Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers found that anti-inflammatory agents are more effective in patients at higher risk of death from sepsis. Spiral computed tomography (CT) scans can help identify up to four times more lung cancers than chest x-rays, with 70% of tumors still in Stage 1.
A new technique called ductoscopy allows surgeons to directly visualize and remove abnormal tissue in the milk ducts, sparing normal breast tissue. This procedure has shown a high success rate in identifying and treating breast cancer, particularly in women with pathologic nipple discharge.
A University of Pittsburgh study found no overall increase in cancer deaths among TMI residents between 1979 and 1998. However, a slight increase in lymphatic and hematopoietic cancers was observed in women, related to everyday background radiation exposure.
A study by Dr Zeba Aziz found that socio-economic status significantly impacts breast cancer treatment and survival rates in developing countries. Women from lower socio-economic backgrounds often delay seeking medical help, resulting in delayed diagnosis and inadequate treatment, leading to poor survival rates.
A new trial shows that high-dose chemotherapy has no significant benefits for women with severe breast cancer. However, molecularly targeted drugs in combination with chemotherapy show promising results.
Research by Dr Anne Chantal Braud and her team has shown that older women with breast cancer can tolerate powerful medication, contradicting initial expectations. The study examined the effects of surgery, radiotherapy, chemotherapy, and hormone therapy on 179 women over 70 years old.
A patient's view on clinical trials highlights the importance of thorough explanations, confidentiality, and compassionate communication. Sylvia Achin emphasizes that patients risk losing their priorities, relationships, and even support when faced with a life-threatening disease like cancer. Effective communication can help alleviate ...
Researchers used precancerous breast cells from patients with Li-Fraumeni syndrome to test the effectiveness of chemopreventive agents in preventing cancer. Treatment with tamoxifen, a p53-rescue drug, and PPAR-ã agonist showed promise in stopping cancer development, suggesting new potential therapies for high-risk individuals.
Researchers found that fermented cabbage produces cancer-fighting isothiocyanates, which may prevent the growth of various types of cancer. The fermentation process also creates healthy compounds like lactic acid, making cabbage easier to digest.
Studies suggest that moderate dietary restriction, exercise, and healthy diet rich in omega-3 fatty acids can delay breast cancer growth and reduce risk. Calorie restriction is effective in both spontaneous and chemically induced rodent tumor models, but may have adverse effects on bone density.
Research found that approximately 20% of the breast cancers detected by screening mammography were ductal carcinoma in situ (DCIS), and the rate of DCIS diagnoses per 1000 mammograms increased with age. Mammograms were also more sensitive at detecting DCIS than invasive breast cancer.
Researchers at NYU will evaluate effectiveness of educational and counseling interventions in helping breast cancer patients cope with diagnosis, treatment, and recovery. The proposed trial compares four groups receiving different approaches to education and counseling.
A recent study published by Georgetown University Medical Center found that female rats exposed to alcohol in utero developed breast tumors at a significantly higher rate, with increased breast density and more estrogen receptors. The findings suggest that mothers who drink during pregnancy may increase their daughter's cancer risk.
A study in the Journal of the National Cancer Institute found that women undergoing prophylactic bilateral mastectomy often overestimate their breast cancer risk. Meanwhile, a separate study uncovered no association between antiperspirant use and increased breast cancer risk. Furthermore, researchers identified a serum protein expressi...
A study recalculated cancer incidence rates from SEER data and found significant percentage changes (3-14%) between reporting-adjusted and unadjusted rates. The authors emphasize the importance of considering these corrections to accurately monitor trends in cancer incidence.
Research suggests that moderate to high levels of maternal alcohol consumption during pregnancy can lead to increased estrogen levels in the fetus. As a result, female offspring are more likely to develop breast tumors later in life.
A study published in Cancer Research found that COX-2 inhibitors, such as celecoxib, can delay the onset of breast cancer in genetically bred HER-2/neu mice. The mice treated with celecoxib experienced a significant reduction in tumor incidence and a longer time to disease progression compared to control mice.
Daily estradiol treatment for three weeks reduces mammary cancer incidence by 90% in rats. The study suggests a simple and safe hormonal prevention method for human breast cancer, comparable to full-term pregnancy or tamoxifen treatment.
A University of Toronto study reveals that women who undergo prophylactic bilateral mastectomy significantly overestimate their breast cancer risk, except for those with BRCA1 and BRCA2 mutations. The study suggests that formal genetic counselling is essential for women considering the procedure to make an informed decision.
Dr. Paskett will lead a study comparing the effects of low-fat and low-sugar diets on breast cancer risk in pre-menopausal women. The study aims to explore potential biomarkers for nutrition's role in preventing breast cancer.
