Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study found that bilateral mastectomy significantly lowers breast cancer risk in high-risk women with BRCA1 and BRCA2 mutations. Short-term hormone replacement therapy is safe after oophorectomy, increasing life expectancy by 3.34 to 4.65 years.
Two studies in the February 18 issue of JNCI investigated aspirin use and its association with two types of cancer. Regular aspirin use was found to lower Hodgkin's lymphoma risk, while patients with Barrett's esophagus may benefit from cost-effective aspirin therapy for esophageal cancer chemoprevention.
A study found that women who used more antibiotics had an increased risk of breast cancer. The researchers also found that all classes of antibiotics were associated with an increased risk, and that long-term use of antibiotics was linked to death due to breast cancer.
The American Association for Cancer Research has honored scientists who have made significant contributions to the prevention, detection, and treatment of cancer. These awards recognize outstanding achievements in basic research, clinical care, therapeutics, and prevention.
Researchers at the University of Pennsylvania are conducting a clinical trial to evaluate the safety and efficacy of a telomerase peptide-based vaccine against breast cancer. The study aims to stimulate an immune response that can target and kill cancer cells, with the goal of improving patient health.
Researchers discuss the need for additional research and standardization in partial-breast irradiation and accelerated partial-breast irradiation. A new study also finds that preoperative chemoradiation may benefit some patients with rectal cancer, while a diet high in glycemic load is linked to an increased risk of colorectal cancer.
A study found that a computer-aided detection system did not change mammography recall rates or breast cancer detection rates, suggesting it may not be beneficial in academic practices. The results were similar even when focusing on the seven highest-volume radiologists at the center.
The HABITS trial was terminated after an unacceptably high risk of recurrent breast cancer was found in women with previous breast cancer who received hormone therapy, compared to those without hormones. Women on active treatment have been advised to discontinue use.
A clinical trial was stopped early after showing an unacceptably high risk of breast cancer recurrence in women who received hormone therapy. The study found that even short-term use of HRT poses a significant risk, prompting the need for alternative safe and effective strategies for managing menopausal symptoms in these women.
Researchers at the University of Iowa have identified a new mode of action for tamoxifen, an anti-estrogen medication used to treat breast cancer. Tamoxifen turns on the tumor suppressor gene maspin, which inhibits tumor invasion and metastasis in normal breast cells.
A recent study suggests that breast augmentation procedures can affect the sensitivity of mammography, with women with implants having lower detection rates. However, this does not necessarily translate to a higher risk of advanced disease at diagnosis. Women with breast implants should still follow recommended screening intervals.
A pooled analysis of 15 clinical trials reveals that radiotherapy significantly reduces breast cancer recurrence and mortality rates after breast-conserving surgery. Women who received radiotherapy had a lower risk of relapse and mortality compared to those who underwent surgery alone.
Research confirms that psychosocial factors significantly influence health outcomes. Studies show how stress levels can overwhelm the body's immune system and increase disease risk. The review emphasizes the importance of understanding psychoendoneuroimmunology to develop effective coping strategies.
Researchers have identified wound-healing genes that are active in prostate and liver cancers, which are more aggressive and likely to spread. This discovery could lead to personalized treatment options by matching patients with specific drugs targeting these abnormal proteins.
Tumors use Stat3 signaling to secrete factors that inhibit the immune system, keeping dendritic cells from maturing. This activation blocks expression of inflammatory mediators required to trigger the immune response. New treatments aimed at flushing cancer cells into the open may help the body's armies against disease destroy them.
A recent study found no association between BRCA mutations and an increased risk of colorectal cancer. Researchers tested blood samples from 1,422 patients with colorectal cancer and 1,566 control subjects for mutations in BRCA1 or BRCA2 genes. The results suggest that BRCA mutation carriers do not need to worry about an elevated risk ...
Researchers found no association between BRCA1/2 mutations and colorectal cancer risk in two studies. No increased risk was observed among Ashkenazi Jewish mutation carriers or those with a family history of breast cancer.
A meta-analysis of six studies found autologous bone marrow transplantation to be more effective in disease-free survival but similar overall survival compared to chemotherapy. Imatinib also shows promise as a treatment for advanced neuroblastoma, while tamoxifen use is linked to increased risk of rare uterine cancers.
A study led by Rutgers University professor Mohamed Rafi founds a compound called ß-hydroxy-DHP (BHP) in licorice root supplements that can stop the growth of prostate and breast cancer cells. This could provide new hope for more effective therapies against these leading cancers.
