Articles tagged with Breast Cancer
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A randomized trial of 605 patients with four or more positive lymph nodes found no difference in 5-year relapse-free survival and overall survival between conventional and high-dose chemotherapy. High-dose chemotherapy was shown to confer extra cost and toxicity without added anticancer benefit.
Researchers developed a novel vaccine by fusing patients' tumor cells with their immune system dendritic cells, resulting in increased T cell response against tumor cells. The treatment showed promise in reducing tumor growth and metastasis in late-stage cancer patients, with some experiencing significant regression of tumors.
Researchers have identified a way to exploit the body's natural protective mechanisms used by tumors to evade the immune system. By targeting an immunosuppressive enzyme called IDO, scientists may be able to create new cancer treatments that make tumors more vulnerable to the immune response.
A study published in Alcoholism: Clinical & Experimental Research found that light-to-moderate drinking has no significant effect on breast cancer risk, regardless of type of beverage. Heavy drinking increases risk primarily among premenopausal women.
A Cornell University-Stanford University meta-analysis of 30 clinical trials found that women starting HRT within two years of menopause had a lower total mortality risk. The study also showed significant reductions in hip fractures and recurrent urinary tract infections, but no change in breast cancer deaths.
Researchers found that high dietary levels of soy isoflavones do not stimulate cell growth and markers for breast cancer risk in postmenopausal monkeys. The study suggests plant estrogens may contribute to an estrogen profile associated with reduced breast cancer risk.
A new study by The Wistar Institute suggests that the MYC protein binds to a large percentage of genes without activating them. This discovery raises questions about MYC's other functions and potential tissue-specific controls.
Dr. Rice received a two-year, $200,000 grant to study chromatin changes contributing to sporadic breast cancers, focusing on epigenetic gene regulation. The GM Cancer Research Scholars Program supports young scientists in cancer research projects.
Researchers found that ALCAM gene expression is significantly lower in higher-grade tumors and those with a worse prognosis. This suggests that decreased ALCAM expression indicates a more aggressive phenotype and poor prognosis in breast cancer.
A University of Toronto professor highlights the disproportionate impact of COPD on women, who experience greater lung damage and are more likely to develop emphysema. By 2010, women will suffer from COPD twice as often as men worldwide.
The European Commission has approved the combination of Herceptin and Taxotere as a first-line treatment for HER2-positive breast cancer, significantly improving median life expectancy by over one-third. The therapy also showed high response rates, with 61% of patients responding to treatment.
A new partial breast radiation procedure using balloon brachytherapy has shown promising results in reducing treatment time and improving cosmetic outcomes. The study found that women treated with this method experienced quick recovery, good cosmetic results, and no evidence of cancer recurrence during a 1-2 year follow-up.
Researchers found tamoxifen stimulates tumor growth in HER2-overexpressing breast cancer cells due to estrogen agonist activity. Combining tamoxifen with growth factor pathway inhibitors like gefitinib may help overcome resistance, according to a new study.
A new study by Cancer Research UK found that common mutations in genes regulating estrogen metabolism are not associated with breast cancer risk. However, a separate study suggests that inhibition of hypoxia-inducible factor 1alpha (HIF-1alpha) activity may be a target for future gastric cancer treatments.
A study found that targeting the Pak1-DLC1 interaction can prevent breast cancer growth. The researchers discovered that when DLC1 is modified, it interferes with cell death signals, allowing cancer cells to survive and multiply.
Research at Fred Hutchinson Cancer Center reveals that African-American women are more likely to develop aggressive and rapidly growing breast cancers. Tumors from black women tend to exhibit abnormal cell-cycle regulatory proteins, which can lead to poorer outcomes if diagnosed at later stages.
Research suggests moderate drinking may lower heart disease risk in older adults but increase breast cancer risk, particularly among women with family history or hormone replacement therapy. Moderate consumption also appears to reduce the risk of diabetes and metabolic syndrome.
Scientists have identified new breast tumor subtypes associated with poor clinical outcomes, which can be recognized and matched with therapies. The discovery uses genomic approaches and microarray analysis to classify tumors into distinct subtypes based on patterns of gene interaction.
Researchers have identified a possible connection between the IRF1 gene and tamoxifen resistance in breast cancer. By adding interferon to antiestrogen therapy, tumors may become sensitive to treatment, potentially inhibiting new cancers or disease reoccurrences.
The study found that cancer research participation is low across all patient groups, particularly among the elderly, racial and ethnic minorities, and women. The analysis of data from the National Cancer Institute Clinical Trial Cooperative Group revealed significant disparities in trial enrollment rates by age, sex, and racial/ethnic ...