Researchers investigate potential link between low-level exposure to zeranol and breast cancer risk. The study explores the biological effects of zeranol, a synthetic non-steroidal agent used in cattle feed, on human breast tissue.
Researchers at Cold Spring Harbor Laboratory have discovered a new breast cancer gene called DBC2, which is associated with sporadic breast cancer. The study shows that the Dbc2 protein kills cancer cells or stops them from growing, making it a promising target for treatment.
The Fred Hutchinson Cancer Center is developing a blood test for breast cancer detection, using biomarkers such as circulating breast-tumor cells and growth factors. The project aims to improve breast-cancer detection and diagnosis by complementing mammography with molecular-screening tools.
A focused microwave heat therapy technique shows promise in killing tumor cells before surgery and radiation, with a majority of patients experiencing significant tumor kill. The technology was invented by MIT researchers and is being developed into a clinical thermotherapy system by Celsion Corporation.
A study of nearly 133,500 female California teachers found a 51% higher rate of breast cancer and 72% greater risk of endometrial cancer compared to comparable women. Researchers believe lifestyle and environmental factors may contribute to the increased risk.
The Lancet Oncology editorial discusses the EPA's 10-year report on diesel exhaust fumes' toxic effects, emphasizing public health implications. The article also reviews mathematical models identifying breast cancer risk factors and explores chemoprevention strategies.
A randomized trial of breast self-examination (BSE) in Shanghai found no difference in breast cancer mortality between BSE and control groups. However, women taught BSE had more benign breast lesions detected during every year of the trial.
The Avon Foundation has awarded $2.5 million in initial grants through its Progress for Patients program, supporting translational research on breast cancer at eight institutions. The grants focus on minority and underserved women, with a goal of closing the gap between discovery and delivery in breast cancer research.
Researchers found that patients with advanced prostate cancer treated with zoledronic acid experienced fewer bone complications and less pain compared to those who received a placebo. Additionally, tumors in patients treated with the HuMV833 antiangiogenic antibody showed marked differences in antibody uptake, distribution, and clearance.
Researchers examine the mechanisms underlying inactivation of BRCA1 and its impact on patient management. The study assesses the potential usefulness of BRCA1 as a prognostic tool and predictive marker for response to different classes of drugs.
A recent study published in New England Journal of Medicine found that genetically identical twin pairs had similar breast densities, while non-identical pairs had breast densities about half as similar. This suggests that genetic factors play a major role in explaining why women of the same age have different breast density.
The Sister Study aims to investigate the causes of breast cancer by recruiting 50,000 sisters of women with breast cancer. The researchers will collect biological and environmental samples, as well as questionnaires about health histories, environmental exposures, and lifestyles.
The study found that hormone replacement therapy (HRT) increases the risk of breast cancer, pulmonary embolism, and stroke in women, while reducing the risk of colorectal cancer and hip fractures. HRT may also increase the risk of cardiovascular disease among older women.
A study of 34,708 postmenopausal women found that compliance with the Dietary Guidelines reduced overall cancer incidence by 5-15% across quintiles. Regular exercise and weight management also played a significant role in reducing breast, colon, and uterine cancer risk.
The National Lung Screening Trial will enroll 50,000 current or former smokers in the US to compare the effectiveness of CT scans and chest X-rays in detecting lung cancer. The trial aims to determine if early detection can lead to a reduction in lung cancer deaths.
Research studies found small but statistically significant increases in cancer risks among BRCA1 mutation carriers, including colon, liver, pancreatic, and cervical cancers. Additionally, male BRCA1 mutation carriers had a slightly elevated risk of prostate cancer.
The Dartmouth team is learning about breast tissue structure and behavior using magnetic resonance elastography, electrical impedance spectral imaging, microwave imaging spectroscopy, and near infrared spectral imaging. By combining these four techniques, they aim to provide a more complete picture of normal and abnormal breast tissue.
The National Functional Genomics Project aims to track genetic changes in cancer to design more effective therapeutic agents and understand hereditary and environmental influences. Moffitt's expertise in translational research will accelerate the translation of molecular medicine into early detection and clinical treatment.
Researchers at Memorial Sloan-Kettering Cancer Center have uncovered the function of the BRCA2 protein, which interacts directly with DNA to repair genetic damage. This new understanding sheds light on how mutations in the BRCA2 gene contribute to inherited breast and ovarian cancers.
A recent clinical trial found that tamoxifen reduces the frequency of breast cancer by a third in women at increased risk. However, tamoxifen use also increases the risk of blood-clotting complications, which may contribute to higher death rates.
