Articles tagged with Breast Cancer
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A recent study by ECCO-the European CanCer Organisation suggests that a significant proportion of interval breast cancers may be detectable during screening, potentially improving detection rates. The researchers reviewed 723 mammograms and found that 27% of previously undetected cancers could have been detected during screening, corre...
A touch screen questionnaire found that breast cancer patients experience similar levels of adverse side-effects from chemotherapy, regardless of age. The study also revealed that older women are more susceptible to fatigue, anorexia, weight loss, and mouth ulcers during treatment.
A new radiotherapy technique delivered during surgery shows promising results in preventing breast cancer recurrence and improving cosmetic outcomes. The 'one stop shop' approach may be more effective and accessible than traditional treatment, especially for women in developing countries.
A new study has validated data on 73 patients with lymph-node negative breast cancer under 55, predicting disease-free survival with 90% certainty. This could lead to a 30-40% reduction in chemotherapy use for these patients, resolving the dilemma of overtreatment.
Researchers have made promising strides in combating breast cancer using novel enzyme inhibitors that target key enzymes involved in cell growth and division. These drugs, such as R115777, work by interrupting cellular signals that promote tumor growth, leading to partial responses and disease stabilization in advanced cancer patients.
A pilot study by a consultant surgeon found that breast reconstruction surgery takes longer and results in more complications, out-patient appointments, and additional surgeries. The study showed that mastectomies with breast reconstruction took 7.1 days to complete, compared to 5.6 days for those without reconstruction.
A study of 608 women found that those from deprived areas had a higher incidence of grade three tumours and oestrogen-receptor negative tumours. These factors contribute to poorer outcomes in terms of cancer progression and treatment response.
Scientists have developed a new compound, TAS-108, which inhibits the growth of tamoxifen-resistant breast tumours. It works by recruiting a co-repressor to help inhibit oestrogen receptors, making it more effective than other anti-oestrogens.
A study found that hormone replacement therapy use is associated with a higher risk of dense breasts and interval cancers. Women who had used HRT were more likely to have dense breasts and cancers detected between screenings.
A new breast cancer vaccine called AutoVac has been developed to stimulate the patient's own immune system and induce specific killer cells and antibodies against HER-2, a protein overexpressed in many tumors. The phase I/II trial is currently underway with 27 patients with advanced breast cancer.
Scientists have developed a test to identify breast abnormalities that are more likely to develop into breast cancer. The test analyzes biological signals in cells and can help doctors determine whether certain women should receive prophylactic anti-oestrogen treatment or more frequent screening.
A recent study demonstrated that including elderly patients in clinical trials for cancer treatments can produce useful results. The research found that two chemotherapy agents were effective and well-tolerated in metastatic breast cancer patients aged 60 or older.
The International Breast Cancer Intervention Study (IBIS) found that tamoxifen reduced breast cancer incidence by 38% in healthy high-risk women. However, the benefits of tamoxifen for prevention in these women are unclear due to potential side effects and risks.
A new booklet aims to improve communication and support between doctors, patients, and partners in cancer care. The booklet was developed with input from patients and healthcare professionals, resulting in a user-friendly document that enhances patient understanding of research and clinical trials.
Researchers developed an easy and affordable way to screen families for underlying genetic mutations that predispose them to developing breast cancer. The new test can indicate the presence of mutations in breast cancer genes in 50% of cases, potentially even more.
Scientists at MGH discover herceptin has additional antitumor properties by targeting multiple factors that maintain tumor blood supply, slowing growth and prolonging survival in animal models.
Recent improvements in hormonal therapy and understanding of molecular mechanisms indicate that hormone therapy is more effective than chemotherapy in treating early breast cancer. The use of GnRH antagonists and aromatase inhibitors holds promise for treating younger women and post-menopausal patients, respectively.
A study found that surgeons rarely offer women a choice between mastectomy and breast-conserving surgery, despite medical appropriateness. Women's perceptions of receiving a choice differ significantly from surgeons' perceptions, with female surgeons focusing on security and male surgeons prioritizing femininity.
Researchers at University College London have developed a non-invasive method to detect breast cancer spread using white light. The technique involves feeding harmless light pulses through a thin fibre onto the tissue surface, which is then analysed on a portable computer to compare with previous examples of normal and cancerous tissue.
Men treated with ADT experienced increased complications, including impotence (80%), breast swelling, and hot flashes. Despite this, many reported feeling free of cancer after treatment.
