Articles tagged with Breast Cancer
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Researchers at Rockefeller University have found evidence of naturally occurring tumor immunity in humans, where the immune system targets a specific protein called cdr2 to fight cancer. This discovery provides support for immunotherapy treatments and offers new insights into cancer biology.
A Cedars-Sinai researcher has identified a gene associated with malignancy in brain, liver, breast, colon, kidney, and reproductive organs, but not in healthy adults. The discovery could lead to the development of a method to block the gene's expression using antisense technology, potentially stopping cancer before it spreads.
Researchers develop a novel microwave imaging technology to detect breast tumors without X-ray radiation, potentially reducing mortality rates. The technology uses microwaves to detect differences in water content between malignant and benign tumors.
The study aims to scientifically evaluate the benefits of a Chinese herbal formula in alleviating multiple side effects of chemotherapy in early-stage breast cancer patients. Participants will receive either the herbal formula or a placebo, with their progress monitored over 180 days.
A new two-year study examines reproductive problems, early menopause, osteoporosis, and psychosocial issues in long-term breast cancer survivors. The study aims to develop a telephone-based counseling intervention to reduce physical and emotional consequences of breast cancer diagnosis and treatment.
Researchers discovered specific genetic changes that indicate whether chemotherapy is effective in treating patients with anaplastic oligodendrogliomas. The discovery allows for immediate determination of chemotherapy response at diagnosis, offering improved treatment options for patients.
A study of eight large clinical trials found that mammography screenings for women in their 40s add only about five days to life expectancy and may not significantly reduce breast cancer deaths. However, the overwhelming proportion of women experience no benefit from screening.
Scientists at Thomas Jefferson University have demonstrated that a normally protective anticancer gene can block tumors from growing. Led by Dr. Antonio Giordano, they found that the damaged version of the gene, pRb2/p130, suppresses tumor growth in animal models, paving the way for gene therapy to treat lung cancer and other cancers.
Scientists are using NASA Bioreactors to culture breast cells on Earth, learning what controls their growth and how to thwart malignancies. The research has the potential to improve healthcare for women, including those traveling to Mars, by developing new therapies that target cancer's genetic weaknesses.
Researchers at the University of Illinois have developed a novel optical biopsy technique using near-infrared light to detect hidden growths in breast tissue. The method shows strong correlation between infrared signatures and tumor types, potentially eliminating painful needle biopsies or expensive MRI procedures.
Researchers have discovered a gene called E2F1 that helps bring about tumor cell death yet is also necessary for their growth. The study found that without E2F1, tumors grew slower but cell death was reduced by 80 percent.
A large-scale randomized study found that chemotherapy improves long-term survival for women under 50 and those in their 50s and 60s, even if the cancer has not spread. The treatment also showed benefits for women without evidence of disease spread.
A new genetic mutation, APC I1307K, is found to modestly increase the risk of hereditary breast cancer in women of Ashkenazi Jewish descent. The mutation's effect is most significant in those who already carry BRCA mutations.
A protein found in copperhead snake venom retards breast tumor growth by blocking tumor cell adhesion and invasion, as well as inhibiting new blood vessel development. Studies with mice implanted with human breast cancer cells showed a 60-70% reduction in growth rate and 90% reduction of tumor metastasis to the lungs.
Researchers are testing whether digitally enhanced mammograms can help detect breast cancer earlier, with a goal of improving radiologists' performance and enabling general radiologists to perform as well as specialized radiologists. The trial involves enhancing images from about 450 mammogram cases in a national database.
Researchers at the University of Michigan have developed a vaccine made from dendritic cells that triggers the immune system to attack malignant tumors and prevent new tumor development in mice. The study found significant results, including a 70% kill rate of sarcoma cells within four hours.
A new diagnostic technique has been found to distinguish benign breast abnormalities from breast cancer in pre-menopausal women. The test, called the Biofield Diagnostic System, performed best in this age group, with a high sensitivity and specificity rate.
The Hilary Koprowski Endowed Professorship will provide long-term support for renowned scientists, setting a precedent for additional endowed professorships at The Wistar Institute. Established in honor of Dr. Koprowski's contributions to medical research, the chair aims to advance vaccine development and cancer research.
Scientists have discovered that interleukin-12 (IL-12) can trigger the production of a protein called interferon-gamma (IFN-), which blocks tumor-induced angiogenesis. This finding suggests that tumor cells may be able to produce their own antiangiogenic elements, potentially leading to new cancer therapies.
