Articles tagged with Breast Cancer
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A study published in the American Journal of Epidemiology found that regular physical activity can lower melatonin levels, which may contribute to a reduced risk of breast cancer. The research, conducted by researchers at the University of Toronto, involved 213 female volunteers and monitored their melatonin levels over time.
A recent study published in The Lancet suggests that high-dose chemotherapy improves both event-free and overall survival for women with advanced breast cancer. This finding contradicts previous studies, highlighting the need for further investigation into this treatment strategy.
Women who started smoking before their first pregnancy have a 20% higher risk of breast cancer compared to nonsmokers. The study also found no link between smoking duration or number of cigarettes smoked per day and breast cancer risk among smokers.
A new study has shown that transmitting full-field digital mammography images over the internet can be done without compromising accuracy or security. The study, which included 1,314 diagnostic screening mammograms, demonstrated the feasibility of regional interpretation centers to improve breast cancer screening access and accuracy.
New research suggests that Herceptin may be cost-effective for certain sub-groups of patients with early breast cancer, but its use as adjuvant therapy could impose a significant financial burden on healthcare systems. The study estimates that the cost of providing Herceptin treatment in Belgium would be around €25.5 million per year.
A new technology called tomosynthesis has been shown to decrease false-positive screening mammography findings by half, allowing for more accurate detection of early breast cancers. In a study of 98 women, tomosynthesis was found to be as good as or better than diagnostic mammography in 88% of cases.
Researchers have developed a biocompatible polymer that briefly changes from liquid to gel at body temperature to block gene-bearing viruses from leaking into the bloodstream and harming other tissues. This method reduces misdirected virus dissemination by a factor of 100-1,000 times, solving the problem of toxic leakage in gene therapy.
Researchers are exploring nanostructures to detect and target cancer cells, offering potential cost-effective diagnostic methods. Nanoshells can destroy tumor cells when heated with laser light, while nanoparticles combined with hormones and peptides are being tested for imaging and targeting.
A recent study published in the Journal of the National Cancer Institute found that regular physical activity may lower breast cancer risk in both black and white women. Women who exercised for at least 1.3 hours a week had a 20% lower risk of breast cancer compared to inactive individuals.
A study published in Cancer Research reveals that patients with high levels of the protein BCA2 are less likely to experience breast cancer re-occurrence. Higher levels of BCA2 are associated with positive estrogen receptor status and increased disease-free survival for regional recurrence.
A follow-up study to the NSABP Breast Cancer Prevention Trial confirms tamoxifen's effectiveness in reducing invasive and noninvasive breast cancer risk. The study found a 43% reduction in invasive breast cancer risk and a 37% reduction in noninvasive breast cancer risk.
A new study found that increased physical activity is associated with a decreased risk of breast cancer in both black women and white women, regardless of disease stage or family history. Additionally, research on plant compound deguelin suggests it may interfere with tobacco-induced lung cancer development, while high plasma levels of...
The available evidence on Herceptin for early breast cancer is insufficient to make reliable judgments, states The Lancet. Drug regulatory agencies must consider the totality of available evidence and be free from external influences.
A terminal cancer patient, D.H., has seen his cancerous tumors shrink to 10% of their original size after increasing his intake of omega-3 fatty acids. The nutritional intervention was part of a case study published in the Nutrition and Cancer journal, showing promising results for cancer treatment.
Dr. Harold F. Dvorak, M.D.'s groundbreaking work on vascular permeability factor/vascular endothelial cell growth factor (VEGF) has led to significant clinical benefits in cancer patients. His discovery has enabled the development of anti-VEGF therapies with outstanding clinical antitumor activity.
Anke Meyer-Baese is developing computer software to mimic the way a radiologist analyzes all of that information -- and to do it better and faster. The goal is to provide doctors with a new tool to better diagnose breast cancer using MRI technology, which holds promise in detecting hard-to-find cases.
Researchers found that treating cancer cells with GLA suppressed protein levels of the oncogene Her-2/neu, leading to a 30-40 fold increased response in breast cancer cells to trastuzumab. GLA's inhibition works differently from Herceptin and may regulate breast cancer cell growth and metastasis.
Researchers followed nearly 1.7 million offspring and siblings of almost 850,000 people with cancer diagnoses to investigate familial cancer risks. The study found that daughters of breast cancer patients were more likely to be diagnosed with in situ breast cancer within a year of their mother's diagnosis.
Alcohol consumption is linked to increased ER-positive breast cancer risk in postmenopausal women. Tamoxifen treatment for 5 years reduces death from coronary heart disease compared to 2-year treatment, according to a new study. The gamma-linolenic acid found in herbal medicine has been shown to affect the expression of the Her-2/neu o...
