Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Research investigates associations between male breast cancer, human papillomavirus (HPV) infections, and genetic variants in DNA repair genes. Ionizing radiation exposure is linked to higher male breast cancer incidence among atomic bomb survivors, while HPV detection is strongly associated with HIV status. Genetic polymorphisms in DN...
Researchers at UCLA isolated biomarkers from saliva that accurately predicted oral squamous cell carcinoma in 90% of cases. These biomarkers, known as salivary transcriptomes, also showed promise for detecting head and neck cancers. The study's findings suggest a potential breakthrough in early disease detection.
Researchers found breast cancers in African women more likely to originate from basal-like cells and often lack estrogen receptors, making them less responsive to standard therapies. This study highlights the need for rethinking screening guidelines and treatment approaches for these patients.
A novel monoclonal antibody targeting S1P has shown promising results in eliminating cancerous tumors in some cases. The therapy not only blocks the effects of S1P on cancer cells but also prevents tumor angiogenesis, a key factor in tumor growth.
Researchers discovered that TGFBR1*6A gene variants significantly increase breast cancer risk in women over 50, with a 69% higher risk for those with low TGF-beta activity levels. The findings may help predict breast cancer risk in a large subset of the population and inform genetic testing options.
Researchers found that collagen VI from adipocytes stimulates the proliferation and survival of malignant cells in breast tumors. The study suggests a potential link between increased adiposity and breast cancer risk, highlighting the role of extracellular matrix proteins in tumor behavior.
Researchers have discovered a new treatment that uses a chemical to prevent PARP repair, making recombination essential for cancer cell growth. This approach shows promise as a potential breakthrough for women with hereditary breast cancer.
Researchers found that tamoxifen significantly reduced the frequency of breast enlargement and breast pain compared to radiotherapy. The study showed that tamoxifen is a more effective treatment for preventing these side effects in prostate cancer patients.
Research on almost 116,000 English and Welsh breast cancer patients found that South Asian women were diagnosed at a significantly younger age, averaging 52 compared to 63 for other women. Additionally, their five-year survival rate was over 70%, with affluence boosting health and survival rates even among the poor.
Women with a family history of breast or ovarian cancer are more likely to receive genetic counseling if they're white. African American women are less aware of genetic testing technology and underestimate their cancer risk. The study found a significant racial disparity in the use of BRCA1/2 testing, which is not explained by socioeco...
A new cancer test uses the physical strength of each cell to diagnose and stage cancer, reducing the need for biopsies and potentially saving lives. The 'optical stretcher' can detect cancer in as few as 50 cells, allowing for early diagnosis and treatment.
Despite extensive education, few high-risk women consider taking tamoxifen to prevent breast cancer due to concerns over side effects and low perceived risk. Only a small percentage of eligible women would take the drug after learning about its benefits.
Two trials found that menopausal hormone therapy may increase breast cancer recurrence risk, but a new trial suggests no association. Researchers call for further study on safe treatment regimens.
Bone SPECT outperforms FDG PET in detecting breast cancer metastases, with a sensitivity of 85% and accuracy of 96%. PET's limitations make it less effective in revealing certain types of lesions.
The American Association for Cancer Research (AACR) has awarded scholarships to 103 full-time graduate, medical, or postdoctoral students and junior faculty members from underrepresented groups. The recipients will receive stipends to attend the AACR Annual Meeting and present their research papers.
Researchers found that combining chemotherapy with Herceptin before surgery in early-stage breast cancer patients resulted in a 42% higher tumor reduction and 66.7% pathological complete remission rate compared to chemotherapy alone. The combination also showed less risk of heart damage, leading the clinical trial to be halted early.
A study found that women with left-sided breast cancer had a higher risk of death from ischemic heart disease after radiation therapy, but this increased risk declined over time. Advances in radiation techniques have reduced the dose to the heart, resulting in lower mortality rates among women diagnosed with right-sided breast cancer.
A new study found that racial and ethnic differences in breast cancer rates can be largely explained by the distribution of risk factors, except in African American women. Among those diagnosed with breast cancer, African American women are more likely to have advanced-stage disease, larger tumors, and estrogen receptor-negative disease.
A recent study published by Harvard researchers found that consuming acrylamide through diet does not increase the risk of breast cancer in women. The study, which analyzed data from over 43,000 participants, also showed no association between acrylamide intake and an increased risk of other cancers.
A recent study found that advancements in radiation techniques have greatly reduced the risk of cardiac death after radiation therapy for breast cancer. Women with left-sided breast cancer had a higher mortality rate from ischemic heart disease compared to those with right-sided breast cancer, but this difference decreased over time.
