Articles tagged with Breast Cancer
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Researchers identify HPV types 16 and 18 as key factors in cervical precancer development, supporting targeted management for high-risk women. Night-shift work linked to increased breast cancer risk, while melatonin levels found to lower risk.
A study of 1,351 deceased women and 2,501 cancer-free women found similar screening rates among both groups. Women with increased risk showed a 26% reduction in mortality, but this was not statistically significant.
A recent study found that foreign-born Asian American and Pacific Island women are significantly less likely to receive breast-conserving surgery than non-Hispanic white women, despite similar demographic and tumor characteristics. Language barriers and cultural factors may contribute to these disparities.
Researchers found that non-cancerous cells surrounding young breast cancers undergo epigenetic modifications, altering gene function and signaling to tumor cells. This discovery may lead to early cancer diagnosis or predicting cancer risk through detection of epigenetic alterations.
Researchers at the University of Texas M. D. Anderson Cancer Center discovered that curcumin stops laboratory strains of melanoma from proliferating by shutting down nuclear factor-kappa B (NF-kB). The spice also induces apoptosis, or programmed death, in cancer cells.
A large-scale randomized trial found that low-dose aspirin had no effect on reducing the risk of total cancer, breast cancer, or colorectal cancer in healthy women. The study also suggested a possible trend toward reduced lung cancer risk, but this finding was not statistically significant.
A survey of women aged 40-44 found they value logistical, harm, and benefit information before their first screening mammogram. Women prefer to participate in the decision-making process, with some preferring clinician input.
Researchers at USF have discovered a tailored therapy for tumors with high levels of active Akt, which is abundant in 40% of women with ovarian cancer. The compound tricirbine has been found to inhibit some cancers and will be tested in clinical trials starting within six to eight months.
A recent study by Yale University researchers found that sEGFR, a breast cancer growth regulator, can indicate the effectiveness of letrozole in postmenopausal women with metastatic breast cancer. Decreased concentrations of sEGFR were seen in 73% and 76% of patients after one month and three months of treatment respectively.
A study of 60 male and 4,181 female breast cancer patients found that men were almost six times more likely to receive radiotherapy than women with similar disease stages. The researchers concluded that men should be treated using the same guidelines as women for radiotherapy treatment.
A study of 58 breast cancer patients found that initial tumor volume and changes in tumor volume during chemotherapy are strong predictors of recurrence-free survival. MRI measurements can help tailor treatment strategies for individual patients.
Research suggests that obese women with breast cancer are more likely to receive reduced doses of adjuvant chemotherapy, leading to poorer outcomes. The study analyzed data from 9,672 women and found that 37% of severely obese patients received a dose reduction of at least 10%, compared to 20% of obese patients.
A study of 580 women found that nearly half experienced persistent lymphedema, a condition causing fluid buildup in arms and hands. Lymphedema affects quality of life, requiring lifestyle changes such as compression garments.
A recent study by ECRI found that digital mammography does not significantly improve breast cancer detection rates compared to traditional X-ray imaging. While the new technology may offer some incremental benefits, such as reduced radiation exposure, its cost-effectiveness and diagnostic accuracy need further evaluation.
At the DoD 'Era of Hope' breast cancer meeting, Vanderbilt-Ingram researchers presented their groundbreaking research on various aspects of breast cancer, including tumor microenvironment, diagnostic imaging, and biological pathways. The conference brought together a diverse group of researchers to share their work and collaborate with...
A recent study published in Cancer Epidemiology, Biomarkers & Prevention found that women with low physical activity levels and higher body mass indexes were at increased risk of developing breast cancer. Conversely, those who engaged in approximately three METs of exercise per day had a lower risk, suggesting that promoting weight con...
Researchers at Mayo Clinic discovered a therapy that removes immune system blockages without harming the immune system, boosting its natural ability to reject breast cancer. T-regulatory cells play a disease-promoting role in breast cancer, and blocking them boosts natural immunity.
A 14-month study found that dexmethyphenidate (d-MPH) significantly reduced fatigue and improved memory in cancer survivors with chemobrain. The medication, taken at dosages of 10-50 mg per day, showed safe and effective results for relieving chemobrain symptoms.
Researchers discovered that combining Omega-3 fatty acids with propofol can inhibit cancer cell adhesion and migration, increasing apoptosis. The study suggests that these novel conjugates may be useful for treating breast cancer.
A recent study published in Patient Education and Counseling found that 89% of women overestimated their lifetime risk of breast cancer, with an average estimate of 46%. Women who did not provide an estimate beforehand were more likely to feel anxious, while those who provided an estimate reported relief after learning the actual risk ...
