Articles tagged with Breast Cancer
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The study identified a new gene associated with breast cancer, C35, which is over-expressed in 65% of breast cancers. Researchers believe that traditional treatment methods alone will not be effective against C35 positive breast cancer and are exploring a two-pronged approach for treatment.
Regular NSAID use for five to nine years reduces breast cancer risk by 21%, while ten-year use increases the reduction to 28%. The study enrolled 80,741 post-menopausal women with no reported history of cancer, other than non-melanoma skin cancer.
Women taking two or more NSAIDs per week for five to nine years reduced their breast cancer risk by 21-28%. Ibuprofen was found to be more effective than aspirin in preventing breast cancer. The study's findings suggest that COX-2 inhibition may play a role in limiting breast tumor growth.
A study demonstrated that low-dose tamoxifen can maintain clinical effect against breast cancer, reducing Ki-67 levels and tumor proliferation. The study found no dose response, suggesting that lower doses of the drug may be equally effective in treating ER-positive breast cancer.
Researchers found women with hypothyroidism are 57% less likely to develop aggressive, estrogen-sensitive breast cancer. The study suggests a possible biological role of thyroid hormone in breast cancer and offers novel preventive strategies.
According to a study by the National Cancer Institute, approximately 10 million women in the US aged 35-79 are eligible for tamoxifen due to high breast cancer risk. After analyzing age-related benefits and risks, researchers found that younger women (40-59) have a higher likelihood of benefiting from the drug.
A recent study found that genes determining breast density are associated with an increased risk of breast cancer. Additionally, researchers discovered a compound called YC-1 that slows tumor growth in mice by blocking angiogenesis, potentially leading to new cancer treatments.
According to a new study, nearly 10 million US women aged 35-79 could benefit from tamoxifen chemoprevention for breast cancer. White women are more likely to benefit than black or Hispanic women due to differences in risk factors and comorbidities.
A phase I clinical trial of cytotoxic T-lymphocyte-associated antigen 4 blockade therapy has shown promising results in boosting the immune system against cancer. The treatment enhanced the anti-tumor activity of certain vaccines and improved responses in patients with melanoma and ovarian cancer.
A study assessing young women with breast cancer in north-west England found that a third had a strong family history of breast cancer and/or ovarian cancer. Women with this history were more likely to carry BRCA1 or BRCA2 gene mutations, emphasizing the need for accurate family history elucidation to predict genetic mutations.
The discovery of KCNK9 reveals a significant role in the development of breast and lung cancers. The study found that overexpression of KCNK9 promotes tumor formation in controlled functional tests.
A study published in the American Journal of Roentgenology found sonography to be more accurate than mammography in detecting breast cancer in women under 45. The test correctly identified 84.9% of breast cancers in symptomatic women aged 25-44, while mammography had a lower accuracy rate of 71.7% in the same age group.
A new study examines the incidence of breast cancer among postmenopausal women with 'probably benign' mammographic findings. The research suggests that short-interval follow-up may not be necessary, and a 1-year follow-up may be as effective as a 6-month follow-up in identifying early-stage breast cancers.
Research on STI571 and paclitaxel shows potential in controlling prostate cancer metastasis to bone. Lung cancer risk varies widely among smokers, with accurate prediction models helping individuals decide on screening. Non-BRCA mutations may be linked to high breast cancer risk in younger women.
Charles J. Sherr and Dennis J. Slamon are being honored with the Landon-AACR Prizes for Cancer Research, recognizing their significant contributions to understanding mechanisms of cell growth control and developing targeted cancer therapies.
The University of Pittsburgh will conduct a new study on acupuncture's effectiveness in alleviating hot flashes, insomnia, and nervousness in breast cancer survivors experiencing menopause. The study aims to explore the potential benefits of acupuncture for reducing cortisol levels and promoting relaxation.
A new study identifies molecular predictors of breast cancer metastasis, including matriptase and HAI-1. The research may lead to a targeted way to treat cancers at risk of spreading, saving women from unnecessary chemotherapy.
A recent study by Penn researchers refutes prior research findings on the mental health impact of genetic testing for breast cancer. The study found that genetic testing is a tool for establishing truth and examining health strategies, rather than a source of anxiety.
Researchers found that women with high levels of AIB1 and HER-2 proteins in their tumors are more likely to experience poor outcomes with tamoxifen therapy. When either protein level is low, the risk of adverse effects decreases significantly.
The study found that 50% of patients started taking dietary supplements, 40% made dietary changes, and 20% began new physical activities. Lifestyle changes were common among cancer patients up to two years after diagnosis and were often associated with improved health and well-being.