Research suggests that adding these foods to the diet can prevent or halt cancer growth. Broccoli sprouts were found to reduce Helicobacteri pylori infection and alleviate gastritis in infected individuals.
A study found that relatives of women with bilateral breast cancer and a normal CHEK2 gene are at a 23.8% risk by age 80, while those with the faulty variant have a 58.8% risk. Testing for the CHEK2*1100delC mutation in women with family history could be useful for predicting personal risks.
Researchers found that breast cancer death rates decreased by an estimated 25-38% due to the combination of screening and adjuvant therapy. The study used advanced statistical models to determine the contribution of each method, finding greater uncertainty with screening mammography estimates.
Researchers propose strength-training as an alternative to current lymphedema treatment guidelines. Studies have shown that women with breast cancer can benefit from upper-body strength training without increasing the risk of lymphedema.
Researchers analyzed data from 79,994 women to evaluate associations of statins, lipid-lowering drugs, and serum cholesterol levels with breast cancer. No link was found between these factors and breast cancer risk.
Contralateral prophylactic mastectomies (CPM) reduce risk of future breast cancer, but may lead to negative feelings towards body appearance and loss of sense of femininity. The study found that satisfaction levels were higher in women who underwent a simple mastectomy compared to those who had bilateral prophylactic mastectomies.
The HERA study found that Herceptin reduces the risk of cancer coming back by 52% and death by 33% in early-stage HER2-positive breast cancer. The results provide new hope for women with this aggressive form of breast cancer, offering improved survival rates.
A study of 208 women with early or advanced breast cancer found that nearly half forgot their tablets and over a tenth deliberately skipped doses. The research highlights the need for doctors to address patients' concerns about hot flushes and injections, which can affect treatment adherence.
The Mayo Clinic report reveals that trastuzumab is the most effective treatment for women with HER2-positive breast cancer. With a disease-free rate of 90.4% at three years, this breakthrough offers new hope to millions of women worldwide affected by this type of cancer.
The Herceptin trial showed a significant reduction in disease recurrence in women with aggressive HER2-positive breast cancer. The treatment improved disease-free survival and overall outcomes, with no serious cardiac side effects reported.
African American women face unique genetic challenges in breast cancer screening due to limited data on mutations. Research confirms that genetic testing models work just as well for African Americans as they do for other populations, but the spectrum of mutations is vastly different.
A study characterized the clinical predictors of BRCA1 and BRCA2 mutations among high-risk individuals of European and African ancestry. Researchers found that early age at diagnosis and family history were associated with an increased likelihood of carrying a deleterious mutation.
A study of 869 women found that radiation therapy after surgery reduced breast cancer recurrence by almost 100%, with an overall survival rate of 97%. Radiation therapy also did not impact patients' quality of life or long-term survival rates.
A large single-institution study evaluated the safety and efficacy of MammoSite, a type of partial breast irradiation. The study found that toxicities were similar to those reported in previous registries, with acceptable complications and comparable cosmetic outcomes.
A new one-week radiation treatment for breast cancer patients has shown promising results, with no patient recurrence after 48 months and 80% of women experiencing good-to-excellent cosmetic outcomes. The treatment uses MammoSite brachytherapy to deliver high doses of radiation to the surrounding tumor area.
A randomized study of 471 women with T1-T2 invasive breast cancer found that those with high-risk factors may benefit from an aromatase inhibitor added to five years of tamoxifen. The study suggests a 1-2% clinical benefit, which is below the commonly used threshold of 3%.
A new study from Fox Chase Cancer Center found that married breast cancer patients do not have different survival rates than unmarried women. However, younger women and those over 70 tend to fare worse despite similar disease characteristics and treatment factors. Age emerged as a significant predictor of relapse-free survival.
A new study published in Fox Chase Cancer Center found that sequential sequencing of radiation and tamoxifen after lumpectomy significantly improves cosmetic outcomes for women with early-stage breast cancer. The study included 1,088 patients who underwent breast-conserving surgery and radiation therapy, and received adjuvant tamoxifen.
Researchers at the Mayo Clinic found that breast conservation surgery followed by radiation therapy can lead to favorable cosmetic results in patients with implanted breasts. The study challenged previous reports of poor outcomes.
Researchers found curcumin suppresses the inflammatory response that induces metastasis, causing cell death and reversing disease progression. Curcumin breaks down chemotherapy doses, making it less toxic while maintaining efficacy, offering new hope for breast cancer treatment.
