Articles tagged with Breast Cancer
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Research suggests that lifetime physical activity can significantly reduce breast cancer risk, particularly among women engaging in moderate-intensity occupational and household activities. The study found that vigorous activity had little impact on risk reduction, highlighting the importance of frequency and duration of total activity.
A recent study published in the American Journal of Clinical Nutrition found that women with good diets tend to eat more fruits and a greater variety of foods. The researchers also discovered a strong association between healthy eating indexes and socioeconomic status, suggesting that access to resources can influence dietary choices.
The study uses DNA microarray analysis to predict estrogen receptor status and lymph node involvement in breast tumors. This technique holds promise for improved clinical diagnosis and treatment strategies, potentially obviating the need for extensive surgery.
The Phase II trial treating women with early-stage breast cancer has shown significant cell kill without damage to the skin. The technology uses adaptively focused microwave radiation that selectively heats and kills cancer cells, potentially reducing or eliminating breast surgery.
Recruitment to breast cancer chemotherapy trials for women at high risk of the disease remains a concern in the UK. A recent study found that only 10% of eligible women opted for these trials, highlighting the need for increased recruitment efforts.
A recent study published in Psycho-Oncology suggests that children of mothers with breast cancer can handle the bad news better than previously thought. The study found that these children experienced fewer behavior problems and anxiety symptoms compared to their peers.
A new study found that PET scans changed clinical management for 60% of women with recurrent breast cancer, including shifting from surgery to radiation therapy or medical treatment. The scan also significantly impacted disease staging, upstaging 28% and downstaging 8%, leading to more patients being classified as stage IV.
A $26.5 million grant has funded a massive study comparing digital and film mammography to determine its effectiveness in breast cancer diagnosis. The Digital Mammographic Imaging Screening Trial will involve almost 50,000 women and provide valuable insights into the technology's ability to detect early breast cancers.
A study found that consuming five or ten grams of ground flaxseed daily for seven weeks reduced blood levels of certain estrogens associated with an increased risk of breast cancer. The researchers believe that lignans in flaxseed may lower estrogen levels by inhibiting enzymes involved in estrogen synthesis.
The Fred Hutchinson Cancer Research Center has received a $2.5 million gift from the Avon Products Foundation to support innovative breast cancer research and clinical care initiatives, including immune response-based treatments and access to quality care for medically underserved women.
A Mayo Clinic study published in Cancer journal reveals that daily alcohol consumption by women whose mothers, sisters or daughters have breast cancer may increase their risk for getting the cancer. The study found an increased risk among first-degree relatives of women with breast cancer, but less evidence among second-degree relatives.
A study of 13,958 Canadian women found that the median time from screening to first assessment was 2.6 weeks and to diagnosis was 3.7 weeks. Women with breast cancer waited shorter times than those with benign findings. However, even with expedited investigations, 10% of women with breast cancer still waited over 12 weeks for a diagnosis.
A new imaging method developed at Ohio State University uses computerized analysis of magnetic resonance images to detect blurred regions that may indicate cancer. This method could significantly reduce the number of painful biopsies women undergo, with a recent study showing nearly 100% accuracy in detecting these regions.
A five-year research project investigates the quality of life of older adult long-term cancer survivors, revealing that while cancer can affect their identity and relationships, it does not fundamentally change who they are. Many survivors report positive family dynamics and hope for the future after treatment.
A statistical analysis of 47 randomized trials involving 18,000 women found that chemotherapy improves survival time adjusted for quality of life for both younger and older women. Younger women treated with chemotherapy gained an average of 10.3 months of relapse-free survival within 10 years.
The new imaging device provides a larger bore diameter, allowing patients with large or obese bodies to receive scans in treatment position. This enables oncologists to obtain more accurate views of the patient's body dimensions and calculate radiation doses for cancer treatment.
Sentinel lymph node biopsy is a promising technique gaining popularity for breast cancer treatment. The new guidelines recommend infrequent surgeons not perform SLN biopsy, and positive results prompt full axillary dissection. However, SLN biopsy is contraindicated in patients with clinically palpable nodes, locally advanced breast can...
Researchers found that 71% of women experienced ovarian function loss and rapid bone loss after six months of chemotherapy, leading to significant bone loss by the end of one year. The study suggests that earlier intervention with calcium, vitamin D, weight-bearing exercise, and counseling may help prevent bone loss in these patients.
Researchers at Virginia Tech are conducting animal trials to test a new compound against breast cancer, which strengthens the immune system. The project aims to determine the involvement of the immune system in the drug's cancer-killing ability and assess its effectiveness in treating breast cancer in humans.
