Articles tagged with Breast Cancer
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Two studies found that common screening techniques for tamoxifen-induced endometrial cancer are ineffective. Tissue biopsies and transvaginal ultrasound screenings detected few abnormalities and led to unnecessary procedures. Patients should be reassured and monitored for abnormal vaginal bleeding instead.
The Puget Sound Oncology Consortium is partnering with the National Surgical Adjuvant Breast and Bowel Project to evaluate Herceptin therapy in women with early stage breast cancer. The trial, Protocol B-31, aims to assess the safety and efficacy of combining Herceptin with chemotherapy in treating node-positive breast cancer patients.
Women with a strong family history of breast cancer who have used early oral contraceptives, particularly those introduced before 1975, may be at heightened risk of developing breast cancer. The study found a 3.3-fold increased risk for first-degree relatives, especially sisters and daughters.
The ECCO organisation urges a streamlined process for new cancer drugs, citing long and cumbersome procedures that hinder patient access. Experts warn of the need for harmonisation between regulatory agencies to avoid duplication and shorten the approval process.
Researchers found radiation therapy to be both safe and effective in preventing cancer recurrence in women with BRCA1 or BRCA2 mutations. However, women with these genetic mutations were more likely to develop cancer in their unaffected breast.
The US cancer community must adopt a new paradigm to develop and test cancer treatments, says Dr Edison Liu. The shift in emphasis is needed due to rapid advancements in biological technology, which could lead to significant improvements in prevention, diagnosis, and treatment.
European cancer specialists expect an overview of anti-oestrogen drug trials by 2005, allowing evaluation of long-term effects on breast cancer incidence and mortality. The US FDA has approved tamoxifen for high-risk women, but European experts are cautious due to differing trial results.
Researchers predict personalized breast cancer treatments using genetic profiles, with potential annual reduction of recurrence risks. Up to 100,000 genes in each cell are being studied for predictive value, leading to a future of tailored therapies.
A novel liposuction treatment has been developed to treat chronic lymphoedema in breast cancer patients, reducing arm swelling by up to 98% and improving mobility and pain levels. The treatment involves removing fatty tissue and accumulated lymph via small incisions along the arm.
Lymphoedema is a chronic condition resulting from breast cancer surgery and radiotherapy, characterized by swelling, pain, and disability. Early diagnosis and proper treatment can help alleviate symptoms, but increased awareness and education for healthcare professionals are crucial to prevent disastrous consequences.
A new endoscopic technique developed by Johns Hopkins surgeon William Dooley improves breast cancer detection and reduces the need for mastectomies. The procedure uses a novel endoscope to visualize breast tissue up to 60 times normal size, allowing for earlier detection of small lesions.
Adjuvant treatments with radiotherapy, chemotherapy, and hormone treatment tamoxifen can prevent late recurrences in breast cancer patients. The new findings show a significant decrease in deaths from breast cancer in middle-aged women, with a 30% fall over the past decade in the UK.
A major international trial found that giving extra radiotherapy to patients with early breast cancer substantially reduces the risk of cancer recurring in the breast. The study, involving 5,569 patients from nine countries, showed a significant benefit in younger women, particularly those under 40.
A new study found that farming overall is protective against breast cancer in women, but pesticide exposure boosts their risk slightly. Women who farmed more than 23 years had a 40% lower risk of breast cancer.
Renowned scientists and clinicians will discuss recent advances in breast cancer science and treatment, including new developments in imaging techniques, hormone replacement therapy, and alternative therapies. The symposium will feature prominent speakers from top medical institutions.
Researchers at Duke University Medical Center and Geron Corp. have made promising findings on a 'universal' cancer vaccine based on the telomerase protein. The active part of telomerase can stimulate development of immune cells that recognize and kill multiple, unrelated mouse and human cancer cells.
Researchers at UNC-CH found that small studies reported higher cancer risks than larger ones, and that the general public is unlikely to get esophageal cancer even with heartburn. The study's findings suggest that widespread testing for Barrett's esophagus may not be necessary.
Researchers found that celecoxib reduced breast tumor incidence by 68% and average tumor size by 81% in rats. The anti-tumor effects of celecoxib are attributed to its ability to inhibit an enzyme that promotes cancer growth.
The 2nd European Breast Cancer Conference will bring together over 3000 healthcare professionals, scientists, and patient advocates to share new developments in breast cancer research, treatment, and care. Distinguished international speakers will address key issues about the future of breast cancer research, treatment, and care.
A new diagnostic tool is highly accurate in detecting cancer spread in women with vulva cancer, potentially sparing them from debilitating lymph node removal. Researchers found that 27 out of 59 patients had cancer spread, and the procedure could spare up to 80% of women from this procedure.
