Articles tagged with Breast Cancer
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Researchers found that increasing dietary fiber intake leads to sharp drops in estrone and estradiol hormone levels. Higher fat intake paradoxically increased hormone levels, but dietary fiber remained a significant predictor of hormone levels when both were included.
A new genetic mechanism has been identified linking diet to breast cancer, with excess omega-6 fats accelerating the disease. The study found that four genes, including one with unknown function, are involved in this effect, highlighting the importance of a balanced fat intake.
Researchers found a sharp drop in estrone and estradiol hormone levels with increased dietary fiber intake. A higher intake of dietary fiber was also associated with lower hormone levels even when dietary fat was present.
A study found that antibiotics are ineffective in treating chronic prostate pain (CP/CPPS) but a-receptor blockers may provide relief for extended periods. Simple exercises improved dizziness in adults, while survivors of childhood cancer are at increased risk for breast cancer.
A recent study has found that combination hormone therapy doubles breast density and quadruples the risk of abnormal mammograms. The study, led by Anne McTiernan, involved 413 postmenopausal women and showed a significant increase in breast density among older participants.
A study by Ann H. Partridge et al highlights the need for better patient-physician communication about fertility in young breast cancer patients. Fifty-seven percent of patients reported being very concerned about becoming infertile, with 29% influencing their treatment decisions.
Researchers found a 29% increased risk of all strokes and an 82% higher risk of ischemic stroke in women taking tamoxifen, compared to controls. The absolute increase in risk was small.
A study of supportive-expressive group therapy for women with BRCA1 or 2 gene mutations found improvements in anxiety, depression, and decision-making. The therapy helped women weigh treatment choices by exploring feelings and perspectives.
A study published by Fox Chase Cancer Center found that obese women with early-stage breast cancer have a higher risk of death compared to their normal-weight peers. The research analyzed data from 2,010 patients and showed that obese women experienced a significantly lower overall survival rate and increased distant metastasis.
Research found that breast density and rapid tumor growth significantly affect mammography's ability to detect cancer in women aged 40-49. To address this issue, the study suggests adjusting screening intervals for these high-risk groups.
Intensity modulated radiation therapy (IMRT) significantly reduces radiation dose to healthy breast tissue, limiting side effects and improving treatment outcomes. By administering precise doses of radiation at the tumor site, IMRT can spare patients from skin irritation, breakdown, and scarring of the lungs.
Researchers at Mount Sinai present groundbreaking studies on prostate and breast cancer treatments, identifying genetic predictors for adverse side effects and developing tailored radiotherapy regimens. The studies aim to improve clinical trials and patient outcomes for these devastating diseases.
A study by the American College of Radiology found that MRI detected more malignant lesions than mammography in women with breast cancer, including larger and more aggressive cancers. The research suggests using MRI to identify potential cancerous areas and downsize mastectomies for some patients.
A novel vitamin E compound, alpha-TEA, has been found to effectively reduce primary tumor mass and prevent lung metastases in genetically identical mice. The compound also shows promise in blocking breast cancer cell proliferation and inducing apoptosis.
The Illinois initiative aims to examine the biological effects of isoflavones on various bodily systems, including breast, brain and adipose tissues. Researchers will investigate the mechanisms at work between isoflavones and estrogen receptors to ensure safety and effectiveness in dietary supplements.
A study surveyed 605 women aged 40-69 to assess eligibility for tamoxifen-based breast cancer prevention. Only a small proportion of white women and none of black women were found to be at high risk, highlighting challenges in targeting discussions about chemoprevention.
A new study found that tamoxifen would only prevent a maximum of 6-8% of breast tumors in eligible women, while its harmful side effects rule out 90% of potential beneficiaries. The researchers suggest that other chemopreventive agents without the same side effects could be more effective in saving lives.
A recent study found that group therapy did not improve survival rates in early-stage breast cancer patients. The researchers, led by David W. Kissane, evaluated the impact of cognitive-existential group therapy (CEGT) on survival and found no significant difference between those receiving CEGT and those not receiving it.
A recent study published in Carcinogenesis found that specific DNA patterns enhance breast cancer protection from marine n-3 fatty acids. Women with low-activity versions of genes associated with GSTs have a lower risk of breast cancer, while high-activity versions show no benefit.
A study of 128 women found that immediate breast reconstruction after mastectomy did not delay the initiation of postoperative chemotherapy. The overall rate of wound complications was 15.5%, with higher rates in patients who underwent immediate breast reconstruction, but these complications did not affect chemotherapy timing.
