Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers found that MMP-9 expression contributes to angiogenesis in human ovarian tumors, while dense breasts compromise diagnostic mammography sensitivity. Aspirin users have a lower risk of developing pancreatic cancer, according to the study.
A computer system developed by Newcastle University researchers accurately predicted the spread of breast cancer and five-year survival rates in nearly 90% of patients. The system uses a combination of neural networks and fuzzy logic to analyze images of cells from tissue samples.
A study of 50,000 women with invasive breast cancer and 97,000 without found that reduced breastfeeding contributed significantly to the disease's high incidence. The research suggests that increased breastfeeding could prevent around 5% of breast cancers each year.
Patients with ER-negative tumors who received chemotherapy had a 15% increase in disease-free survival and 89% overall survival rate. In contrast, those with ER-positive tumors did not show additional survival benefits from chemotherapy. The study suggests tailoring cancer treatments to patient characteristics.
A randomized trial found that adding chemotherapy to tamoxifen significantly increases disease-free and overall survival rates for postmenopausal women with lymph node-negative, ER-negative breast cancer. In contrast, no survival benefit was observed for those with ER-positive tumors.
A national study on estrogen for postmenopausal women was halted after five years, showing a 26% increased risk of breast cancer and no significant cardiovascular benefits. The study found moderate reductions in fracture and colorectal cancer risk, but the risks outweighed the benefits.
A hormone therapy study involving 16,608 women was stopped early due to a 26% increase in breast cancer risk. The study found that the risks of estrogen plus progestin outweighed any potential benefits for heart disease and hip fractures.
Researchers at Massachusetts General Hospital developed a tri-modality approach to combat invasive bladder cancer, combining surgery, radiation, and chemotherapy. The treatment strategy showed comparable ten-year survival rates to radical bladder removal, with 90% of patients surviving without bladder removal.
Anastrozole, an aromatase inhibitor, has been shown to be more effective than tamoxifen in reducing the risk of breast cancer recurrence, hot flushes, and thromboembolic events. The treatment also reduces the incidence of endometrial abnormalities and vaginal bleeding, providing a significant benefit for postmenopausal women with early...
Regular physical exercise can significantly improve physical and mental health in breast cancer patients, reducing fatigue and weight gain. Physical activity may also extend survival rates by improving immune function and hormone levels.
The new high-resolution breast-specific gamma camera has been shown to detect more breast cancers than standard gamma cameras, with a sensitivity increase of 20% in lesions <1cm. The study used 50 women with 58 lesions and found that the new scanner detected 3 additional lesions not visible on mammography.
A study found that hereditary BRCA1 and BRCA2 ovarian cancers have similar gene expression profiles to sporadic ovarian cancers. The research suggests shared molecular mechanisms between hereditary and sporadic ovarian carcinogenesis exist.
A new study suggests that medications like tamoxifen and raloxifene could potentially lower the risk of breast cancer in women at high risk. These drugs have shown to decrease the likelihood of breast cancer by up to 50% in some cases, but they also carry side effects such as blood clots and hot flashes.
The US Preventive Services Task Force (USPSTF) advises women at low risk for breast cancer to avoid taking drugs like tamoxifen or raloxifene. Women at high risk, however, should have open discussions with their doctors about the benefits and risks of these medications.
A large-scale study of over 9,200 women aged 35-64 found no association between oral contraceptive use and increased breast cancer risk. The research provides reassurance for women who have used oral contraceptives during their reproductive years.
A new study of over 10,000 women nationwide found no increased risk of breast cancer from taking birth control pills. Meanwhile, similar studies suggest oral contraceptives may reduce the risks of uterine and ovarian cancers by as much as 40%.
Researchers found that women with breast cancer were more likely to have lived closer together at birth and at menarche than those without the disease. Early environmental exposure may influence breast-cancer risk, according to the study's findings.
Mayo Clinic researchers have developed a new imaging test for diagnosing breast cancer using the MR elastography technique, which provides data on tissue stiffness. This technology has shown promising results in detecting breast cancer with high accuracy and may reduce the need for biopsies.
A new laser-imaging system could detect tumors not visible on mammograms and predict benign or malignant growths, reducing unnecessary biopsies. The technology uses light to produce a 3D image of the breast's interior, promising to be a valuable diagnostic tool.
A study found that customizing HRT education materials can personalize risk versus benefit for individual women, increasing their confidence in decision-making. The intervention helped women accurately perceive their breast cancer risk and weigh its benefits against HRT.
