Articles tagged with Breast Cancer
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Researchers at Dartmouth Medical School have developed a new breast imaging technique using electrical impedance, microwave imaging, and near-infrared spectroscopy. The method can identify specific breast characteristics that differ in normal and diseased tissue, potentially leading to early detection of breast cancer.
A study confirmed that BRCA2 mutations are linked to prostate cancer, with a risk 4.8 times higher than in healthy individuals. The results suggest that prostate cancer screening may begin at age 50 for men carrying these mutations.
A new study separates and purifies normal luminal and myoepithelial cells from breast tissue, revealing distinct gene expression profiles. This dataset enables the discrimination between genetic changes due to cell type differences and cancer, leading to more accurate tumor classification and potential new therapeutic avenues.
A new analysis from Duke University Medical Center uses breast cancer data to develop personalized risk predictions and prognoses for individual patients. The study integrated traditional clinical variables with genomic information, including genetic fingerprints of a patient's tumor, to improve accuracy.
A survey of oncologists and nurses found that while most agree to offer trial results to patients, only 62% actually do so due to concerns over potential negative effects, patient interpretation, and resource consumption. Additionally, a new study demonstrates tamoxifen's association with reduced breast density, particularly in younger...
Researchers will analyze tumor samples, protein releases and patient responses to chemotherapy agents to develop individualized treatments. The goal is to minimize side effects while improving response based on patient chemistry and tumor type.
Researchers found that hormone-sensitizing compounds can boost estrogen and progestin activity eight- to 10-fold, increasing cancer risk. Exposure to these compounds may be linked to reproductive toxicity, miscarriages, and irregular ovulation.
A new study by Dr. Thomas Walle found that resveratrol, a widely sold dietary supplement, is unlikely to have an effect on breast and prostate cancers when consumed in the diet or as a supplement. However, it may still prevent cancers along the aerodigestive tract, suggesting further research is needed.
Researchers at MIT have developed a technique that uses focused microwave energy to kill early-stage breast cancer cells, reducing the need for additional surgery. The treatment has shown promising results, with women experiencing a 43% reduction in cancer cells found close to surgical margins.
A recent study has found a dramatic increase in lung cancer incidence in women, with many cases occurring in non-smokers who stopped smoking years ago. The study also reveals that women's response to targeted therapies is more favorable than men, raising questions about the differences between male and female lung cancer.
Women are more susceptible to lung cancer due to genetic mutations and hormonal changes, resulting in increased adenocarcinoma prevalence. Effective tobacco control measures are crucial to prevent a similar surge in lung cancer rates among women in developing countries.
A study found that immediate mammogram reading can decrease stress and anxiety in women, especially those receiving false-positive results. Women who received rapid evaluation of their mammograms reported less anxiety than those who had to wait several days for results.
Two new studies found no association between aspirin use and mortality from pancreatic cancer, while elevated insulin production was linked to an increased risk of colorectal cancer. Hyperinsulinemia, a condition associated with type 2 diabetes, also appears to be linked to an increased risk of colorectal cancer.
A study of Dutch women exposed to famine during World War II found a significant association between short-term famine and increased breast cancer risk. Women who experienced severe hunger and weight loss had a 48% higher risk of breast cancer compared to those with no exposure.
A study found that breast cancer patients with BRCA 1/2 mutations are twice as likely to opt for a double mastectomy after receiving genetic counseling and testing. Genetic counseling and testing have been shown to significantly impact treatment decisions among high-risk patients.
Research suggests that women with BRCA1 or BRCA2 mutations are more likely to choose double mastectomy, with 48% of those who tested positive opting for the surgery compared to 24% without a mutation. Genetic counseling and testing can help patients make informed decisions about their treatment.
Researchers successfully treated 21 small breast cancers with RF ablation, destroying malignant tissue with no adverse effects. However, surrounding tissue was not removed, limiting the procedure's effectiveness as a standalone treatment.
Researchers found that early exposure to environmental toxins reprograms the uterus to promote tumor growth in genetically susceptible rats. This new model of gene-environment interaction may explain why some people develop cancer while others don't, especially considering inherited BRCA1 mutations.
The European Society for Medical Oncology survey found that stem cell transplants for breast cancer decreased from 2,629 in 1997 to 330 in 2002. The use of autologous transplants continued to rise for certain types of solid tumours, while allogenic transplants saw a slight increase, particularly for metastatic tumours.