Giorgia Gri, a Wistar Institute visiting scientist, has received a $25,000 fellowship award from the American-Italian Cancer Foundation to study the regulation of Interleukin-12 receptor b2 chain expression. Her research aims to develop safer and more effective IL-12 therapies against cancer.
A new international study analyzed fat samples from 642 European women, finding no protective effect of oleic acid on breast cancer risk. Higher weight and family history were strong associations with breast cancer among participants.
Researchers analyzed data from over 72,000 screening mammograms to show a steady increase in cancer detection across all ages, with no abrupt jump at 50. The study challenges previous conclusions that suggested an age-related change in mammography's effectiveness, supporting the continued use of screening for women aged 40-49.
Caroline Sokol, a researcher at The Wistar Institute, has been awarded the Goldie Simon Preceptorship Award for her work on autoreactive B-cells in systemic lupus erythematosus. She aims to earn a joint M.D./Ph.D. to conduct clinical research and improve understanding of the chronic autoimmune disease.
A rare medical archive enabled researchers to determine that patients with high nm23 levels and low density of newly formed blood vessels were more likely to survive 14 years after treatment. Low micro-vessel count was also a predictor, with 92% of patients surviving at least 14 years.
A new study by NYU Langone Health researcher Susan Harlap found that breast cancer surgery timing has no impact on survival rates since the mid-1980s. Changes in medical practice, including improved anesthesia and post-operative care, may have contributed to this shift.
A multi-center study provides clear guidelines for genetic testing in women with breast cancer, identifying those at high risk of ovarian cancer. The study found that nearly 40% of participants had abnormalities in BRCA1 and BRCA2 genes, associated with a 10-fold increase in ovarian cancer risk.
A study found that postmenopausal women with excess body hair are 33% more likely to develop breast cancer. Excess sebum production also increases the risk in premenopausal women, while an 'apple' shape is linked to a higher risk of breast cancer in this age group.
Women in their 40s benefit more from annual mammography screening due to detectable cancers being larger and more aggressive. Mammograms for younger women are less effective compared to breast palpation, which also faces similar limitations in denser pre-menopausal breasts.
A large randomized phase III study confirmed the efficacy of paclitaxel plus carboplatin in treating non-small cell lung cancer. Patients who received paclitaxel/carboplatin experienced a greater response rate and improvement in quality of life compared to cisplatin/etoposide.
Researchers demonstrate intratumoral delivery of the E1A gene, downregulating HER-2/neu expression and tumor responses. The study shows promise for using E1A gene therapy to treat a broad range of cancers.
UCSF researchers report that the osteoporosis prevention drug raloxifene drastically reduces the risk of breast cancer in postmenopausal women without increasing the risk of endometrial or uterine cancer. The study found a 70 percent reduction in breast cancer cases among participants taking raloxifene compared to those receiving placebo.
A study found that the ability to read mammograms varies significantly among general radiologists, with scores ranging from 8% to 98%. The experts detected more cancers but were also more likely to flag normal cases as abnormal.
A new study found that shrinking tumors can reduce blood vessel pore sizes, making it harder for chemotherapy agents to reach their targets. Researchers recommend designing smaller, more agile drugs to overcome this challenge.
A new analysis found that Michigan's strict mammography regulations, enacted in 1989 and 1994, significantly improved the quality of mammograms without limiting access to cancer-screening procedures. The study suggests that federal mammography standards will also have positive results.
Researchers at Johns Hopkins Bloomberg School of Public Health found a significant link between GST gene variations and breast cancer risk. The study suggests that testing for these genetic mutations may help prevent breast cancer in women with the variants by advising them to avoid certain environmental cancer risk factors.
Researchers successfully delivered and expressed an E1A gene in both diseased and normal human cells using a proprietary non-viral liposomal delivery mechanism. The study showed decreased levels of surrogate tumor markers in three patients with breast and ovarian cancers, indicating potential as a treatment for various types of cancer.
Researchers have developed new radiotracer chemicals that can predict how well antiestrogen therapies will treat cancer in individual patients. The technique uses positron emission tomography (PET) and shows promise for improving treatment outcomes.
Researchers at UNC-CH and Washington University found that only 3.3% of white patients carry the BRCA1 mutation, significantly lower than previous estimates. The study suggests that widespread screening is not warranted due to high costs and limited interpretability.
A recent study published in JAMA found that only 3.3% of white women and 0% of black women with breast cancer had disease-related BRCA1 mutations. The researchers conclude that widespread screening is not necessary for the general American population, but may be beneficial for high-risk families.