Researchers at Dana-Farber Cancer Institute have charted the chain of events by which estrogen receptor-negative (ER-negative) breast cancer cells are formed. By understanding this process, scientists can identify potential targets for specific therapies to stop ER-negative tumors from growing.
A new laser treatment being tested at Rush University Medical Center has shown promise in eliminating the need for surgery in women with small breast cancers. The procedure uses a laser delivered through a needle to destroy tumors detected by mammography, resulting in no complications and minimal pain.
Researchers at UNC Lineberger Comprehensive Cancer Center are conducting a clinical trial using a genetically engineered protein fragment to stimulate the immune system to recognize and kill breast cancer cells. The goal is to treat advanced breast cancer, where the disease has spread beyond the breast.
Researchers at Duke University Medical Center developed a tumor-specific antibody, Y10, that targets mutated protein found only in cancer cells. This antibody can eradicate brain tumors in mice and has shown promise as a potential treatment for human patients.
A new vaccine has shown promise in boosting immune responses against HER-2/neu protein in patients with breast and ovarian cancer. Researchers have identified a key protein fragment that can trigger an immune response, leading to sustained detectable immunity up to two years after vaccination.
Researchers have developed a new technique for detecting atypical cells in breast ducts, which could identify pre-cancerous abnormalities years before mammographically detectable lesions develop. A device that retrieves ductal cells has shown promising results in clinical trials, identifying abnormal cells in 15% of the population.
Researchers at the University of Pittsburgh Cancer Institute found that triggering an anti-tumor immune response significantly potentiates the effects of the anti-angiogenic drug endostatin. The study showed that half of treated animals experienced complete and permanent regression of tumors, suggesting a highly effective cancer therapy.
A new study found that cancer genetic testing can impact marital satisfaction, with couples experiencing increased anxiety and distress when discussing the process. Supportive spouses play a crucial role in mitigating these effects, while unsupportive responses can exacerbate relationship strain.
Researchers are using focused microwave radiation to heat and kill breast cancer cells, achieving significant tumor shrinkage in clinical trials. The technique uses high water content in cancer cells to deliver precise heat damage.
Researchers at Wake Forest University School of Medicine report a significant increase in breast cancer risk among Eastern Band Cherokee women who use smokeless tobacco. The study found that the risk of breast cancer rose almost eightfold compared to non-users, highlighting potential health concerns with alternative nicotine products.
A new medical imaging approach using 3D color Doppler ultrasound shows promise for better cancer detection and recognition in breast cancer patients. The technique uses sound waves and computerized equipment to visualize blood flow in the vessels around suspicious areas, distinguishing between tumors and benign masses.
A recent study by Dr. Andreas Constantinou suggests that soy protein mixes without isoflavones may be more effective in reducing mammary gland tumors in rats than previously thought. The study also found that the anti-tumor ingredient in soy works by increasing detoxification enzymes that eliminate free radicals.
Researchers found greater numbers of estrogen receptors on lung cancer cells, suggesting a role for this hormone in enhancing tumor growth. Estrogen was shown to increase cell division and tumor growth in both cultured lung cancer cells and animal models.
New research suggests that non-mutational gene defects, involving DNA methylation, contribute significantly to the development of cancer. Up to 10% of genes in some tumor types are found to be inactivated by aberrant DNA methylation, suggesting a much larger role for this process than previously thought.
Researchers aim to uncover molecular signatures of cancer initiation using gene expression profiles. They will compare genes in hereditary colon, breast, and kidney cancers with normal tissues to identify altered genes and target potential chemopreventive agents.
Three Cedars-Sinai physicians are leading a fight against women's cancers through innovative research, clinical care, and genetic screenings. Beth Karlan focuses on curing and preventing ovarian cancer, while Maren Scheuner develops personalized prevention plans for breast, endometrial, and ovarian cancers.
Participation in breast cancer support groups can help women cope and function better when their spouses are not supportive. However, for those with adequate support at home, peer-discussion groups may worsen daily functioning. The study suggests that exposure to weekly discussions may re-evaluate relationships or spur conflict at home.
Researchers found that aberrant cytosine methylation and chromatin condensation can silence maspin gene expression, allowing tumors to grow and spread. The discovery provides critical information on the regulatory mechanisms of maspin, paving the way for potential cancer therapies.
Researchers found that Pin1 depletion allows cell division despite DNA damage, suggesting drugs inhibiting Pin1 could trigger cancer cells to divide and die even with lethal damage. This approach may spare normal cells from uncontrolled division.
Researchers identified a biological marker that predicts breast cancer return in some women, with higher levels of damaged p53 protein found in those whose cancer recurred within four years. The finding may lead to personalized treatments, such as higher doses of radiation and novel therapies.
Researchers developed Diffraction Enhanced Imaging (DEI), a new X-ray imaging method that produces significantly better pictures of breast tissue than conventional X-rays. The technology has shown superior tumor visibility in six out of seven specimens, and further work aims to make it clinically portable.