Researchers from the University of Texas M. D. Anderson Cancer Center have developed a novel approach to gene therapy that harnesses mesenchymal progenitor cells (MSC) to target cancer metastasis. The strategy has shown promising results in animal studies, with MSC gene therapy curing up to 70% of mice implanted with human ovarian cancer.
Scientists at Johns Hopkins Kimmel Cancer Center have found a link between the HOXB7 gene and increased activity in breast cancer biomarkers. The study shows that the gene is overexpressed in more than 60% of breast cancer cell lines and 90% of primary breast cancers.
Regular exercise can reduce a woman's risk of endometrial cancer by up to 30-40% and improve breast cancer survival rates. Studies found that moderate physical activity, including walking and household chores, had significant benefits on cancer risk and survival.
New nanotech imaging techniques offer improved precision in detecting tumors, including lymphatic drainage imaging for breast cancer, and molecular fingerprints for prostate and ovarian cancer. These advancements aim to improve diagnosis and treatment options for cancer patients.
Researchers found that COX-2 over-expression promotes loss of basement membrane in ovarian epithelium cells, leading to disorganization and cancer. The study suggests COX-2 inhibitors may prevent cancer development by reducing basement membrane loss.
Researchers have found that higher serum levels of vitamin E are associated with lower risks of prostate and bladder cancers. In contrast, a diet rich in antioxidants is linked to a reduced risk of breast cancer among women with specific genetic profiles.
A large-scale re-analysis of data from 53 studies suggests that pregnancies ending in miscarriage or induced abortion do not increase the risk of developing breast cancer. The findings contradict previous, less reliable studies that suggested a potential link between abortion and breast cancer.
The AACR International Scholars in Breast Cancer Research program aims to improve cancer research and clinical care worldwide. Principal Investigators will mentor talented scientists from under-resourced countries, enhancing their skills and knowledge for successful breast cancer research.
Researchers at Whitehead Institute have developed a new experimental model of human breast cancer in mice, allowing for the study of early stage development and tumor growth. The model involves grafting human breast tissue into mouse mammary glands, enabling the production of human breast milk and pre-cancerous tumors.
A new study reveals that doctors offer tamoxifen primarily to women with higher risk profiles, despite those with lower side effect risks not being offered the drug. The research highlights a need for better educational strategies to help women make informed decisions about chemoprevention.
The ECCO conference emphasized the need for risk-reducing interventions, genetic counseling, and psychological support for breast cancer patients. Delegates called for no upper age limit in treatment plans and patient participation in clinical trials based on performance status.
A Canadian study found that breast cancer patients who participated in clinical trials had a 60% lower risk of dying, compared to those who did not. Larger treatment centers also showed better survival rates, attributed to participation in research.
A new study found a significant disparity in breast conservation rates between countries, with Poland having the lowest rate of only 2% and the USA the second-highest at 56%. The variation was attributed to factors such as tumour characteristics, access to radiotherapy, and screening programmes.
A new large-scale trial will test the efficacy of a genetically personalised treatment for breast cancer, using microarrays to identify specific molecular signatures. The MINDACT trial aims to spare patients at low risk of relapse from unnecessary chemotherapy, resulting in reduced side effects and healthcare costs.
Dr. Eric Winer emphasizes the importance of rigorous testing for complementary and alternative therapies (CAMs) due to safety concerns and limited scientific evidence. Many CAMs have not undergone thorough evaluation, leading to potential interactions with standard treatments.
Scientists have discovered that breast cancer metastases have a strikingly similar genetic profile to their primary tumours. This breakthrough discovery could enable doctors to choose the best treatment for each patient based on their unique tumour characteristics.
Dr. Berrino suggests that dietary factors play a major role in breast cancer prevention, particularly for women carrying BRCA mutations. By adopting a healthier diet, these women can reduce their risk of developing the disease.
Dr Yeo's study found that prophylactic lamivudine significantly reduces the incidence of HBV reactivation and hepatitis in breast cancer patients. The drug was effective in reducing the risk of liver damage caused by HBV reactivation during and after chemotherapy.
Breast cancer patients in Europe increasingly use complementary and alternative therapies (CAMs) to improve quality of life. CAMs may complement conventional treatments but can also interact dangerously with drug regimes, requiring careful consideration by doctors and patients.
Recent breast cancer trials using aromatase inhibitors (AIs) reported results early due to significant advantages over tamoxifen. However, Dr. Martine Piccart argues that this can lead to unanswered questions about long-term efficacy and side effects. She proposes new guidelines for better data collection and risk-benefit analysis.