Researchers identified frequent BRAF mutations in intermittent sun-exposed skin melanomas, but rare mutations in chronically sun-damaged or unseen skin. Additionally, bladder cancer cell lines showed defective checkpoint function, suggesting barriers to carcinogenesis. These findings may inform therapeutic strategies for these diseases.
Researchers found that oral drug ZD1839 suppressed the growth of ER-negative breast cancer cells and delayed the formation of tumors in transgenic mice. The treatment also reduced proliferation of normal breast cells by 20.3% and tumor cells by 42%. However, long-term safety data are needed for further research.
A new study suggests that premenopausal women with ER-negative breast cancer may benefit from adjuvant chemotherapy alone or followed by goserelin, while those with ER-positive tumors show no significant difference in outcomes. The findings support the idea of ovarian suppression as a treatment alternative for some premenopausal women.
A study found that heterozygous disruption of the beclin 1 autophagy gene promotes tumorigenesis. Autophagy has been shown to have a tumor suppressor role, and this study highlights its importance in cancer development.
A nationwide survey found that 56% of women with early stage breast cancer received less than 85% of their prescribed chemotherapy dose intensity. Treatment delays and dose reductions were common due to neutropenia, a shortage of infection-fighting white blood cells.
Researchers at Johns Hopkins Medicine developed a multiparametric MRI technique combining T1, T2, and 3D imaging with contrast agents to improve breast cancer detection. The study successfully identified benign and malignant tissue clusters in all 36 patients, revealing the effectiveness of the combined approach.
The study aims to identify new forms of therapy and hope for those at high risk of developing cancer. Six institutions will design and conduct experiments to test the cancer prevention potential of substances affecting various processes involved in cancer's formation and spread.
A study found that EGFR-positive breast cancer patients had worse disease-free and overall survival rates compared to those with negative EGFR expression. The findings suggest potential prognostic significance of EGFR status in breast cancer.
Researchers at Moffitt will evaluate vaccine therapy INGN 225 in a phase I/II study for patients with advanced breast cancer. The treatment has shown promising results in preclinical trials, with 100% protection against tumors achieved when dendritic cells were activated.
The BCIRG 001 trial showed a significant reduction in recurrence of disease in hormone-receptor-positive and negative patients with a Taxotere-based treatment, improving disease-free survival by 28% and overall survival by 30%. The regimen demonstrated effectiveness across various stages of breast cancer.
A new study reveals that young breast cancer survivors are worried about their fertility and that healthcare providers often fail to address these concerns. The study's findings highlight the need for better education and support for women with breast cancer who want to have children.
Breast cancer tumors that become resistant to tamoxifen over-produce a protein called MTA-1, which can be used to predict treatment outcomes and guide therapy selection. Testing for MTA-1 prior to treatment may help devise more aggressive strategies to combat breast cancer.
A recent study found that over 20% of patients with estrogen-negative breast cancer had a complete pathologic response to treatment, compared to just 5% in estrogen-positive cancers. The researchers suggest that endocrine therapies may be a more effective initial treatment for these patients.
A study by Michigan Medicine found that seeking a second opinion for breast cancer may significantly alter diagnosis and treatment plans. The research, led by Dr. Amy Rochester Guest, suggests that patients with complex cases or those who are diagnosed with both breasts affected benefit most from consulting specialized teams.
The new device detects subtle changes in cells before tumor formation, enabling early detection and potentially improved treatment outcomes. It can image small breasts and axillary lymph nodes, and works without breast compression, making it more comfortable for patients.
A new nomogram developed by Memorial Sloan Kettering Cancer Center accurately predicts the likelihood of axillary lymph node metastasis in breast cancer patients. The model considers various pathological factors, including tumor size and type, estrogen-receptor status, and detection methods.
A new cryoablation technique has shown promising results in killing most small malignant breast cancers, with seven out of nine patients experiencing complete tumor necrosis. The technique also showed no cosmetic changes to the breast's appearance and may be a viable option for women with early-stage disease.
A new procedure using cryotherapy has been shown to effectively reduce the size of benign breast lumps by an average of 73% without significant complications. Patients report satisfactory cosmetic results and a high level of patient acceptance for this non-invasive treatment.
A study of 362 patients has shown that breast conservation after neoadjuvant chemotherapy is a safe and effective alternative to mastectomy for many patients. The key to success lies in careful patient selection and coordination among treatment specialists, with low rates of local-regional recurrence reported.
A study found that patients with high levels of low molecular weight cyclin E have aggressive, invasive breast cancer, and the protein may be a better predictor of patient outcome than current markers. This altered form of cyclin E can induce genetic instability, making tumors unresponsive to treatment.
