Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study of nearly 81,000 women found that regular use of ibuprofen reduced breast cancer risk by 28%, while aspirin use reduced it by 22%. Both NSAIDs showed a significant effect in reducing the incidence of breast cancer, especially among high-risk groups.
A recent study found that women with higher plasma cysteine levels had a significantly reduced risk of developing breast cancer. The association was strongest among leaner women, suggesting potential chemopreventive benefits against breast cancer.
Researchers found a direct link between low dose cadmium exposure and increased risk for breast cancer in female rats. Cadmium mimics estrogen's effects, leading to changes in mammary gland density and uterine weight, similar to early onset of breast cancer.
David Botstein, known as 'The Father of Modern Genetics', was awarded the 2003 Gruber Prize for his groundbreaking work on human genetic mapping and the discovery of transposons in bacteria. He will continue to lead research at Princeton University's Lewis-Sigler Institute for Integrative Genomics.
Researchers have developed a new generation of targeted cancer therapies using bispecific antibodies that target multiple proteins in cancer cells, increasing radiation sensitivity and specificity. The therapy is expected to improve treatment outcomes for patients with breast and ovarian cancers.
A study at Duquesne University found that black cohosh, commonly used for menopausal symptoms, may promote progression to metastatic disease in women with early stage breast cancer. The research suggests women who develop breast cancer or are at high risk should proceed with caution or avoid taking the herbal extract.
Two studies suggest that regular use of ibuprofen and aspirin inhibits breast cancer formation, while a low-dose tamoxifen regimen may effectively treat breast cancer with fewer side effects. Another study found that a combination of low-dose COX-2 inhibitors and fish oil may reduce colon cancer risk.
Dr. Halas' nanoshell technology has the potential to revolutionize breast cancer detection and treatment by providing earlier diagnosis, increased imaging resolution, and real-time information about tumor cells. This innovative approach uses near infrared light to target and destroy tumors without harming healthy tissue.
Researchers at PNNL and UCLA have discovered six times more proteins in NAF than previously identified, suggesting its potential as a biomarker for breast cancer. The study aims to develop a more accurate, non-invasive method for early diagnosis.
A study of over 5,980 women aged 67 or older found that breast cancer survivors had 34% fewer hospitalizations for heart attacks than non-survivors. The protective effect increased with higher cardiac risk factors, suggesting that female hormone levels may play a role in preventing heart disease.
A recent study found that high-dose chemotherapy followed by autologous stem cell transplant did not significantly increase survival rates for women with early stage breast cancer. The study, which included 511 patients, showed a higher number of relapses in the treatment group but also nine deaths due to transplantation complications....
A randomized clinical trial of over 500 women with primary breast cancer found no significant improvement in disease-free survival or overall survival with high-dose chemotherapy and stem cell transplantation. However, time to recurrence was longer for patients who received the treatment.
Studies on prophylactic surgery for women with BRCA1/2 mutations show a significant reduction in breast and ovarian cancer risk. However, potential biases in study designs, such as confounding by indication and familial-event bias, may lead to underestimation of risk reduction.
Researchers found that the p53 gene plays a crucial role in distinguishing which lung cancer patients are most likely to survive four years or more. The study identified a sub-group of early-stage lung cancer patients without p53 mutations who had a significantly higher survival rate, providing hope for a new treatment approach.
Women treated with radiation therapy and chemotherapy had a 61% lower risk of developing breast cancer compared to those who received only radiation. The authors suggest that ovarian hormones play a role in promoting tumor growth after radiation, which may explain the increased breast cancer risk in young women exposed to radiation.
Researchers found that the normal form of the BRCA-2 gene enhances androgen receptors' activity to suppress tumors. The mutant form of BRCA-2 fails to enhance activity, allowing cancer cells to proliferate. The study provides new insights into male breast cancer and its connection to the BRCA-2 gene.
Researchers have identified a set of genes specifically associated with breast cancer's ability to metastasize to bone. The study found that these 'poor prognosis signature' genes enable tumor cells to home in on bone and trigger growth of blood vessels. The discovery does not invalidate the classical model of tumor cell metastasis, bu...
A study by Dr. Pio and colleagues found that FLT-PET imaging outperforms FDG-PET in predicting tumor response to chemotherapy in breast cancer patients. The researchers compared the two imaging modalities in 11 newly diagnosed patients, taking scans before treatment began, after the first dose, and following the final cycle.
Pregnant women should undergo thorough breast examinations to detect breast cancer, as diagnosis is often delayed due to hormonal changes. Ultrasonography is the best method for detecting cancerous lumps during pregnancy.