Researchers found that inhibiting NF-kB or TNFα can prevent inflammation-induced tumor growth, allowing TRAIL to tip the balance in favor of cancer killing. The study suggests using NF-kB inhibitors with anti-TNFα drugs and TRAIL-inducing cytokines to promote tumor killing.
Researchers found no clear association between atrazine exposure and cancer in a large cohort study. Additionally, studies on alcohol consumption and gastric cancer incidence revealed mixed results, while an animal study demonstrated the potential of mammaglobin-A immunotherapy as breast cancer treatment.
A study of 236 women with BRCA1 and BRCA2 mutations found that MRI screenings detected 77% of cancers, compared to 36% for mammography. The addition of annual MRI and ultrasound to mammography improved the sensitivity of breast cancer surveillance.
A study of 72,417 women found that many began mammography between ages 35-40 and delayed follow-up. Women without insurance or a primary care doctor faced longer delays in starting screening. The authors suggest encouraging prompt return to screening may be more critical than initial start.
A new diabody targeting breast tumor growth has been developed, showing significant inhibition of human breast tumor xenografts in mice. The mini-antibody C6.5K-A specifically targets the HER2/neu human tumor-associated antigen and demonstrates great affinity for its target, leading to prolonged retention in antigen-laden tumors.
A long-term study at Ohio State University found that counseling improved immune function, reduced stress, and boosted healthier eating habits in breast cancer patients. The study's findings support the value of psychological intervention in cancer treatment and suggest potential benefits for other types of cancers.
A study of over 600 older women with receptor-positive breast tumors found that tamoxifen alone was as effective as radiation therapy in preventing recurrence. The research suggests that radiation may not be necessary for these patients, improving their quality of life and reducing side effects.
A study published in JAMA Network found that women with breast cancer detected by mammography screening have better estimated 10-year distant disease-free survival rates compared to those without screening. The researchers also discovered that tumors detected through screening had a lower risk of distant recurrence, suggesting that mam...
Researchers analyzed data from over 400,000 breast cancer patients to estimate the probability of death after diagnosis. The study found that breast cancer patients with ER-negative tumors were more likely to die from their cancer than those with ER-positive tumors.
Researchers at the University of Illinois have found that sulforaphane, a compound in broccoli and other cruciferous vegetables, can block the growth of late-stage breast cancer cells by disrupting microtubules. This discovery could lead to new strategies for preventing and treating breast cancer.
Researchers analyzed data from over 400,000 breast cancer patients to calculate probabilities of death from breast cancer vs. all other causes combined. They found that patients with ER-negative tumors and larger tumors were more likely to die from their cancer than those with ER-positive tumors and smaller tumors.
A recent study found that cancer survivors experience significant long-term burdens, including lower quality of life and lost productivity, persisting even beyond 10 years after diagnosis. The burden varies by cancer type, with those diagnosed with shorter-survival cancers reporting greater impacts.
Researchers at McGill University have identified a new gene, beta1-integrin, that plays a crucial role in the growth and development of breast cancer. Blocking this gene's function has been shown to halt tumour proliferation and prevent tumours from growing.
African-American women are less likely to undergo immediate or delayed breast reconstruction after mastectomy compared to Caucasian, Hispanic, Asian, and Middle Eastern women. Physicians' referral patterns and patient acceptance also contribute to these racial discrepancies.
A study by Solveig Hofvind and colleagues found that women who undergo biennial mammography between ages 50-69 have a 20.8% cumulative risk of false positive recall after 20 years. This risk is lower for benign procedures, with only 1 in 66 women requiring a core biopsy and 0.9% undergoing open biopsy.
A new non-invasive imaging technique using magnetic resonance imaging and a novel MRI agent can help surgeons determine the extent of cancer in breast patients. The technology has the potential to reduce surgical trauma and improve patient outcomes.
Researchers identified a key mechanism of trastuzumab resistance, highlighting the importance of PTEN activation and PI3K pathway activity. PTEN-deficient breast cancers show poorer responses to trastuzumab, while inactivation of PI3K rescues cells from resistance.
Researchers have uncovered a powerful new cancer-fighting property of Herceptin, which targets HER-2 positive breast cancer cells. The study found that high levels of PTEN in tumor cells predict response to the drug, and offers potential combination therapy with PI3K inhibitors.
A study using CellSearch technology found that women with high tumor cell levels in their blood had poor treatment outcomes. Women whose circulating tumor cell levels dropped after starting therapy fared much better.