A study suggests that emphasizing the risks of avoiding breast cancer screening is effective in motivating women to get screened, particularly for white and Hispanic participants. However, black participants showed no significant change in mammography rates during the study period.
A new study suggests tamoxifen may decrease risk of first breast cancer but increase risk of estrogen-receptor negative, more difficult-to-treat contralateral tumors in the opposite breast.
Researchers found that Raloxifene stimulated the growth of ovarian cancer cell lines, raising concerns about its use in ER+ patients. The study advises caution when prescribing Raloxifene to women with a history of breast cancer and ovarian cancer.
A new statistical approach identifies four DNA sequence variations in three genes that work together to heighten a woman's risk of breast cancer. The technique, called Multifactor Dimensionality Reduction, can analyze multiple gene interactions using data from a reasonable number of patients.
A study published in The New England Journal of Medicine reveals that weight gain and chemotherapy-induced ovarian failure are common problems among younger women with early-stage breast cancer. Researchers emphasize the importance of monitoring bone density and taking calcium supplements to mitigate potential long-term side effects.
A study by University of Pennsylvania researchers found that the human myelocytomatosis (MYC) gene can induce spontaneous mutations in other genes, such as Nras or Kras2, leading to more tumor growth even after the MYC gene is shut off. This has implications for the search for therapeutics in cases of MYC-induced breast cancer.
Researchers at Massachusetts General Hospital identify a new mechanism of breast cancer metastasis involving the growth of lymphatic vessels inside tumors. This discovery could lead to new approaches to treating and preventing cancer metastasis.
Researchers have identified a pivotal early event in breast cancer development, where mammary epithelial cells spontaneously surmount senescence and acquire genomic instability. This finding could lead to new targets for very early detection and treatment of breast cancer, as well as broader implications for understanding carcinogenesis.
Researchers found that women who exercised on their own had better aerobic results than those in supervised groups. Exercise improved physical functioning by 5.7 points, with significant weight loss among tamoxifen users.
A recent study published in the American Journal of Epidemiology found that breastfeeding for two or more years significantly reduces breast cancer risk among Chinese women. The study showed a 50 percent reduction in breast cancer risk for women who breastfed for more than 24 months, compared to those who did not.
A new study found that women treated in teaching hospitals for initial breast cancer surgery had a five-year survival rate of 93%, compared to 89% for those treated in community hospitals. Comprehensive care approaches and multidisciplinary services may contribute to these differences.
A study by Dr. Vivek Goel and colleagues found that women with early-stage breast cancer treated in specialized teaching hospitals had a higher 5-year survival rate than those treated in community hospitals. The results suggest that initial treatment at specialized centers may be advantageous for women with small tumors.
The Canadian Medical Association Journal has published new clinical practice guidelines for managing lymphedema related to breast cancer treatment. The guidelines include an updated patient version for women battling the condition. These updates aim to improve patient care and outcomes.
A study published in Radiology found that women who receive further testing on the same day as an abnormal screening mammogram experience significantly less stress than those who have to wait. The researchers also found that offering immediate diagnostic imaging can reduce the stress of a false positive mammogram, but would increase ov...
A large clinical trial found that tamoxifen does not increase cardiovascular risk in healthy women or those with coronary heart disease. Women who received tamoxifen had the same rate of cardiovascular events as those receiving a placebo, regardless of prior heart problems.
A new study confirms previous findings that hair color, number of moles on the legs, and history of sunburn are risk factors for malignant melanoma. The study also found that use of sunbeds and other tanning devices is associated with an increased risk of the disease.
Scientists successfully transform human mammary epithelial cells into breast cancer cells by introducing three cancer-associated genes, revealing key mechanisms underlying tumorigenesis. The study also highlights the importance of cross-talk between cancer cells and their microenvironment in metastasis.
New research reveals estrogen can regress tamoxifen-resistant breast tumors by increasing apoptosis. Low levels of estradiol also inhibit tumor growth in raloxifene-resistant breast cancer cells.
A new study by University of North Carolina researchers finds that financial factors are a major contributor to the racial disparities in mammography rates among black women. The study, which controlled for other variables, found that black women who received a recommendation for mammography were more likely to have health insurance an...
Researchers are applying their radar technology to detect missiles to a FDA-approved Phase II clinical trial for treating breast cancer. The treatment involves heated microwave radiation that kills cancer cells without burning the skin.
A study of 120 Asian women found that those with the highest isoflavone levels had a 50% decrease in breast cancer risk compared to those with lower levels. The researchers recommend including soy in the diet from teenage years to reduce cancer risk.