A study found that higher plasma folate levels were associated with lower risk of breast cancer, while higher plasma vitamin B6 levels increased breast cancer risk. Plasma vitamin B12 levels inversely associated with breast cancer risk among premenopausal women. Cystic fibrosis patients may have an increased risk of digestive tract can...
High levels of AIB1 expression in breast cancer tumors are associated with poorer tamoxifen treatment outcomes. Patients with both high AIB1 and HER-2 expression have significantly worse disease-free survival compared to other patient groups.
A study found that personalized mailings can significantly increase mammogram use among older women with Medicare, who may need an extra push to get screened due to age-related risk factors. The intervention targeted women over 70 years old without recent mammograms and those with medical conditions preventing screening.
A study by German researchers found nearly half breast cancer patients struggle with incomprehensible or incomplete information, while over half want more opportunities to discuss their treatment. The report emphasizes the importance of improving communication between medical staff and patients.
A study found that minority breast cancer patients who used the internet for medical information experienced greater social support, which was associated with better mental and physical health outcomes. The research suggests that internet use may help prolong survival among these patients.
Researchers have identified stem cells in human breast cancer that can form new tumors and are resistant to treatment. The discovery may explain why current treatments for metastatic breast cancer often fail, and could lead to the development of new therapies targeted at these cells.
A new study published in Breast Cancer Research found that higher levels of egg consumption during adolescence are associated with a decreased risk of breast cancer. Eating dietary fiber and vegetable fat was also attributed to a reduced risk, while butter appeared to increase the risk.
A researcher is studying how tumors pirate angiogenesis, the formation of new blood vessels, to survive. Dr. Motamed focuses on protein SPARC, which regulates growth factors and has multiple roles in cancer and new blood vessel formation.
The session addresses heart disease in postmenopausal women, including sub-clinical atherosclerosis predictors and prevention measures. It also explores sarcopenia and frailty in older women, discussing muscle mass loss and body composition changes that contribute to disability.
Tamoxifen treatment reduced the risk of benign breast disease and biopsies in high-risk women. Women treated with tamoxifen had a 28% lower incidence of benign diseases than those on placebo.
Researchers have discovered a novel photoreceptor system in the human eye that controls melatonin production, which plays a key role in circadian rhythms. The study suggests that exposure to blue light at night may disrupt melatonin production and increase the risk of breast cancer.
Researchers are using toxicogenomics to study the genetic and protein changes in individual breast cancer cells to assign effective drug treatments. This approach allows for more precise treatment options and earlier detection of toxicity, enabling doctors to make informed decisions.
Researchers at Johns Hopkins have determined the 3D structure of the HER2 breast cancer receptor, shedding light on its interactions with the Herceptin antibody. The findings could lead to the design of more effective drugs for treating breast cancer.
Researchers identified BRCA2 germline mutations in 19% of families with familial pancreatic cancer. The presence of specific frameshift mutations was found in 12% of the families studied. These findings suggest an important role for BRCA2 mutations in a subpopulation of families with familial pancreatic cancer.
Research by Dr. Karen Hjerl and colleagues found that depression before diagnosis may boost the risk of death for women with advanced breast cancer, but not those in early stages. The study used Danish national health registries to analyze data from 20,593 women.
A study on breast cancer treatment found that many women do not receive adjuvant chemotherapy as recommended, with age being a significant factor. In contrast, women with known heart disease are at high risk of future heart events but often lack preventive treatments, highlighting the need for better care coordination.
The study found a significant discrepancy between recommended adjuvant chemotherapy and actual use, with younger women more likely to receive treatment. Overall, only 29% of women received chemotherapy, highlighting the need for re-evaluation of current NIH guidelines.
A study of 286 girls ages 8-10 found that a low-fat diet resulted in reductions in estrogen hormone concentrations. After 5 years, girls in the intervention group had 29.8% lower estradiol levels and 27.2% higher testosterone levels compared to those on usual care.
Women with atypical lobular hyperplasia are three times more likely to develop invasive breast cancer, often on the same side as the atypia. The study challenges current beliefs that risk is equal in both breasts after a diagnosis of this condition.
Breast cancer patients with HER-2/neu overexpression have lower hormone receptor levels, affecting treatment response. HFE gene mutations increase colon cancer risk in the US population.
A recent update of the Italian Randomized Trial of Tamoxifen found that tamoxifen significantly reduced breast cancer incidence by 82% in high-risk women. The study suggested that factors such as early menstruation, childlessness, and tall stature increase a woman's risk of developing ER+ breast cancer.
