Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study of 85 breast cancer patients reveals low complication rates for reconstruction after radiation therapy, with no major complications in TRAM flap recipients and only 5% of implant patients experiencing major complications. The study also found that TRAM patients had superior cosmetic scores compared to implant recipients.
A study published in JAMA compared screening mammography performance in the US and UK among similar aged women, analyzing 5.5 million mammograms. Despite lower recall rates in the UK, both countries showed similar cancer detection rates, but US women experience more anxiety and false-positive scares.
A recent study found that whole-breast irradiation after lumpectomy significantly reduces the risk of recurrence in other parts of the breast. The use of tamoxifen in addition to radiation was associated with the lowest risk of recurrence.
Researchers at the Beckman Laser Institute are developing a laser-based technology to detect and analyze tumors, providing detailed information on blood, fat, and water composition. The center aims to transform this cutting-edge science into a versatile tool for cancer research.
A recent study published at Fox Chase Cancer Center found that breast cancer patients who did not smoke had significantly better long-term outcomes than those who smoked after undergoing lumpectomy and radiation treatment. The study of over 1,000 patients showed that smoking cessation is crucial in managing breast cancer.
Researchers found a significant reduction in breast cancer risk among women taking statins and non-statin lipid-lowering drugs. The study analyzed data from over 7,500 older white women and found a 60-70% lower risk of developing breast cancer.
Researchers analyzed 1.2 million screening result records, finding that extending Pap tests to 3-year intervals carries a small risk of 3-5 cancers per 100,000 people, similar to annual breast cancer incidence in men ages 45-64.
Michigan State University (MSU) is one of four national centers studying the link between environmental exposures and breast cancer. The center will focus on hormonal factors, including progesterone, and community outreach to better understand breast cancer risk.
The new Bay Area Breast Cancer and the Environment Research Center aims to study the impact of prenatal-to-adult environmental exposures on breast cancer risk. The center will focus on two counties: Marin County, with high reported rates of breast cancer, and Alameda County.
A study analyzed patterns of SNB use in academic comprehensive cancer centers and found that its use was associated with breast-conserving surgery. The procedure's popularity increased over time, from 8% in 1997 to 58% in the last half of 2000.
The Fox Chase Breast Cancer and Environmental Research Center will investigate how natural environmental exposures affect breast cancer predisposition. The center, funded by NIH agencies, will collaborate with other centers to analyze the effects of specific environmental agents on mammary tissue development.
Commentaries question the benefit of early breast cancer screening for women aged 40-49, citing higher mortality rates among screened women. Experts highlight possible biologic explanations and the importance of informed consent, while also warning of potential harms such as false positives and overtreatment.
A study found that physicians have distinct approaches to explaining clinical trials, which can impact patient enrollment. The research suggests that understanding these differences is crucial for improving doctor-patient interactions and overall care.
A clinical trial found that taking letrozole after five years of tamoxifen therapy can substantially increase the chance of remaining cancer-free. The study showed a significant reduction in breast cancer recurrence and deaths among women on letrozole compared to those on the placebo.
A clinical trial has found that letrozole significantly improves the long-term outlook for breast cancer survivors, reducing the risk of recurrence by 43%. The study showed that women taking letrozole had a lower risk of disease recurrence and deaths from breast cancer compared to those on the placebo.
A new study shows that letrozole picks up where tamoxifen leaves off in preventing breast cancer recurrence. Women who have been treated for breast cancer and are now cancer-free may need to consider additional treatment options, such as letrozole, based on their individual risk factors.
A new, highly accurate breast cancer mannequin is being launched to assist women in spotting breast lumps and provide a unique training experience. The device features interchangeable breast implants and realistic skin texture, benefiting not only those with learning difficulties but also women from diverse cultural backgrounds.
A Clemson University bioengineer has developed an innovative 'injectable' tissue implant that could repair the ravages of breast cancer surgery. The implant, made from donor cells grown on tiny beads, aims to reduce scarring and promote quicker recoveries by promoting natural tissue growth.
Researchers at Duke University Medical Center have developed a strategy using erythropoietin to enhance heart function and prevent cell death after ischemic injury. A novel protective effect of erythropoietin has been shown in the infarcted heart, demonstrating a therapeutic window of opportunity for acute protection and long-term pres...
The Sisters Peer Counseling in Reproductive Health after Treatment (SPIRIT) program provides free peer counseling to address concerns faced by African-American breast cancer survivors. The four-year study aims to empower survivors and address cultural and socio-economic factors that contribute to conservative attitudes about sexuality.