A study by University of Toronto researchers found that only 38.5% of Urdu- and Hindi-speaking women had undergone a clinical breast examination, despite 83% being aware of the procedure. The study highlights gaps in knowledge about breast cancer risk and screening methods among South Asian immigrant women.
Researchers found that AMPK plays a vital role in protecting cells under conditions of a heart attack, including glucose uptake and preventing cardiac dysfunction. In contrast, mice without functional AMPK exhibited impaired contractile function and increased cell death after blood flow reduction.
Researchers found that NF-kB is essential for the initial transition stage of epithelial-mesenchymal transition in breast cancer cells. Inhibiting NF-kB after transition prevents cells from becoming invasive.
Fewer than 20% of US surgeons have high enough volume to optimize breast cancer outcomes, with median surgeon performing only 6 operations in two years. High-volume surgeons provide more consistent standard care, such as hormone receptor testing and breast conserving surgery.
UC Davis researchers have created a PET scanner that can image tiny cancer growths in mice, allowing them to monitor tumor development over time. The system enables early detection of cancer transformation and could lead to more sensitive screening tests for cancer-fighting drugs.
Research found that African-American women are four times more likely to show significant alterations in the p53 gene, which is associated with poor prognosis. The study confirms earlier reports of racial differences in breast cancer outcomes and highlights the need for further investigation into underlying mechanisms.
A study found that low levels of high-density lipoprotein (HDL) cholesterol are associated with an increased risk of postmenopausal breast cancer in overweight and obese women. The association was strongest in women who gained weight over the years of follow-up.
Researchers found that adherence to St-Gallen guidelines improved overall survival at 7 years, especially for those at moderate risk of recurrence. Women whose treatment conformed to guideline recommendations experienced better survival and lower recurrence rates compared to those with non-guideline therapy.
A sub-study of the FASG-05 trial found that a higher dose of ELLENCE improved disease-free and overall survival in patients with node-positive breast cancer. The study also showed a low risk of adverse cardiac events, despite concerns about cardiotoxicity.
Recent court cases show patients sued doctors for delayed breast cancer diagnosis, with average awards being $250,000. Dr. Berlin argues that mammography is not perfect and overzealousness in radiology communities led to unfounded fears among women.
A new UCI study has identified a gene linked to breast cancer that can also suppress tumor growth by blocking estrogen and growth factor signals. The research provides further insight into how estrogen interacts with mutated BRCA1 genes to promote breast cancer development.
A new computer program was found to be more effective in increasing knowledge about breast cancer risk and genetic testing among low-risk women, reducing their perceived risk of getting breast cancer. However, one-on-one genetic counseling was superior in helping women better understand their risk and reduce anxiety.
Two studies found that interactive computer programs improve women's knowledge of breast cancer and genetic testing, while also reducing anxiety and increasing satisfaction. The programs can supplement standard genetic counseling for those at high risk and stand alone for those at low risk.
A study found that physical symptoms, such as shortness of breath and weakness, predict cancer prognosis. Physical health-related quality of life (hrQoL) factors were stronger predictors of survival than psychosocial factors.
A new method, QM-MSP, detects cancer by analyzing methylation levels in genes associated with breast cancer. The test was found to accurately identify cancerous samples in 84% of cases and detect no cancer in 89% of normal tissues.
Accelerated partial breast irradiation (APBI), also known as brachytherapy, treats breast cancer with minimal radiation exposure. This technique reduces treatment time to four to five days and improves convenience for women with busy lifestyles or rural locations.
Four clinical trials are underway to determine the effectiveness of digital mammography, ultrasound, and MRI in detecting breast cancer and preventing deaths. These non-radiation based techniques could lead to a lower screening age and increased regular screenings for high-risk women.
A recent study found that computer-aided detection (CAD) software can identify 71 percent of missed breast cancers on mammograms. CAD marked tumors as suspicious, leading to earlier detection and potentially better patient outcomes.
Thermal ablation, utilizing ultrasound or MRI imaging, effectively destroys breast tumors by applying heat or freezing abnormal tissue. The procedure has been successfully performed on over 50 patients, with no scarring and no cosmetic deformity remaining after treatment.
Despite significant declines in breast cancer death rates due to mammography, one in three American women over 40 has not had a mammogram in the last two years. Mammography is the best screening tool for early detection of breast cancer, and Dr. Feig emphasizes its importance regardless of age.
A study analyzing the Surveillance, Epidemiology, and End Results (SEER) database found that it is reasonably reliable for collecting cancer incidence and mortality data. Researchers compared histologic tumor types from patients reported to the SEER database with those obtained through an independent review, finding no difference in di...