The European CanCer Organisation's Dr Robin Wilson says current evidence supports breast cancer screening's effectiveness in reducing mortality, but acknowledges drawbacks such as false positives and anxiety for women. Countries with full national screening programmes have seen significant benefits, including improved quality of care.
A recent study found that Prozac significantly reduced hot flashes in women with breast cancer, providing a viable treatment option. The medication was compared to placebo and showed a 50% decrease in hot flash frequency and severity.
The Swedish trials indicate a significant reduction in breast cancer mortality among women given mammography screening, with the greatest benefit seen in age groups 60-69 years. The trials found no significant difference in death from all causes between screening and control groups.
A study published in The Journal of Nuclear Medicine found that PET imaging was more accurate than conventional imaging in detecting recurrent breast cancer. PET correctly predicted the outcome in 80% of cases vs. 20% for conventional imaging, with a higher sensitivity and specificity.
A UCSF study found that radiologists who interpreted a high volume of mammograms were more accurate in detecting cancer. High volume readers had higher sensitivity and accuracy rates compared to low volume readers, suggesting that fewer biopsies are needed to find cancers.
A study at Memorial Sloan Kettering Cancer Center found that BRCA mutation carriers are more likely to be diagnosed with early-stage breast and ovarian cancers. The research showed that intensive screening and preventive surgery can lead to the detection of these cancers, but also highlights the limitations of screening.
Researchers found that raloxifene did not further prevent the growth of breast tumors previously exposed to more than 5 years of tamoxifen. Raloxifene also failed to block the growth of endometrial tumors caused by low-dose estrogen, suggesting it may increase endometrial cancer risk.
Researchers found that raloxifene did not prevent growth of breast tumors previously exposed to tamoxifen, while being less effective in blocking endometrial tumor growth. The study suggests that raloxifene may not further reduce the risk for breast cancer recurrence after five years of tamoxifen therapy.
A recent study by Mayo Clinic researchers has confirmed that long-term use of venlafaxine provides women with breast cancer significant relief from hot flashes, with a 60% reduction in frequency over eight weeks. The antidepressant is considered a safe and effective non-hormonal alternative to estrogen for treating hot flashes.
Researchers found that response rates, survival rates, and quality-of-life outcomes are similar between elderly patients (ages 70+) and younger patients with non-small-cell lung cancer. Additionally, studies report an increased risk of lung cancer after Hodgkin's disease treatment, especially in smokers, and analyzed cost-effectiveness...
Combining trastuzumab and ZD1839 has been shown to be more effective in inhibiting breast cancer cell growth than using either treatment alone. The findings suggest a potential new approach for treating multiple types of cancers, including those with HER2 and EGFR gene mutations.
Researchers at Vanderbilt University Medical Center found that combining Herceptin with Iressa reduces tumor cell death and tumor size in HER2-overexpressing breast cancers. The clinical trial will enroll 150 patients and aims to shrink tumors with minimal side effects.
Researchers investigate DNA repair capacity and its association with melanoma risk, while also exploring the predictive value of HPV testing in managing equivocal Pap tests. Additionally, a study on breast cancer biomarkers finds that measuring uPA and PAI-1 levels may help predict disease course and inform treatment strategies.
Researchers at Rensselaer Polytechnic Institute have developed a new terahertz imaging technique that allows for faster and more detailed imaging of biological tissue. The technique uses single pulses of terahertz radiation to produce high-resolution images with the potential to automate diagnostic analysis.
A new study finds that raloxifene, an osteoporosis medication, reduces breast cancer risk by 76% in postmenopausal women with high estrogen levels. Women with low estrogen levels receive no reduction in risk.
A follow-up study of 763 long-term breast cancer survivors found they maintain high levels of health, physical functioning, and emotional well-being. Social support was a significant predictor of current quality of life.
Researchers found that the most accurate method of detecting genetic mutations, direct nucleotide sequence analysis, is also the most expensive and labor-intensive. This method was used correctly to identify all previously identified mutations, while other methods, such as SSCP and CSGE, failed to detect over 20% of the mutations.
A study of 928 children with Hodgkin's disease found a 45-fold increase in breast cancer risk for girls, particularly those diagnosed with early-stage disease. The increased risk may be linked to treatment protocols and radiation dosages.
A Phase II trial found an overall response rate of 78% with the combination, compared to 75% with single-agent treatment. The addition of Navelbine to Herceptin was well-tolerated, with no severe side effects reported.
A recent study at Duke University Medical Center found that letrozole, a new breast cancer treatment, was more effective than tamoxifen in shrinking tumors and reducing cell division. Patients taking letrozole showed significant tumor shrinkage and underwent fewer mastectomies compared to those on tamoxifen.