A study by Nikola Pavletich and colleagues reveals that BRCA2 protein binds to damaged DNA, repairing it. This discovery sheds light on the mechanism of breast cancer development and opens new avenues for treatment strategies.
Research suggests that diet is a second leading cause of cancer, accounting for approximately 30% of cancers in developed countries. A healthy weight, restricted alcohol consumption, and a balanced diet rich in fruits, vegetables, and cereals can help reduce cancer risk.
A recent study by OHSU suggests that hormone replacement therapy (HRT) can lead to improved breast cancer detection and survival rates. The research found that HRT users had a 100% survival rate after six years, compared to an 87% survival rate for non-users.
Researchers discovered tetrathiomolybdate (TM) inhibits tumor angiogenesis by reducing copper levels and blocking NFkB signaling pathway. TM suppressed tumor growth in mice with aggressive breast cancer, prevented blood vessel formation, and induced disease-free survival.
A study found no association between carbohydrate and sucrose intake and pancreatic cancer risk, but a diet high in glycemic load increased the risk among overweight women. Dairy product consumption was not associated with reduced breast cancer risk among postmenopausal women, but may be protective in premenopausal women.
A newly developed 200-channel hyperspectral remote sensing capability has shown astounding results in improving breast cancer diagnosis accuracy. The algorithm, invented by ONR scientists Dr. Harold Szu and James Buss, uses a brain-like approach to analyze thermal heat distribution and detect early-stage ductal carcinoma in situ.
A Canadian National Breast Cancer Screening Study found that annual mammography for five years had no impact on breast cancer deaths in women aged 40-49. The US Preventive Services Task Force recommends starting mammography at age 40, but evidence is considered 'fair' due to conflicting results.
A large-scale study involving 50,000 Canadian women in their 40s found that annual mammography screenings did not reduce breast cancer deaths, but increased cancer detection rates. The study's results, published in Annals of Internal Medicine, challenge the long-held assumption that mammography screening saves lives.
A study by University of Southern California researchers found that Asian-American women who consumed soy on a weekly basis during their teen years and adulthood had about half the risk of developing breast cancer. The risk was also lowered for those who ate soy regularly during adolescence but consumed little during adulthood.
Research identifies young women with breast cancer at increased risk of ovarian cancer, including those with BRCA1 and BRCA2 gene mutations. The study suggests that these women may benefit from prophylactic oophorectomy or counseling.
A recent study by Ohio State University researchers found that cancer patients with a history of mood disorders are most at risk for developing post-traumatic stress disorder (PTSD). The study suggests that doctors should screen all cancer patients for depressive and anxiety symptoms, particularly those with past mood disorders.
The incidence of Kaposi's sarcoma and non-Hodgkin's lymphoma declined sharply in the mid-1990s, mainly due to AIDS treatment improvements. However, non-AIDS-associated non-Hodgkin's lymphoma incidence has continued to rise.
A recent study suggests that breast cancer susceptibility gene may be associated with lower penetrance than previously estimated. Genetic counselors must consider multiple risk factors when predicting an individual's risk for breast cancer, as the presence of a BRCA mutation does not define her overall risk.
A synthetic compound called oxomate has been developed to target breast cancer, with promising results in animal tests and potential for a once-a-day pill or vitamin component. If confirmed, oxomate could offer an alternative to current treatments and provide benefits to those at high risk of cancer
A study found that tailored telephone and mail reminders increased mammography screenings in women over 51. The combination of both methods led to more than twice as many follow-up screenings compared to usual care.
A major NCI study reveals that long-term survivors of Hodgkin's disease are twice as likely to develop a solid tumor compared to the general population. The study found that certain treatments for Hodgkin's disease increase the risk of second cancers, but effective therapies have a significant survival benefit.
Researchers at Cedars-Sinai Medical Center have found that a potent experimental drug called 2C4 slows tumor growth in both breast and prostate cancer tumors in mice, even when small amounts of HER-2/neu are expressed. The study's findings may lead to a new way to treat breast and prostate cancers.
A study by researchers at the University of Southern California found that obesity and weight gain in Hispanic women are associated with a nearly two-fold increased risk of breast cancer. The risk was elevated regardless of menopausal status, and particularly among those who gained substantial weight after age 18.
A research team led by Dr. Rakesh Kumar has discovered a new form of a protein associated with aggressive forms of cancer, including breast cancer. MTA1s appears to intercept the key protein receptor responsible for communicating with estrogen inside cells.
A randomized trial found that a shorter radiation therapy course did not increase breast cancer recurrence or cosmetic issues, but may have quality-of-life benefits. The study suggests that women with small, completely removed tumors could potentially receive shorter, more convenient treatment.