A survey of Swedish breast cancer patients found that women prefer follow-up visits at breast centers rather than with their GP, but want more time for discussion. The study suggests that nurse-led follow-ups could increase patient satisfaction and reduce healthcare costs.
A South African doctor is criticizing the government's prioritization of arms deals over women's health, citing a lack of investment in breast cancer care. The doctor urges developed countries to apply political pressure to help build better breast cancer care in Africa.
A recent study has confirmed that women with BRCA breast cancer who undergo conservation surgery and radiotherapy have a lower risk of recurrence compared to those without genetic mutations. The only factor associated with a higher risk of recurrence is young age, according to the researchers.
Researchers found a 1.7-fold increase in cardiovascular death among breast cancer patients who received radiotherapy compared to those who didn't. However, the risk was lower for non-irradiated patients, suggesting that breast cancer may have a protective effect on cardiovascular disease.
Older women with breast cancer often lose out on effective treatments, with prognosis not linked to tumour factor. Health policymakers need to develop strategies for elderly patients, while doctors must find suitable treatments tailored to their needs.
In the phase III trial, exemestane demonstrated superior efficacy over tamoxifen in patients with hormone-responsive metastatic breast cancer, with a median progression-free survival of 10.9 months compared to 6.7 months for tamoxifen. The study also showed improved response rates and safety profile for exemestane.
A new diagnostic tool, BCPC, uses microarray technology to analyze tumor genetic signatures and provide personalized treatment recommendations for breast cancer patients. The tool aims to improve patient outcomes by avoiding over-treatment and reducing costs of treatment.
A recent study found that young breast cancer survivors experience more severe long-term after effects, including arm problems and fatigue. Women diagnosed over 50 years old tend to report fewer symptoms than younger women.
The European Parliament and Commission are urging a unified EU approach to combat breast cancer, citing the potential for 90% of patients to be cured with early diagnosis. Breast cancer centers must meet specific requirements, including 150 operations per year and multidisciplinary case conferences.
Patients with stage I disease experienced longer intervals than those with more advanced disease. A multidisciplinary approach could help reduce anxiety and mistrust by allowing sufficient time for information digestion and procedure recovery.
Researchers found that high S-phase fraction and diploid status were key predictors of early and late recurrence rates. Patients with poor prognostic indicators, including older age at diagnosis and larger tumor size, had poorer outcomes.
A study found that a quarter of 50-69-year-old women had dense breast patterns more commonly associated with younger women. Breast cancer screening in postmenopausal women is effective, but cancers can still go undetected due to high mammographic density.
Scientists have pinpointed a new cancer gene target, PIK3CA, which is mutated in 32% of colon cancers and may be involved in tumor growth. The study suggests that targeted therapies could be more effective with fewer side effects, leading to personalized cancer treatment.
A team of researchers has identified a protein called APC that regulates cell growth and limits the development of cancer. By controlling the levels of another protein Skp2, APC helps prevent cancer cells from growing uncontrollably.
A large international study found that patients switched from tamoxifen to AROMASIN after 2-3 years experienced a significant reduction in breast cancer recurrence and longer disease-free survival. The study suggests a potential new treatment option for post-menopausal women with estrogen-receptor positive breast cancer.
A randomised controlled trial of breast self-examination in nearly 100,000 Russian women found no reduction in deaths from breast cancer. Instead, women who performed regular self-examinations had more frequent consultations for benign breast lesions, leading to increased anxiety and unnecessary surgical biopsies.
Researchers have discovered that short-term use of estrogen plus progestin is associated with a decreased incidence of colorectal cancers. However, these cancers are diagnosed at more advanced stages, suggesting further study is needed to understand this phenomenon.
Women experience a range of physical symptoms, including hot flashes and vaginal dryness, following breast cancer treatment. Mood and emotional functioning are similar among all women at the end of primary treatment.
Researchers developed a model to calculate the optimal length of follow-up time for breast cancer patients without significantly reducing detection rates. By reducing follow-up periods from ten years to four years, six years' worth of physician time and outpatient costs could be redirected to more effective treatment processes.
A new imaging technique uses MRI and spectroscopy to analyze choline levels in tumors, accurately identifying malignant carcinomas in 8 out of 8 cases. The study suggests MRSI may aid physicians in diagnosing breast cancer and could potentially replace biopsy in certain cases.
A recent study, PROSE, found that double mastectomies significantly reduce the risk of breast cancer in women with BRCA1 and BRCA2 gene mutations by 95%. The study followed 483 at-risk women for over six years, showing that prophylactic mastectomies can be an effective preventive measure.