A study published by the University of Pittsburgh found that hormone therapy has no benefit to postmenopausal women, even those at high risk of fracture. The research suggests that estrogen plus progestin increases bone mineral density but does not outweigh risks associated with breast cancer and heart disease.
A new dual-energy, contrast-enhanced digital subtraction mammography technique has shown promising results in revealing hard-to-detect breast cancers. The study found that the technique was able to identify cancerous tumors in 13 out of 26 patients, with accuracy rates similar to those achieved by breast magnetic resonance imaging (MRI).
A recent study of early-stage breast cancer patients found that tamoxifen is effective in reducing recurrence and mortality regardless of body mass index. However, obesity was linked to increased risks of second cancers and all-cause mortality.
A new treatment approach uses a Trojan Horse technique to deliver a radioactive isotope into breast cancer cells, slowing tumour growth. The therapy combines EGF with Indium-111, exploiting the natural uptake of EGF by breast cancer cells.
Researchers found that combining anti-angiogenic and Hsp90 inhibitor drugs completely inhibited tumor growth in Id deficient mice, but had limited effect in mice with normal Id function. The study suggests a new approach for treating advanced breast cancer.
The report analyzed data from 22 countries and 42 types of cancer, showing average five-year survival rates ranging from 94% for lip cancer to less than 4% for pancreatic cancer. Regional variations were found, with some Eastern European countries having lower survival rates and western Europe performing better.
A multi-center study found improved overall survival and time to disease progression for women with metastatic breast cancer treated with Taxotere, compared to paclitaxel. The results suggest that Taxotere may be a more effective treatment option for this patient population.
A Phase III trial found that docetaxel significantly improved survival rates and overall response rates compared to paclitaxel in women with advanced, incurable breast cancer. The median survival time was 15.4 months for docetaxel patients versus 12.7 months for paclitaxel patients.
A new study by ATAC found that Anastrozole enhances disease-free survival and reduces breast cancer recurrence, but increases bone fracture risk. The fracture rate peaks at 18-24 months before stabilizing, suggesting the overall benefit of Anastrozole remains
A study of 2,604 children with solid tumours found a significant link between mothers' breast cancer and their child's age at diagnosis. The risk is higher for younger children and boys, suggesting hormonal disruption during pregnancy may play a role.
A recent study found a statistically significant positive relationship between stress and breast cancer, independent of potential confounding factors. Women who experienced stress had double the risk of developing breast cancer over a 24-year period compared to those with no stress.
Prostate cancer mortality rates are falling fast in the US and Europe due to earlier diagnosis and hormonal treatments. Research shows that prompt surgery and hormonal therapy can improve 10-year survival rates for both prostate and breast cancers.
A Phase III study shows that Avastin, an anti-angiogenic agent, extends patient survival time to 20.3 months when added to first-line chemotherapy. The treatment also improves response rates and duration of response across all relevant patient subgroups.
Breast cancer patients participating in an online support group experienced improved well-being and empowerment through sharing personal experiences, asking for advice, and expressing emotions. The study highlights the importance of internet access for social support and low-income groups.
In a phase II clinical study, exemestane demonstrated a higher tumor response rate (41%) compared to tamoxifen (17%) in shrinking tumors. Exemestane was also well-tolerated with fewer side effects than tamoxifen.
The UIC Center for Population Health and Health Disparities will explore how individual and socio-ecological factors affect prognosis and outcome for breast cancer victims. The study aims to design better interventions to lower the incidence of death in minorities due to late-stage diagnosis and treatment.
Researchers at Georgetown University Medical Center have discovered a direct link between genes causing breast and other cancers, and those linked to diabetes. The study suggests that drugs blocking the effects of one gene may be useful in stopping the conversion of normal tissue to malignant tissue.
Researchers developed a powerful new method called ROMA to compare normal cell DNA with breast cancer DNA, revealing chromosomal amplifications and deletions involved in breast cancer. The study also found large copy number polymorphisms in healthy cells that may underlie human traits.
Researchers discovered a group of breast cancer tumors unrelated to typical patterns, with no clear link between tumor size and axillary lymph node cancer. This finding has significant implications for early diagnosis and treatment of women carrying the BRCA1 gene mutation.
A randomized trial found that increased physical activity reduced breast cancer risk in postmenopausal women, with longer duration providing the most benefit. Moderate-intensity physical activity also promoted significant weight loss and improved cardiorespiratory fitness, with benefits sustained for a year.
