for every dollar spent. The research demonstrates the value of estimating the impact of health care investments and challenges policymakers to consider cost-effectiveness in their decision-making.
Researchers found that BRCA1 and BRCA2 mutation carriers experience a similar reduction in breast cancer risk with increasing number of pregnancies carried to full-term, parallel to that in the general population. Additionally, they discovered that first childbirth at age 20 years or older is associated with increased risk of breast ca...
A nationwide cohort of 3486 Swedish women who underwent cosmetic surgery for breast implants between 1965 and 1993 were followed until the end of 2002. The study found that women with implants had a reduced incidence of breast cancer and an increased incidence of lung cancer compared to the general population.
A six-year study analyzing data from 1 million mammograms reveals racial and ethnic disparities in breast cancer screenings. African-American women are more likely to have inadequate screening before diagnosis, whereas Asian and Native American women tend to underutilize mammography, leading to higher advanced-stage tumor rates.
Researchers found that chemotherapy improvements reduced recurrence risk by 21-55% in ER-negative tumors, while 9-26% in ER-positive tumors. This suggests that newer chemotherapies offer substantial benefits for patients with ER-negative disease.
A new study finds that estrogen-only therapy does not increase the risk of breast cancer in postmenopausal women, contradicting previous findings. In contrast, hormone therapy combining estrogen and progestin was linked to a 26% higher risk of breast cancer.
A study of postmenopausal women found that those taking conjugated equine estrogens (CEE) had a lower rate of invasive breast cancer, total breast cancer, and localized disease compared to placebo group. CEE also showed a decrease in the risk of ductal carcinomas, but not lobular disease.
Researchers found significant improvements in disease-free survival and overall survival rates for patients with ER-negative breast cancer treated with modern chemotherapy regimens. These findings underscore the need for tailored treatments based on tumor subtypes.
Research reveals chemotherapy works better for ER-negative tumors, with significant survival benefits, while tamoxifen is effective but less impactful for ER-positive tumors. Modern chemotherapy regimens show promise for treating ER-negative patients.
Researchers have developed a nano-particle system that targets and kills cancer cells using a combination of paclitaxel and doxorubicin. This innovative approach overcomes the challenge of delivering multiple drugs to tumors efficiently.
Researchers at the University of Cincinnati have discovered a hormone receptor involved in breast cancer growth, finding that it can be slowed by a synthetic neuropeptide Y hormone. The study suggests that targeting this receptor may lead to more effective drug therapy for breast cancer patients.
A study of 23,191 black women found a significant association between hormone use and breast cancer risk, with the longest cumulative exposure increasing the risk. The strongest association was seen in leaner women, who may be more susceptible to the effects of estrogen due to fat tissue producing this hormone.
A meta-analysis of 18 studies suggests that soy food intake is associated with a reduced breast cancer risk, particularly in premenopausal women. However, the study found insufficient evidence to support the use of soy supplements as a breast cancer preventive measure.
Researchers found that combining a PI3K inhibitor with Herceptin can reverse lack of response in HER2-positive breast cancer patients. The addition of a PI3K inhibitor showed significant benefit in halting tumor growth, especially in tumors lacking PTEN protein.
A meta-analysis of 18 studies found a small association between soy food intake and reduced breast cancer risk, particularly in premenopausal women. However, the data were inconsistent enough that no clear recommendation could be made for using soy supplements to prevent breast cancer.
Research suggests that Vitamin D, along with outdoor activities and diet, may lower breast cancer risk. Studies found significant reductions in breast cancer among individuals exposed to high levels of Vitamin D, particularly during adolescence.
A meta-analysis of 18 epidemiologic studies found a small association between soy intake and reduced breast cancer risk. The risk appeared to be greater in premenopausal than postmenopausal women, but the data have limitations due to inaccurate measurements and potential surrogate effects.
Regular use of antihistamines has been linked to a higher risk of developing low-grade and anaplastic astrocytomas, two types of brain tumors. Conversely, anti-inflammatory medications may help protect against glioblastoma, a more deadly type of tumor.
A pilot study found elevated Bcl-2 levels in patients with ovarian cancer, associated with 92% of cases, while CA125 tests identified only 68%. The research aims to develop a safe, non-invasive detection method for ovarian cancer.
Research at a public hospital found that African-American and white women have similar prognostic profiles for estrogen receptor and tumor grade. Low economic standing is linked to poor outcomes, regardless of racial background. Socioeconomic status, not biological factors, may contribute to breast cancer disparities.
Researchers have developed novel diagnostic tests for lung cancer using airway gene expression assays, which identified three times as many early-stage cancers as conventional bronchoscopy. Genetic signatures from epithelial cells complement clinical results to diagnose 95% of patients with lung cancer.
The team, led by Joerg Lahann, aims to create a non-invasive and inexpensive over-the-counter breast cancer screening test using metabolites present in breath. The device will utilize switchable surfaces that can attract and detect cancer-indicating metabolites.