A new non-invasive technique using modified breast pumps to collect breast fluid samples shows promise in predicting breast cancer risk. Women with normal cells in their fluid are 30% more likely to develop cancer, while those with abnormal cells are twice as likely.
A genetic vaccine developed by the University of Nebraska Medical Center has shown promising results in mice studies, combining DNA and adenovirus to deliver a tumor suppressor factor. The vaccine improved survival rates up to 40% in mice with metastatic breast cancer.
Researchers have successfully treated kidney tumors using radio frequency energy, achieving a 91% tumor ablation rate and no cancer recurrences in 9 of 11 patients. The minimally invasive procedure is less expensive, safer, and easier than surgery.
UCLA researchers found that anxiety about breast self-examination leads to low compliance among high-risk women. Only 34% of participants performed regular breast self-exams, despite high rates of mammogram and Pap smear adherence.
A Mayo Clinic study found that prophylactic mastectomy reduced the risk of breast cancer in women with BRCA1 and BRCA2 mutations by 89.5% to 100%. The study followed 26 high-risk women for 13.4 years without developing breast cancer, despite predicted risks of 6-9 cases.
A study of 430 women with a family history of breast cancer found that anxiety about breast self-examination was the primary barrier to compliance. Only 34% performed regular breast self-exams, despite 79% getting regular mammograms and 89% getting Pap smears.
Researchers developed a Herceptin-DM1 conjugate that targets HER2-positive breast cancer and shows complete regression in mice. Additionally, a new Bcr-Abl inhibitor called PD173955 demonstrates greater potency than Gleevec against leukemia cells, providing new hope for treatment-resistant cancers.
Researchers found that introducing charges for breast-cancer screening reduced attendance rates, particularly among younger women. In Turku, Finland, the introduction of a fee sent a message to the female population questioning regular mammography screening.
Researchers found that the number of affected relatives is a stronger predictor of breast cancer risk than the age at diagnosis. Women with one or two affected relatives have significantly higher lifetime incidence rates (7.8% and 13.3%, respectively), while those with three affected relatives face the highest risk (21.1%).
The TALENT trial assesses Tarceva's value in NSCLC treatment, showing promising anti-tumor activity. Additionally, a Phase Ib study evaluates Tarceva's feasibility in combination with chemotherapy for advanced breast cancer.
The HERA (HERceptin Adjuvant) Study aims to determine if earlier use of Herceptin increases disease-free survival for women with early breast cancer. The trial will recruit over 3000 patients across 600 trial sites globally.
A recent survey found that patients with breast cancer in Europe have limited knowledge about innovative treatments like Herceptin and HER2 diagnostic testing. This lack of awareness can lead to women not making informed decisions about their treatment, highlighting the need for improved education and communication.
Researchers believe that identifying specific genetic mutations could create more effective genotype profiles to determine individual risk of breast cancer. These profiles may be more accurate than current established clinical risk factors, which only predict but not identify high-risk individuals.
A new computer tool forecasts individualized treatment outcomes and risk assessments for patients with breast cancer. The program provides easy-to-read reviews of different treatment options, helping patients make informed decisions about their care.
A new approach reduces lymph node removal in breast cancer patients, reducing surgical trauma and complications. The technique uses a radioactive tracer to locate the sentinel node, allowing for targeted biopsy and minimizing false negatives.
A recent analysis published in The Lancet suggests that routine breast cancer screening through mammography may not be effective in reducing deaths. The study found that the two best trials failed to show an effect of screening on deaths ascribed to breast cancer after 13 years, and that screening leads to more aggressive treatment.
Researchers found Thrombospondin-1 (TSP1) regulates tumor growth by suppressing MMP9 activation, which promotes angiogenesis. The discovery could lead to new treatments targeting malignancies by cutting off the blood supply to tumors.
A recent study found that women who worked the graveyard shift had a 60% increased risk of breast cancer compared to those who did not work nights. The risk also increased with each additional hour of graveyard shift work.
Biochemistry assistant professor Mark Glover has recreated the three-dimensional structure of a critical portion of the BRCA1 protein, a breakthrough that could lead to early detection and genetic screening for breast cancer. The findings may also provide new insights into how the protein prevents cells from becoming cancerous.
The incidence of outpatient total mastectomy increased significantly between 1990 and 1996, particularly in states like Colorado and Maryland. Insurance coverage also played a role, with Medicaid patients being more likely to require hospital stays.