A recent study found that Medicaid patients diagnosed with late-stage cancer have significantly poorer survival rates than those diagnosed earlier. The median survival was 18 months for late enrollers compared to 38 months for early enrollers and non-Medicaid patients.
Breast cancer in sub-Saharan Africa shows similarities with African-American women's disease patterns, suggesting possible hereditary factors. Incidence rates are lower due to protective behaviors like reproductive patterns and dietary habits.
Researchers found that postmenopausal breast cancer survivors have a higher risk of bone fractures, with 68.6 excess fractures per 10,000 person-years compared to the general population. The study also identified factors associated with increased fracture risk, including age, ethnicity, and depression.
Researchers discover ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, arrests cell division in human cancer cells and inhibits a variety of tumors. Clinical studies are currently underway to determine the best way to utilize this potent anticancer agent.
A new tumor-suppressor gene called mats has been discovered by researchers at Penn State, which works with another tumor suppressor to control tissue growth. The study found that the mats gene can shrink tumors in flies and may regulate cell number and tissue growth by restricting cell proliferation.
Researchers have made significant progress in developing a breast cancer vaccine, using a protein called mammaglobin-A found in 80% of breast tumors. The DNA vaccine has been shown to stimulate an immune response that can recognize and attack tumor cells expressing the protein.
A recent study found that only 1 in 4 minority women under 40 have documented family history of breast cancer. The research highlights the need for primary care providers to ask about breast cancer histories, as disparities were observed between minority and white women.
A study by Yale University reveals that 0.8% of women with non-invasive breast cancer (DCIS) have BRCA1 mutations, while 2.4% have BRCA2 mutations, similar to those found in more advanced breast cancers. Women with these mutations are at higher risk for early detection and may benefit from high-risk screening protocols.
The PEM unit detects breast cancer by pinpointing tumors with increased glucose metabolism, outperforming mammography in dense breast tissue. The device uses fluorodeoxyglucose to identify cancerous lesions, with 18 of 20 detected abnormalities proven to be cancerous.
A new study finds that MRI is more accurate than current standards in assessing the effectiveness of neoadjuvant chemotherapy for breast cancer. The imaging technique correctly identified the presence of residual tumor in 71% of cases, while sonography and clinical examination were less accurate.
A study by American College of Radiology found MRI to be useful in assessing suspected breast cancer patients, detecting additional cancers not visible on mammography or sonography. The use of computer-assisted diagnosis improved accuracy and led to recommended mastectomies for some patients.
A study found that Computer-Aided Detection (CAD) systems can effectively detect small and subtle breast cancers, with a sensitivity of up to 92% for lesions of 5 mm or less. CAD also helps reduce missed cancers and positively impacts breast cancer prognosis without increasing patient recall rates.
A study analyzing data from four clinical trials found that older patients with lymph node-positive breast cancer can tolerate standard and intensive chemotherapy regimens similarly to younger patients. The findings suggest that age is not a barrier to the effectiveness of adjuvant chemotherapy in healthy older women.
A Cornell University study found that tumor incidence was reduced by 17, 39, and 44 percent in rats fed the human equivalent of one, three, or six apples a day. The researchers also discovered that phytochemicals present in apples have potent antioxidant and anticancer activities.
A study of over 1.2 million mammograms found that experienced physicians detected cancer with higher accuracy and had lower rates of false positives. The research suggests that raising the minimum annual volume requirements for qualified mammographers could improve the overall quality of screening mammography in the US.
A new study found that colorectal cancer screening strategies had similar participation rates, regardless of the screening method offered. Tamoxifen use was also associated with an increased risk of endometrial cancer in both pre- and postmenopausal women.
Physician experience and annual mammogram volume are associated with improved mammographic accuracy, according to a US study. Physicians who interpret 2,500-4,000 mammograms annually have lower false-positive rates and miss fewer cancers compared to those with less volume.
Researchers have developed an MRI approach using shutter speed analysis, which provides more accurate information on breast cancer detection. This method distinguishes between malignant and benign tumors, improving diagnosis and treatment outcomes.
The mathematical model developed by Sandra Lee and Marvin Zelen provides quantitative predictions of the mortality benefits of different screening schedules. The study suggests that annual screenings from age 50 to 79 can reduce mortality by 37%, while starting mammograms at age 40 reduces overall risk of death by five percent.
Researchers identified a 76-gene signature that can predict disease relapse in patients with lymph-node negative breast cancer. The signature showed high sensitivity (93%) but lower specificity (48%) in predicting distant recurrence within five years.
