Articles tagged with Breast Cancer
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A new study by UCSF researchers suggests that screening for breast cancer in elderly women may not be worth the cost, citing a small increase in life expectancy. The study also highlights the potential downsides of mammograms, including false positives and anxiety caused by abnormal results.
The Comprehensive Cancer Center at Wake Forest University has been approved to participate in a national breast cancer study evaluating the effects of sentinel node biopsy versus standard axillary dissection. The trial aims to determine if removing only the sentinel node impacts cancer control and survival.
Dr. Showe's laboratory is conducting research on CTCL, the most common primary T-cell lymphoma of the skin, using state-of-the-art robotic systems. The goal of her work is to give clinicians and pathologists new molecular tools to identify CTCL accurately in its early stage.
A study of 292 breast cancer survivors found that involvement in decision-making about follow-up tests improved physical and emotional health, but did not affect post-cancer survival rates. Leading cancer experts recommend mammography and clinical breast exams instead.
A new study reveals that social network characteristics and healthcare provider recommendations significantly influence women's breast cancer screening practices. The research found that women who perceive regular mammography as common among their peers are more likely to get screened regularly.
Researchers from the Howard Hughes Medical Institute have identified a protein that works closely with Brca1 to initiate DNA repair. Mutations in this trigger protein may be responsible for more instances of breast cancer than Brca1 mutations, accounting for nearly ten percent of all breast cancers.
A five-year clinical trial found that premenopausal women taking fenretinide had a lower risk of developing another breast cancer, while postmenopausal women showed no significant benefit. The study also detected a reduced risk of ovarian cancer in younger women treated with fenretinide.
A clinical trial is underway at UCSF to test the effectiveness of traditional Tibetan medicine as a sole therapy for advanced breast cancer. The trial, led by Yeshi Dhonden and Dr. Debu Tripathy, aims to evaluate the impact of individualized herbal therapies on tumor size in women with stage IV breast cancer.
Researchers advocate for standardized examination techniques to improve physicians' precision and accuracy in screening for breast cancer. The study found that spending adequate time on the clinical breast examination (CBE) and using proper techniques can increase early detection of lumps in the breast.
A study led by University of Southern California researchers found that tamoxifen therapy for breast cancer increases the risk of endometrial cancer by about 50 percent. The risk is higher in women who have previously used estrogens, are overweight, or have a history of estrogen replacement therapy.
A Yale study suggests that breast cancer patients with BRCA1 or BRCA2 genes are at higher risk of late relapses after treatment. Women with these mutations respond well to initial therapy but may develop second tumors years later.
Researchers found that women with BRCA1 or BRCA2 mutations have a 40% risk of local recurrence and developing new tumors, making breast-conserving therapy less optimal. The study suggests that mastectomy may be a more suitable treatment option for these women to reduce the risk of recurrent disease.
Researchers found that losing function of one copy of the PTEN tumor suppressor gene can lead to chronic fatal conditions, including cancer and autoimmune diseases. The study showed that this disruption allows white blood cells to accumulate unchecked and attack their own organs.
Research shows that moderate levels of worry about breast cancer motivate women to get screened, but high levels may inhibit use. Educational programs that focus on raising worry and fear alone may not be effective without an action plan.
A new study published in Health Psychology contradicts long-held notions about the connection between breast cancer and psychological factors. The researchers found modest associations with certain psychosocial factors, but emphasized that biology remains the primary factor in breast cancer development.
A University of Iowa-led study found that women with Stage I breast cancer who did not receive axillary node dissections had significantly worse 10-year survival rates compared to those who underwent the procedure. The analysis suggests that many women with early-stage disease are not receiving this crucial treatment, which may impact ...
Scientists at Oregon Health & Science University have discovered a naturally occurring protein, herstatin, that inhibits the functions of the HER-2 oncogene, a major factor in breast and other cancers. Herstatin blocks the HER-2 signaling activity that causes tumor cells to grow, ultimately killing those cells.
Researchers at the University of Michigan Comprehensive Cancer Center have identified two genes that may control the development of inflammatory breast cancer. The discovery, published in Clinical Cancer Research, could lead to more effective forms of cancer treatment, particularly for newly diagnosed women.
A new test developed by USC scientists and colleagues can accurately detect hidden breast cancer cells in lymph nodes, improving the detection of metastases. This breakthrough enables customized treatments tailored to individual patients' characteristics, such as tumor size and hormone receptor status.