Venlafaxine has been shown to alleviate hot flashes in postmenopausal women, including those with breast cancer, by reducing symptoms by 61%. The study found that a daily dose of 37.5-75mg was optimal for effect, with mild improvements in quality of life and no significant impact on libido.
A new UB study reveals a significant association between breast cancer risk and physical characteristics of insulin resistance, including abdominal fat distribution and higher-than-normal male and female sex hormones. Women with increased waist-to-hip ratio and oily skin are at greater risk of developing breast cancer.
A new study by UCSF/SFVAMC researchers found that mammography is equally effective in detecting breast cancer in women with and without a family history. The study analyzed data from over 389,000 women and showed that mammography detects nearly 85% of cancers in women aged 50-69, regardless of family history.
Recent findings on autophagy, a vital cellular process, reveal its connection to various human diseases such as breast cancer, cardiovascular disease, and neurodegenerative conditions. Autophagy's role in maintaining cell development is also highlighted, alongside the challenges researchers face in understanding its mechanisms.
Scientists have discovered that the protein ATR is responsible for activating BRCA1 in response to UV light-induced DNA damage, increasing breast cancer susceptibility. This discovery provides new evidence for ATR as a breast cancer susceptibility gene.
A Yale study reveals that stereotactic core needle biopsy can underestimate breast cancer severity, particularly in cases of calcification and atypical ductal hyperplasia. The study found a 9.5% underestimation rate overall, with higher rates for these conditions.
The symposium aims to provide state-of-the-art information on breast cancer research. Five plenary speakers will discuss various topics, including targeted therapies and hormone replacement therapy.
Researchers found that the Ku protein plays a key role in mediating mammalian telomere capping, preventing chromosomal fusion. The discovery sheds light on cellular growth control and aberrations leading to cancer. Mouse cells lacking Ku develop chromosome fusions.
MARstem demonstrates potential as a multilineage hematopoietic therapy to treat or prevent pancytopenia following chemotherapy in breast cancer patients. The study's results show excellent safety and preliminary efficacy, suggesting MARstem may improve debilitating side effects of cancer treatment.
Randomized trials demonstrate the effectiveness of mammography programs in reducing breast cancer mortality. The studies showed that recall rates after first and subsequent screens were 9.5% and 4.6%, respectively. Additionally, organized breast cancer screening programs can provide more comprehensive monitoring for at-risk populations.
A large study of 381 postmenopausal women found no association between high fat intake and increased estrogen levels, contrary to long-held assumptions. The researchers concluded that reducing fat intake to lower hormone levels is unlikely to be a useful strategy in preventing breast cancer.
Women with BRCA 1 or 2 mutations may not have to fear radiation therapy due to no increased incidence of side effects. The study suggests similar recurrence rates and survival after five years, with additional treatment keeping cancer in check.
Researchers at UNC have developed a method to identify hypoxic tumor cells that are resistant to radiation and chemotherapy. The pimonidazole hypoxia marker allows scientists to focus on key factors associated with tumor aggressiveness and treatment resistance, offering new avenues for understanding cancer therapy.
A new study finds that breast cancer patients who actively express their emotions, such as talking about fears, experience less distress and improved health outcomes. This type of emotional expression is associated with fewer medical appointments for cancer-related issues.
Researchers found that women at high risk for breast and ovarian cancer scored very low on measures of psychological distress and disorders. Despite having a high-risk profile, these women had little or no worries about developing the disease.
Researchers at Northwestern University are conducting six studies on the role of diet and hormones in breast cancer prevention and development, as well as innovative translational therapies.
A study suggests that dietary fat is unlikely to cause breast cancer, but rather depletes the body of an essential nutrient that protects against the disease. The research concludes that age and oestrogen also play a role in breast cancer development.
A prospective study of 10,786 Italian women found a 40% lower risk of breast cancer in premenopausal women with the C-2 estrogen metabolism pathway, which produces less active by-products. Lifestyle changes such as physical activity and a low-fat diet high in cruciferous vegetables may shift estrogen metabolism from high-risk to low-risk.
Women taking tamoxifen for breast cancer prevention don't need regular uterine biopsies to detect early endometrial cancer. Abnormal vaginal bleeding is a more effective indicator of the rare but curable condition.
A study published in Cancer Research reveals that a gene called RhoC GTPase contributes to the development of an aggressive and deadly form of breast cancer. The research found that overexpression of this gene in normal cells leads to rapid tumor growth, invasion, and metastasis.