Researchers analyzed 3,500 breast cancer patients to identify factors associated with relapse. Patients with ER+/PgR- status, HER2 overexpression, or fewer than 10 positive axillary nodes did not show increased risk of relapse. Massive involvement of axillary nodes was linked to a higher risk of developing distant or local relapse.
A new test using Ki67 levels has been shown to predict the aggressiveness of breast cancer in early stages with high accuracy. The test correlates with tumor size, nodal status, and other parameters, providing valuable information for clinicians to make informed treatment decisions.
Researchers found that women with breast cancer were less likely to have two versions of the TCATA haplotype, associated with increased IL-10 expression. High levels of IL-10 may be protective against breast cancer due to its anti-angiogenic effects.
Research suggests long-term exposure to passive smoking increases premenopausal breast cancer risk by 68%. Active smoking also poses significant risk, with a 108% increase in breast cancer risk among those who have smoked.
A home-based physical activity program increased physical activity levels and improved fitness among breast cancer survivors. Participants reported reduced fatigue, increased vigor, and improved body image after 12 weeks of counseling via weekly phone calls and mail-delivered tip sheets.
Research on the ATM gene suggests that women carrying one mutated copy are twice as likely to develop breast cancer, with a lifetime risk of one in six compared to one in 11 in the general population. Meanwhile, a new study on ursodeoxycholic acid treatment found a 39% reduction in colorectal adenoma recurrence among patients who recei...
Research found that primary care physicians have only 3.5 hours per day to provide care for common chronic diseases, increasing to over 10 hours per day when accounting for poorly controlled conditions. The authors suggest collaborative guideline development and team approaches to patient education to address this issue.
Researchers found that early-life exposure to diethylstilbestrol (DES) can increase the incidence of uterine tumors in rats with a genetic predisposition. The study suggests that environmental exposures during development can interact with a preexisting genetic susceptibility to increase disease risk.
A new study found that long-term daily use of aspirin was associated with an increased risk of ER/PR-negative breast cancer, while long-term daily use of ibuprofen was linked to a higher risk of nonlocalized breast cancer. Regular NSAID use was not associated with breast cancer risk.
Researchers study natural products that may prevent certain cancers. Propolis and turmeric, rich in plant polyphenolic compounds, exhibit potent antitumor activities, protecting mice against radiation-induced inflammation and rats against chemotherapy-induced heart muscle damage.
The study examined 79 studies from 11 countries to investigate the association between personal hair dye use and cancer risk. The authors found no global effect on breast and bladder cancer, but a borderline effect for hematopoietic cancers like leukemia and multiple myeloma. Further investigation is needed for these high-risk groups.
Researchers at Penn State have developed a new ceramide-based therapy that targets and destroys breast cancer cells while sparing healthy tissue. The treatment uses liposomes to deliver ceramide to the tumor, where it disrupts mitochondria and causes cell death.
A study of 2,987 female registered nurses found that higher levels of physical activity after a breast cancer diagnosis were linked to longer survival. The adjusted relative risk of death from breast cancer was 20-50% lower for women engaging in more than 3 MET-hours per week of physical activity.
Research found that premenopausal women with higher birth weights (above 8.5 pounds) and those who were not breastfed as infants have an almost two-fold increased risk of developing breast cancer. Breastfeeding during infancy was found to be protective against breast cancer in these high-risk groups.
A new CAD system has improved the accuracy of breast MRI analysis, allowing radiologists to better determine cancer lesion sizes. The system reduced analysis time by an average of 7 minutes compared to standard software.
A recent study analyzed 10 studies on HRT and breast cancer, finding that randomized controlled trials show an increased risk of recurrence. The authors conclude that qualitative studies are unreliable due to methodological limitations and potential publication bias.
A randomized multicenter study found that the doxorubicin-docetaxel combination is associated with an increased risk of severe sepsis and life-threatening complications in breast cancer patients. The incidence of febrile neutropenia was significantly higher with this regimen, resulting in 2 deaths related to drug toxicity.
A new study found that increasing breast cancer screening recall rates can detect more breast cancers earlier, but the benefit levels off. Premenopausal women with elevated hormone levels have an increased risk of breast cancer.
Research found that MRI was nearly twice as sensitive as X-ray mammography in detecting breast cancer in high-risk women. Combining both methods increased detection to 94%. Women with the BRCA1 gene mutation saw a significant boost in tumor detection, making MRI an effective screening tool.
A study found that inhibiting EGFR with gefitinib can reduce breast tumor size by 30-99% in some cases. Researchers are now designing studies to assess the potential of this approach as a neoadjuvant treatment for breast cancer.