University of Delaware researchers have developed a new therapeutic agent called 'nanobombs' that use carbon nanotubes to selectively kill cancer cells. The nanobombs are created by bundling carbon nanotubes and can be triggered by light, causing microscopic explosions that target specific areas within the body.
A Columbia University study reveals that black women with early-stage breast cancer are two times more likely to die within five years after diagnosis compared to white women. The study found that only 68% of black patients completed all prescribed chemotherapy cycles, compared to 76% of white patients.
Researchers are studying disease at molecular levels to develop personalized medicine, leveraging the analytical skills of engineers in discovery and understanding biological systems. The goal is to create a quantitative-plus-molecular equation that enables intelligent computing tools to aid diagnosis and treatment planning.
A study of 906 breast cancer patients found that comorbidities such as diabetes and hypertension contributed to racial disparities in survival rates. Black patients had shorter overall survival rates, while whites were more likely to die from competing causes.
A study by Laura Potts found that opinions on breast cancer causes are divided, with theories citing genetic, hormonal, and environmental factors. The research team recommends building common ground for preventative policies amidst concerns about government inaction.
Performing a sentinel lymph node biopsy as an outpatient procedure prior to mastectomy can help guide the optimal surgical procedure for patients. This approach allows for more informed decisions regarding radiation therapy and reconstruction, potentially improving cosmetic results.
The consensus panel recommends minimizing open surgical biopsies in favor of minimally invasive needle breast biopsies, which can help reduce complications and costs. They also suggest using sentinel lymph node biopsy and MRI for accurate staging and diagnosis.
A pilot study at Michigan State University found reflexology to be the most effective complementary therapy for women receiving chemotherapy for late-stage breast cancer. Reflexology applied firm pressure to certain parts of the foot helped reduce depression, anxiety, and improved spirituality and emotional quality of life.
A model predicts that young women treated for Hodgkin lymphoma are at increased risk of developing breast cancer, with risks rising with age and radiation exposure. Current treatment guidelines may be reconsidered to minimize these risks.
A study published in Tissue and Cell reveals that defects in the adult stem cell niche can lead to breast cancer development. Researchers found that each cell population plays a different role in breast cancer and that environmental factors influence the risk of becoming cancerous.
Researchers discovered that TGFBR1*6A, a gene variant, significantly increases the risk of developing metastases in colorectal and head & neck cancers. In the presence of TGF-beta, cancer cells with this gene variant exhibit a selective growth advantage.
Researchers found no link between breast-feeding and adult cancer risk, but high red meat consumption is associated with increased pancreatic cancer risk. A new vaccine approach may enhance tumor-specific immune response when combined with chemotherapy.
The annual report shows cancer death rates decreasing for 12 of the top 15 cancers in men and nine in women, with lung cancer remaining a leading cause. Overall incidence rates have been stable since 1992, but breast cancer incidence has increased due to rising rates for six other cancers.
A Canadian study explores how men cope with breast cancer diagnoses, revealing a wide range of reactions from shock to advocacy. Researchers aim to raise awareness and encourage male participation in clinical trials.
The School of Medicine will research and apply nanotechnology for the diagnosis and treatment of cancer. The nanotechnology offers several advantages, including precise targeting of tumor cells and drug therapies.
Researchers identified genetic signatures that predicted patient prognosis and response to treatment, outperforming existing clinical markers. The technique of DNA microarray analysis holds promise for developing new prediction methods, sparing patients from unnecessary treatments.
Researchers identify 64 genes used to separate breast cancer patients with good and poor prognoses. The technique of DNA microarray analysis could help predict patient response to adjuvant therapy, avoiding unnecessary treatments.
Researchers studied over 450 women with family histories of breast cancer to understand their soy product use. Key findings include that nearly half of the women consume soy products and believe they may reduce cancer risk, while others cite taste preferences or difficulties in preparation.
Researchers added optical tomography to ultrasound, allowing for non-invasive detection of malignant tumors with higher accuracy. The new technique uses near-infrared light to measure oxygen-carrying blood cells and microvessels in breast lesions.
A new protocol has been developed to identify women with high-risk family histories of breast or ovarian cancer, allowing for more accurate data collection and analysis. The study found that 20.6% of participants had elevated risk levels, with higher rates among those with Ashkenazi Jewish ancestry.
A population-based study found that women with breast cancer are more likely to be absent from work for 4 weeks or more compared to healthy women. However, by the third year, work absence patterns become similar. The study also reveals factors that modulate work absence, such as stable relationships and self-employment.