A new study found that combining radiofrequency ablation with chemotherapy can effectively treat larger liver tumors. The treatment, which involves using heat to destroy tumor tissue and administering a chemotherapeutic agent intravenously, resulted in a tripling of survival rates compared to those receiving no treatment.
Research suggests that frequent consumption of miso soup and high intake of isoflavones may lower breast cancer risk. Vitamin D analog paricalcitol also demonstrates antitumor activity against myeloid leukemia, myeloma, and colon cancer cells.
Researchers found that girls entering puberty with breast development are more likely to be obese by late adolescence. Additionally, earlier age of menarche is associated with increased risk of breast cancer.
A study by University of Illinois Chicago nutrition scientists reveals a potential genetic link between selenium and breast cancer prevention. The research identifies specific versions of a gene that may require more selenium in the diet for cancer-preventive benefits.
The Early Detection Initiative aims to identify proteins that signify cancer presence or risk in human blood samples using proteomics techniques. Researchers will analyze data from large groups of individuals with known health histories and behaviors.
A new study links premenopausal breast cancer to where women were born and lived during early life. Researchers found clustering of cancer patients based on their place of birth and residence at the time of menarche in Western New York's Erie and Niagara counties.
Using a modified version of a naturally occurring human protein, researchers were able to significantly reduce the spread of disease and decrease tumor growth without evidence of toxicity. The modified protein was able to interfere with cancer cells' ability to stick to one another and other healthy cells.
Researchers found that twins who started menstruating earlier were more likely to develop breast cancer, suggesting a link between puberty hormones and genetic susceptibility. The study provides new insights into the causes of hereditary breast cancer and potential targets for intervention.
A recent study found that paroxetine significantly reduced the frequency of hot flashes in menopausal women by 64.6%, with up to 30% experiencing no flashes after six weeks. The medication worked by inhibiting serotonin reuptake, a natural chemical modulating mood and temperature control.
Two studies found that paclitaxel-based chemotherapy regimens and mini-transplants can help preserve ovarian function in younger patients. The paclitaxel regimen improved a woman's chance of regaining her ovarian function, while mini-transplants showed better results in preserving ovaries compared to high-dose chemo.
A new study found that tamoxifen is effective in reducing breast cancer cell proliferation at lower doses, with decreases in biomarkers associated with cardiovascular disease and blood clots. The results support a potential dose reduction for tamoxifen therapy without compromising its effectiveness.
Researchers found that men with male breast cancer are more likely to be older when diagnosed, have later stage disease, and ductal papillary cancers. The study suggests important biological differences between male and female breast cancer.
Researchers at the University of Texas M. D. Anderson Cancer Center have developed a gene screen that can accurately predict which chemotherapy regimens will be effective for patients with newly diagnosed breast cancer. The test is 75% accurate in forecasting complete eradication of cancer, eliminating the need for trial and error.
Researchers found a slight benefit of allogeneic stem cell transplantation in patients with metastatic breast cancer, experiencing delayed tumor progression despite poor prognosis. The study's findings suggest a potential
A new DNA array technology test has identified differences in gene patterns that predict which breast cancer patients will respond to chemotherapy. The study, led by Dr. Jenny Chang at Baylor College of Medicine, found that 88% of genes were correctly classified, allowing for personalized treatment strategies.
An early clinical trial at Cedars-Sinai Medical Center shows 2C4 effectively shrank tumors in several types of cancer, targeting a common growth signaling pathway. Eighteen out of twenty-one patients responded to treatment, with some achieving partial remission and stabilizing disease for over a year.
A Phase II study shows that administering ADVEXIN, a p53 drug, directly to tumors can improve the results of neoadjuvant chemotherapy in locally advanced breast cancer. The treatment resulted in dramatic tumor shrinkage and minimal residual tumor cells.
In a Phase II clinical trial, C225 and docetaxel combination achieved a 25.5% tumor shrinkage rate in advanced non-small cell lung cancer patients, significantly higher than the median response rate of 5-10%. The results are encouraging and suggest further development of this treatment approach.
Researchers developed a new method to assess breast cancer patients' prognosis by analyzing 185 genes. The study found that tumors with specific gene expressions can predict long-term survival, even among women with multiple positive nodes.
Functional MRI can help identify tumor heterogeneity and biological quirks that predict response to treatment. The imaging technology offers insight into a tumor's character beyond its superficial structure, enabling targeted therapies for specific sites.