A study of nearly 125,000 women found significant disparities in breast cancer stage, treatment, and survival rates based on race and ethnicity. Japanese women fared best overall, while Puerto Rican women were more likely to receive substandard care.
Researchers found women with atypical lobular hyperplasia (ALH) are three times more likely to develop breast cancer in the same breast, leading to a reevaluation of surgical management and risk reduction strategies. The study's findings also highlight the importance of diligent breast screening for these women.
Researchers found that tamoxifen stimulation increased mature eggs and embryos compared to natural cycle IVF, with one patient already giving birth to twins. A larger study is planned to include low amounts of FSH for additional benefits.
A recent study published in the Journal of the National Cancer Institute found that combination hormone therapy was associated with a 3-5% increase in breast density, while estrogen alone had no effect. This suggests that increased breast density may be a valid marker for the effect of interventions on breast cancer risk.
Researchers discovered that the Id1 gene regulates angiogenesis in melanoma, breast, head and neck, brain, cervical, prostate, pancreatic, and testicular cancers by reducing thrombospondin-1 production. This reduction leads to increased tumor blood vessel formation.
Researchers discovered that tamoxifen-resistant breast cancer cells alter their traits and become responsive to Herceptin and other HER-2 targeted drugs. A new GlaxoSmithKline drug, GSK572016, shows promise in shrinking tumors resistant to both tamoxifen and Herceptin.
The CALGB 9741 study found significant improvements in disease-free survival and overall survival for women with axillary node-positive operable breast cancer treated with dose-dense chemotherapy regimens. The study showed a 26% proportional reduction in risk of recurrence and improved quality of life with dose-dense therapy.
A clinical trial showed that dose-dense chemotherapy regimens improved disease-free and overall survival in breast cancer patients by 7-12 percentage points. The regimens, which involve giving drugs more frequently, resulted in fewer side effects and less neutropenia compared to conventional therapy.
Breast reconstruction rates in Canada are low due to a lack of knowledge among physicians, with only 7.9% undergoing the procedure. Plastic surgeons and primary care physicians alike have expressed lower levels of knowledge on the subject.
A new gene profiling technique could help predict which breast cancer patients will respond to hormonal therapies and which will require additional chemotherapy. The study aims to identify the cellular programs that must be engaged or shut off for aromatase inhibitors to be successful.
A study found that long-term oral contraceptive use is associated with a 33% increase in breast cancer risk among women with BRCA1 mutations, particularly those who started using contraceptives before age 30. In contrast, no significant increase in breast cancer risk was observed in women with BRCA2 mutations.
Researchers suggest that improving coping mechanisms could positively affect immune function, hormone levels and potentially influence cancer outcomes. Studies show a link between active coping strategies and improved health benefits.
Researchers found that inhibiting PDGF signalling increases tumour uptake of cytotoxic drugs without increasing toxicity. Combination therapies with Glivec and other drugs induced better anti-tumour effects in animal models, suggesting a new strategy for improving drug treatment for cancer patients.
The annual conference discussed sex differences in development, immune system responses, and hormone effects on disease progression. Key findings included the role of microchimerism, fetal cells in maternal circulation, and steroid hormones in autoimmune diseases, such as multiple sclerosis and breast cancer.
Two new studies published in the Journal of the National Cancer Institute identified key risk factors for classical Kaposi's sarcoma and found that smoking may decrease the risk of this disease. Meanwhile, research on leptin suggests it controls breast cancer cell proliferation. Additionally, a potential screening tool for ovarian canc...
Researchers have identified two compounds that inhibit PTHrP production, reducing metastatic bone breakdown and tumor burden. The findings suggest potential therapeutic benefits for treating both bone metastasis and hypercalcemia in breast cancer patients.
Researchers at Cornell University aim to learn how enzymes modify estrogen receptors, potentially leading to better diagnostic and therapeutic options for breast cancer patients. The study aims to clarify the molecular details of the estrogen-signaling pathway in normal and diseased tissues.
A new study supports routine mammography screening for women over 75, while a separate study finds that postmenopausal hormone use and heavy drinking increase breast cancer risk. The guidelines also recommend against combined estrogen and progestin therapy for preventing cardiovascular disease in postmenopausal women.
A recent study found that high levels of cyclin E are closely associated with aggressive breast cancer, making it a powerful predictive marker. The presence of low molecular weight forms of cyclin E also showed strong prognostic value, indicating a higher risk of recurrence and spread.