A new study at Dana-Farber Cancer Institute finds that surgery alone is not sufficient to treat DCIS, a common type of breast lesion. Recurrence rates were higher than expected, with 13 patients experiencing repeated DCIS lesions and four diagnosed with invasive breast cancer.
Researchers discovered a new metabolite, endoxifen, which is present in higher concentrations than previously thought and varies with genetic composition. This finding suggests that tamoxifen's effectiveness may be influenced by individual differences in metabolism.
Researchers at Michigan Medicine developed computer-assisted breast imaging systems that improve the accuracy of interpretation of digital mammograms and breast ultrasound images. The systems were shown to improve the ability of highly experienced radiologists to detect cancerous tumors, potentially sparing women from unnecessary biops...
A study of annual CT screenings found that 80% of diagnosed Stage I lung cancers were curable. Long-term follow-up showed a high cure rate for patients with screen-diagnosed lung cancer who underwent surgery. The findings support the use of widespread annual low-dose CT screening in high-risk smokers to detect early-stage lung cancer.
The University of Pennsylvania School of Medicine has established a first-of-its-kind peer-support helpline for individuals concerned about hereditary breast and ovarian cancer. The helpline provides direct access to trained volunteers who offer emotional support, referrals, and information on genetic counseling and risk management.
Researchers developed a magnetic resonance spectroscopy method to quantify choline levels in breast tissue, distinguishing malignant lesions from benign lumps. The technique uses high magnetic fields and mathematical approach to account for tissue variations.
Researchers discovered two new proteins, BRCC36 and RCC45, that are part of the BRCC complex and linked to sporadic breast cancers. The complex regulates DNA repair and cell division, influencing cancer susceptibility.
Researchers found that PABA significantly improves the effects of chemotherapy drugs and radiation on cancer cells. Additionally, FES PET imaging can predict response to endocrine therapy in breast cancer patients by measuring regional target expression.
A UCLA study has found that younger women with breast cancer often experience persistent energy loss and psychological difficulties, despite overall good quality of life. The study highlights the need for targeted interventions to support these subgroups.
A study by Ohio State University found that financial stress was a significant contributor to depression in breast cancer patients, even stronger than grief from a loved one. Researchers analyzed data from 210 women with stage II or III breast cancer and found a strong link between money-related stress and depressive symptoms.
Researchers found decreased tumor blood flow correlated significantly with survival in patients treated with neoadjuvant chemotherapy. The study suggests tumor biology should be an important factor in considering patient response to treatment.
Researchers demonstrate that removing beta-1 integrin gene prevents breast cancer growth in mice, halting tumor progression and even regressing advanced cancers. However, some tumors spontaneously recur over time, highlighting the need for further investigation into mechanisms of resistance.
A study by French researchers found that young breast cancer patients who undergo lumpectomy have a higher risk of late recurrence compared to those who opt for mastectomy. The risk is particularly high among women under 40 years old.
Researchers successfully grew breast cancer tissue from human and mouse mammary stem cells, paving the way for new treatments. The findings aim to overcome drug resistance and relapse in breast cancer patients, with potential to transform cancer treatment.
Current drinkers who consume at least 30 grams of alcohol daily have an 80% higher risk of breast cancer compared to nondrinkers. Alcohol is associated with a strong increase in hormonally responsive types of breast cancer, including lobular and ER+/PR+ tumors.
Research studies reveal that weight loss, exercise, and dietary changes can lower breast cancer risk by up to five percent of body weight and increase physical activity levels associated with reduced mammographic breast density. Additionally, a low-carbohydrate diet may be more effective in preventing prostate cancer progression.
A new OHSU study reveals that consuming four or more servings of fruits and vegetables per day can significantly lower the risk of breast cancer. The research, conducted in Shanghai, China, found a 50% reduced risk among participants who met this daily intake threshold.
The Mayo Clinic research reveals a molecular mechanism involved in cell cycle regulation of the BRCA1 tumor suppressor gene. The team found that phosphorylation is required at certain stages to activate proteins associated with the BRCA1 gene.
A landmark study provides accurate lifetime risk estimates for BRCA1 and BRCA2 gene mutations, with women carrying the BRCA1 gene facing a 54% risk of ovarian cancer. The study also highlights the negative impact of obesity and lack of exercise on breast cancer development in women with the mutation.
Women with BRCA1 mutations have a poorer prognosis for breast cancer compared to those without the mutation. However, chemotherapy may improve survival rates for these patients. The study suggests that physicians should consider BRCA1 mutation status when making treatment decisions.
Women with BRCA1 and BRCA2 mutations have a high risk of developing breast cancer, but exercising during adolescence and maintaining a healthy weight may slow its onset. The study found that these lifestyle factors were protective regardless of birth year or family history.