The UCSF Women's Health 2000 event explores risk factors for breast cancer, including genetic predisposition and hormonal influences. The conference also delves into the unique health concerns of lesbian women, such as cervical cancer and mental health issues.
A large case-control study of nearly 1,000 Connecticut women found no significant association between PCBs or DDE exposure and breast cancer risk. The research suggests that previous studies on the topic have been inconclusive due to small sample sizes and lack of consideration for modifying factors.
A recent study by UCSF researchers has found a strong genetic link between early stage, non-invasive breast cancer cells and disease recurrences. The study suggests that second tumors are caused by residual cells left over from the primary lesion, highlighting the importance of wide surgical margins to prevent recurrence.
The international Consensus Conference Committee outlines treatment options for DCIS to determine the appropriate treatment for each patient. The committee recommends treating women with DCIS with breast conservation through lumpectomy or lumpectomy along with radiation therapy, while mastectomy may still be an option.
A new treatment combination of paclitaxel and carboplatin has shown encouraging results in a clinical trial, achieving a 62% response rate and a projected 72% one-year survival rate. The treatment, which is compatible with prior anthracycline therapy, offers additional benefits for women with metastatic breast cancer.
The Charter of Paris Against Cancer aims to improve cancer care, research, and treatment worldwide. The initiative brings together global partners to fight cancer, with a focus on patient involvement and advocacy.
A study of postmenopausal women in Los Angeles County found that long-term use of hormone replacement therapy combining estrogen and progestin increases breast cancer risk by 24%. The risk was highest for sequential therapy, but continuous combined therapy showed lower risks. Researchers suggest lowering doses to decrease disease risk.
A University of California, San Francisco study found that screening mammography in elderly women aged 66-79 reduced their risk of developing metastatic breast cancer by 43% compared to those who were not screened. This is the first evidence that mammography is beneficial for these women.
A study by UCSF researcher Shelley Adler found that only a third of women with breast cancer disclose using alternative treatments to their medical doctors. The main reasons for remaining silent were attitudes toward physicians and the perception that disclosure was not relevant to the doctor-patient relationship. Women tend to discuss...
A new trial found that lowering copper levels with a cheap compound called tetrathiomolybdate stabilized tumors and prevented their growth in five out of six patients. The copper strategy targets angiogenesis, a process allowing tumors to expand beyond a cluster of cells. Researchers hope it could contribute to cancer eradication in th...
A new study links human breast cancer to the mouse mammary tumor virus, proposing that humans acquire the virus from infected mice. The authors found a similar viral sequence between human breast cancer and mouse mammary tumor virus, suggesting a potential preventive vaccine.
Researchers documented the earliest steps of tumor formation in mice and rats, showing that cancer cells can grow new blood vessels when just hundreds are present. The study suggests that angiogenesis inhibitors might be useful at the earliest stages of tumor development to prevent recurrence and spread.
Researchers found that low E-cadherin levels are the strongest prognostic factor for a poor long-term outcome in node-negative breast cancer patients. High or intermediate levels add little assurance of good prognosis, but abnormally low levels indicate a substantially increased risk of metastasis.
A review paper by University of Pittsburgh researcher James J. Dignam suggests that physiological responses to treatments are not responsible for poorer outcomes among blacks. Black women with the same stage of breast cancer have more advanced disease conditions due to less access to or utilization of healthcare resources.
A retrospective study published in Cancer journal shows an inverse correlation between the number of lymph nodes and 5-year survival rates. Patients with 20 or more tumor-free lymph nodes had a 4.33 times greater relative risk of dying from metastatic breast cancer, compared to those with fewer than 20.
The Vanderbilt-Ingram Cancer Center has been selected to participate in the National Cancer Institute's new Mouse Models of Human Cancers Consortium. Researchers will develop and evaluate mouse models for eight major organ systems, focusing on breast, prostate, lung, ovary, skin, blood and lymph system, colon, and brain cancers.
Researchers at Fox Chase Cancer Center are conducting a clinical trial to investigate the efficacy of fenretinide, a vitamin A-related medicine, in preventing ovarian cancer. Women with high-risk factors for breast and ovarian cancer will take part in this study to examine the molecular effects of fenretinide on ovarian tissue.
Researchers found a link between reduced TGFb receptor expression and increased breast cancer risk in women with benign breast disease. The study identified 54 women who developed invasive breast cancer after initial hyperplasia diagnosis, highlighting the importance of molecular markers in predicting breast cancer risk.
Researchers discovered that high levels of BAG-1 protein correlate with better long-term survival and overall survival rates for women with early breast cancer. The study found a significant difference in 10-year survival rates between women with high and low BAG-1 protein levels.