A USC/Norris study reveals how genistein suppresses the mammalian stress response, preventing cancer growth in cell cultures and animal models. This mechanism may provide insight into soy's anti-cancer effects and its potential as an effective agent.
A large study by Ohio State University researchers has found that stress experienced after a breast cancer diagnosis and surgery can weaken the immune response in women. The study, published in the Journal of the National Cancer Institute, used biochemical indicators to measure the impact of stress on immune function.
A study found that older women, especially minorities, get the fewest mammograms due to fears of finding a lump and erroneous beliefs about breast cancer. Tailoring messages to address these concerns can encourage more women to undergo screening.
Researchers are developing a new approach to treat cancer by boosting the immune system using dendritic cells, which can be grown in large quantities in culture. The therapy has shown promise in clinical trials, particularly for patients with advanced melanoma or breast cancer.
Researchers have discovered a way to quickly determine if women with advanced breast cancer are responding to hormone therapy using positron emission tomography (PET). The finding could reduce the need for harsher chemotherapy and improve quality of life for patients.
Two studies support annual mammography starting age 40, reducing breast cancer deaths by 35-45% and outpacing radiation risks. The benefits of screening far outweigh the negligible risk of developing breast cancer from mammography.
A recent study found that premenopausal women who breastfed for at least 20 months had a 50% lower risk of breast cancer compared to those who did not breastfeed. The study also revealed no effect on the risk of breast cancer for postmenopausal women.
The technique correctly ruled out a diagnosis of cancer in 18 of 30 women whose suspicious mammograms were later shown to be benign. Additionally, none of the 14 cancers in the group were misdiagnosed by the 3D imaging method.
Researchers found that fragments of chromosome 11 slow tumor growth in mice and cell cultures, suggesting a tumor suppressor gene may be present. The study provides new hope for treating lung cancer patients by identifying a potential target for therapy.
Researchers at Columbia University Irving Medical Center identified the P-TEN gene as a new breast cancer susceptibility gene. The discovery could lead to better tests for early detection and more effective treatments for women with Cowden's syndrome, an autosomal dominant disorder that increases breast cancer risk by 50-75%.
A recent study found that women who perform specific components of Breast Self Examination (BSE) may have a reduced risk of dying from breast cancer. The three key components associated with this benefit are visually examining the breast, using finger pads to examine the breast, and using three middle fingers to examine the breast.
A consensus group of breast cancer specialists has developed a classification system for DCIS, taking into account nuclear grade, necrosis, polarization, and architecture. The new system aims to improve patient treatment and discrimination between less aggressive and more aggressive cases.
A new X-ray technique called defraction-enhanced imaging (DEI) produces sharper images of breast tissue, potentially diagnosing tumors earlier and reducing cancer deaths. The method uses a single-energy X-ray source to reduce scatter and improve contrast, highlighting the edges of structures in cancerous tumors.
Researchers at the University of Maryland Greenebaum Cancer Center have linked the PTEN gene to endometrial cancer in a study published in Nature Genetics. The findings suggest that up to 50% of all endometrial cancers may contain a mutation in this gene, highlighting the potential for improved detection and treatment options.
A new analysis linked short-acting calcium channel blockers to a twice increased risk of breast cancer in postmenopausal women. However, longer-acting varieties were not found to have the same association.
Researchers at Duke University Medical Center have found that a Tie2 inhibitor can significantly slow the growth of tumors on rats by preventing nearby blood vessels from forming capillaries to feed the cancer. The treatment slowed tumor growth by 75 percent and reduced vessel length density by 40 percent.
The number of women dying from breast cancer is decreasing due to earlier detection through mammography. Physicians play a key role in recommending and performing mammograms, with 93-94% of women complying with requests.
Researchers found a strong correlation between low levels of the Rb-2/p130 protein and aggressive, metastasizing lung cancer. The study's findings may lead to a new lung cancer tumor-grading test to enable early diagnosis and tailor treatments.
A study found that 81% of women at risk for breast cancer planned to undergo genetic testing, driven by perceived benefits such as increased breast self-examination and better treatment options. Counseling is crucial to help them make informed decisions and manage potential psychological reactions.
A new international study has found a significant association between high levels of trans fatty acids and breast cancer in European women. The research suggests that reducing trans fatty acid consumption through dietary changes may help protect against breast cancer development.
Research suggests that women under 50 may experience false-negative mammogram results when screened during the luteal phase of their menstrual cycle. By scheduling mammograms during the first half of their cycle, the accuracy of breast cancer detection can be improved.