Researchers at the University of Pennsylvania Cancer Center found that bilateral prophylactic oophorectomy reduces breast cancer risk in women with a BRCA1 gene mutation. After 10 years, the incidence of breast cancer among women who had their ovaries removed was significantly lower than those who did not.
Cancer patients who participate in regular physical exercise programs show significant improvements in physical and mental health, including enhanced stamina, muscle strength, and pain management. The studies found that exercise has a positive effect on quality of life, including functional, psychological, and emotional well-being.
A new study found that a psychological intervention program boosted antibody levels and reduced stress hormone cortisol in women with breast cancer, leading to improved quality of life and higher chemotherapy doses.
A University of Iowa research team has identified two new genes linked to the invasive and metastatic spread of breast cancer. The findings, published in Breast Cancer Research and Treatment, provide important new insights into the complex process of tumor cell invasion and metastasis.
Scientists at Rockefeller University have found that persistent activation of Stat3 protein can cause normal cells to behave like cancer cells. This discovery presents a promising new target in the fight against cancer and suggests that drugs inhibiting Stat3 activation may be effective.
A new computer model suggests that more frequent mammogram screenings can dramatically reduce breast cancer deaths. The study found that prompt annual screening could result in a 51% reduction in breast cancer deaths, with twice-yearly screenings potentially cutting death rates by as much as 80%.
A new study found that women at high risk for breast cancer who are also anxious and lack self-control are less likely to get a mammogram. Researchers suggest problem-solving training may help address this issue among the most distressed women.
A study conducted by researchers at the University of Southern California found that regular exercise over a lifetime significantly reduces the risk of breast cancer in postmenopausal women. Women who maintained a relatively stable weight throughout their adulthood saw a 45-55% lower risk, with the greatest benefits seen when exercisin...
A UCSF study found that raloxifene, an osteoporosis prevention drug, significantly reduced the risk of invasive breast cancer in postmenopausal women by 76 percent. The drug also showed promise in preventing both breast and osteoporosis simultaneously.
A comprehensive approach to cancer treatment is needed, considering a patient's total life situation, including stress, environmental toxins, and nutritional deficiencies. Research highlights the importance of evaluating alternative and complementary therapies, which have poorly documented effectiveness but are widely used by patients.
A study by Northwestern University and the Mayo Clinic found that postmenopausal hormone replacement therapy increases the risk for specific types of breast cancer with favorable prognoses, particularly invasive ductal or lobular carcinoma. The risk is higher among women who used hormone replacement therapy for five or fewer years.
Researchers at the University of Iowa report improved survival rates for women with stage IV breast cancer using a four-drug, high-dose chemotherapy treatment followed by a bone marrow transplant. The study found an overall survival rate of 38 percent, compared to projected rates of 32-30 percent in other studies.
A retrospective statistical analysis of patients with advanced breast cancer found no survival benefit from high dose chemotherapy and bone marrow transplant. The study analyzed data from over 1,300 patients treated in the 1980s and early 1990s.
A USC study suggests that radiation therapy is not necessary for DCIS patients with margin widths of 10mm or more, and may even be counterproductive due to side effects and costs. Patients with narrower margins may benefit from postoperative radiation therapy.
Dr. Daniela Santoli to develop TALL-104 regimen for effective and safe treatment of metastatic melanoma patients; trials expected to start later this year.
Researchers found that axillary lymph node dissection, a common surgery used to determine the extent of disease in early stage breast cancer patients, may not benefit a large number of them. The study concluded that knowing lymph node status was unlikely to affect survival and may not be worth the risks associated with the surgery.
Researchers used genetically modified mice to elucidate the mechanism underlying hereditary breast cancer. The study found that mutations in the BRCA-1 gene lead to genetic instability, favouring further mutations and tumour growth.
A new scanner, the T-Scan 2000, can detect tumors in breast tissue using a tiny electric current, allowing doctors to avoid biopsies. This device has the potential to reduce negative biopsies and increase early biopsy referrals for women with suspect lesions.
Scientists discover that breast tumors produce high levels of a fetal form of insulin receptor, stimulating rapid cell division and cancer growth. The finding offers a potential target for new cancer drugs, which could block or slow breast tumor growth.
A recent study found that excessively frequent breast self-examinations may reduce detection efficacy and increase false-positive findings. Women with a family history of breast cancer who examine themselves daily or weekly showed the highest levels of general anxiety.
A study found that breast cancer patients' top concerns after surgery are mortality, pain, and financial burdens, not previously thought to be the primary worries. The survey involved 223 women from diverse ethnic backgrounds and highlighted the importance of addressing these issues in counseling.