A survey of US radiology residents found that most were hesitant to pursue breast imaging training or interpret mammograms due to negative attitudes and perceived drawbacks. The shortage of qualified radiologists is expected to worsen as demand for screening mammography services increases with an aging population.
A study of 7,257 patients with rectal cancer found that those treated at high-volume hospitals had lower mortality rates and higher survival rates compared to those treated at low-volume hospitals. Patients at high-volume hospitals also experienced a lower risk of permanent colostomy.
Researchers at UW-Madison have successfully created the world's first knockout rats using a novel combination of techniques, enabling further study of breast cancer and potential treatments. The development restores the rat as a key model for biomedical research, leveraging its genetic flexibility to gain insights into various diseases.
Researchers developed new methods for diagnosing breast cancer based on gene expression signatures, correlating with traditional pathological classifications. The study found that early-stage lesions contain molecular signatures reflecting tumor aggressiveness, potentially changing the course of cancer progression.
A possible predictor of tamoxifen resistance has been identified in a University of Illinois Chicago study. High levels of protein kinase C alpha may indicate reduced effectiveness of the drug, and researchers hope to develop more effective strategies for treating cancer recurrence.
Researchers found that 3D mammography (TOMO) outperforms traditional mammography in detecting breast lesions, including masses and architectural distortions. The technique has the potential to reduce anxiety for patients by providing a more accurate diagnosis upfront.
Researchers have identified genetic defects causing excessive estrogen production in three male patients, including a man and his son, leading to severe gynecomastia. The defects involved misplaced promoters associated with housekeeping genes, resulting in continuous aromatase enzyme production and elevated estrogen levels.
A study reviewed the records of 367 high-risk women who underwent MR imaging screening and found that 59 required biopsies, with 17 cases revealing new cancers not detected on mammograms or physical exams. The majority of detected cancers were ductal carcinoma in-situ (DCIS), an early stage of breast cancer.
A recent study shows that whole body PET scans are twice as sensitive as CT scans in detecting breast cancer spread, with a higher accuracy rate of 93% compared to 46%. This breakthrough technology also offers less radiation exposure to patients, making it a more efficient and safer option.
A new study found that exercise training improves quality of life and increases survival rates among breast cancer survivors. Regular physical activity can help reduce the negative impact of treatment on cardiopulmonary function, leading to improved overall well-being.
A new study has found that a 14-gauge automated tru-cut needle is highly accurate in diagnosing breast cancer, with over 99% accuracy rate. The study also showed that smaller biopsy needles can be just as effective as larger ones, offering a less invasive option for patients.
Researchers found that PPAR-g is abundantly expressed in human pituitary tumors, including non-functioning and hormone-secreting types. The study suggests that PPAR-g binding compounds may be suitable oral therapies for these tumors.
A study evaluated online resources for breast cancer clinical trials in Canada, finding that only 29% were listed. The US National Cancer Institute's PDQ Clinical Trials Database identified 86% of trials globally.
The BP1 gene is found to be active in 57% of Caucasian women and 89% of African American women with breast cancer. Gene therapy targeting BP1 may help treat non-hereditary breast cancer, which accounts for 95% of cases.
Mammography screening has been shown to significantly reduce breast cancer mortality in European countries. Studies found that women aged 40-69 years who received screening had a 44% reduced risk of dying from breast cancer, while those not screened had a 16% reduction.
Researchers at Emory University Health Sciences Center identified a critical molecular link between estrogen receptors and invasive growth in breast cancer. The study reveals that a protein called MTA3 regulates cell adhesion molecule E-cadherin expression, leading to cancer progression.
A decision aid called Decision Board improved patients' understanding of their disease, risk of recurrence, and treatment options. Women who used the board were more satisfied with decision making and preferred a more active role in their care.
A recent study found that most women (72%) experience some level of pain during mammography, but this does not deter them from returning for follow-up screening. The study also discovered a link between the timing of mammograms and pain levels in premenopausal women.
A new study found that strengthening upper leg muscles does not protect against knee osteoarthritis and may even worsen it in people with certain knee conditions. Researchers also discovered that one-third of cancer patients who died received chemotherapy in their last six months of life.
Prolactin's role in breast cancer has been redefined with the discovery of its ability to travel directly into cell DNA. This finding suggests a new paradigm for hormone function and offers potential therapies for blocking tumor growth.
The Avon Foundation-AACR International Scholars in Breast Cancer Research program provides two-year grants to four junior-level faculty members from limited opportunities countries. The program aims to enhance breast cancer research and clinical care globally.