Researchers found that women with ovarian cancer typically experience symptoms 20-30 times per month and have more severe and recent-onset symptoms. In contrast, women with benign masses or controls have fewer and milder symptoms.
A new study published at ASCO finds that MRI is more effective than mammography in detecting the number and size of breast cancer tumors. The research involved over 1000 women across 17 sites, revealing that MRI detected additional cancerous lesions in 56 women, while mammograms only identified 17.
A recent study by the University of Michigan Comprehensive Cancer Center found that breast cancer patients who made their own treatment decisions were more likely to choose mastectomies over breast-conserving surgeries. The study also revealed that fewer than a third of women with mastectomies received reconstructive surgery, and those...
A prospective study of 89 caregivers found that as breast cancer patients progressed to the last stages of their illness, caregivers experienced increased depression and burden. The authors emphasize the need to address family caregiver needs during patient care, given hospital bed shortages for palliative and hospice care.
The UT Southwestern Medical Center team developed a blood test that can detect amplification of the HER-2 gene in circulating cells associated with breast cancer. This detection could enable personalized treatment decisions for patients with HER-2 amplified tumors.
The CAMPTOSAR plus cisplatin regimen demonstrated improved one-year survival rates (59.2%) and response rates (31%) compared to current standard treatments. Patient toxicities were also significantly reduced, with fewer grade 3-4 neutropenia and thrombocytopenia cases.
In a Phase III trial, over 65% of early-stage HER-2 positive breast cancer patients achieved a complete response rate when treated with Herceptin and chemotherapy. The results were so striking that the trial was halted early after accruing 42 patients.
Lapatinib, a new breast cancer drug, has shown promising results in shrinking tumors or slowing growth in 46% of patients. The medication targets both Her-2 and Epidermal Growth Factor (EGFR) receptors, which blocks cell signaling and inhibits tumor growth
Researchers found that women with a specific gene mutation in the CYP2D6 gene had lower levels of endoxifen, a byproduct of tamoxifen metabolism. This suggests that the gene mutation may affect the potency of tamoxifen when combined with certain antidepressants like paroxetine and sertraline.
A new breast cancer treatment, gemcitabine with paclitaxel, has been shown to extend overall survival in women with advanced breast cancer. The study found that median overall survival was 18.5 months for the combination therapy, compared to 15.8 months for paclitaxel alone.
A new sequential dose-dense chemotherapy regimen including ELLENCE significantly improves survival in high-risk breast cancer patients, with estimated 3-year relapse-free and overall survival rates of 80% and 90%, respectively. The study confirms the benefits of this optimal dose dense therapy for women at highest risk of recurrence.
Women's lungs are more damaged by cigarette smoke, leading to a different treatment response and outcomes. Research funding is needed to understand the causes of this disparity in lung cancer incidence among women.
Researchers found that tamoxifen-resistant breast cancers grow due to PKA-activated estrogen receptor modification. Identifying patients with activated PKA may lead to alternative treatments with aromatase inhibitors or fulvestrant.
Researchers from MGH and Arcturus found that the HOXB13/IL17BR gene expression ratio predicts tumor recurrence in estrogen-receptor-positive breast cancer patients receiving tamoxifen. The higher expression of HOXB13 and lower IL17BR levels indicate increased risk of recurrence.
Researchers discovered a molecular marker, the HOXB13:IL17BR ratio, that accurately predicts the reoccurrence of tumors in breast cancer patients treated with tamoxifen. This finding suggests that HOXB13 may contribute to tumor invasion and metastasis.
A study of 60 Korean women with breast cancer found a high rate of genetic mutations in BRCA1 and BRCA2 genes. The average age of diagnosis was 40-50 years old, which is younger than in the US population. The study suggests different genetic and environmental factors may be at play for Korean patients diagnosed at a young age.
A study by the American Society of Plastic Surgeons suggests that breast reduction can decrease the chance of developing breast cancer by 50-70 percent in high-risk women. The report is based on six observational studies conducted in the US, Canada, Denmark, and Sweden, examining over 32,000 women.
A Clemson researcher has received a grant from the Komen Foundation to further study the combination of a mutated prolactin receptor antagonist (PRL antagonist) and Herceptin, a breast cancer drug. The goal is to develop an effective treatment for aggressive subtypes of breast cancer.
Researchers found that women with breast tumors retaining the Stat5 protein biomarker have a highly favorable prognosis and may be cured by surgery alone. The study suggests that detection of this marker could lead to improved individualized therapy, including more careful follow-up and aggressive treatment for high-risk patients.