A new study reveals that regular use of COX-2 inhibitors, such as celecoxib and rofecoxib, significantly reduces the risk of breast cancer. Women who used these drugs for at least two years experienced a 71% lower risk of breast cancer compared to non-users.
A Mayo Clinic study found that a specific gene profile of HOXB13 and IL17BR is an independent marker of early breast cancer relapse or death in lymph node-negative breast cancer. This discovery has significant clinical implications, suggesting the potential for improved treatment outcomes for high-risk patients.
Researchers at the University of Liverpool have identified a new gene, S100P, that causes the rapid spread of cancerous cells. The discovery builds on previous findings and aims to develop drugs that can switch off the action of metastasis-inducing genes.
Researchers have discovered a potential new treatment for breast cancer metastasis to bone, where 70% of patients develop bone metastases. The study found that osteoprotegerin inhibits RANKL, a protein promoting bone breakdown and cancer cell growth.
Researchers have identified certain metabolites that can trigger breast and prostate cancer, paving the way for early detection and prevention. The study's findings suggest a novel approach to cancer prevention by eliminating these initiating steps.
Researchers developed a nimesulide derivative that selectively inhibits aromatase production in breast cancer cells, reducing the risk of hormone-related side effects. This could lead to more targeted treatments for postmenopausal women with estrogen-dependent breast cancer.
A study found that ultrasound identified all cancers, while mammography detected 90% of tumors in pregnant women. Imaging helped diagnose and treat cancer in pregnancy without harm to the fetus.
Dr. Bernard Fisher's pioneering research on tumor metastasis and clinical trials has transformed the management of breast cancer. His systematic studies revealed that a combination of lumpectomy and radiation therapy is equally effective as total mastectomy, changing the way physicians approach patient care.
A new study found that weight training significantly improved the quality of life for breast cancer survivors, reducing symptoms such as depression and anxiety. The exercise program also increased lean body mass and upper body strength.
The European School of Oncology task force recommends a multidisciplinary approach to managing metastatic breast cancer, prioritizing patient psychological wellbeing and disease-specific treatment goals. Patients with MBC should be offered psychosocial support and involved in decision-making.
The new web resource provides instant access to cancer information materials in 11 Asian languages, including Chinese, Korean, and Vietnamese. The site features over 12 organizations' contributions, with all materials reviewed for medical accuracy and cultural relevance.
Tamoxifen, originally designed as an anti-oestrogen, has proven effective in cancer treatment and is now licensed for preventing breast cancer in high-risk women. Raloxifene, developed to treat osteoporosis, also demonstrates potential in reducing invasive breast cancer risk by 76% in postmenopausal women.
The Nice Manifesto outlines seven key goals to improve breast cancer care in Europe, including increasing screening programs, supporting research, and expanding breast unit accreditation. The manifesto represents a promise to improve breast cancer care for all patients across Europe.
A new dictionary of terms has been developed to convert medical jargon into everyday speech, helping patients understand their breast cancer experience. The French dictionary, which will be bilingual, aims to bridge the language gap between patients and doctors.
Researchers found a higher risk of developing lobular and tubular breast cancer in women taking HRT, with combined HRT increasing the risk even more. No increase in ductal breast cancer risk was observed, and some cancers were more hormone-receptive than others.
A recent study published in Health Communication found that participation in computer-mediated support groups improved emotional well-being and reduced negative mood among breast cancer patients. The analysis of text messages revealed a higher percentage of insightful words associated with these benefits.
The COSMIC database has expanded to include data on 538 genes and 124,367 tumours, highlighting the need for further research to uncover additional breast cancer susceptibility genes. Scientists believe that many somatic mutations are caused by a combination of faulty gene and environmental factors.
A breakthrough project in the Netherlands dramatically improved patient care for breast cancer patients by implementing structured best practices. The initiative reduced waiting times to under a week and increased pre-operative multidisciplinary consultations, leading to more clear-cut diagnoses and fewer unnecessary operations.
The study found that patients receiving the combination of paclitaxel and bevacizumab had a significantly improved progression-free survival of 11.4 months, compared to 6.11 months with paclitaxel alone. This trend also suggested improved overall survival in patients treated with the new drug combination.
A study found that commercial genetic testing does not detect all cancer-predisposing mutations in BRCA1, BRCA2, CHEK2, TP53, and PTEN among women with breast cancer from high-risk families. The researchers identified previously undetected mutations in 17% of patients, highlighting the need for more accurate genetic testing methods.
Researchers found no association between mammography and increased risk of breast cancer in women with BRCA mutations. The study suggests that screening may be safe for this high-risk group, but prospective studies are needed to confirm the results.
The American Association for Cancer Research (AACR) has expanded its scholarship program to promote inclusivity in cancer research, supporting early-career scientists from underrepresented groups. The program provides financial support for conference attendance and research expenses.