New research from Mayo Clinic reveals that adding trastuzumab to chemotherapy reduces breast cancer recurrence by 52% and death risk by 33%. The study's findings could change the standard of care for thousands of women with HER-2 positive breast cancer.
Researchers discovered an antibody compound that effectively targets and destroys blood vessels within cancerous tumors, reducing tumor growth by 93% when combined with docetaxel. This promising treatment approach may offer a new solution to treating breast cancer patients with limited effectiveness from traditional therapies.
A new mathematical model simulates 10-year disease-free survival in postmenopausal women with hormone-receptor positive breast cancer. The model reveals that the best treatment strategy depends on tumor biology, recommending tamoxifen and aromatase inhibitor treatment for different cases.
A new study found that women taking tamoxifen for breast cancer are nearly four times more likely to have a Factor V Leiden mutation, which increases the risk of blood clots. The research suggests testing for this mutation could help identify women who may benefit from alternative treatments or anticoagulants.
A recent study published by Dana-Farber Cancer Institute found that moderate alcohol consumption may elevate the risk of breast cancer in some postmenopausal women. The researchers analyzed data from over 122,000 registered nurses and discovered a higher incidence of breast cancer among those who consumed small amounts of alcohol daily.
Researchers found tamoxifen does not lower heart attack risk in breast cancer survivors and increases risk with radiation therapy. Tamoxifen use was linked to a doubled heart attack risk among women who also received radiation therapy, regardless of the duration or dose of the drug.
A large collaborative analysis of early breast cancer trials found that standard treatments such as chemotherapy and hormonal therapy can halve the 15-year risk of death from breast cancer. The study included data from 145,000 women with early breast cancer in 194 randomised trials.
A spinoff company has received a $2.5 million NIH grant to build a prototype scanner that can detect early-stage breast cancers with high accuracy, potentially changing medical practice in breast imaging. The scanner uses Cone Beam CT technology to eliminate structural overlap and capture clearer images of small tumors.
The breast CT scanner developed at UC Davis has reached clinical testing and shows promise in detecting breast tumors earlier than mammography. The technology requires no breast compression and takes images of virtual slices to provide a detailed view of breast tissues.
A new study found that nearly half of women perceived mammography screenings as unaffordable due to misperceptions about insurance coverage. The researchers suggest that private insurers can play a significant role in reducing these misconceptions by providing better educational efforts.
A study found that lack of accurate knowledge of insurance coverage, rather than actual costs, deters many women from getting screened. More than half of participants identified cost as a barrier to screening, with those who misunderstood their coverage being more likely to do so.
The new facility expands Columbia's laboratory space for cancer research, housing nine floors of research facilities, classrooms, and the Avon Foundation Breast Imaging Center. The center is dedicated to investigators conducting disease-specific research on various cancers.
Breast cancer tumors hijack normal wound-healing processes by exploiting stromal cells' production of SDF-1, which recruits endothelial precursor cells for tumor growth. This process enables tumors to access nutrients and grow unchecked.
A new study found that increasing Pap screening adherence and improving its accuracy could reduce the incidence of invasive cervical cancer among women with access to screening. The study also identified factors associated with screening failure, including lack of Pap testing and unrelated outpatient visits.
A study of 717,000 postmenopausal women found that oestrogen-only HRT and tibolone increase the risk of womb cancer, while combined HRT does not. The risk also varies according to bodyweight and is reduced in obese women
A study found that commercially available extracts of black cohosh increased cell killing by two of four drugs used in cancer therapy for breast cancer patients. However, the herb also decreased the effectiveness of one drug. Further research is needed to understand why these effects occur.
A recent study, led by Dr. Edward Romond, found that adding trastuzumab to chemotherapy significantly improves prognosis for women with aggressive HER-2 positive breast cancer. The study involved over 3,300 patients and demonstrated substantial benefits of combining trastuzumab with chemotherapy.
A new study using microarray technology has identified genes that distinguish between non-metastatic and highly metastatic breast cancer tumors. The research, led by Dr. David Tarin, used cell lines with varying capabilities to spread to distant organs and found that several genes were altered in expression patterns between the two typ...
Researchers used RNAi to silence STAT3 in mouse breast cancer cells, finding a 75% reduction in protein expression. This reduced the ability of cancer cells to invade normal tissues, offering new insights into cancer metastasis.
Research suggests that maternal diets high in omega-3 fatty acids during pregnancy and breastfeeding may reduce the risk of breast cancer in daughters. In contrast, high consumption of omega-6 fatty acids has been linked to increased estrogen levels, which can contribute to the development of breast cancer. The study's findings support...