Research found that moderate-intensity physical activities like walking, biking, or swimming can reduce breast-cancer risk in postmenopausal women by about 20 percent. Regular exercise also offers a similar protection among high-risk groups, such as those with a strong family history of breast cancer.
Researchers discover dermcidin protein in 10% of invasive breast tumors, contributing to faster cell growth and cachexia. The finding may lead to new treatments for breast cancer and conditions like Alzheimer's disease.
The Annual Report to the Nation on Cancer statistics shows stabilized cancer rates. A study found carboplatin-paclitaxel is better tolerated in ovarian cancer patients than cisplatin-paclitaxel. Another study linked blood transfusions with HHV-8 seropositivity, while HPV status may predict cervical lesion prognosis
A recent study found that the TGFBR1*6A gene is associated with a 26% increase in cancer risk, particularly for breast, ovarian, and colon cancers. The study's findings suggest that genetic testing and counseling can help identify individuals at high risk and provide targeted prevention strategies.
Contrast digital mammography has been shown to accurately identify cancers in patients with suspicious abnormalities, reducing false positives and unnecessary biopsies. The new technique uses intravenous iodine contrast to enhance blood vessels created by tumors, improving detection in dense breast tissue.
A team of researchers has discovered that injecting radioactive glucose can selectively kill cancer cells without harming healthy tissues. The treatment exploits the fact that cancer cells use more glucose than normal tissue, allowing for targeted delivery of radioactivity.
Research suggests that obesity increases breast cancer risk in postmenopausal women by raising serum estrogen levels. The study analyzed blood samples from over 1,600 women and found a significant link between obesity and increased estrogen levels, highlighting the importance of controlling this modifiable risk factor.
A study examined whether limited-field radiation therapy could be an effective alternative to whole-breast radiation therapy for patients at low risk of recurrence. The results showed no significant difference in local recurrence rates or overall survival between the two groups after five years of follow-up.
Researchers found that postmenopausal women with a higher body mass index have an increased risk of breast cancer due to elevated estrogen levels. In contrast, heavier men under age 60 or those with family history of prostate cancer may experience lower risks of developing the disease.
A breast cancer program for low-income women found a significant rate of 12.3 cancers per 1,000 women, exceeding results from other screening programs. Excellent compliance with surgical recommendations was also observed, attributed to the program's translation and transportation services.
A substantial increase in breast cancer risk is associated with combination hormone replacement therapy, particularly oestrogen-progestogen therapy. Current users of HRT have a 22% increased risk of death from breast cancer compared to never-users.
A UCLA study discovered that fatigued breast cancer survivors have increased levels of circulating T lymphocytes and CD4+ T cells, which correlate with elevated inflammation markers. The findings suggest an immunologic basis for fatigue in breast cancer survivors.
Health food store employees frequently advise customers on unproven products for breast cancer treatment, raising concerns about patient safety. The high cost of these products, up to $600 per month, is also a significant burden on vulnerable patients.
Consuming phytoestrogens found in plant foods like soy is associated with a reduced risk of endometrial cancer. Imiquimod has been shown to induce apoptosis in skin cancer cells, while an integrin polymorphism may increase cancer progression. The study on breast cancer survivors also found increased numbers of circulating T lymphocytes.
A new gene expression profile test could identify which breast cancer patients are likely to respond to chemotherapy, helping reduce unproductive treatment and toxicity. The test uses biopsy samples from primary tumors before treatment and measures the tumor's response to docetaxel.
A UCSF-led team has identified a potential cancer susceptibility gene, the Ile31 variation of the Aurora2 gene, which disrupts cell regulatory controls and increases cancer risk. The study suggests that low penetrance genes can confer significant susceptibility to cancer.
A new test method aims to predict which early-stage cancer patients are at high risk for relapse, allowing for more precise treatment decisions. By analyzing apoptosis proteins in patient tumors, researchers hope to identify molecular and genetic signatures that indicate the likelihood of cancer recurrence.
Researchers Peter Sasieni and Jack Cuzick argue that starting mammographic screening at age 47 can save more life-years than current guidelines. They claim that the incidence rate of breast cancer is as great in women aged 48-49 years as it is in those aged 50-54 years, making earlier screening a viable option.
A study found that food diaries were more accurate than questionnaires in measuring fat intake, which could explain why no association was found between increased fat intake and breast cancer risk. However, the results highlight the importance of using reliable dietary assessment methods in nutrition research.
Research highlights the link between high animal fat intake and increased breast cancer risk, as well as the benefits of gynecologic surgeries in reducing ovarian cancer risk. Protein overexpression is also linked to esophageal cancer development, suggesting a potential target for prevention.