A new study suggests that aspirin reduces breast cancer risk by 20% among women with ER-positive tumors, a type of postmenopausal breast cancer. The protection is strongest among daily aspirin users and those taking seven or more tablets per week.
Researchers found that collecting comorbidity information from cancer registrars improves prognostic accuracy for various cancer types. Comorbidity data complements tumor stage in predicting patient outcomes.
Fox Chase Cancer Center and Wilex partner to accelerate development of anti-cancer drug for breast cancer treatment. The open-label Phase I study will evaluate safety and biological activity of WX-UK1 in combination with chemotherapy agent capecitabine.
Researchers found that comorbidities are strongly correlated with cancer survival rates, with severe comorbidities reducing overall survival by 33% after five years. Comorbidity data is most useful in treatable types of tumors, like prostate and breast cancer.
A study found that frequent users of aspirin and other NSAIDs had a 20-28% lower risk of breast cancer compared to nonusers. The inverse association was most pronounced among frequent users and those with hormone receptor-positive tumors.
Researchers have found that male breast cancer incidence has increased by 26% over the past 25 years, with men being diagnosed at a later stage than women. The study also revealed differences in tumor biology, including higher rates of estrogen receptor-positive tumors in men.
Researchers found a synergistic effect between Herceptin and chemotherapy agents, increasing tumor shrinkage in 79% of patients. The combination also showed unusually long times to progression, providing hope for improved breast cancer treatment options.
Researchers discovered feasible chemotherapy combinations that include trastuzumab for HER2-positive advanced breast cancer, with higher overall response rates and lower cardiac dysfunction. Two phase II clinical trials showed promising results, paving the way for future randomized phase III trials.
A large prospective cohort study found that body size was more strongly associated with breast cancer risk in postmenopausal women than premenopausal women. Obesity was linked to an increased risk of breast cancer in women not using hormone replacement therapy (HRT), while those on HRT with a low BMI had an increased risk.
A recent study found that even health-conscious women are more likely to have had a mammogram or Pap smear than undergone a colonoscopy. Doctors suggest using breast cancer screening appointments as an opportunity to educate women about colorectal cancer risk and increase awareness.
Cardiovascular disease is a leading cause of death in US women over 45, with inadequate screening contributing to high mortality rates. Women often fail to receive aggressive risk factor management, exacerbating poor outcomes compared to men.
Researchers found that taxanes significantly improved immune function in breast cancer patients, with a 37% increase in T cell growth and a 39% boost in NK cell activity. The study's findings suggest that taxanes may improve patient outcomes or quality of life by enhancing the body's ability to respond to infection or cancer recurrence.
A study found that MRI scans can detect breast cancer in 70% of cases at stage 1, and in 62% of cases without a mass. Most women who underwent the test chose mastectomy due to early detection.
A study found that highly processed isoflavone products may pose a risk to postmenopausal women with estrogen-responsive breast cancers. Minimally processed soy flour was associated with less tumor growth in mice, suggesting a potential health benefit for consumers of whole soy foods.
A recent multi-center trial has shown cryoablation to be effective in killing cancerous cells in small tumors, offering a promising alternative to traditional surgery for early-stage breast cancer. The study found that the procedure was equally effective for tumors between 1.0 and 1.5 centimeters in diameter, but not larger than 1.5 cm.
A new biopsy system has been shown to be effective in completely removing benign breast masses as large as 3 cm, with minimal pain and discomfort. The procedure takes around 20-40 minutes and compares favorably to traditional surgical procedures.
A new MRI-guided breast biopsy system has been developed, showing that it is safe and efficient for retrieving tissue under MRI guidance. The procedure was found to be technically successful with no complications in all 38 biopsies performed on 28 patients.
A new computer technique has been developed to differentiate between malignant and benign calcifications on digital mammograms. The system achieved performance comparable to radiologists in classifying these calcifications, with a 79% accuracy rate in a test using one malignant case and one benign case.
A study by Johns Hopkins Bloomberg School of Public Health found that the US spends more on healthcare than other developed countries, but its health outcomes are not better. The US excels in breast cancer survival rates and cervical cancer screening, but struggles with asthma mortality rates and smoking.
Researchers found higher plasma selenium levels are associated with a decreased risk of advanced prostate cancer, while DNAzymes targeting c-Jun may inhibit tumor growth. Glucocorticoid prescriptions are linked to an increased risk of skin cancers and non-Hodgkin's lymphoma.
Researchers at Dartmouth College developed and tested three alternative breast imaging methods to learn about breast tissue structure and behavior. The non-invasive techniques include electrical impedance spectral imaging, microwave imaging spectroscopy, and near infrared spectral imaging.