A new study found that anastrozole improved disease-free survival and was better tolerated than tamoxifen. Anastrozole may be a viable alternative to tamoxifen for adjuvant treatment of early breast cancer in postmenopausal women.
A new study found that anastrozole improved disease-free survival and was better tolerated than tamoxifen, a current standard treatment. The ATAC trial also showed no additional benefit from combining both drugs.
Researchers found less racial variation in female preventive services than expected, with some disparities closing and disappearing. Having a usual source of care significantly boosted the chances of receiving screening for conditions like breast cancer and cervical cancer.
A study by Dartmouth/VA researchers found that major US news media favored routine use of screening mammography and urged caution about tamoxifen, with greater emphasis on the negative aspects of the latter. The coverage of these issues highlights the need for balanced media reporting to focus on science rather than emotions or politics.
A study of female radiologic technologists found that prolonged exposure to low dose radiation is associated with a higher risk of breast cancer mortality. Women who started working as radiologic technologists before 1940 were nearly three times more likely to die from breast cancer than those who began working in 1960 or later.
Researchers at Dana-Farber Cancer Institute have identified six new breast cancer-susceptibility genes, expanding the current list of eight known genes. The discovery provides a promising lead for developing targeted treatments and genetic tests to gauge inherited breast cancer risk.
A recent study by the University of Southern California reveals that breast cancer incidence rates have increased significantly among Asian-American women, particularly those of Japanese descent. The study found that breast cancer rates for Japanese and Filipino women were about double those for Chinese and Korean women.
A study published in the Journal of the National Cancer Institute found that genetic testing using breast cells can accurately predict breast cancer risk. The Gail model, a computer-based predictor, was correlated with DNA deletions and precancerous changes in cells, suggesting an individualized approach to risk assessment.
A new report by Dartmouth and VA researchers has introduced simple, low-tech risk charts that place cancer mortality in context. These charts show the 10-year chance of dying from various causes, such as heart disease, stroke, or breast cancer, side-by-side for men and women of different ages and smoking statuses.
Two studies found high discordance between local laboratory tests and central testing facilities, raising concerns about patient eligibility for trastuzumab trials. These discrepancies could lead to unnecessary costs and cardiotoxicity. Trials have since modified their criteria to require central laboratory testing to confirm HER2 status.
Researchers developed a test to predict which patients with locally advanced breast cancer are likely to respond to chemotherapy, and found it was accurate 100% of the time. The test used radiotracer uptake and washout rates to identify patients who would benefit from specific drugs to boost their response.
A diet rich in phyto-oestrogen-rich foods like soy and whole grains may protect against certain cancers. Jetlag's impact on hormone regulation could increase breast-cancer risk in flight attendants.
Research by Professor Malcolm Koo found that higher dietary fibre intake is associated with a later onset of menstruation in girls. Girls consuming over 25g of fibre per day had approximately half the risk of early menarche compared to those with less than 18g of fibre daily.
Researchers have developed a new breast cancer therapy that combines heat therapy, chemotherapy, and fat liposomes to deliver drugs directly to tumors. The treatment has shown promising results, destroying tumors and saving patients' breasts from surgical removal.
Researchers discovered PRDX3, a key powerhouse enzyme, plays a crucial role in controlling tumor growth. By manipulating PRDX3 activation, tumors can be halted or accelerated. Understanding this pathway could lead to new cancer treatments.
Researchers found that women at high and elevated risk of ovarian cancer are less likely to get screened than those at lower risk. Most women overestimate their risk, with only 11% correctly estimating it.
Chernobyl exposure linked to increased thyroid cancer in children, while HRT use may increase breast-cancer risk with long-term use. The Lancet Oncology reviews these findings and highlights the need for prospective trials. Increasing age is associated with rising cancer incidence, making geriatric oncology crucial.
Researchers found that elevated troponin I levels may predict future heart failure in cancer patients, even if the heart appears to be functioning normally. ACE inhibitors have shown promise in restoring cardiac function and preventing cardiotoxicity in breast cancer patients treated with anthracyclines.
Researchers found that genistein in dietary supplements negates the tumor-fighting effects of tamoxifen for women with estrogen-dependent breast cancer. High doses of isoflavones, commonly used in US supplements, can stimulate breast cancer growth.
A new study found that neoadjuvant therapy can significantly improve long-term survival rates for women with locally advanced breast cancer. The treatment allows for less drastic and breast-sparing surgery, increasing the chances of successful tumor downstaging and improved outcomes.