A new study published by Vanderbilt University Medical Center researchers found that estrogen replacement therapy (ERT) does not significantly elevate the risk of breast cancer in women with histories of benign breast disease. Women already face a higher risk, but ERT does provide benefits for heart and bone health.
Researchers at Ohio University have discovered a unique retrovirus linked to skin tumors in walleye, which shares similarities with human cyclin D1. The study reveals that the presence of a specific mRNA precedes protein production, potentially leading to tumor cell death.
A study by Johns Hopkins Medicine reveals that nearly 90% of prostate cancers are linked to a common genetic process called 'gene switching,' which can be reversed with drugs. This finding has the potential to correct one of the most common cancers in men without using typical gene therapy.
A University of Michigan cancer vaccine combination with interleukin-2 was found to be effective in mobilizing the immune system to attack and destroy malignant cells. Eighty percent of mice showed complete regression of their tumors after treatment.
The Susan G. Komen Breast Cancer Foundation is now accepting applications for its 1999 National Grants program, offering over $11 million in funding for groundbreaking research and education. The program aims to eradicate breast cancer as a life-threatening disease by advancing research, education, screening, and treatment.
Researchers found that FTIs activate features of RHO by stimulating the production of an isoform with altered properties, making it possible for RHO to perform activities it could not previously perform. This understanding will lead to more effective and targeted cancer treatments.
A study published in Annals of Internal Medicine suggests that high levels of serum estradiol and testosterone are associated with a three-fold increased risk of developing breast cancer. Researchers hope this information will help clinicians identify high-risk women who may benefit from chemoprevention.
A large study has identified a microscopic change in breast tissue that may double the risk of breast cancer in some women. Radial scars were found in nearly 100 out of 1,400 women with benign breast biopsies, doubling their risk of breast cancer independently of other tissue abnormalities.
A preclinical study published in Nature Medicine demonstrated that Immunex's TRAIL molecule suppresses tumor growth and induces complete remission in a high proportion of treated mice. The study shows promise for the treatment of various cancers, with the potential for minimal toxicity.
Researchers at Yale University have successfully inserted a human cancer-suppressing gene into fruit flies, demonstrating a direct link between human and fly tumor suppressor genes. The study reveals that the insects can provide important new insights into human cancers.
Research suggests that soy supplements may decrease breast and endometrial cell proliferation, potentially lowering cancer risk. However, individual differences in metabolism and response to estrogens limit the benefit.
A Wistar scientist has been awarded a $30,000 grant from the Cancer Research Foundation of America to develop a vaccine against Human Papilloma Virus-16. The grant will support research aimed at finding a vaccine that uses either the E6 or E7 protein from HPV-16 to activate T-cells.
Researchers conducted in-depth interviews with 21 women with cancer, revealing their experiences with alternative and complementary therapies. The study highlights the importance of patients having better information about treatment options, including a mix of conventional and holistic approaches.
Researchers at Johns Hopkins University have linked specific gene mutations to the growth of fatal brain tumors in flies, mirroring human cancer progression. The study's findings suggest that a key signaling pathway may be responsible for tumor growth, offering potential new avenues for cancer treatment.
Researchers at Vanderbilt Cancer Center found that overproduction of TGF-beta contributes to tamoxifen resistance. They also discovered the importance of immune system's natural killer activity for tamoxifen's effectiveness. This discovery may lead to strategies to prolong tamoxifen response or even reverse resistance.
Aromatic amines, used in industrial processes, have been detected in human milk, raising concerns about breast cancer risk and infant exposure. The study's findings suggest that breast ductal epithelial cells are also exposed to these substances, highlighting the need for further investigation.
A new study from Northwestern University found that Evista (raloxifene) significantly reduces the risk of invasive breast cancer in postmenopausal women, with a 63% decrease in newly diagnosed cases. The medication has also been shown to lower cholesterol and protect against bone loss and osteoporosis-related fractures.
The Wistar Institute has been awarded a $20,000 grant to support continued research on TALL-104 cells, which show promise in treating breast cancer. The grant allows the Linda Creed Breast Cancer Foundation to be involved in supporting clinical trials for new treatments and perhaps a cure.
A new study finds that digital mammography provides better information for diagnoses, allowing radiologists to use multiple views of images. The technology has the potential to lead to earlier tumor detection and treatment, reducing breast cancer mortality rates.
A recent study at Wake Forest University Baptist Medical Center shows that radiologists can accurately detect breast cancer using digital mammography technology as effectively as traditional film-based methods. The technology has the potential to improve detection rates and reduce deaths from breast cancer.