Researchers have developed stem-cell generated natural tissue implants that retain their shape and size over time, avoiding issues like implant rupture or cancer detection interference. This approach could eliminate the need for extensive surgery and provide a more natural-looking solution for reconstructive surgeries.
The report reveals that nearly 2.9 million new cases of cancer were diagnosed in Europe in 2004, with lung cancer being the most common form. Breast cancer is also on the rise, while stomach cancer rates are falling. The study emphasizes the need for a joint European effort to combat these diseases.
Researchers found that women with primary hypothyroidism had a 61 percent lower risk of developing invasive breast cancer and those newly diagnosed were 57 percent less likely to have the condition. Women with both conditions tended to be older when diagnosed with a less aggressive, indolent disease.
A Swedish cohort study found that larger babies had a higher risk of certain adult cancers, including lymphatic and digestive cancers. Women who were large at birth were also more likely to develop breast cancer before age 50.
The research found that active Stat5 suppressed invasive tumor cell activities and aggregated breast cancer cells into clusters resembling healthy cells. Loss of Stat5 stimulated invasion, supporting its potential as a biomarker to predict risk and outcome in early-stage breast cancer patients.
A study of 61,688 women found that adding clinical breast examination to mammography screening detected an additional 25 cancers, but also led to false positive reports and increased biopsies in women with dense breasts
Researchers found that dietary kelp increased the length of rat estrous cycles by 37%, which is associated with lower risk of breast, ovarian and endometrial cancers. Kelp may act as an estrogen antagonist, reducing estradiol levels and potentially lowering breast cancer risk.
A $10-million study is recruiting 3,000 healthy men to investigate the transmission of human papillomavirus (HPV), a leading cause of cervical cancer. The research aims to determine whether vaccinating men could help prevent cervical cancer in women.
A meta-analysis of nine randomized trials found no significant difference in death rates or disease progression between neoadjuvant and adjuvant systemic therapy. However, neoadjuvant therapy was associated with a higher risk of loco-regional disease recurrence when radiation therapy was used without surgery.
A meta-analysis of 156 studies found that heavy alcohol drinking is strongly associated with an increased risk of primary liver cancer, breast cancer, large bowel cancer, and other related diseases. The risks are shown to increase with the amount of alcohol consumed, but no threshold below which no effect is evident.
Researchers found that high weight prior to diagnosis was associated with poorer survival, particularly in women who had never smoked. Weight gain after diagnosis also increased the risk of recurrence and death, especially among normal-weight women.
The Journal of Nuclear Medicine Supplement offers a comprehensive overview of radionuclide therapy, including its applications in thyroid cancer, lymphoma, and other diseases. The supplement highlights the growing importance of nuclear medicine in patient care and provides insight into emerging trends and technologies.
The addition of locoregional radiation therapy significantly improved breast cancer survival and reduced mortality in high-risk patients. A 20-year follow-up study found that the regimen resulted in a 32% reduction in breast cancer mortality and a 27% reduction in overall mortality compared to chemotherapy alone.
A new study found that adding more types to the current HPV DNA test would detect relatively few additional cases of cervical cancer but lead to thousands of unnecessary exams for women without cancer. Meanwhile, esophageal adenocarcinoma has increased by sixfold over the last 25 years, with no clear explanation for the rise.
A study found that breast cancer patients have lower DNA repair capacity compared to control subjects, increasing their risk of breast cancer. Deficient DNA repair capacity was associated with a threefold higher risk in women with poor DNA repair capacity.
Researchers aim to understand the growth and spread of breast cancer by targeting tumor stem cells, which are hypothesized to perpetuate cancer growth. The project may lead to a critical adjunct therapy targeting these cells.
A large European study found no association between vegetable and fruit intake and reduced breast cancer risk. The researchers analyzed data from 285,526 women and reported no significant associations for six specific vegetable subgroups.
The new technique uses gamma camera technology to detect smaller breast lesions and improve cancer diagnosis, particularly in women with dense breast tissue. The study found a high sensitivity rate of 86% for detecting small breast tumors, outperforming conventional gamma cameras.
A new gene vaccine has shown high efficacy in protecting mice against Her2/neu breast cancer, using a viral-vectored approach to stimulate a long-lasting immune response. The vaccine protected 86% of experimental mice from developing the disease.
US researchers found that oleic acid in olive oil suppresses the Her-2/neu oncogene, a key driver of aggressive breast cancer. The study suggests that dietary interventions based on oleic acid may delay or prevent drug resistance in patients with high levels of this gene.