Postmenopausal women with higher serum concentrations of estrogen and testosterone have twice the risk of developing breast cancer as those with lower levels. This is according to an international study published in the Journal of the National Cancer Institute.
A new study has found that women with the highest levels of sex hormones are at roughly twice the risk of developing breast cancer compared to those with lower levels. Additionally, researchers have discovered a potential therapy for glioblastomas using a fusion protein that shows little toxicity. Reproductive hormones have also been l...
Researchers found that women treated with tamoxifen or estrogen had lower levels of myo-inositol in the brain compared to untreated women. The study suggests that both hormones may be neuroprotective and have favorable effects on aging, but further studies are needed to confirm these findings.
Researchers at The Wistar Institute have identified a new enzyme required for silencing certain genes, which can lead to cancer. The discovery could lead to new cancer therapies by targeting the enzyme's activity.
A test to detect the RhoC protein has shown promising early results, detecting invasive cancers with high specificity and identifying tiny tumors that have already metastasized. The study aims to identify early-stage cancer that could be vulnerable to aggressive treatment, potentially leading to improved patient outcomes.
A study of over 27,000 breast cancer patients in Finland found that excessive weight gain during pregnancy increases breast cancer risk after menopause. Researchers discovered that each 1 kg increase in pregnancy weight boosts the risk by 3.9%, with women who retain excess pounds post-pregnancy facing the greatest threat.
Researchers at Thomas Jefferson University found that low doses of paclitaxel and docetaxel inhibit the growth of endothelial cells, leading to smaller tumors. The study suggests that oral versions of these drugs could be effective in treating cancer with chronic, low dose concentrations.
A recent study found that women with lower incomes and those insured by Medicaid had worse breast cancer treatment outcomes, including later-stage diagnoses, reduced radiation therapy, and higher mortality rates. Socioeconomic factors accounted for most of the disparities in these outcomes.
Researchers found that a network of lay health advisers increased mammography use among rural black women over age 50 by 6 and 11 percent, respectively. The program's effectiveness in boosting breast cancer screening rates was demonstrated through data from the North Carolina Breast Cancer Screening Program.
A recent report highlights nuclear fallout in the US from Cold War testing, which increases cancer incidence and affects global populations. The editorial also critiques South Africa's delay in providing antiretroviral treatment to pregnant women with HIV.
Researchers have identified the mechanism behind tamoxifen's side effects, which may lead to the development of safer alternative medications. The study found that tamoxifen and raloxifene work differently in various cell types, with potential implications for breast cancer treatment.
Researchers have developed new markers capable of detecting minute numbers of cancer cells in blood, using three genes shown to be over-expressed in invasive breast cancer. The markers' sensitivity and specificity are greatly enhanced when used in combination.
Younger women with Hodgkin's Disease are at a higher risk of developing breast cancer after radiotherapy, particularly if they have a family history or underwent splenectomy. Modern treatment methods aim to lower this increased risk.
A large study of Norwegian and Swedish women found that using oral contraceptives may increase the risk of developing breast cancer, particularly when used later in reproductive life. The risk was highest among women aged 45 or over who were still taking the pill.
Researchers have discovered four biochemical markers that can predict a woman's likelihood of developing metastatic disease in node-negative breast cancer. These markers, including p53, E-cadherin, and nm23H1, were found to be significant predictors of outcome, allowing for more accurate identification of patients at risk. This breakth...
Researchers analyzed 99 patient samples and identified patterns of gene activity strongly associated with oestrogen receptor status and tumour grade. These findings may help characterize tumours more effectively and predict patient outcomes, including survival rates and relapse risk.
Researchers suggest that biopsying internal mammary sentinel nodes can help doctors detect more accurate spread of breast cancer, leading to better treatment options. The procedure involves a small cut through the breast bone to remove the node, and has been found to be successful in 65% of cases.
Cancer specialists at the European Breast Cancer Conference express concerns about EU regulations on clinical trials, revised Declaration of Helsinki, and animal rights affecting breast cancer research. They urge policymakers to challenge rules that undermine research, citing increased bureaucracy as a major obstacle.
The microendoscopy technique uses a tiny endoscope to detect abnormal cell changes in breast ducts, potentially identifying breast cancer up to a decade before it develops. Researchers have had successes with the procedure and plan to use it as a diagnostic tool for high-risk patients.
DIPEx, a website offering video, audio, and text interviews with patients, has launched its newest modules on breast cancer and bowel cancer. The site provides a unique resource for patients and healthcare professionals, aiming to improve communication and shared decision-making.